美国成年人咖啡因摄入与蛋白尿之间的反向关联:2005-2016年NHANES分析。

IF 1.6 4区 医学 Q2 Medicine
Acta Clinica Belgica Pub Date : 2023-12-01 Epub Date: 2023-06-06 DOI:10.1080/17843286.2023.2222243
Qiqi Ma, Shuaihua Song, Gaosi Xu
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引用次数: 0

摘要

目的:白蛋白尿是各种肾脏疾病的重要生物标志物,与肾脏预后有关。最近,摄入咖啡因显示出潜在的肾脏保护作用。然而,咖啡因摄入和蛋白尿之间的关系仍然难以捉摸。方法:我们进行了一项横断面研究,旨在利用2005-2016年国家健康和营养检查调查(NHANES)获得的数据,探讨美国成年人群中咖啡因摄入与蛋白尿之间的关系。咖啡因摄入量通过24小时饮食回忆进行评估,白蛋白尿通过白蛋白与肌酐的比值进行评估。采用多因素逻辑回归分析来探讨咖啡因摄入与蛋白尿之间的独立相关性。还进行了分组分析和相互作用测试。结果:在23060名参与者中,11.8%的人出现蛋白尿,并且蛋白尿的患病率随着咖啡因摄入三分位数的增加而降低(三分位数1:13%;三分位数2:111.9%;三分位位数3:110.5%;P P = 0.007),尤其是在女性和老年参与者中。结论:本研究首次表明咖啡因摄入与蛋白尿之间呈负相关,这进一步证实了咖啡因对肾脏的潜在保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inverse association between caffeine intake and albuminuria in US adults: an analysis of NHANES 2005-2016.

Objectives: Albuminuria is a significant biomarker of various kidney diseases and is associated with renal outcome. Recently, caffeine intake has shown potential renoprotective effects. However, the relationship between caffeine intake and albuminuria remains profoundly elusive.

Methods: We conducted a cross-sectional study aimed to explore the association between caffeine intake and albuminuria in the American adult population using the data acquired from the National Health and Nutrition Examination Survey (NHANES) 2005-2016. Caffeine intake was assessed by 24-h dietary recalls, and albuminuria was assessed by albumin-to-creatinine ratio. Multivariate logistic regression was performed to explore the independent association between caffeine intake and albuminuria. Subgroup analysis and interaction tests were also conducted.

Results: Among 23,060 participants, 11.8% of the individuals exhibited albuminuria, and the prevalence of albuminuria decreased with higher caffeine intake tertiles (Tertile 1: 13%; Tertile 2: 11.9%; Tertile 3: 10.5%; P < 0.001). After adjusted potential confounders, the results of logistic regression indicated that a higher caffeine intake was associated with a decreased risk of albuminuria (OR = 0.903; 95% CI: 0.84, 0.97; P = 0.007), especially in females and the participants aged <60 years and chronic kidney disease stage II.

Conclusion: The present study first indicated an inverse correlation between caffeine intake and albuminuria, which further confirmed the potentially protective effects of caffeine on the kidney.

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来源期刊
Acta Clinica Belgica
Acta Clinica Belgica 医学-医学:内科
CiteScore
2.90
自引率
0.00%
发文量
44
审稿时长
6-12 weeks
期刊介绍: Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine primarily publishes papers on clinical medicine, clinical chemistry, pathology and molecular biology, provided they describe results which contribute to our understanding of clinical problems or describe new methods applicable to clinical investigation. Readership includes physicians, pathologists, pharmacists and physicians working in non-academic and academic hospitals, practicing internal medicine and its subspecialties.
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