他汀类药物诱导的坏死性自身免疫性肌病(SINAM):病例报告和文献回顾

IF 1.6 4区医学 Q2 Medicine

Acta Clinica Belgica Pub Date : 2023-08-01 DOI:10.1080/17843286.2022.2156701

Leander Cornelis, Julien Duyck, Franciska Dedeurwaerdere, Gert De Schoenmakere, Thomas Malfait

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引用次数: 1

摘要

他汀类药物是一种众所周知且非常有效的治疗高胆固醇血症的药物，可以预防心血管疾病。偶尔，患者可能会经历肌肉相关事件，如肌痛或肌肉痉挛。最近，在使用他汀类药物的患者中有SINAM(他汀类药物诱导的坏死性自身免疫性肌病)的报道。虽然非常罕见，但它可能导致与横纹肌溶解相关的危及生命的情况。我们提出一个病例，涉及一个71岁的妇女谁提出了几个星期的肌肉疲劳。他汀类药物治疗停止，但症状没有缓解。进一步的检查诊断为SINAM，并开始使用免疫抑制剂治疗。

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Statin-induced necrotizing autoimmune myopathy (SINAM): case report and review of the literature.

Statins are a well-known and highly effective treatment for hypercholesterolemia in order to prevent cardiovascular disease. Occasionally, patients may experience muscle-related events such as myalgia or muscle cramps. Recently, SINAM (statin-induced necrotizing autoimmune myopathy) has been described in patients using statins. Although very uncommon, it may cause a life-threatening situation associated with rhabdomyolysis. We present a case concerning a 71-year-old woman who presented with muscle fatigue for several weeks. Statin therapy was discontinued but symptoms did not resolve. Further workup led to a diagnosis of SINAM for which treatment with immunosuppressants was started.

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来源期刊

Acta Clinica Belgica 医学-医学：内科

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine primarily publishes papers on clinical medicine, clinical chemistry, pathology and molecular biology, provided they describe results which contribute to our understanding of clinical problems or describe new methods applicable to clinical investigation. Readership includes physicians, pathologists, pharmacists and physicians working in non-academic and academic hospitals, practicing internal medicine and its subspecialties.