结核病研究(英文)最新文献

{"title":"Indications, Interpretation and Clinical Consequences of Tuberculin Skin Tests in Resource Limited Settings","authors":"F. Gopie, A. Hassankhan, W. Zijlmans, S. Vreden","doi":"10.4236/jtr.2021.93016","DOIUrl":"https://doi.org/10.4236/jtr.2021.93016","url":null,"abstract":"Objective: to evaluate the policy of TST testing in Suriname. As there is no gold \u0000standard to diagnose latent tuberculosis infection (LTBI), the tuberculin skin \u0000test (TST) is used to diagnose LTBI. However, internationally, the cut-off \u0000values of the TST are not uniform and depend on local tuberculosis (TB) \u0000epidemiology and guidelines for test initiation. In Suriname, where currently several \u0000indications exist for TSTs, cut-off values are set at 5 mm or 10 mm, depending \u0000on the age and/or medical history of the patient. LTBI classification is \u0000performed by pulmonologists primarily based on the American Thoracic Society \u0000targeted TB testing guidelines. Method: retrospective \u0000analysis of outpatient TST data between 2011 and 2019 from Suriname’s sole \u0000pulmonary medicine clinic. Result: 1373 patients were \u0000evaluated. 590 patients were from the screening group of whom 253 had a \u0000positive TST result, 46 of whom were classified as LTBI. In the contact tracing \u0000group of 649 patients, 616 had a positive TST, 352 of whom were classified as \u0000LTBI. In the medical condition group of 134 patients, 96 had a positive TST, 38 \u0000of whom were classified as LTBI. Eventually, positive TST results were found \u0000for 965 tested patients: 436 patients were classified as LTBI and 529 non-LTBI \u0000patients were not prescribed chemoprophylaxis. None of the non-LTBI \u0000TST-positive patients were diagnosed with active TB, including 174 patients \u0000with a TST result of 15 mm or greater and in need of IPT, but not prescribed by \u0000judgement of the pulmonologist or because of loss to follow-up. Conclusion: the overrepresentation of positive TST results in Suriname is attributable \u0000to stringent cut-off values, especially among patients who do not disclose TB \u0000risk factors. In our opinion the TST cut-off value for such patients in \u0000Suriname and other similar settings could be set at 15 mm. We also promote that \u0000for all patients with a TST result of 15 mm or greater, offering IPT should be \u0000considered (after excluding active TB).","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44809663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Sputum Dashboard and Dispatch Riders in Mitigating Delay in Sputum Samples’ Processing—Evidence from an Intervention in Lagos State, Nigeria","authors":"M. O. Fadeyi, A. Akindele, Adebayo Bakare, Bolaji Ahmed, Osman El-Tayeb, Taofeekat Ali, Yasir Othman, Obioha C Udunze, G. Dairo, Aderonke Agbaje","doi":"10.4236/jtr.2021.93014","DOIUrl":"https://doi.org/10.4236/jtr.2021.93014","url":null,"abstract":"The act of referring TB \u0000presumptive individuals after verbal screening to another health \u0000facility/diagnostic centres for testing often results in large loss to \u0000follow-up, owing to the many barriers people face in accessing care. The \u0000transportation of sputum samples is an efficient method of increasing access to \u0000tuberculosis (TB) diagnostics in areas where testing is not currently \u0000available. One of the major reasons for the low yield of TB cases in the field \u0000was delay in sputum sample transportation to diagnostic laboratories among \u0000other factors. Damien Foundation Belgium, carried out a unique sputum riders \u0000initiatives in 20 LGAs of Lagos state between Q3-2019 and Q4-2020. A total of \u000025 sputum dispatch riders across the 20 LGAs in the State who are monitored \u0000routinely on an electronic dashboard were engaged for sputum logistics. \u0000Therefore, this report highlights how the initiatives have contributed to increased TB case notification in a \u0000densely populated metropolitan city in Nigeria. Overall, 48,265 units of sputum \u0000samples were transported to the laboratory from the facilities 99.9% of results which were received from the \u0000laboratory by the dispatch riders. The contribution of sputum riders to the overall TB \u0000case detection by the project progressively increased from 9% when the \u0000intervention began to 57% as at Q4 2020. The transportation of sputum samples \u0000by motorcycle dispatch riders is an efficient method of increasing access to TB \u0000diagnostic services in communities where testing is not currently available.","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48916896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Pancreatic Lymphadenitis Tuberculosis Causing Inferior Vena Cava Thrombosis in Syria","authors":"M. K. Albuni, Ruba Zuhri Yafi, B. Sabbagh, M. Moubarak, Lina Khouri","doi":"10.4236/jtr.2021.93011","DOIUrl":"https://doi.org/10.4236/jtr.2021.93011","url":null,"abstract":"Background: Pancreatic tuberculosis (TB) \u0000is very rare, mostly due to the antibacterial effects of the pancreatic \u0000enzymes. The association of thrombosis and tuberculosis has been reported \u0000but that of inferior vena cava (IVC) thrombosis and pancreatic tuberculosis is \u0000extremely rare and has only been reported once. Case presentation: A case of pancreatic Tuberculosis and IVC thrombosis presented with \u0000constitutional symptoms. Ultrasonography and computerized tomography showed a \u0000lesion in the head of the pancreas and a large lymph mass. Magnetic resonance \u0000imaging (MRI) of (IVC) showed thrombosis in the IVC. Histological examination \u0000revealed necrotizing granulomas after a laparotomy. The patient received \u0000antituberculosis chemotherapy and low molecular weight heparin. Conclusion: Pancreatic TB is a challenge to diagnose especially in Resource-poor \u0000countries, which might lead to delay in treatment and worse complications.","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42900862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Qualitative Assessment of People-Centeredness of Inpatient Tuberculosis Treatment Services in Armenia","authors":"Z. Grigoryan, N. Truzyan, L. Musheghyan, V. Petrosyan","doi":"10.4236/jtr.2021.93017","DOIUrl":"https://doi.org/10.4236/jtr.2021.93017","url":null,"abstract":"Background: People-centered tuberculosis (TB) care promotes treatment adherence and \u0000outcomes. TB patients’ and families’ health education and protection of their \u0000rights are among the core components of people-centered care. We aimed to \u0000assess the level of people-centeredness of TB care as a proxy to quality in the \u0000largest inpatient unit of the National Pulmonology Center (NPC) in Armenia. Methods: We conducted a qualitative study by interviewing clinical and \u0000administrative staff, TB patients, and family members to learn their \u0000experiences about patient and family education and rights (PFE&R) \u0000protection practices focusing on two Joint Commission International (JCI) \u0000Standards for Hospital Accreditation. Mixed-conventional \u0000inductive and directed deductive content approach guided the analysis of data. Results: The study revealed various gaps in the \u0000provided services. According to the TB physicians and nurses, they routinely \u0000educated patients and families and took actions to protect their rights. \u0000However, practices reported by TB providers varied across clinical departments \u0000and professionals and did not meet the recommendations of the JCI standards. \u0000The document review revealed that no written policies or procedures existed in \u0000the NPC inpatient unit to guide the implementation of PFE&R. Lastly, \u0000patients’ inconsistent experiences were also indicative of the lack of \u0000standardization and issues with PFE&R implementation. Conclusion: Bridging the gap between existing and recommended practices by establishing \u0000and enforcing new people-centered policies and procedures is a pledge for \u0000improving operations and patients’ experiences with a potential nationwide \u0000impact in Armenia.","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44377309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does “Latent Tuberculosis Infection” (LTBI)” Really Exist? Genealogy of a Medical Nosology","authors":"P. Etienne","doi":"10.4236/jtr.2021.93018","DOIUrl":"https://doi.org/10.4236/jtr.2021.93018","url":null,"abstract":"Introduction: The diagnosis of latent tuberculosis infection (LTBI) is based on secular \u0000ways: chest radiography and tuberculin skin test (TST). In front of a recent \u0000enthusiasm for LTBI, this paper reports a historical perspective of this \u0000concept. Method: Bibliometric analysis and literature review from medical databases, using the terms “latent tuberculosis \u0000infection (“LTBI”), “primary tuberculosis”, “tuberculin skin test”, “tuberculosis”, \u0000and from reference books on tuberculosis. Results: In the PubMED/MEDLINE \u0000search for LTBI, a total of 7787 articles were found between 1901 and 2020, 95% from 2000 to 2020. In the first part of the 20th century, LTBI term \u0000was used for sub-clinical tuberculosis \u0000disease, the latency being also called “primary \u0000tuberculosis” or “abortive tuberculosis infection”. From 1960, randomized prospective therapeutic studies mentioned “tuberculosis chemoprophylaxis”. By the end of the 20th century, the epidemic of AIDS impeded tuberculosis decrease, making LTBI search more efficient. In 2000, the American Thoracic Society and the Centers for Disease Controls and Prevention proposed the systematic used of LTBI, relayed \u0000through public health policies. A significant higher scientific production about LTBI was noted, supported by \u0000IGRA tests commercialization. Conclusion: In the recent years, health public policies, combined with epidemiologic \u0000and economic factors, strengthened the use of LTBI terminology.","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43935263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Value of TB-IGRA, PPD, TB-DNA-PCR and ADA in Tuberculous Pleural Effusion","authors":"Weijia Lin, Zhi Liu, Ya-ping Zhang, Yanan Yu, Yang Liu, Ping Feng, Feng Li, Zhihua Zhang","doi":"10.4236/jtr.2021.93012","DOIUrl":"https://doi.org/10.4236/jtr.2021.93012","url":null,"abstract":"Objective: To investigate the clinical \u0000diagnostic value of TB-IGRA (Tuberculosis-Interferon \u0000Gamma Release Assay), PPD (Intradermal Tuberculin Test), TB-DNA-PCR (Tuberculosis-Deoxyribonucleic-Polymerase \u0000Chain Reaction) and ADA(Adenosine Aeaminase) in tuberculous pleural effusion. Methods: 60 patients with tuberculous pleural effusion discharged from our department \u0000from January 1, 2018 to December 31, 2019 were selected. Moreover, the TB-IGRA \u0000in peripheral blood, PPD test, TB-DNA-PCR and ADA in pleural effusion were \u0000detected. Subsequently, the positive rate, negative rate, sensitivity and \u0000omission diagnostic rate of TB-IGRA, PPD, \u0000TB-DNA-PCR, ADA and combined TB-IGRA were calculated. Results: The positive rate and sensitivity of TB-IGRA, \u0000PPD,TB-DNA-PCR, and ADA were 95%, 71.67%, 5% and 86.67% \u0000respectively. The omission diagnostic rate was 5%, 28.33%, 95% and 13.33%. TB-IGRA showed the highest positive rate \u0000and sensitivity, and TB-DNA-PCR \u0000represented the highest omission diagnostic rate. The sensitivity of TB-IGRA + \u0000PPD was 98.33%, while the omission diagnostic rate was 51.67%. The sensitivity \u0000of TB-IGRA + TB-DNA-PCR was 95%, while the omission diagnostic rate was 5%. The \u0000sensitivity of TB-IGRA + ADA was 100%, while the omission diagnostic rate \u0000was 0%. In addition, the TB-IGRA + ADA had the highest sensitivity and the lowest omission diagnostic rate. Conclusion: TB-IGRA \u0000has high positive rate, high sensitivity and low omission diagnostic rate, \u0000which is superior to the traditional sputum test for tuberculosis. Notably, the \u0000combination of PPD, TB-DNA-PCR, ADA is capable of improving the diagnosis \u0000rate, and the diagnosis rate can reach 100% when combined with ADA, which is able to provide solid diagnostic value \u0000in clinical practice.","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42495025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects Community Tuberculosis Care Makes in the Early Identification and Referral of Tuberculosis Patients from Active Case Findings in Botswana","authors":"Unami Mathebula-Modongo, M. Moleki, T. Agizew","doi":"10.4236/jtr.2021.93022","DOIUrl":"https://doi.org/10.4236/jtr.2021.93022","url":null,"abstract":"Setting: Twenty-two public health clinics offering Tuberculosis (TB) care at \u0000Francistown and Gaborone cities in Botswana. Objectives: To \u0000assess the effects of community tuberculosis care (CTBC) on the early \u0000identification and referral of patients and to identify perceived factors that \u0000contribute to effective active case findings and community referral system. Design: We adopted a concurrent triangulation mixed-method research design. \u0000Convenient purposive sampling was followed for both qualitative and \u0000quantitative phases. Data were collected from participants who met the \u0000inclusion criteria in both phases from July 2016-Dec. 2018. Consent was obtained from the all eligible \u0000participants. Results: We interviewed 40 \u0000caregivers with mean age of 43.4 years. We identified different themes, 83% (n \u0000= 33) accepted the caregiving role, 50% (n = 20) reported Social and \u0000physiological support from health workers, 23% (n = 10) received health \u0000education on TB, 20% (n = 8) and 30% (n = 12) reported teamwork and \u0000communication respectively between the health workers and caregivers as factors \u0000that contribute to effective active case findings in CTBC. 670 patients were \u0000enrolled in the quantitative phase and only 55% (n = 369) had their contact \u0000details documented in the patient’s TB records, while 94% (1311/1398) active \u0000case finding suspects/contacts screened for TB. Only 18% (115/1398) had been \u0000referred for investigated and 3% (35/1398) were TB positive. All patients \u0000underwent treatment. Conclusion: The \u0000caregiving role has been accepted in CTBC. Moreover, effects of CTBC on the early \u0000identification and referral of TB patients are commendable and can be improved.","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48074219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Presentation of Cervical Pott’s Disease: A Case Report","authors":"E. Okwudire, U. Ezenwugo, J. Ugwoegbu, C. Okoro, Ifeanyichukwu Isiozor","doi":"10.4236/jtr.2021.93020","DOIUrl":"https://doi.org/10.4236/jtr.2021.93020","url":null,"abstract":"Tuberculous spondylitis, also known as Pott’s \u0000disease, is due to infection of the spine by mycobacterium tuberculosis (MTB) leading to vertebral body and inter-vertebral disc destruction. It is the most common form \u0000of musculoskeletal tuberculosis most \u0000frequently affecting the thoracolumbar spine and is commoner in young people. Onset of this condition is \u0000insidious and its clinical presentation is non specific. However, Pott’s disease may be complicated \u0000by neurologic deficits including paraplegia \u0000or even quadriplegia, with huge health, economic and psychological burden. Following is a case report of Pott’s disease involving the \u0000cervical spine in a 33-year old farmer presenting unusually with paraplegia \u0000and a negative Mantoux test. It is reported because this very uncommon condition is highly \u0000treatable, and there is \u0000need for a raised index \u0000of suspicion in order to diagnose this condition early, thus limiting its \u0000complications. The role of MRI in diagnosis of Pott’s disease is also highlighted.","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46901023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Sectional Study of Tuberculosis and HIV/AIDS Co-Infections among Patients Attending Directly Observed Treatment Centers in Bayelsa State, Nigeria","authors":"A. Enoch, Goodluck Silas, M. Pius, Innocent Agbesor Nwozuke","doi":"10.4236/jtr.2021.93013","DOIUrl":"https://doi.org/10.4236/jtr.2021.93013","url":null,"abstract":"Introduction: Mycobacterium tuberculosis (TB) \u0000infects about one quarter of the global population and is transmitted via \u0000aerosols by coughing, sneezing, etc. Some socio-behavioral factors may \u0000predispose an individual to the disease. Methodology: The study used a cross-sectional design with random stratified sampling \u0000technique. Sputum samples from suspected TB patients totaling 600 were obtained \u0000from patients attending directly observed treatment (DOTs) centers from \u0000different local government areas in Bayelsa. The sputum samples were examined \u0000for tuberculosis using the Ziehl-Neelsen staining technique and Gene \u0000Xpert molecular method while HIV/AIDS tests were carried out with EDTA blood \u0000using the Alere HIV12 test kit and others. Results: The Prevalence of TB by Gene Xpert was 294 (49.0%) and by AFB 217 (36.1%), \u0000while TB/HIV co-infection was 94 (32.0%), RRMTB was 34 (11.9%) and HIV 249 (41.5%). \u0000Prevalence by age group showed the 20 - 39 years had the highest prevalence of TB 98 (47.0%), TB/HIV 35 (47.0%), \u0000RRMTB 17 (48.0%) and HIV 90 (57.0%). By gender the male had slightly higher prevalence of TB 109 (52.0%), TB/HIV 51 (54.0%), RRMTB 20 \u0000(56.0%) and HIV 126 (51.0%) than the female. Prevalence among smokers and alcoholics and subjects who engaged in both habits had high prevalence TB 109 (37.0%), \u0000TB/HIV 14 (40.0%), RRMTB 14 (40.0%) and HIV 72 (29.0%). For educational status \u0000those with tertiary and secondary education had similar high prevalence and for \u0000occupation, the self-employed and civil servants had similar elevated prevalence. The \u0000prevalence by local government area showed that Yenegoa had the highest with TB \u0000235 (80.0%), TB/HIV 72 (76.6%), RRMTB 24 (68.5%) and HIV 202 (81.2%). Conclusion: An increase in the development of resistance by M. tuberculosis also \u0000contributes to the persistence of the disease as well as some socio-economic \u0000factors.","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48846131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Xpert MTB/RIF Ultra for Diagnosis of Extrapulmonary Tuberculosis: A Retrospective Analysis in a Low-Tuberculosis Prevalence Setting","authors":"A. Giudice, R. Perna, Teresa Baldoni, F. Scarano, A. D. Rosa, A. Pontarelli, M. Marco, Martha Alicia Falca, Clelia Di Tella, L. Atripaldi, S. Harari, A. Bianco, R. Parrella","doi":"10.4236/jtr.2021.93021","DOIUrl":"https://doi.org/10.4236/jtr.2021.93021","url":null,"abstract":"Background: Extrapulmonary tuberculosis (EPTB) remains difficult to diagnose because the \u0000clinical specimens to be examined are often paucibacillary and obtained with difficulty from inaccessible sites. An updated Xpert® MTB/RIF Ultra (Ultra) test \u0000has been designed and licensed to improve sensitivity in the detection of \u0000Mycobacterium tuberculosis complex. The aim of the present study is to evaluate the \u0000performance of Ultra assay for the clinical diagnosis of EPTB in a low tuberculosis prevalence country. Methods: A retrospective analysis was \u0000performed at “A. O dei Colli” of Naples on consecutive extrapulmonary \u0000specimens for EPTB across a three-year period. All different types of \u0000extrapulmonary specimens were tested for EPTB by smear microscopy, culture and \u0000Ultra assay in accordance with relevant guidelines. Results: A total of 606 EPTB samples, 561 culture negative EPTB and 45 culture \u0000positive EPTB were included. Using culture as reference standard, the overall \u0000sensitivities and specificities of Ultra assay were 95.6% (95% CI 84.8 - 99.5) and 97.5% (95% CI 95.8 - 98.6) respectively. Sensitivity and specificity of \u0000Ultra for individual category of specimens were also performed. Conclusion: In a low-tuberculosis \u0000prevalence setting, Ultra assay confirms to have a good performance in the \u0000diagnosis of EPTB for all different extrapulmonary samples.","PeriodicalId":70603,"journal":{"name":"结核病研究(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48009363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}