Diagnostic Value of TB-IGRA, PPD, TB-DNA-PCR and ADA in Tuberculous Pleural Effusion

结核病研究(英文) Pub Date : 2021-07-07 DOI:10.4236/jtr.2021.93012

Weijia Lin, Zhi Liu, Ya-ping Zhang, Yanan Yu, Yang Liu, Ping Feng, Feng Li, Zhihua Zhang

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引用次数: 1

Abstract

Objective: To investigate the clinical diagnostic value of TB-IGRA (Tuberculosis-Interferon Gamma Release Assay), PPD (Intradermal Tuberculin Test), TB-DNA-PCR (Tuberculosis-Deoxyribonucleic-Polymerase Chain Reaction) and ADA(Adenosine Aeaminase) in tuberculous pleural effusion. Methods: 60 patients with tuberculous pleural effusion discharged from our department from January 1, 2018 to December 31, 2019 were selected. Moreover, the TB-IGRA in peripheral blood, PPD test, TB-DNA-PCR and ADA in pleural effusion were detected. Subsequently, the positive rate, negative rate, sensitivity and omission diagnostic rate of TB-IGRA, PPD, TB-DNA-PCR, ADA and combined TB-IGRA were calculated. Results: The positive rate and sensitivity of TB-IGRA, PPD,TB-DNA-PCR, and ADA were 95%, 71.67%, 5% and 86.67% respectively. The omission diagnostic rate was 5%, 28.33%, 95% and 13.33%. TB-IGRA showed the highest positive rate and sensitivity, and TB-DNA-PCR represented the highest omission diagnostic rate. The sensitivity of TB-IGRA + PPD was 98.33%, while the omission diagnostic rate was 51.67%. The sensitivity of TB-IGRA + TB-DNA-PCR was 95%, while the omission diagnostic rate was 5%. The sensitivity of TB-IGRA + ADA was 100%, while the omission diagnostic rate was 0%. In addition, the TB-IGRA + ADA had the highest sensitivity and the lowest omission diagnostic rate. Conclusion: TB-IGRA has high positive rate, high sensitivity and low omission diagnostic rate, which is superior to the traditional sputum test for tuberculosis. Notably, the combination of PPD, TB-DNA-PCR, ADA is capable of improving the diagnosis rate, and the diagnosis rate can reach 100% when combined with ADA, which is able to provide solid diagnostic value in clinical practice.

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结核性胸腔积液TB-IGRA、PPD、TB-DNA-PCR和ADA的诊断价值

目的：探讨TB-IGRA、PPD、TB-DNA-PCR和ADA对结核性胸腔积液的诊断价值。方法：选择我科2018年1月1日至2019年12月31日出院的结核性胸腔积液患者60例。此外，还检测了外周血中的TB-IGRA、PPD试验、胸腔积液中的TB-DNA-PCR和ADA。随后，计算TB-IGRA、PPD、TB-DNA-PCR、ADA和联合TB-IGRA的阳性率、阴性率、敏感性和漏诊率。结果：TB-IGRA、PPD、TB-DNA-PCR和ADA的阳性率和敏感性分别为95%、71.67%、5%和86.67%。漏诊率分别为5%、28.33%、95%和13.33%，TB-IGRA阳性率和敏感性最高，TB-DNA-PCR漏诊率最高。TB-IGRA+PPD的敏感性为98.33%，漏诊率为51.67%，TB-IGRA+TB-DNA-PCR的敏感性为95%，漏诊断率为5%。TB-IGRA+ADA的敏感性为100%，漏诊率为0%。此外，TB-IGRA+ADA的敏感性最高，漏诊率最低。结论：TB-IGRA阳性率高，敏感性高，漏诊率低，优于传统痰检。值得注意的是，PPD、TB-DNA-PCR、ADA的组合能够提高诊断率，与ADA组合时诊断率可以达到100%，能够在临床实践中提供坚实的诊断价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

结核病研究(英文)

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发文量

150