Acta medica portuguesa最新文献

{"title":"[Managing Sexual Risk Behaviors in Acute Psychiatric Inpatient Units: An Institutional Proposal].","authors":"Maria João Amaral, Ema Conde, Catarina Klut, Maria João Heitor","doi":"10.20344/amp.24357","DOIUrl":"https://doi.org/10.20344/amp.24357","url":null,"abstract":"","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":"39 9","pages":"579-580"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Assessment of Informed Consent by Ethics Committees in Portugal: Procedures and Constraints in an Observational Study].","authors":"Joana M Xavier, Carla Barbosa, Helena Leitão","doi":"10.20344/amp.24899","DOIUrl":"10.20344/amp.24899","url":null,"abstract":"<p><strong>Introduction: </strong>Ethics committees (ECs) play a central role in ethical oversight and in protecting research participants. However, empirical evidence on their composition and practices in Portugal remains limited. The aim of this study was to characterize members of ECs, assess their activity and main constraints, and explore their views on the assessment of informed consent (IC) in research.</p><p><strong>Methods: </strong>A cross-sectional observational study was conducted between March and June 2025 using an anonymous online questionnaire distributed to ECs in healthcare institutions, higher education institutions and research centers. The survey collected sociodemographic data, information on EC composition and functioning, and perceptions regarding IC documents.</p><p><strong>Results: </strong>Eighty-one EC members participated. Most respondents were women (63.0%), aged 51 - 60 years (33.3%) or 61 years and older (30.9%), and nearly half had more than five years of EC experience (49.4%). The ECs represented were mainly based in healthcare institutions (50.6%) and higher education institutions (42.0%). The most frequently reported constraints were lack of training (87.7%) and insufficient time allocated to EC work (79.0%). Respondents reported no previous training in bioethics (56.8%) or data protection (47.0%). However, requests for revisions to the consent form were frequent, primarily due to unclear language (91.4%). Twenty-one percent rated the IC as poor or average, identifying lack of investigator training as the main reason. Regarding withdrawal of consent, 35.8% stated that it would depend on compliance with certain formalities, whereas 5,0% reported not knowing. In addition, nearly half of the respondents (45.7%) indicated that they had no personal experience in obtaining IC. Variability emerged regarding the importance attributed to certain consent components, particularly study conditions and procedures related to the communication of new information, the format of data retention, and contact details for the EC and the data protection officer.</p><p><strong>Conclusion: </strong>Portuguese EC members recognize informed consent as a central ethical safeguard, but their responses reveal heterogeneity in the assessment of some informational components, together with structural constraints related to training and time allocated to EC activities. Strengthening training, harmonizing guidance and improving institutional support may enhance the consistency and pedagogical value of EC review.</p>","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":" ","pages":"517-527"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148652765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translation, Cultural Adaptation and Validation of the Tinnitus Functional Index to European Portuguese].","authors":"Maria José Lucas Dos Santos, Cláudia Rosa, Tiago Eça, Leonel Luís","doi":"10.20344/amp.24305","DOIUrl":"https://doi.org/10.20344/amp.24305","url":null,"abstract":"<p><strong>Introduction: </strong>Tinnitus is defined as the conscious perception of an auditory sensation in the absence of any corresponding external stimulus. It is associated with significant negative consequences across multiple domains of an individual's life, namely physical, psychological, cognitive, auditory, social, and financial. Several questionnaires can be used to measure its impact on quality of life, however, these instruments are not sensitive in quantifying possible treatment-related changes. Therefore, the Tinnitus Functional Index (TFI) was developed, allowing the evaluation not only of tinnitus severity, but also of changes triggered by a clinical intervention. The aim of this study was the translation, validation and cultural adaptation of the TFI into European Portuguese for later use in intervention studies.</p><p><strong>Methods: </strong>This cross-sectional study was carried out in a Portuguese tertiary hospital center and conducted in two stages: translation and cultural adaptation; analysis of internal consistency and validation. A total of 30 participants were included. The internal consistency of the questionnaire was assessed using Cronbach's alpha coefficient. Convergent validity was assessed using the Spearman correlation coefficient between the TFI and the Tinnitus Handicap Inventory (THI).</p><p><strong>Results: </strong>The European Portuguese version was obtained through a process of initial translation, synthesis of translations, back-translation and review by a panel of professionals. The 30 participants were aged between 26 and 80 years (57 ± 11.5 years), and 19 were female. The European Portuguese version of the TFI showed a strong correlation (rho = 0.823, p < 0.001) with the THI. Internal consistency was high, with a Cronbach's alpha of 0.96.</p><p><strong>Conclusion: </strong>The validation of the TFI scale for European Portuguese showed strong internal consistency, correlation with the THI scale, and similarity to the positive results obtained in other studies and the original scale. Therefore, this translation is considered an instrument supported by evidence of adequacy and validity, useful for assessing tinnitus severity and for monitoring the effect of clinical interventions.</p>","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":"39 9","pages":"511-516"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Leydig Cell Tumor: Biochemical Mimicry of Adrenal Disease and a Cause of Central Precocious Puberty.","authors":"Marta Isabel Dias, Rita Silva Pereira, Ana Miguel Simões, Ana Rita Batista, Vânia Martins","doi":"10.20344/amp.24921","DOIUrl":"https://doi.org/10.20344/amp.24921","url":null,"abstract":"","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":"39 9","pages":"591-592"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The Imperious Need for Molecular Tumor Boards in Portugal].","authors":"João Martins Gama, Rui Caetano Oliveira","doi":"10.20344/amp.24485","DOIUrl":"https://doi.org/10.20344/amp.24485","url":null,"abstract":"","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":"39 9","pages":"509-510"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Regional Trends in Antidiabetic Drug Prescribing in Portugal: Eight Years of Nationwide Real-World Evidence (2017 - 2024) (TREND-8 REGIONS Study)].","authors":"Ana Rita Leite, Célia Ramalho, Daniel Ramos, Mafalda Marcelino, Miguel Melo, Paula Freitas, Tiago Maricoto, Fátima Pinto, Sónia Do Vale, Eduardo Calçada, João Sérgio Neves","doi":"10.20344/amp.24706","DOIUrl":"https://doi.org/10.20344/amp.24706","url":null,"abstract":"<p><strong>Introduction: </strong>The nationwide TREND-8 study revealed significant changes in antidiabetic prescribing patterns in Portugal between 2017 and 2024, with marked increases in the use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA). The aim of the TREND-8 REGIONS study was to analyze variations across regions and healthcare settings.</p><p><strong>Methods: </strong>This nationwide, cross-sectional, retrospective study analyzed antidiabetic drug prescriptions in Portugal between 2017 and 2024, stratified by healthcare setting (primary care, public hospitals, and private institutions) and geographic region (North, Center, Lisbon, Alentejo, Algarve, Madeira, and the Azores).</p><p><strong>Results: </strong>Biguanides remained the most prescribed antidiabetic class across all regions, despite there being a uniform national decline in the proportion of prescriptions (2.3%/year), accounting for 37.5% of prescriptions in 2024. Insulin prescriptions showed a proportional decline across all regions (-5.3%/year), representing 7.5% of prescriptions in 2024, with significantly lower proportions in Madeira (5.5%; p < 0.001). The SGLT2i class exhibited the largest increase (34.5%/year), with modest regional variation. It accounted for 29.3% of total prescriptions in 2024; lower proportions were observed in Alentejo (27.5%; p = 0.002). The GLP-1RA class showed the second highest increase (24.1%/year), more pronounced in Alentejo (34.4%/year; p < 0.001) and Azores (38.4%/year; p < 0.001), accounting for 4.9% of prescriptions in 2024. Their proportion was higher in the Azores (7.1%) and Lisbon (5.6%) and lower in Alentejo (4.0%), Center (4.3%), and Madeira (4.4%) (all p < 0.05). Across healthcare settings, GLP-1RA prescribing increased more in primary care (32.0%/year), although the highest proportion of prescribing was observed in private institutions (10.4% of prescriptions in 2024). The greatest increase in SGLT2i prescribing occurred in primary care (35.4%/year), while public hospitals accounted for the highest proportion of prescriptions (34.5%) in 2024.</p><p><strong>Conclusion: </strong>The TREND-8 REGIONS study showed an evolution that is consistent with international recommendations across the different regions of Portugal and healthcare settings analyzed, with only slight variability observed in GLP‑1 RA prescribing.</p>","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":"39 9","pages":"528-538"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The Importance of Recognizing Benign Transient Hyperphosphatasemia of Childhood].","authors":"Rita Dos Santos João Carvalho, Inês Ferrão Carvalho, Rafaela Gonçalves, Isabel Raminhos","doi":"10.20344/amp.24660","DOIUrl":"https://doi.org/10.20344/amp.24660","url":null,"abstract":"","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":"39 9","pages":"583-584"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalized Pustular Psoriasis in Portugal: Expert Perspectives on Patient Journey, Diagnosis, Therapeutic Goals, and Healthcare Optimization.","authors":"Tiago Torres, Ângela Roda, César Magalhães, Joana Frade, Maria João Cruz, Maria José Guimarães, Margarida Gonçalo","doi":"10.20344/amp.24535","DOIUrl":"10.20344/amp.24535","url":null,"abstract":"<p><p>Generalized pustular psoriasis (GPP) is a rare, severe, and potentially life-threatening inflammatory skin disease associated with high morbidity and significant healthcare burden. Acute flares require rapid and effective treatment to prevent severe complications, including hospitalization and death. This work aimed to gather insights from a Portuguese expert panel on the management of GPP, focusing on the patient journey, diagnostic approaches, treatment goals, and healthcare resource utilization. This qualitative study collected in-depth insights from seven dermatologists geographically distributed across Portugal during a virtual expert panel meeting in June 2025. Several critical challenges in GPP management were identified, including diagnostic delays, lack of disease awareness among non-dermatologists, limited access to novel therapies, and inconsistent referral pathways. The expert panel emphasized the need for urgent treatment of flares, improved diagnostic protocols, and systematic referral of GPP patients to existing specialized centers, better coordination between healthcare levels, and faster access to treatments with proven efficacy. Spesolimab was highlighted for its potential to reduce long-term healthcare expenditure by shortening hospital stays, lowering the need for intensive care, and decreasing the risk of complications, factors that collectively support more efficient resource use and overall cost reduction. This expert insight highlights actionable strategies to optimize GPP care in Portugal, emphasizing early diagnosis, timely initiation of effective treatment, improved multidisciplinary collaboration, and healthcare system reforms as key priorities to improve clinical outcomes, enhance resource efficiency, and reduce the overall burden of GPP.</p>","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":" ","pages":"565-575"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Supraventricular Tachycardia During Pregnancy: A Case Report.","authors":"Julia Martín Martínez, Mariano Laguna Olmos, Cristina Bujeda Hernández","doi":"10.20344/amp.24683","DOIUrl":"https://doi.org/10.20344/amp.24683","url":null,"abstract":"","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":"39 9","pages":"587-588"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[p.Gly143Glu Variant in CES1 Gene Associated with an Adverse Response to Methylphenidate in a Child: Case Report].","authors":"Catarina M Nascimento, Iolanda Faustino, Henrique Brito, Sílvia Afonso","doi":"10.20344/amp.24657","DOIUrl":"https://doi.org/10.20344/amp.24657","url":null,"abstract":"","PeriodicalId":7059,"journal":{"name":"Acta medica portuguesa","volume":"39 9","pages":"581-582"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}