Acta Biotheoretica最新文献_第4页

Fast Track Treatment of Hypothyroidism with Levothyroxine: Reaching Homeostasis within Four Weeks 左旋甲状腺素快速治疗甲状腺功能减退:在四周内达到体内平衡

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-03-07 DOI: 10.1007/s10441-023-09461-x

Simon L. Goede

{"title":"Fast Track Treatment of Hypothyroidism with Levothyroxine: Reaching Homeostasis within Four Weeks","authors":"Simon L. Goede","doi":"10.1007/s10441-023-09461-x","DOIUrl":"10.1007/s10441-023-09461-x","url":null,"abstract":"<div><p>With the current clinical method for the treatment of hypothyroidism the target for the optimum individual values for free thyroxine concentrations [FT4] and thyrotropine concentrations [TSH] of the specific patient are unknown. This situation leads to unnecessary long experimental medication administration that can take a period of sometimes one year. In this article a method will be described where hypothyroid patients are characterized with weekly measured FT4 and TSH concentrations during the first three weeks of synthetic thyroxine or levothyroxine (L-T4) treatment to predict their optimum [FT4] and belonging [TSH] endpoint for a euthyroid homeostatic state. The treatment with levothyroxine will start for all patients with a reference dose of 100 µg, which can be adjusted by the treating physician to a more safe and appropriate dose for the individual which is monitored with weekly thyroid function tests to observe the progress. After three weeks all characteristics of the patient can be inferred from the measured data. The final titration target together with the individual thyroxine half life can be calculated. With the known characteristics and the L-T4 titration target the clinician or treating physician has an instrument to reduce the experimental treatment burden for the patient from one year to a maximum of four weeks.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"71 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9074943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mathematical Model of COVID-19 Pandemic with Double Dose Vaccination 双剂量疫苗下COVID-19大流行的数学模型

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-03-06 DOI: 10.1007/s10441-023-09460-y

Olumuyiwa James Peter, Hasan S. Panigoro, Afeez Abidemi, Mayowa M. Ojo, Festus Abiodun Oguntolu

{"title":"Mathematical Model of COVID-19 Pandemic with Double Dose Vaccination","authors":"Olumuyiwa James Peter, Hasan S. Panigoro, Afeez Abidemi, Mayowa M. Ojo, Festus Abiodun Oguntolu","doi":"10.1007/s10441-023-09460-y","DOIUrl":"10.1007/s10441-023-09460-y","url":null,"abstract":"<div><p>This paper is concerned with the formulation and analysis of an epidemic model of COVID-19 governed by an eight-dimensional system of ordinary differential equations, by taking into account the first dose and the second dose of vaccinated individuals in the population. The developed model is analyzed and the threshold quantity known as the control reproduction number <span>(mathcal {R}_{0})</span> is obtained. We investigate the equilibrium stability of the system, and the COVID-free equilibrium is said to be locally asymptotically stable when the control reproduction number is less than unity, and unstable otherwise. Using the least-squares method, the model is calibrated based on the cumulative number of COVID-19 reported cases and available information about the mass vaccine administration in Malaysia between the 24th of February 2021 and February 2022. Following the model fitting and estimation of the parameter values, a global sensitivity analysis was performed by using the Partial Rank Correlation Coefficient (PRCC) to determine the most influential parameters on the threshold quantities. The result shows that the effective transmission rate <span>((alpha ))</span>, the rate of first vaccine dose <span>((phi ))</span>, the second dose vaccination rate <span>((sigma ))</span> and the recovery rate due to the second dose of vaccination <span>((eta ))</span> are the most influential of all the model parameters. We further investigate the impact of these parameters by performing a numerical simulation on the developed COVID-19 model. The result of the study shows that adhering to the preventive measures has a huge impact on reducing the spread of the disease in the population. Particularly, an increase in both the first and second dose vaccination rates reduces the number of infected individuals, thus reducing the disease burden in the population.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"71 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10441-023-09460-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9568735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

A Very Nice Meal with an Unsatisfying Appetizer 一顿非常美味的饭，开胃菜却不令人满意

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-03-03 DOI: 10.1007/s10441-023-09458-6

Antonella Tramacere

引用次数: 0

Heuristics Facilitates the Evolution of Transitive Inference and Social Hierarchy in a Large Group 启发式促进了大群体传递推理和社会等级的进化

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-03-03 DOI: 10.1007/s10441-023-09459-5

Kazuto Doi, Mayuko Nakamaru

{"title":"Heuristics Facilitates the Evolution of Transitive Inference and Social Hierarchy in a Large Group","authors":"Kazuto Doi, Mayuko Nakamaru","doi":"10.1007/s10441-023-09459-5","DOIUrl":"10.1007/s10441-023-09459-5","url":null,"abstract":"<div><p>Transitive inference (TI) refers to social cognition that facilitates the discernment of unknown relationships between individuals using known relationships. It is extensively reported that TI evolves in animals living in a large group because TI could assess relative rank without deducing all dyadic relationships, which averts costly fights. The relationships in a large group become so complex that social cognition may not be developed adequately to handle such complexity. If members apply TI to all possible members in the group, TI requires extremely highly developed cognitive abilities especially in a large group. Instead of developing cognitive abilities significantly, animals may apply simplified TI we call reference TI in this study as heuristic approaches. The reference TI allows members to recognize and remember social interactions only among a set of reference members rather than all potential members. Our study assumes that information processes in the reference TI comprises (1) the number of reference members based on which individuals infer transitively, (2) the number of reference members shared by the same strategists, and (3) memory capacity. We examined how information processes evolve in a large group using evolutionary simulations in the hawk–dove game. Information processes with almost any numbers of reference members could evolve in a large group as long as the numbers of shared reference member are high because information from the others’ experiences is shared. TI dominates immediate inference, which assesses relative rank on direct interactions, because TI could establish social hierarchy more rapidly applying information from others’ experiences.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"71 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10441-023-09459-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9925875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Multi-Causal Basis of Developmental Potential Construction 发展潜能构建的多因基础

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-01-30 DOI: 10.1007/s10441-023-09456-8

Davide Vecchi, Gil Santos

{"title":"The Multi-Causal Basis of Developmental Potential Construction","authors":"Davide Vecchi, Gil Santos","doi":"10.1007/s10441-023-09456-8","DOIUrl":"10.1007/s10441-023-09456-8","url":null,"abstract":"<div><p>In this article we analyse the issue of what accounts for developmental potential, i.e., the possible phenotypes a developing organism can manifest during ontogeny. We shall argue in favour of two theses. First, although the developing organism is the unit of development, the complete causal basis for its potential to develop does neither lie entirely in itself as a whole nor in any specific part of itself (such as its genome). Thus, the extra-organismal environment must be counted as one of the three necessary, partial and complementary causal bases for development potential. Secondly, we shall defend a constructivist view of the developmental process. If the genome, the developing organism and the extra-organismal environment are to be counted as proper elements of the causal basis for an organism’s developmental potential, the latter is not a given. Rather, it is the result of an interaction-based construction, a process sometimes generating genuine developmental novelty. We will thus argue for an interactionist multi-causal basis view of developmental potential construction. We contend that our view provides a biologically tenable and metaphysically coherent account of developmental dynamics.</p></div>","PeriodicalId":7057,"journal":{"name":"Acta Biotheoretica","volume":"71 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10441-023-09456-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9449104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Connection of the Generalized Robinson–Foulds Metric with Partial Wiener Indices 广义Robinson-Foulds度量与部分Wiener指标的联系

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2023-01-25 DOI: 10.1007/s10441-023-09457-7

Damir Vukičević, Domagoj Matijević

引用次数: 0

Model of Morphogenesis with Repelling Signaling 具有排斥信号的形态发生模型

IF 1.3 4区生物学

Acta Biotheoretica Pub Date : 2022-12-20 DOI: 10.1007/s10441-022-09454-2

A. Minarsky, S. Krymsky, C. Soulé, N. Morozova

引用次数: 0

Correction to: Stem Cells and the Microenvironment: Reciprocity with Asymmetry in Regenerative Medicine 修正:干细胞和微环境:再生医学中的互惠与不对称