Random with Respect to Fitness or External Selection? An Important but Often Overlooked Distinction

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-03-18 DOI:10.1007/s10441-023-09464-8

Jonathan Bartlett

引用次数: 1

Abstract

Mutations are often described as being “random with respect to fitness.” Here we show that the experiments used to establish randomness with respect to fitness are only capable of showing that mutations are random with respect to current external selection. Current debates about whether or not mutations are directed may be at least partially resolved by making use of this distinction. Additionally, this distinction has important mathematical, experimental, and inferential implications.

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适应性随机还是外部选择?一个重要但经常被忽视的区别

突变通常被描述为“在适应性方面是随机的”。在这里，我们证明了用于建立关于适应度的随机性的实验只能证明突变是关于当前外部选择的随机性。目前关于突变是否定向的争论可以通过利用这一区别至少部分地解决。此外，这种区别具有重要的数学、实验和推论意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.