Acta neurobiologiae experimentalis最新文献

{"title":"N‑acetylcysteine prevents hypothyroidism‑induced impairment of learning and memory in adolescent male rats via affecting oxidative status, inflammatory response and BDNF in hippocampal tissues.","authors":"Amir Basiri, Saeid Izadi, Samaneh Kakhki, Vida Alikahni, Saeedeh Askarian, Farimah Beheshti","doi":"10.55782/ane-2024-2587","DOIUrl":"https://doi.org/10.55782/ane-2024-2587","url":null,"abstract":"<p><p>The present study was assumed that N‑acetylcysteine (AC) might improve cognitive function in adolescent rats with hypothyroidism through various mechanisms. Sixty adolescent rats were randomly divided into the following groups: Vehicle (received normal saline intraperitoneally (IP)); Propylthiouracil (PTU)‑induced hypothyroidism (0.05%, dissolved in drinking water); Hypothyroid rats were IP treated with different doses of AC (50, 100, and 150 mg/kg/day) for a period of six weeks; Normal rats treated with the highest doses of AC (150 mg/kg/day). Behavioral and biochemical analyses were studied for all groups. In the Morris water maze test, AC significantly reduced both the time to find the hidden platform and the distance travelled as compared to non‑treated hypothyroid rats. In the passive avoidance test, the latency of entering the dark chamber was significantly increased by AC, whereas decreased the time spent in the darkroom of the chamber compared to the hypothyroid rats. In biochemical results, AC reduced both malondialdehyde content and nitrite while increased the thiol content, catalase and superoxide dismutase enzymes activity in both the cortex and the hippocampus, and a notable improvement in brain‑derived neurotrophic factor (BDNF) levels in hippocampal tissues of the hypothyroid rats, while decreasing the level of interleukin‑6 in rat hippocampal region. Therefore, based on the results, the beneficial effects of AC on cognitive impairment in adolescent hypothyroid rats are probably related to its anti‑oxidant properties and notable improvement in BDNF levels.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"84 2","pages":"218-229"},"PeriodicalIF":1.4,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary somatosensory cortex CB1 and 5‑HT1A receptors interaction in the penicillin model of epilepsy.","authors":"Amir Erfanparast, Sina Tamaddonfard, Parastoo Jafarzadeh-Balagafsheh, Esmaeal Tamaddonfard","doi":"10.55782/ane-2024-2420","DOIUrl":"https://doi.org/10.55782/ane-2024-2420","url":null,"abstract":"<p><p>Cannabinoid and serotonin systems regulate many biological processes. The aim of the present study was to investigate the functional interaction between the cannabinoid and serotonergic systems of the primary somatosensory region (S1) of the brain in epileptiform activity caused by penicillin. The ACEA (an agonist of CB1 receptor), AM‑251 (an antagonist of CB1 receptor), 8‑OH‑DPAT (an agonist of 5‑HT1A receptor) and WAY‑100635 (an antagonist of 5‑HT1A receptor) were administered into the S1 after the same site administration of penicillin in urethane‑anesthetized rats. Electrocorticographic recording was done for a 90‑min period. The spike waves number and amplitude were recorded in 15‑min intervals. Areas under the curve (AUC) of the above‑mentioned spike alterations was calculated in 90 min. Spike waves with frequency of 30/min and amplitude of 1.3 mV were appeared after penicillin microinjection. The ACEA (50 ng), 8‑OH‑DPAT (500 ng) and ACEA (10 ng) plus 8‑OH‑DPAT (100 ng) reduced epileptiform activity. The AM‑251 (50 ng) and WAY‑100365 (500 ng) prevented the reducing effects of ACEA (50 ng) and 8‑OH‑DPAT (500 ng). The AM‑251 alone increased spike waves frequency. The AUC results supported the effects of the above‑mentioned treatments. The results showed that activating CB1 and 5‑HT1A receptors in the S1 may reduce the epileptiform activity caused by penicillin. Therefore, alone and together activation of central CB1 and 5‑HT1A receptors might be considered in the management of epilepsy treatment.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"84 2","pages":"180-190"},"PeriodicalIF":1.4,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of miR‑155‑5p on long‑term memory of sleep‑deprived mice through the BDNF/NF‑κB pathway.","authors":"Dan Hou, Jialing Zhong, Yujie Hu, Guoshuai Yang","doi":"10.55782/ane-2024-2586","DOIUrl":"https://doi.org/10.55782/ane-2024-2586","url":null,"abstract":"<p><p>Sleep deprivation (SD) is a prevalent sleep issue in modern society that significantly impairs neurological function and quality of life in affected individuals. This study seeks to investigate the involvement of the miR‑155‑5p/BDNF axis in SD mice, aiming to establish a theoretical foundation for potential treatment strategies. Male C57BL/6 mice were utilized in the construction of a SD model using the flower pot technique. HT22 cells were selected for cellular experiments. The Morris water maze was employed to assess the learning and memory capabilities of the mice. HE staining was utilized to observe pathological changes in hippocampal tissue. Levels of IL‑1β, IL‑6, and TNF‑α were analyzed using ELISA. The expression level of miR‑155‑5p was quantified via RT‑qPCR. The binding between miR‑155‑5p and brain‑derived neurotrophic factor (BDNF) was confirmed through a dual‑luciferase reporter assay. Apoptosis of hippocampal neurons was assessed using TUNEL. Western blot analysis was conducted to evaluate the expression levels of BDNF, p65, and p‑p65. The Morris water maze test revealed that the mice exhibited prolonged escape latency, decreased swimming velocity, and reduced time spent in the target platform quadrant, which are indicative of a successful construction of the SD model. The observed cognitive deficits in the mice were associated with SD‑induced damage to the hippocampal tissue, leading to increased levels of miR‑155‑5p and decreased levels of BDNF. miR‑155‑5p was found to directly bind to BDNF, thereby suppressing its mRNA and protein expression. The upregulation of BDNF effectively mitigated hippocampal damage by attenuating cell apoptosis and reducing inflammation levels in SD mice. Additionally, the BDNF/NF‑κB pathway was found to be suppressed in SD mice through the downregulation of miR‑155‑5p. Therefore, the silencing of miR‑155‑5p inhibited the activation of the NF‑κB pathway by upregulating BDNF, which improved long‑term memory and reduced neuronal damage in SD mice.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"84 2","pages":"203-217"},"PeriodicalIF":1.4,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of hand dominance on myoelectric signal of non‑fatigued lumbar multifidus muscle during single arm lifts.","authors":"Dawid Łochyński, Grzegorz Stępień, Silvija Angelova, Rositsa Raikova, Marcin Grześkowiak","doi":"10.55782/ane-2024-2584","DOIUrl":"https://doi.org/10.55782/ane-2024-2584","url":null,"abstract":"<p><p>Some evidence indicates that lower back muscles located at the non‑dominant side of the body are more fatigue resistant than their opposite counterparts presumably due to preferential use of the dominant hand. The aim of the study was to determine if any distinction exists in the surface electromyographic activity of corresponding contralateral non‑fatigued lumbar multifidus (LM) muscles as a function of hand dominance. The relative to maximum root mean square, the median frequency (MdF) and spike shape parameters were computed from the surface myoelectric signals of ipsilateral and contralateral lumbar multifidus muscle of 46 adult healthy subjects (27 right‑handed, 19 left‑handed) during voluntary contractions evoked by the single arm lifts in prone position. Activation of LM as a contralateral muscle to lifted arm was greater than as ipsilateral muscle, independently of handedness. Regardless if LM performed ipsi‑ or contralateral action to the lifted arm, the mean spike amplitude, slope, number of peaks per spike and spike duration were greater and mean spike frequency as well as MdF were smaller in the muscle of dominant than non‑dominant side. Combined changes of spike shape measures indicate increased recruitment, lower firing rates and higher synchronization of motor units in the LM of dominant side as compared to its counterpart.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"84 2","pages":"191-202"},"PeriodicalIF":1.4,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the neuropsychological basis of behavioral contagion during learning about another agent's social preferences: Evidence from an ERP study.","authors":"Mostafa Deldoost, Reza Khosrowabadi, Maciej Kamiński","doi":"10.55782/ane-2024-2500","DOIUrl":"https://doi.org/10.55782/ane-2024-2500","url":null,"abstract":"<p><p>Social contagion is a pervasive phenomenon and an important social influence that involves the rapid dissemination (propagation) of behaviors, attitudes, emotions, or ideas from one person to another, often without conscious reflection or rational thought. This phenomenon is closely related to conformity, by which a person changes his/her original ideas and attitude and imitates certain behavior of others. Although some behavioral research has been carried out on contagion and conformity, there is very little neuropsychological understanding of these phenomena. Existing research on social influence and conformity has predominantly focused on tasks like mental rotation or rating tasks involving facial expressions, with fewer studies exploring risk preferences and temporal discounting. However, there is a notable gap in the literature when it comes to examining social influence and conformity using other‑regarding preference models derived from heterodox economics. To address this research gap, the present study investigates the neuropsychological underpinnings of social contagion by utilizing event‑related potentials (ERPs) recorded while subjects engage in mini‑dictator games. The behavioral analysis revealed that contagion had an impact on the participants' preferences, leading to a change in their choices. We observed a P300 component in the midline and right posterior during the time window of 200‑350 ms after stimulus onset, which showed a significant increase in mean amplitude when participants observed others' behavior, compared to when they made decisions based on their own preferences. Moreover, the lack of late positive potential in the time window of 500‑650 ms suggests that the presence of P300 may indicate difficulty in making decisions. In summary, by analyzing both behavioral and ERP data, this study may provide a more comprehensive understanding of the cognitive and neural processes that drive conformity and contagion behavior. Our analysis has the potential to inform policymakers in developing effective interventions for promoting positive social behaviors and reducing negative ones.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"84 2","pages":"165-179"},"PeriodicalIF":1.4,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of PPARγ agonists on long‑termpotentiation and apoptosis in the hippocampusarea of juvenile hypothyroid rats.","authors":"Mahmoud Hosseini, Fatemeh Seyedi, Mahdiyeh Hedayati-Moghadam, Mohammad Ali-Hassanzadeh, Hedyeh Askarpour, Somaieh Mansouri, Hadi Shafieemojaz, Yousef Baghcheghi","doi":"10.55782/ane-2024-2451","DOIUrl":"https://doi.org/10.55782/ane-2024-2451","url":null,"abstract":"<p><p>The aim of the present study was to evaluate the effect of rosiglitazone (RSG) or pioglitazone (POG) on the synaptic plasticity, neuronal apoptosis, brain-derived neurotrophic factor (BDNF), and nitric oxide (NO) metabolites in the hippocampus of juvenile hypothyroid rats. The animals were divided into four groups: control; propylthiouracil (PTU), 0.05% dose in drinking water for 42 days; PTU-POG; and PTU-RSG. The POG (20 mg/kg) and the RSG (4 mg/kg) were administered by IP injection. We conducted long‑term potentiation (LTP) in the cornu ammonis 1 area of the hippocampus using high‑frequency stimulation of the Schaffer collateral pathway. Then, the hippocampal tissues were collected to determine BDNF and NO levels and the degree of apoptosis. PTU administration decreased the slope (10-90%) and amplitude of the fEPSPs compared to control. Injection of RSG or POG increased the slope, slope (10-90%), and amplitude of the fEPSP in the PTU‑POG or PTU‑RSG groups compared to the PTU group. TUNEL‑positive neurons and NO metabolites in the hippocampus of the PTU group were higher than those of the control group. RSG or POG increased BDNF content in PTU-POG or PTU-RSG groups. Treatment of the rats with POG or RSG decreased apoptotic neurons and NO metabolites in the hippocampus of PTU-POG or PTU-RSG groups, respectively, compared to the PTU group. This study's results revealed that POG or RSG normalized LTP impairment, neuronal apoptosis, and improved BDNF content in the hippocampal tissue of juvenile hypothyroid rats.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"84 2","pages":"153-164"},"PeriodicalIF":1.4,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissociable neuronal mechanism for different crossmodal correspondence effects in humans","authors":"C. Jaap, Michael Rose","doi":"10.55782/ane-2024-2439","DOIUrl":"https://doi.org/10.55782/ane-2024-2439","url":null,"abstract":"Crossmodal correspondences (CMCs) refer to associations between seemingly arbitrary stimulus features in different sensory modalities. Pitch‑size correspondences refer to the strong association of e.g., small objects with high pitches. Pitch‑elevation correspondences refer to the strong association of e.g., visuospatial elevated objects with high pitches. We used functional magnetic resonance imaging (fMRI) to study the neural components, which underlie the CMCs in pitch‑size and spatial pitch‑elevation. This study focuses on answering the question of whether or not different CMCs are driven by similar neural mechanisms. The comparison of congruent against incongruent trials allows the estimation of CMC effects across different CMCs. The analysis of the measured neural activity in different CMCs strongly pointed toward different mechanisms which are involved in the processing of pitch‑size and pitch‑elevation correspondences. Differential, whole brain effects were observed within the superior parietal lobule (SPL), cerebellum and Heschls’ gyrus (HG). Further, the angular gyrus (AnG), the intraparietal sulcus (IPS) and anterior cingulate cortex (ACC) were engaged in processing the CMCs but showed different effects for processing congruent compared to incongruent stimulus presentations. Within pitch‑size significant effects in the AnG and ACC were found for congruent stimulus presentations whereas for pitch‑elevation, significant effects in the ACC and IPS were found for incongruent stimulus presentations. In summary, the present results indicated differential neural processing in different simple audio‑visual CMCs.","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"85 4","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141116298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of professional dance training on characteristics of postural sway","authors":"J. W. Błaszczyk, Artur Fredyk","doi":"10.55782/ane-2024-2399","DOIUrl":"https://doi.org/10.55782/ane-2024-2399","url":null,"abstract":"The stability of human upright posture determines the range and dynamics of movements performed. Consequently, the repertoire and quality of the movements performed by a dancer are mainly determined by the efficiency of postural control. This is of particular importance in professional dance training that should focus on shaping optimal movement‑posture interaction. To get a deeper insight into this problem, the impact of the training on postural sway characteristics during quiet stance was analyzed in 16 female students in the seventh grade of a ballet school and compared with the size‑ and age‑matched group of secondary school students. Center of pressure trajectories were recorded for 25.6 s while standing quiet with eyes open (EO) and then with eyes closed (EC). The assessment of postural control was based on novel normalized sway parameters including sway vector (SV), sway anteroposterior (AP) and mediolateral (ML) directional indices (DIAP and DIML), and sway ratios (SRAP and SRML). The results document a significant contribution of vision to postural stability control in ballet students, which seems to compensate for training‑related changes in joint mobility and altered activity ranges of the legs’ muscles. In the control group standing with EC, SV amplitude increased only by 18% whereas in the ballet students tested in the same conditions, the increase exceeded 72%. Under full control of standing posture (EO test), the training‑related increase of leg muscle forces allows dancers to maintain balance with lesser effort as documented here by 21% reduced SRAP. Additionally, the dancers while tested with their EC exhibited a 12% increase in the anteroposterior sway with a concomitant reduction of the mediolateral sway. The resulting changes in the postural control asymmetry were documented by both DIAP/DIML and SV azimuth. In conclusion, our novel analysis of postural sway seems a useful tool in monitoring the effects of trainingas well as the proper course of postural control development in children and adolescents.","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"11 6","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141114436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial direct current stimulation in the treatment of alcohol, tobacco and opioid use disorder in clinical studies.","authors":"Begüm Merve Çabuk, Zozan Guleken","doi":"10.55782/ane-2024-2479","DOIUrl":"https://doi.org/10.55782/ane-2024-2479","url":null,"abstract":"<p><p>Transcranial direct current stimulation (tDCS) is a promising research tool to address substance abuse, including alcohol, tobacco, opioid, and drug use disorders. The present literature review compared previous studies conducted with various current intensities, application regions, durations of stimulations, and different region targets of the brain. Studies based on the analyses conducted after tDCS administration in substance use disorder were promising for the use of tDCS as adjunctive therapy to reduce visible psychological and neurological symptoms of the addiction. Therefore, we aimed to provide an insight into the current state of research on tDCS as a therapeutic intervention in substance use disorders, identify gaps in the literature, and emphasize future investigation areas. Ultimately, the review sought to contribute to the understanding of the role of tDCS in addressing the complex challenges posed by substance use disorder, and its potential as a complementary or adjunctive treatment modality in addiction care. The present study identified that the left dlPFC and brain regions were effective targets for 1 mA and 2 mA tDCS current density in tobacco/nicotine use disorder. Also, the left dlPFC and 2 mA current density were identified as effective targets for tDCS in alcohol use disorder. Furthermore, left dlPFC and 2 mA current density were identified as effective targets for tDCS in opioid use disorder. Additionally, the right/left dlPFC, orbital frontal cortex, thalamus, and 2 mA current density were identified as effective targets for tDCS in other drug or substance use disorders. Animal studies demonstrated that tDCS was promising in reducing neuropathic pain, modulating neuropeptide Y activity, and reducing the redevelopment of ethanol consumption in animal models. However, further research is required to fully understand the optimal tDCS application parameters.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"84 2","pages":"111-127"},"PeriodicalIF":1.4,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel insight into the neuroprotective effects ofcannabidiol: maintained apelin/dopamine synthesis, NRF2 signaling, and AKT/CREB/BDNF gene expressions","authors":"Melike DOĞAN ÜNLÜ, S. Asci, O. Imeci, Adem Milletsever, Özlem Özmen, S. Sezer, Serpil Demirci","doi":"10.55782/ane-2024-2546","DOIUrl":"https://doi.org/10.55782/ane-2024-2546","url":null,"abstract":"Neuroinflammation is a process associated with degeneration and loss of neurons in different parts of the brain. The most important damage mechanisms in its formation are oxidative stress and inflammation. This study aimed to investigate the protective effects of cannabidiol (CBD) against neuroinflammation through various mechanisms. Thirty‑two female rats were randomly divided into 4 groups as control, lipopolysaccharide (LPS), LPS + CBD and CBD groups. After six hours following LPS administration, rats were sacrificed, brain and cerebellum tissues were obtained. Tissues were stained with hematoxylin‑eosin for histopathological analysis. Apelin and tyrosine hydroxylase synthesis were determined immunohistochemically. Total oxidant status and total antioxidant status levels were measured, and an oxidative stress index was calculated. Protein kinase B (AKT), brain-derived neurotrophic factor (BDNF), cyclic‑AMP response element‑binding protein (CREB) and nuclear factor erythroid 2‑related factor 2 (NRF2) mRNA expression levels were also determined. In the LPS group, hyperemia, degeneration, loss of neurons and gliosis were seen in all three tissues. Additionally, Purkinje cell loss in the cerebellum, as well as neuronal loss in the cerebral cortex and hippocampus, were found throughout the LPS group. The expressions of AKT, BDNF, CREB and NRF2, apelin and tyrosine hydroxylase synthesis all decreased significantly. CBD treatment reversed these changes and ameliorated oxidative stress parameters. CBD showed protective effects against neuroinflammation via regulating AKT, CREB, BDNF expressions, NRF2 signaling, apelin and tyrosine hydroxylase synthesis.","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"8 7","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}