Acta Medica PhilippinaPub Date : 2025-02-28eCollection Date: 2025-01-01DOI: 10.47895/amp.vi0.8797
Suherman, Budi Anna Keliat, Novy Helena Catharina Daulima, Besral
{"title":"Risk Factors for Suicide among Adolescents in Bangka Belitung Island, Indonesia: a Qualitative Study Approach.","authors":"Suherman, Budi Anna Keliat, Novy Helena Catharina Daulima, Besral","doi":"10.47895/amp.vi0.8797","DOIUrl":"10.47895/amp.vi0.8797","url":null,"abstract":"<p><strong>Background: </strong>Suicide among adolescents is a critical global health problem. Identifying risk factors for suicide in adolescents is crucial because it is one of the most severe mental health issues and can result in loss of life. Risk factors serve as indicators that have the potential to bring life to an end. However, people around adolescents often display indifference and even tend to overlook the suicide risk factors experienced by them.</p><p><strong>Objective: </strong>This study aimed to explore the risk factors for suicide in adolescents in Indonesia.</p><p><strong>Methods: </strong>This study used qualitative descriptive research design conducted at State Vocational High Schools (SMKN) and Puskesmas. Data collection was done through Focus Group Discussion (FGD) of 10 students, and in-depth interviews of eight participants (two parents of adolescents who attempted suicide, two guidance counseling teachers, two adolescents who attempted suicide, and two mental nurses) The data were analyzed using thematic analysis.</p><p><strong>Results: </strong>The risk factors for suicide experienced by adolescents are biological, psychological, and social factors. These risk factors for suicide are stressors that contribute to adolescents engaging in suicidal behavior. Identifying the risk factors experienced by adolescents is crucial for suicide prevention.</p><p><strong>Conclusion: </strong>The risk factors that lead to suicide in adolescents encompass biological, psychological, and social factors. A thorough understanding of suicide among parents, teachers, and peers can significantly assist in implementing suitable prevention measures and interventions for adolescent suicide.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 3","pages":"116-124"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Medica PhilippinaPub Date : 2025-02-28eCollection Date: 2025-01-01DOI: 10.47895/amp.vi0.9739
Kerwyn Jim C Chan, Marie Carmela M Lapitan, Cynthia P Cordero
{"title":"Goal Attainment Scaling and Quality of Life of Autistic Children Receiving Speech and Language Therapy in a Higher Educational Institution in the Philippines.","authors":"Kerwyn Jim C Chan, Marie Carmela M Lapitan, Cynthia P Cordero","doi":"10.47895/amp.vi0.9739","DOIUrl":"10.47895/amp.vi0.9739","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to describe the demographic profile, intervention sessions, goal attainment scaling (GAS), and health-related quality of life (HRQOL) of autistic children receiving speech and language therapy (SLT) in a higher educational institution in the Philippines.</p><p><strong>Methods: </strong>Deidentified data from 18 autistic children aged 4-16 years (mean=8.2; SD=2.9) who received SLT for two months were analyzed. Their demographic profile, intervention sessions, GAS scores, and generic HRQOL scores were documented.</p><p><strong>Results: </strong>Most participants were school-age children (n=12; 66%) and were boys (n=14; 78%). After two months, the GAS scores of 11 participants (61%) increased by 1-2 points, whereas the scores of the remaining participants decreased (n=6; 33%) or did not change (n=1; 6%). Their mean generic HRQOL scores before and after SLT were 65.6 (SD=15.2) and 61.2 (SD=17.4), respectively.</p><p><strong>Conclusions: </strong>While the GAS scores increased for most participants, their generic HRQOL scores did not show clinically significant changes after two months of SLT. This can be attributed to the few therapy sessions and short follow-up period. The findings highlight the need to provide long-term support to SLT services of autistic children in the Philippines to document more desirable quality of life outcomes.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 3","pages":"7-20"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Medica PhilippinaPub Date : 2025-02-28eCollection Date: 2025-01-01DOI: 10.47895/amp.v59i3.13090
Jocelyn Christina Marzan
{"title":"Outcomes Measures in Philippine Speech-Language Pathology Service Delivery.","authors":"Jocelyn Christina Marzan","doi":"10.47895/amp.v59i3.13090","DOIUrl":"10.47895/amp.v59i3.13090","url":null,"abstract":"","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 3","pages":"5-6"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fractal Dimension Approach for Quantitative Analysis Radiograph in Periapical Inflammation: A Systematic Review.","authors":"Azhari, Lusi Epsilawati, Dwi Putri Wulansari, Ichda Nabiela Amiria Asykarie","doi":"10.47895/amp.vi0.7186","DOIUrl":"10.47895/amp.vi0.7186","url":null,"abstract":"<p><strong>Background and objective: </strong>Periapical inflammation on visual interpretation, especially in conditions of early inflammation, is very dependent on visual acuity. Visual ability can only detect if the inflammatory condition in the periapical area is more than 30%. This study reviewed the use of fractal dimension (FD) for quantitative assessment radiographs in periapical inflammation.</p><p><strong>Methods: </strong>The search was performed using PubMed, Web of Science, and Scopus databases. The inclusion criteria were clinical research, the area was in the periapical inflammation, used the periapical radiograph, measured the fractal dimension in human bone, the article studies were in the English language. There was no restriction for publication date.</p><p><strong>Results: </strong>Five articles were found in which fractal dimension was applied for the assessment of periapical lesions visually indiscernible in radiographs, for evaluation of apical inflammation, for imaging diagnosis of the periapical lesion, for analysis of trabecular bone, and for analysis of trabecular bone structure around the bone of periapical inflammation. Various sizes and sites of the regions of interest were used to evaluate the bone structure of periapical inflammation with fractal dimension.</p><p><strong>Conclusion: </strong>Fractal dimension in Dentistry has been widely applied to the study of images. Periapical radiographs were the most frequently used. The Image J software and the fractal analysis method were extensively adopted in the studies reviewed herein. Further studies are encouraged to improve the use of fractal dimension in assessing quantitative radiographs in periapical inflammation.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 3","pages":"125-130"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Medica PhilippinaPub Date : 2025-02-28eCollection Date: 2025-01-01DOI: 10.47895/amp.vi0.9136
Lyanne Kae C Campo, Aldren R Remon
{"title":"Knowledge and Practices of Nurses on the Prevention and Control of Healthcare-acquired Infections in a Private Tertiary Hospital in Baguio City.","authors":"Lyanne Kae C Campo, Aldren R Remon","doi":"10.47895/amp.vi0.9136","DOIUrl":"10.47895/amp.vi0.9136","url":null,"abstract":"<p><strong>Background: </strong>Healthcare-acquired infections (HAIs) are adverse events brought about by non-compliance of the healthcare staff to set of infection prevention and control (IPC) standards. Consequently, additional medical costs, increased mortality and morbidity rates, and decreased quality of life among patients can happen. As valuable players in preventing and controlling HAIs, nurses must have good knowledge and strict compliance with infection control; however, recent evidence suggests that nurses may need more knowledge or better integration into practice. Nurses' degree of knowledge and practice in preventing and controlling HAIs and factors influencing them should be determined to provide solutions appropriately.</p><p><strong>Objectives: </strong>The study specifically sought answers to the following questions: (1) What is the level of knowledge of nurses in the prevention and control of HAIs? (2) What is the degree of practice of nurses in the prevention and control of HAIs? (3) Is there a significant relationship between nurses' knowledge level and degree of practice in the prevention and control of HAIs? (4) What are the facilitating and hindering factors that affect nurses' practice in the prevention and control of HAIs?</p><p><strong>Methods: </strong>The study utilized a quantitative descriptive correlational design. The study was conducted from May to June 2023 at a private tertiary hospital in Baguio City. The study included 128 nurses who fit the inclusion criteria. The respondents were asked to answer three questionnaires, and the data were statistically treated using mean, Spearman Rank correlation, frequency, percentage, and rank distribution.</p><p><strong>Results: </strong>The study found that nurses possess good knowledge and a suboptimal degree of practice in preventing and controlling HAIs. The results showed that no significant relationship existed between nurses' knowledge level and degree of practice in preventing and controlling HAIs. Perceived personal benefits and organizational encouragement were seen to primarily facilitate the prevention and control practices of nurses. The primary hindrance identified was work-load due to staff shortage, poor dissemination of guidelines, and personal discomfort associated with the use of PPE.</p><p><strong>Conclusions: </strong>A good level of knowledge is a derivative of learnings obtained through various educational modalities and these strategies are considered effective means of knowledge formulation. However, created knowledge without actual application into practice results in overuse of unhelpful interventions. To avoid the unnecessary effects of ineffective knowledge translation, a multifactorial consideration is necessary to identify other factors that may influence the practices of nurses on HAI prevention and control because knowledge does not solely improve or worsen actual practices. Identified facilitating factors should be supported, and hindering ","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 3","pages":"92-103"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Medica PhilippinaPub Date : 2025-02-28eCollection Date: 2025-01-01DOI: 10.47895/amp.vi0.9439
Leniza G de Castro-Hamoy, Ma Anna Lourdes A Moral, Loudella V Calotes-Castillo, Mary Ann R Abacan, Cynthia P Cordero, Maria Lourdes C Pagaspas, Ebner Bon G Maceda, Sylvia C Estrada, Mary Anne D Chiong
{"title":"Clinical, Biochemical, and Radiologic Profiles of Filipino Patients with 6-Pyruvoyl-Tetrahydrobiopterin Synthase (6-PTPS) Deficiency and their Neurodevelopmental Outcomes.","authors":"Leniza G de Castro-Hamoy, Ma Anna Lourdes A Moral, Loudella V Calotes-Castillo, Mary Ann R Abacan, Cynthia P Cordero, Maria Lourdes C Pagaspas, Ebner Bon G Maceda, Sylvia C Estrada, Mary Anne D Chiong","doi":"10.47895/amp.vi0.9439","DOIUrl":"10.47895/amp.vi0.9439","url":null,"abstract":"<p><strong>Background: </strong>Six-pyruvoyl-tetrahydrobiopterin synthase (6-PTPS) deficiency is an inherited metabolic disorder which results in tetrahydrobiopterin (BH4) deficiency causing hyperphenylalaninemia.</p><p><strong>Objective: </strong>This study aimed to describe the clinical, biochemical, and radiologic profiles, and neurologic and developmental outcomes of patients diagnosed with 6-pyruvoyl tetrahydrobiopterin (PTPS) deficiency through newborn screening and confirmed by BH4 loading test, pterin analysis, and gene sequencing who were following-up with the metabolic team.</p><p><strong>Methods: </strong>The research was a single-center descriptive case series study design that was done at the Philippine General Hospital, a tertiary government hospital. The clinical, biochemical, radiologic profiles and neurodevelopmental evaluation of each patient were described.</p><p><strong>Results: </strong>Nine patients from 1 year 2 months to 14 years 5 months of age were enrolled in the study. Clinical manifestations before treatment were hypotonia, poor suck, and seizure. The most common clinical manifestation even after treatment initiation was seizure. The mean phenylalanine level on newborn screening was 990.68 umol/L, but after treatment was started, mean levels ranged from 75.69 to 385.09 umol/L. Two of the patients had focal atrophy of the posterior lobe on brain imaging. Pathogenic variants on molecular analysis were all missense, with two predominant variants, c.155A>G and c.58T>C. Eight of the nine patients had varying degrees of developmental delay or intellectual disability, while the remaining patient had signs of a learning disorder.</p><p><strong>Conclusion: </strong>Newborn screening has played a crucial role in the early identification and management of patients with hyperphenylalaninemia due to 6-PTPS deficiency. Confirmation of diagnosis through determination of DHPR activity, urine pterins and/or molecular analysis is necessary for appropriate management. However, despite early initiation of treatment, neurodevelopmental findings of patients with 6-PTPS deficiency were still unsatisfactory.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 3","pages":"39-44"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Medica PhilippinaPub Date : 2025-01-31eCollection Date: 2025-01-01DOI: 10.47895/amp.vi0.8950
Gabrielle P Flores, Reiner Lorenzo J Tamayo, Robert Neil F Leong, Christian Sergio M Biglaen, Kathleen Nicole T Uy, Renee Rose O Maglente, Marlex Jorome M Nuguid, Jason V Alacapa
{"title":"Diagnostic Performance of a Computer-aided System for Tuberculosis Screening in Two Philippine Cities.","authors":"Gabrielle P Flores, Reiner Lorenzo J Tamayo, Robert Neil F Leong, Christian Sergio M Biglaen, Kathleen Nicole T Uy, Renee Rose O Maglente, Marlex Jorome M Nuguid, Jason V Alacapa","doi":"10.47895/amp.vi0.8950","DOIUrl":"10.47895/amp.vi0.8950","url":null,"abstract":"<p><strong>Background and objectives: </strong>The Philippines faces challenges in the screening of tuberculosis (TB), one of them being the shortage in the health workforce who are skilled and allowed to screen TB. Deep learning neural networks (DLNNs) have shown potential in the TB screening process utilizing chest radiographs (CXRs). However, local studies on AI-based TB screening are limited. This study evaluated qXR3.0 technology's diagnostic performance for TB screening in Filipino adults aged 15 and older. Specifically, we evaluated the specificity and sensitivity of qXR3.0 compared to radiologists' impressions and determined whether it meets the World Health Organization (WHO) standards.</p><p><strong>Methods: </strong>A prospective cohort design was used to perform a study on comparing screening and diagnostic accuracies of qXR3.0 and two radiologist gradings in accordance with the Standards for Reporting Diagnostic Accuracy (STARD). Subjects from two clinics in Metro Manila which had qXR 3.0 seeking consultation at the time of study were invited to participate to have CXRs and sputum collected. Radiologists' and qXR3.0 readings and impressions were compared with respect to the reference standard Xpert MTB/RiF assay. Diagnostic accuracy measures were calculated.</p><p><strong>Results: </strong>With 82 participants, qXR3.0 demonstrated 100% sensitivity and 72.7% specificity with respect to the reference standard. There was a strong agreement between qXR3.0 and radiologists' readings as exhibited by the 0.7895 (between qXR 3.0 and CXRs read by at least one radiologist), 0.9362 (qXR 3.0 and CXRs read by both radiologists), and 0.9403 (qXR 3.0 and CXRs read as not suggestive of TB by at least one radiologist) concordance indices.</p><p><strong>Conclusions: </strong>qXR3.0 demonstrated high sensitivity to identify presence of TB among patients, and meets the WHO standard of at least 70% specificity for detecting true TB infection. This shows an immense potential for the tool to supplement the shortage of radiologists for TB screening in the country. Future research directions may consider larger sample sizes to confirm these findings and explore the economic value of mainstream adoption of qXR 3.0 for TB screening.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 2","pages":"33-40"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Medica PhilippinaPub Date : 2025-01-31eCollection Date: 2025-01-01DOI: 10.47895/amp.vi0.9316
Adrian I Espiritu, Carl Froilan D Leochico, Isabella E Supnet, Emilio Q Villanueva, Marie Charmaine C Sy, Veeda Michelle M Anlacan, Roland Dominic G Jamora
{"title":"Risk of COVID-19 Outcomes among Healthcare Workers: Findings from the Philippine CORONA Retrospective Cohort Study.","authors":"Adrian I Espiritu, Carl Froilan D Leochico, Isabella E Supnet, Emilio Q Villanueva, Marie Charmaine C Sy, Veeda Michelle M Anlacan, Roland Dominic G Jamora","doi":"10.47895/amp.vi0.9316","DOIUrl":"10.47895/amp.vi0.9316","url":null,"abstract":"<p><strong>Objectives: </strong>While many healthcare workers (HCWs) contracted COVID-19 during the pandemic, more information is needed to fully understand the potential for adverse health effects in this population segment. The aim of the present study is to examine the association between healthcare worker status and neurologic and clinical outcomes in COVID-19 infected inpatients.</p><p><strong>Methods: </strong>Using the nationwide database provided by the retrospective cohort Philippine CORONA study, we extracted relevant data and performed a secondary analysis primarily focusing on the presentation and outcomes of healthcare workers. Propensity score matching in a 3:1 ratio was performed to match HCWs and non-HCWs. We performed multiple logistic and Cox regression analyses to determine the relationship between HCWs and COVID-19 clinical outcomes.</p><p><strong>Results: </strong>We included 3,362 patients infected with COVID-19; of which, 854 were HCWs. Among the HCWs, a total of 31 (3.63%) and 45 (5.27%) had the primary outcomes of in-hospital mortality and respiratory failure, respectively. For both overall and 3:1 propensity-matched cohorts, being an HCW significantly decreased the odds of the following outcomes: severe/critical COVID-19 at nadir; in-hospital mortality; respiratory failure; intensive care unit admission; and hospital stay >14 days.</p><p><strong>Conclusion: </strong>We found that being an HCW is not associated with worse neurologic and clinical outcomes among patients hospitalized for COVID-19.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 2","pages":"25-32"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta Medica PhilippinaPub Date : 2025-01-31eCollection Date: 2025-01-01DOI: 10.47895/amp.vi0.9091
Danna Mae S Opiso, Germana Emerita V Gregorio, Catherine Lynn T Silao
{"title":"Association of <i>TP53</i> Germline Variant and Choledochal Cyst among Clinically Diagnosed Filipino Pediatric Patients.","authors":"Danna Mae S Opiso, Germana Emerita V Gregorio, Catherine Lynn T Silao","doi":"10.47895/amp.vi0.9091","DOIUrl":"10.47895/amp.vi0.9091","url":null,"abstract":"<p><strong>Background and objective: </strong>Choledochal cysts (CC) are rare congenital, cystic dilations of the biliary tree occurring predominantly in Asian populations and in females. Patients are usually children presenting with any of the following: abdominal pain, palpable abdominal mass, and jaundice. Its congenital nature hints at a potential genetic cause. A possible causal gene is <i>TP53</i>, a tumor suppressor with a germline variant called rs201753350 (c.91G>A) that changed from a G allele to an A allele, decreasing the cell proliferation suppressing activity of its functional protein. Currently, there is no information on the <i>TP53</i> rs201753350 germline variant available for the Filipino population. This study determined the prevalence of rs201753350 and the association between the functional G allele, the rs201753350 germline variant A allele, and the occurrence of CCs in Filipino pediatric patients in a tertiary government hospital.</p><p><strong>Methods: </strong>Genomic DNA was extracted from blood samples of pediatric patients clinically diagnosed with CC. Controls were DNA samples collected from a previous study. The samples underwent PCR, electrophoresis, and sequencing.</p><p><strong>Results: </strong>A total of 109 participants (22 cases and 87 controls) were included in the study. The A allele (22.94%) occurs at a lower frequency than the G allele (77.06%) among both cases and controls. More individuals have a homozygous G/G genotype (54.13%) than a heterozygous A/G genotype (45.87%) while the homozygous A/A genotype was not observed. The estimated risk of choledochal cyst occurrence is significantly lower in individuals with the A allele (PR: 0.08, 95% CI: 0.01 - 0.55) and the A/G genotype (PR: 0.06, 95% CI: 0.01 - 0.40).</p><p><strong>Conclusion: </strong>There is no significant evidence to suggest an association between the <i>TP53</i> rs201753350 germline variant and the occurrence of choledochal cysts in Filipinos. It is recommended that other mutations within and beyond the <i>TP53</i> gene be investigated for possible associations with choledochal cyst occurrence.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 2","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rare Vulvar Lesions: A Case Series.","authors":"Parul Sinha, Vandana Verma, Apala Priyadarshini, Amrita Upadhyaya, Shruti Gupta","doi":"10.47895/amp.vi0.7933","DOIUrl":"10.47895/amp.vi0.7933","url":null,"abstract":"<p><p>Mass of the vulva include both benign and malignant lesions. Benign mass lesions of the vulva include tumors, hamartomas, cysts, infectious disorders, and non-neoplastic epithelial disorders. Some are rare mass lesions. Here, we presented three rare mass lesions of the vulva. The first case presented with the complaint of vulvar lesion since childhood, while the two cases presented in reproductive age and perimenopausal age. All three cases presented as mass lesions in the vulva with pain or uneasiness during work. In all these cases, excision was done. On histopathological examination, the lesions have different diagnoses which are common in other parts of the body, but rarely present at the vulva. A definitive diagnosis of a vulvar mass lesion is difficult to make, especially in the case of rare mass lesion. Histopathology is the principal tool of diagnosis.</p>","PeriodicalId":6994,"journal":{"name":"Acta Medica Philippina","volume":"59 2","pages":"81-84"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}