Acta biochimica et biophysica Sinica最新文献_第4页

Pearl peptides ( Hyriopsis Cumingii) as tyrosinase inhibitors: identification, characterization, inhibitory activity, conformational change and mechanism. 三角帆蚌珍珠肽作为酪氨酸酶抑制剂：鉴定、表征、抑制活性、构象变化及机制

IF 3.4 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2026-02-26 DOI: 10.3724/abbs.2025226

Jingying Pei, Yufei Wang, Hao Yan, Juan Sun, Peilong Sun, Yan Wang

{"title":"Pearl peptides ( Hyriopsis Cumingii) as tyrosinase inhibitors: identification, characterization, inhibitory activity, conformational change and mechanism.","authors":"Jingying Pei, Yufei Wang, Hao Yan, Juan Sun, Peilong Sun, Yan Wang","doi":"10.3724/abbs.2025226","DOIUrl":"https://doi.org/10.3724/abbs.2025226","url":null,"abstract":"Pearl protein extracted from freshwater mussels has been shown to inhibit tyrosinase activity. However, the unclear inhibitory mechanism and associated conformational changes limit their practical applications. In this study, peptides from the crude extract of pearl powder are analyzed via liquid chromatography-tandem mass spectrometry (LC-MS/MS). These peptides are subsequently assessed for their tyrosinase inhibitory potential via molecular docking techniques. Notably, experiments reveal that a small-molecule peptide effectively prevents the interaction between 3,4-dihydroxyphenylalanine (L-DOPA) and tyrosinase, impeding the formation of dopaquinone. The peptide GLGGGLAGAGGADGA (95P, 1099.54 Da) shows particular promise, with synthesized 95P inhibiting both the monophenolase and diphenolase activities of tyrosinase, with IC 50 values of 30.97 ± 0.75 μM and 64.62 ± 3.08 μM,respectively. 95P inhibits tyrosinase activity in a mixed competitive and reversible manner. Molecular dynamics simulations suggest that 95P stabilizes 5M8N, impeding structural contraction identified by model number 5M8N. In conclusion, 95P is a powerful and stable tyrosinase inhibitor with the potential to be used as a skin whitening agent in the pharmaceutical field and an anti-browning agent in the food industry.","PeriodicalId":6978,"journal":{"name":"Acta biochimica et biophysica Sinica","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient production of recombinant mAbs mediated by a MAR-enhanced transposon vector combined with blasticidin selection in CHO cells. 在CHO细胞中利用mar增强转座子载体结合囊胚杀虫素选择介导高效生产重组单克隆抗体。

IF 3.4 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2026-02-13 DOI: 10.3724/abbs.2025251

Xiaoyin Wang, Xuelian Han, Ting Liu, Shiqi Zhang, Zimeng Han, Ruoyuan Feng, Tianyun Wang

{"title":"Efficient production of recombinant mAbs mediated by a MAR-enhanced transposon vector combined with blasticidin selection in CHO cells.","authors":"Xiaoyin Wang, Xuelian Han, Ting Liu, Shiqi Zhang, Zimeng Han, Ruoyuan Feng, Tianyun Wang","doi":"10.3724/abbs.2025251","DOIUrl":"https://doi.org/10.3724/abbs.2025251","url":null,"abstract":"Recombinant antibodies, primarily produced in Chinese hamster ovary (CHO) cells, are widely used to treat various diseases. For industrial production, a rapid and efficient method to screen stable, high-expressing clones is essential. However, conventional screening based on random integration is often cumbersome and labor intensive. This study establishes a novel strategy for generating stable, high-yielding clones by combining a MAR-based piggyBac (PB) transposon semitargeted integration system with blasticidin (BSD) selection. Compared to the random integrated vector pMAR-mAb, the MAR-PB system increases the titers (3.95- to 5.61-fold) and specific protein productivity (Qp; 4.28- to 6.07-fold) of four monoclonal antibodies in stable cell pools. When compared to PB-only vectors, the MAR-PB transposon system enhances the titers (by up to 2.50-fold) and Qp (1.96- to 2.77-fold), respectively. The increased antibody production correlates with elevated mRNA expression. Furthermore, this approach increases the proportion of high-expressing clones by more than 10-fold and significantly improves volumetric yield. Importantly, this approach promotes the long-term stability of recombinant mAb expression for over 60 generations. Transcriptome analysis reveals that the system modulates genes involved in DNA binding, transcriptional regulation, and protein binding. In conclusion, the MAR-based PB transposon system combined with BSD selection presents a significant improvement for efficiently generating high-yielding and stable CHO cell clones, offering a valuable tool for recombinant antibody production.","PeriodicalId":6978,"journal":{"name":"Acta biochimica et biophysica Sinica","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural basis for the conformational changes of insulin receptor induced by three different hormone ligands. 三种不同激素配体诱导胰岛素受体构象变化的结构基础。

IF 3.4 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2026-02-11 DOI: 10.3724/abbs.2026020

Xi Zhang, Ting Zhang, Cang Wu, Yuanzhu Gao, Shuo Zhang, Zhenglin Li, Linshan Zhong, Chenyu Xia, Liuqing Yang, Fengquan Dong, Qing Shu, Yang Fu, Renhong Yan

{"title":"Structural basis for the conformational changes of insulin receptor induced by three different hormone ligands.","authors":"Xi Zhang, Ting Zhang, Cang Wu, Yuanzhu Gao, Shuo Zhang, Zhenglin Li, Linshan Zhong, Chenyu Xia, Liuqing Yang, Fengquan Dong, Qing Shu, Yang Fu, Renhong Yan","doi":"10.3724/abbs.2026020","DOIUrl":"https://doi.org/10.3724/abbs.2026020","url":null,"abstract":"The insulin receptor (IR) is central to the regulation of glucose and lipid metabolism. Although insulin is its primary ligand, insulin-like growth factors I and II (IGF-I and IGF-II) also engage IR, albeit with reduced affinity. The structural basis of cooperative ligand binding, however, has remained poorly understood. Here, we report cryo-Electron Microscopy (cryo-EM) structures of IR in complex with insulin, IGF-I, and IGF-II, revealing that all three ligands engage the receptor at overlapping binding sites and can induce a conserved T-shaped quaternary assembly involving four ligand molecules at site 1/1' and site 2/2'. Despite this shared overall architecture, distinct ligand-specific conformational changes are observed. Notably, IGF-I and IGF-II adopt different binding sequence at site 1 and site 2 compared to insulin, suggesting unique interaction dynamics. These structural insights highlight divergent mechanisms of ligand recognition and cooperative binding, providing a deeper understanding of hormone-induced conformational modulation of the IR.","PeriodicalId":6978,"journal":{"name":"Acta biochimica et biophysica Sinica","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CAR-macrophages: a new chapter in cancer immunotherapy. car -巨噬细胞：癌症免疫治疗的新篇章。

IF 3.4 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2026-02-11 DOI: 10.3724/abbs.2026017

Xucai Tang, Qian Xiao

{"title":"CAR-macrophages: a new chapter in cancer immunotherapy.","authors":"Xucai Tang, Qian Xiao","doi":"10.3724/abbs.2026017","DOIUrl":"https://doi.org/10.3724/abbs.2026017","url":null,"abstract":"Chimeric antigen receptor T (CAR-T) cell therapy achieves remarkable success in hematological cancers, but its efficacy is severely limited in solid tumors by formidable obstacles including physical barriers, the highly immunosuppressive tumor microenvironment (TME), and antigen escape. To address these persistent challenges, chimeric antigen receptor-macrophage (CAR-M) therapy emerges as a promising alternative, leveraging intrinsic advantages of macrophages like unparalleled tumor infiltration, powerful phagocytosis, and high plasticity. The evolution of CAR-M is primarily defined by the intracellular signaling domain. CAR-M exerts its anti-tumor effects through multifaceted mechanisms, including direct enhanced phagocytosis and tumor cell killing, TME remodeling by repolarizing to a pro-inflammatory M1-like phenotype, releasing anti-tumor effectors, and degrading the extracellular matrix (ECM), and the activation of adaptive immunity via efficient antigen presentation. Despite its promise, CAR-M faces hurdles such as TME physical barriers and the potential for M2-like re-education. Current optimization strategies focus on enhancing tumor infiltration, overcoming immunosuppression with \"armored\" CAR-Ms, and improving safety with suicide switches. Encouraging pre-clinical data accelerates CAR-M into early-phase clinical trials for solid tumors, and the platform's utility is also being explored beyond oncology in infectious, autoimmune, and neurodegenerative diseases.","PeriodicalId":6978,"journal":{"name":"Acta biochimica et biophysica Sinica","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146155460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered gut microbial dynamics and the antivascular remodeling effect of carnosine in hypobaric hypoxic pulmonary hypertension rats. 低氧缺氧肺动脉高压大鼠肠道微生物动力学改变及肌肽的抗血管重构作用。

IF 3.4 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2026-02-10 DOI: 10.3724/abbs.2025237

Huaying Wei, Shikun Guo, Wenjing Ding, Yifan Yang, Xinyu Hu, Ailifeila Aili, Xiaolan Chen, Xinying Xue, Lei Pan

{"title":"Altered gut microbial dynamics and the antivascular remodeling effect of carnosine in hypobaric hypoxic pulmonary hypertension rats.","authors":"Huaying Wei, Shikun Guo, Wenjing Ding, Yifan Yang, Xinyu Hu, Ailifeila Aili, Xiaolan Chen, Xinying Xue, Lei Pan","doi":"10.3724/abbs.2025237","DOIUrl":"https://doi.org/10.3724/abbs.2025237","url":null,"abstract":"Exposure to chronic hypobaric hypoxia provokes marked alterations in the gut microbiota and its metabolome, yet the functional significance of histidine-derived metabolites in hypobaric hypoxic pulmonary hypertension (PH) remains underexplored. Here, we employ 16S rDNA, metagenomic, and untargeted metabolomic sequencing to characterize longitudinal shifts in the fecal microbiota and metabolites during hypobaric hypoxic PH development in Sprague-Dawley rats. Fecal carnosine levels and the abundance of its producer, Ruminococcus bromii, both decrease significantly over 28 days of hypobaric hypoxia ( P < 0.05). Spearman correlation shows that carnosine is inversely correlated with the percentage of pulmonary arteriole media thickness (MT%; r = -0.8741, P < 0.001). Therapeutic supplementation with carnosine restores systemic and pulmonary antioxidant defenses and attenuates vascular remodeling without altering right ventricular pressures. In vitro, carnosine inhibits hypoxia-induced pulmonary artery smooth muscle cell (PASMC) proliferation and migration and suppresses nuclear factor erythroid 2-related factor 2 (Nrf2) accumulation. These findings reveal dynamic gut-lung crosstalk in hypobaric hypoxic PH and nominate carnosine as a metabolite-based intervention to mitigate hypoxia-driven pulmonary vascular remodeling.","PeriodicalId":6978,"journal":{"name":"Acta biochimica et biophysica Sinica","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146155433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibroblast growth factor 13 deficiency attenuates doxorubicin-induced cardiotoxicity by regulating Parkin-mediated myocardial injury. 成纤维细胞生长因子13缺乏通过调节帕金森介导的心肌损伤减轻阿霉素诱导的心脏毒性。

IF 3.4 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2026-02-09 DOI: 10.3724/abbs.2025223

Jiabing Han, Xuyan Li, Yiming Dong, Yidan Wang, Simeng Lv, Yiyi Zhang, Ran Zhao, Yingke Yan, Yanxue Han, Yu Wang, Jing Yang, Cong Wang, Chuan Wang

{"title":"Fibroblast growth factor 13 deficiency attenuates doxorubicin-induced cardiotoxicity by regulating Parkin-mediated myocardial injury.","authors":"Jiabing Han, Xuyan Li, Yiming Dong, Yidan Wang, Simeng Lv, Yiyi Zhang, Ran Zhao, Yingke Yan, Yanxue Han, Yu Wang, Jing Yang, Cong Wang, Chuan Wang","doi":"10.3724/abbs.2025223","DOIUrl":"https://doi.org/10.3724/abbs.2025223","url":null,"abstract":"The clinical use of doxorubicin (DOX) as a chemotherapeutic agent is limited by its cardiotoxic effects. Fibroblast growth factor (FGF) isoform 13, a distinct type of FGF, has been increasingly recognized as an important regulator of cardiovascular disease. However, its role in doxorubicin-induced cardiotoxicity remains unknown. Therefore, the objective of this study is to investigate the role and mechanism of FGF13 in doxorubicin-induced cardiac injury. C57BL/6 mice are used to establish Dox-induced cardiotoxicity models. The results reveal that mouse weight, cardiomyocyte cross-sectional area, ejection fraction and fractional shortening are decreased in the DOX group. In contrast, Fgf13 deficiency mitigates doxorubicin-mediated cardiotoxicity, as indicated by increased mouse weight, cardiomyocyte cross-sectional area, ejection fraction and fractional shortening. Mechanistically, the protein expressions of bax and cleaved caspase 3 are elevated in the DOX-treated group, along with decreased JC-1 fluorescence intensity and bcl-2 expression, whereas Fgf13 knockout prevents these alterations. In addition, Parkin, but not p53, interacts with FGF13 and is upregulated in response to Fgf13 deficiency in a mouse model of doxorubicin-induced cardiotoxicity. Overall, Fgf13 knockout attenuates doxorubicin-induced cardiomyocyte apoptosis and mitochondrial damage through the modulation of Parkin, indicating that FGF13 may serve as a promising therapeutic target for DOX-induced cardiotoxicity.","PeriodicalId":6978,"journal":{"name":"Acta biochimica et biophysica Sinica","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression characteristics of serum exosomal microRNAs in patients with liver injury induced by anti-tuberculosis drugs. 抗结核药物肝损伤患者血清外泌体microrna的表达特征

IF 3.4 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2026-02-06 DOI: 10.3724/abbs.2025242

Yinpeng Jin, Xiaofang Yu, Mingquan Guo, Li Li, Shuangshuang Sun, Liling Yang, Ying Yuan, Qingchun Fu, Rongfeng Shi, Meng Jin

引用次数: 0

Predictive value of LCP1 and ADPGK for immune-related adverse events across multiple cancer types in patients receiving immunotherapy-based regimens. LCP1和ADPGK对接受免疫治疗方案的多种癌症类型患者免疫相关不良事件的预测价值。

IF 3.4 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2026-02-06 DOI: 10.3724/abbs.2026016

Xi Zhang, Yaqian Li, Li Zhang, Hongyu Liu, Wei Sun, Junhua Li, Dan Xue, Fan Zhang, Yuting Bai, Jing Zhang, Xing Gou, Dongzi Pang, Xueqin Zeng, Shuqing Wei

引用次数: 0

Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling. 心脏PTN-SIRT1轴通过AMPK/PGC1α信号通路缓解氧化应激，促进线粒体能量重编程，减轻阿霉素诱导的心脏毒性。

IF 3.4 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2026-02-05 DOI: 10.3724/abbs.2026018

Yuxiao Sun, Tianwen Wei, Hongping Xu, Hongda Li, Chang Zhou, Xianliang Liu, Yafei Li, Shangwei Huang, Qi Zhang, Xia Duan

{"title":"Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.","authors":"Yuxiao Sun, Tianwen Wei, Hongping Xu, Hongda Li, Chang Zhou, Xianliang Liu, Yafei Li, Shangwei Huang, Qi Zhang, Xia Duan","doi":"10.3724/abbs.2026018","DOIUrl":"10.3724/abbs.2026018","url":null,"abstract":"Doxorubicin (DOX) remains a cornerstone chemotherapeutic agent for malignancies, yet its clinical utility is severely limited by dose-dependent cardiotoxicity, which can lead to progressive left ventricular dysfunction and heart failure. Pleiotrophin (PTN), a heparin-binding growth factor with diverse physiological functions, regulates glucose and lipid metabolism and promotes oxidative energy pathways. However, whether PTN exerts protective effects against DOX-induced cardiotoxicity (DIC) remains unclear. In this study, we establish cellular and animal models of DIC. DOX administration induces pronounced myocardial injury in both models, characterized by impaired ventricular contractility, increased fibrotic remodeling, and reduced cell viability. Concurrently, PTN protein expression is significantly downregulated in cardiomyocytes under DOX treatment. Overexpression of PTN substantially alleviates these pathological changes. In vitro, PTN reduces mitochondrial oxidative stress and apoptosis while restoring energy production and cell viability. In vivo, PTN improves mitochondrial ultrastructure, decreases cardiomyocyte apoptosis, and enhances cardiac function. Mechanistically, PTN directly binds to SIRT1 and activates AMPK phosphorylation at Thr172, triggering a downstream cascade through the AMPK-PGC1α axis that reprograms mitochondrial energy metabolism and attenuates cardiotoxicity. In conclusion, the PTN-SIRT1 axis protects against DIC by reducing oxidative stress and promoting mitochondrial energy homeostasis via the AMPK/PGC1α pathway, highlighting its potential as a novel therapeutic target for preventing chemotherapy-related cardiac injury.","PeriodicalId":6978,"journal":{"name":"Acta biochimica et biophysica Sinica","volume":" ","pages":"421-436"},"PeriodicalIF":3.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12900733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PD-1 blockade elicits a systemic immune response but not in the tumor of TNBC mice. PD-1阻断引起全身免疫反应，但在TNBC小鼠肿瘤中没有。

IF 3.4 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2026-02-04 DOI: 10.3724/abbs.2025240

Xiaodan Hong, Mei Ma, Hongmei Cui, Xiaojuan Yang, Feifei Li, Meiling Chu, Yiyi Ye, Ziwei Jiang, Lixia Pei, Sheng Liu, Ying Xie

{"title":"PD-1 blockade elicits a systemic immune response but not in the tumor of TNBC mice.","authors":"Xiaodan Hong, Mei Ma, Hongmei Cui, Xiaojuan Yang, Feifei Li, Meiling Chu, Yiyi Ye, Ziwei Jiang, Lixia Pei, Sheng Liu, Ying Xie","doi":"10.3724/abbs.2025240","DOIUrl":"https://doi.org/10.3724/abbs.2025240","url":null,"abstract":"Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited treatment options due to the absence of hormone receptors and HER2 amplification. Immune checkpoint blockade, particularly targeting PD-1/PD-L1, has emerged as a promising therapeutic strategy. However, the response rate of TNBC patients to this monotherapy remains low. This study explores the systemic effect of PD-1 blockade on the immune and hematopoietic systems in 4T1 TNBC mice and demonstrates its limited efficacy in reducing the tumor burden and changing the number of tumor-infiltrating immune cells. However, PD-1 blockade increases systemic immune activity, as demonstrated by increased T cells and DCs in the peripheral blood, which may be associated with inflammatory side effects of this treatment. In addition, PD-1 blockade does not rescue the hematopoietic damage caused by TNBC, highlighting a limitation in long-term response. Furthermore, PD-1 blockade in tumor-free mice leads to an increase in hematopoietic stem/progenitor cells, suggesting that PD-1 blockade may yield better benefits post-tumor resection.","PeriodicalId":6978,"journal":{"name":"Acta biochimica et biophysica Sinica","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0