Acta biochimica et biophysica Sinica最新文献_第5页

Structure-based insights into fluorogenic RNA aptamers. 基于结构的荧光 RNA 对映体研究。

IF 3.3 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2024-08-16 DOI: 10.3724/abbs.2024142

Qianqian Song, Xiaoqing Tai, Qianyu Ren, Aiming Ren

引用次数: 0

Glycosylation in aging and neurodegenerative diseases. 衰老和神经退行性疾病中的糖基化。

IF 3.3 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2024-08-15 DOI: 10.3724/abbs.2024136

Weilong Zhang, Tian Chen, Huijuan Zhao, Shifang Ren

{"title":"Glycosylation in aging and neurodegenerative diseases.","authors":"Weilong Zhang, Tian Chen, Huijuan Zhao, Shifang Ren","doi":"10.3724/abbs.2024136","DOIUrl":"10.3724/abbs.2024136","url":null,"abstract":"Aging, a complex biological process, involves the progressive decline of physiological functions across various systems, leading to increased susceptibility to neurodegenerative diseases. In society, demographic aging imposes significant economic and social burdens due to these conditions. This review specifically examines the association of protein glycosylation with aging and neurodegenerative diseases. Glycosylation, a critical post-translational modification, influences numerous aspects of protein function that are pivotal in aging and the pathophysiology of diseases such as Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions. We highlight the alterations in glycosylation patterns observed during aging, their implications in the onset and progression of neurodegenerative diseases, and the potential of glycosylation profiles as biomarkers for early detection, prognosis, and monitoring of these age-associated conditions, and delve into the mechanisms of glycosylation. Furthermore, this review explores their role in regulating protein function and mediating critical biological interactions in these diseases. By examining the changes in glycosylation profiles associated with each part, this review underscores the potential of glycosylation research as a tool to enhance our understanding of aging and its related diseases.","PeriodicalId":6978,"journal":{"name":"Acta biochimica et biophysica Sinica","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11466714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring glyco-signatures and their clinical implications: a special issue focused on glycosylation studies. 探索糖基特征及其临床意义：聚焦糖基化研究的特刊。

IF 3.3 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2024-08-15 DOI: 10.3724/abbs.2024143

Haojia Lu, Xing Chen

引用次数: 0

Immunoglobulin G glycosylation and its alterations in aging-related diseases. 免疫球蛋白 G 糖基化及其在衰老相关疾病中的改变

IF 3.3 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2024-08-08 DOI: 10.3724/abbs.2024137

Yongqi Wu, Zhida Zhang, Lin Chen, Shisheng Sun

{"title":"Immunoglobulin G glycosylation and its alterations in aging-related diseases.","authors":"Yongqi Wu, Zhida Zhang, Lin Chen, Shisheng Sun","doi":"10.3724/abbs.2024137","DOIUrl":"10.3724/abbs.2024137","url":null,"abstract":"Immunoglobulin G (IgG) is an important serum glycoprotein and a major component of antibodies. Glycans on IgG affect the binding of IgG to the Fc receptor or complement C1q, which in turn affects the biological activity and biological function of IgG. Altered glycosylation patterns on IgG emerge as important biomarkers in the aging process and age-related diseases. Key aging-related alterations observed in IgG glycosylation include reductions in galactosylation and sialylation, alongside increases in agalactosylation, and bisecting GlcNAc. Understanding the role of IgG glycosylation in aging-related diseases offers insights into disease mechanisms and provides opportunities for the development of diagnostic and therapeutic strategies. This review summarizes five aspects of IgG: an overview of IgG, IgG glycosylation, IgG glycosylation with inflammation mediation, IgG glycan changes with normal aging, as well as the relevance of IgG glycan changes to aging-related diseases. This review provides a reference for further investigation of the regulatory mechanisms of IgG glycosylation in aging-related diseases, as well as for evaluating the potential of IgG glycosylation changes as markers of aging and aging-related diseases.","PeriodicalId":6978,"journal":{"name":"Acta biochimica et biophysica Sinica","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11399422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methyltransferase DNMT3B promotes colorectal cancer cell proliferation by inhibiting PLCG2. 甲基转移酶 DNMT3B 通过抑制 PLCG2 促进结直肠癌细胞增殖。

IF 3.3 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2024-08-07 DOI: 10.3724/abbs.2024117

Yong Ji, Yang Wang, Jiacheng Zou, Guanghao Liu, Mingyu Xia, Jun Ren, Daorong Wang

{"title":"Methyltransferase DNMT3B promotes colorectal cancer cell proliferation by inhibiting PLCG2.","authors":"Yong Ji, Yang Wang, Jiacheng Zou, Guanghao Liu, Mingyu Xia, Jun Ren, Daorong Wang","doi":"10.3724/abbs.2024117","DOIUrl":"https://doi.org/10.3724/abbs.2024117","url":null,"abstract":"Aberrant DNA methylation patterns in the promoter region of PLCG2 are associated with dysregulated signaling pathways and cellular functions. Its role in colorectal cancer cells is still unknown. In this study, qRT-PCR is used to measure DNMT3B expression in colorectal cancer. Western blot analysis and immunohistochemistry are used to analyze DNMT3B and PLCG2 protein levels in colorectal tissues and cell lines. Cell Counting Kit-8 (CCK-8) and colony formation assays are used to assess the proliferation of colorectal cancer cells. Methylation-specific PCR (MSP) and bisulfite-sequencing PCR (BSP) are used to measure DNA methylation level. Our results show that DNMT3B is overexpressed in colorectal cells in the TCGA datasets according to Kaplan-Meier plots. DNMT3B is significantly overexpressed in tumor tissues compared to that in adjacent nontumor tissues. Western blot analysis results demonstrate high expression of DNMT3B in tumor tissues. Compared to normal colonic epithelial cells, colorectal cancer cell lines exhibit elevated level of PLCG2 methylation. Overexpression of PLCG2 effectively prevents the growth of colorectal cancer xenograft tumors in vivo. PLCG2 is identified as a key downstream regulatory protein of DNMT3B in colorectal cancer. DNMT3B inhibits PLCG2 transcription through methylation of the PLCG2 promoter region. DNMT3B controls colorectal cancer cell proliferation through PLCG2, which is useful for developing therapeutic approaches that target PLCG2 expression for the treatment of colorectal cancer.","PeriodicalId":6978,"journal":{"name":"Acta biochimica et biophysica Sinica","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SUN5, a testis-specific nuclear membrane protein, participates in recruitment and export of nuclear mRNA in spermatogenesis. SUN5是一种睾丸特异性核膜蛋白，参与精子发生过程中核mRNA的招募和输出。

IF 3.3 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2024-08-06 DOI: 10.3724/abbs.2024134

Xiyi He, Yunfei Zhang, Zenghui Mao, Gang Liu, Lihua Huang, Xiaowen Liu, Yuyan Su, Xiaowei Xing

{"title":"SUN5, a testis-specific nuclear membrane protein, participates in recruitment and export of nuclear mRNA in spermatogenesis.","authors":"Xiyi He, Yunfei Zhang, Zenghui Mao, Gang Liu, Lihua Huang, Xiaowen Liu, Yuyan Su, Xiaowei Xing","doi":"10.3724/abbs.2024134","DOIUrl":"https://doi.org/10.3724/abbs.2024134","url":null,"abstract":"SUN5, a testis-specific gene, is associated with acephalic spermatozoa syndrome (ASS). Here, we demonstrate that Sun5 is involved in mRNA export. In Sun5-knockout mice ( Sun5 -/-), poly(A) + RNA accumulates in the nuclei of germ cells, leading to reduced sperm counts, decreased sperm motility and disrupted sperm head-to-tail junctions. Additionally, in the GC-2 germ cell line with RNA interference of Sun5, heterogeneous nuclear ribonucleoproteins (hnRNPs) and poly (A) + RNA (mainly mRNA) are retained in the nucleus. Further mechanistic studies reveal that Sun5 interacts with Nxf1 (nuclear RNA export factor 1) and nucleoporin 93 (Nup93). Interference with Nup93 inhibits mRNA export. Treatment with leptomycin B to block the CRM1 pathway indicates that Sun5 regulates mRNA export through an Nxf1-dependent pathway. In Sun5 -/- mice, the binding of Nxf1 and Nup93 decreases due to loss of Sun5 function, and the process of submitting Nxf1-binding mRNPs to Nup93 is inhibited, resulting in abnormal spermatogenesis. Together, these data may elucidate a novel pathway for mRNA export in male germ cells.","PeriodicalId":6978,"journal":{"name":"Acta biochimica et biophysica Sinica","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

lncRNA CYTOR promotes lung adenocarcinoma gemcitabine resistance and epithelial-mesenchymal transition by sponging miR-125a-5p and upregulating ANLN and RRM2. lncRNA CYTOR通过疏导miR-125a-5p并上调ANLN和RRM2，促进肺腺癌吉西他滨耐药和上皮-间质转化。

IF 3.3 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2024-08-05 DOI: 10.3724/abbs.2024113

Qijun Cao, Haixia Wang, Jialong Zhu, Chen Qi, Hairong Huang, Xiaoyuan Chu

引用次数: 0

Evolutionary analysis of paired box gene family and biological function exploration of Lr. Pax7 in lamprey ( Lethenteron reissneri). 配对盒基因家族的进化分析及Lr.Pax7的生物学功能探索灯鱼（Lethenteron reissneri）中的 Pax7。

IF 3.3 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2024-08-05 DOI: 10.3724/abbs.2024121

Ayqeqan Nurmamat, Zihao Yan, Yao Jiang, Haoran Guan, Ruyu Zhuang, Shuyuan Zhang, Yuesi Zhou, Min Xiu, Ya Pang, Ding Li, Liang Zhao, Xin Liu, Yinglun Han

引用次数: 0

Deciphering disease through glycan codes: leveraging lectin microarrays for clinical insights. 通过糖代码破译疾病：利用凝集素芯片洞察临床。

IF 3.3 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2024-08-01 DOI: 10.3724/abbs.2024123

Hangzhou Yang, Zihan Lin, Bo Wu, Jun Xu, Sheng-Ce Tao, Shumin Zhou

引用次数: 0

FOXM1 mediates methotrexate resistance in osteosarcoma cells by promoting autophagy. FOXM1 通过促进自噬介导骨肉瘤细胞对甲氨蝶呤的耐药性。

IF 3.3 2区生物学

Acta biochimica et biophysica Sinica Pub Date : 2024-07-31 DOI: 10.3724/abbs.2024084

Luoyang Wang, Dongchang Zhai, Lei Tang, Hui Zhang, Xinlong Wang, Ning Ma, Xiaoyue Zhang, Mingguo Cheng, Ruowu Shen

{"title":"FOXM1 mediates methotrexate resistance in osteosarcoma cells by promoting autophagy.","authors":"Luoyang Wang, Dongchang Zhai, Lei Tang, Hui Zhang, Xinlong Wang, Ning Ma, Xiaoyue Zhang, Mingguo Cheng, Ruowu Shen","doi":"10.3724/abbs.2024084","DOIUrl":"10.3724/abbs.2024084","url":null,"abstract":"Osteosarcoma (OS) is a primary bone cancer mostly found in adolescents and elderly individuals. The treatment of OS is still largely dependent on traditional chemotherapy. However, the high incidence of drug resistance remains one of the greatest impediments to limiting improvements in OS treatment. Recent findings have indicated that the transcription factor FOXM1 plays an important role in various cancer-related events, especially drug resistance. However, the possible role of FOXM1 in the resistance of OS to methotrexate (MTX) remains to be explored. Here, we find that FOXM1, which confers resistance to MTX, is highly expressed in OS tissues and MTX-resistant cells. FOXM1 overexpression promotes MTX resistance by enhancing autophagy in an HMMR/ATG7-dependent manner. Importantly, silencing of FOXM1 or inhibiting autophagy reverses drug resistance. These findings demonstrate a new mechanism for FOXM1-induced MTX resistance and provide a promising target for improving OS chemotherapy outcomes.","PeriodicalId":6978,"journal":{"name":"Acta biochimica et biophysica Sinica","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0