Acta Cardiologica Sinica最新文献

{"title":"Ovarian Cancer - Related Paraneoplastic Myositis Mimicking Statin Intolerance.","authors":"Po-Sen Peng, Yuen-Yee Kan, Wei-Chen Lin, Shoa-Lin Lin","doi":"10.6515/ACS.202605_42(3).20251209A","DOIUrl":"10.6515/ACS.202605_42(3).20251209A","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 3","pages":"486-490"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracking Lipoprotein(a) Risk Through Inflammatory Biomarkers.","authors":"Chao-Yun Cheng, Ping-Yen Liu","doi":"10.6515/ACS.202605_42(3).20260213A","DOIUrl":"10.6515/ACS.202605_42(3).20260213A","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 3","pages":"449-452"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biatrial Thrombus Crossing Foramen Ovale in a Patient with Atrial Fibrillation.","authors":"Shabnam Javadova, Saadet Guven, Kursat Oz, Meryem Ertekin, Ahmet Oz, Turgut Karabag","doi":"10.6515/ACS.202605_42(3).20260210A","DOIUrl":"10.6515/ACS.202605_42(3).20260210A","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 3","pages":"500-503"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2026 Expert Consensus Recommendations on Hypertrophic Cardiomyopathy: A Report of the Task Force of the Taiwan Society of Cardiology.","authors":"Chung-Lieh Hung, Yen-Wen Wu, Chih-Hung Lai, Mei-Ling Chen, Hsin-Yueh Liang, Ling Kuo, Chun-Li Wang, Hsinyu Tseng, Jimmy Jyh-Ming Juang, Yen-Wen Liu, Wei-Chuan Tsai, Hung-Yu Chang, Wei-Ting Chang, Po-Sheng Chen, I-Chang Hsieh, Wen-Chung Yu, Yi-Heng Li","doi":"10.6515/ACS.202605_42(3).20260410A","DOIUrl":"10.6515/ACS.202605_42(3).20260410A","url":null,"abstract":"<p><p>Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease worldwide. However, only a small percentage of cases are diagnosed clinically, suggesting under-recognition, with most clinicians exposed to small segments of the broad disease spectrum, in which effort intolerance, heart failure, arrhythmias, and sudden cardiac death can occur. Comprehensive evaluations and longitudinal assessments with echocardiography, ambulatory electrocardiography, stress testing, and, in some cases, cardiac magnetic resonance imaging, are important for diagnosis, risk stratification, distinguishing obstructive from nonobstructive forms, and guiding therapy. Symptomatic patients can be treated with various medications, including a new class of cardiac myosin inhibitors. For patients whose symptoms do not respond to medical therapy or in whom medical therapy is not desired, invasive septal reduction therapy options, when performed at expert centers, have been shown to lead to successful outcomes. The Taiwan Society of Cardiology recently appointed a task force to formulate a consensus on HCM. Based on the most up-to-date information, the consensus emphasizes a comprehensive diagnostic approach, including imaging and genetic testing, family screening and risk assessment, and provides current evidence-based important recommendations to guide clinicians in the management of patients with HCM.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 3","pages":"296-338"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Rehabilitation in Patients with Chronic Coronary Syndromes: Does Obesity Affect Outcomes?","authors":"Hanife Baykal Şahin","doi":"10.6515/ACS.202605_42(3).20251007A","DOIUrl":"10.6515/ACS.202605_42(3).20251007A","url":null,"abstract":"<p><strong>Background: </strong>Obesity is highly prevalent among patients with chronic coronary syndrome (CCS) and is associated with impaired functional capacity and increased cardiovascular risk. Cardiac rehabilitation (CR) is a key intervention shown to improve exercise capacity and outcomes in this population.</p><p><strong>Objective: </strong>This study aimed to compare the effectiveness of CR between obese and non-obese patients with CCS.</p><p><strong>Methods: </strong>In this retrospective study, we analyzed data from CCS patients who completed an exercise-based CR program between January 2020 and December 2024. Participants were categorized into obese (body mass index [BMI] ≥ 30 kg/m²) and non-obese (BMI < 30 kg/m²) groups. Cardiopulmonary exercise testing (CPX) parameters including VO2 peak (ml/kg/min), VO2 peak (%), VO2 peak (L/min), and VO2 at anaerobic threshold (AT) (%) were assessed before and after the CR program.</p><p><strong>Results: </strong>The records of 92 obese and 124 non-obese patients were analyzed. At baseline, the obese patients had significantly lower VO2 peak values (p = 0.003). However, post-rehabilitation, both groups demonstrated significant improvements in CPX parameters, with the obese patients demonstrating greater percentage gains in VO2 peak (%) (p < 0.001) and VO2 at AT (p < 0.001). CR adherence did not differ significantly between groups.</p><p><strong>Conclusions: </strong>Despite lower baseline functional capacity, the obese patients had substantial improvements in exercise capacity post-CR, comparable to or exceeding those of non-obese individuals. These findings highlight the importance of CR in managing obesity-related cardiovascular risks and emphasize the need to promote CR participation among obese patients.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 3","pages":"395-402"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Inflammation-Oxidative Stress and Lipoprotein (a) Levels in Healthy Subjects.","authors":"Murat Ziyrek, Emrah Özdemir, Orhan İnce, Esra Dönmez, Sevgi Özcan, Emre Melik Faideci, İrfan Şahin, Ertuğrul Okuyan","doi":"10.6515/ACS.202605_42(3).20250825A","DOIUrl":"10.6515/ACS.202605_42(3).20250825A","url":null,"abstract":"<p><strong>Background: </strong>Lipoprotein (a) [Lp(a)] is a major carrier of pro-atherogenic oxidized phospholipids. It is widely recognized as an independent risk factor for cardiovascular diseases. Oxidative stress caused by oxidized phospholipids is a crucial trigger of chronic vascular inflammation, leading to atherosclerosis. Although various parameters provide information about oxidative stress, the relationship between oxidative stress and Lp(a) levels has not been thoroughly investigated. This study aimed to analyze this relationship and evaluate the diagnostic accuracy of these parameters in identifying high-risk patients.</p><p><strong>Methods: </strong>Healthy subjects were grouped according to Lp(a) levels: those with Lp(a) ≥ 30 mg/dl were classified as high risk, and those with Lp(a) < 30 mg/dl as low risk. Monocyte to high-density lipoprotein ratio (MHR) and lymphocyte to monocyte ratio (LMR) were calculated and compared between groups.</p><p><strong>Results: </strong>MHR (23.61 ± 6.73 vs. 13.17 ± 4.56; p < 0.0001), LMR (5.17 ± 1.53 vs. 3.99 ± 1.11; p < 0.0001), lymphocyte count (3.15 ± 0.73 vs. 2.48 ± 0.62; p < 0.0001), and monocyte count (0.73 ± 0.23 vs. 0.58 ± 0.15; p < 0.0001) were significantly higher in the high-risk group. There were moderate positive correlations between Lp(a) level and monocyte count (r = 0.467; p < 0.0001), MHR (r = 0.598; p < 0.0001), and LMR (r = 0.464; p < 0.0001). A cut-off value of 14.73 for MHR was associated with 83.55% sensitivity and 83.03% specificity [area under the curve (AUC): 0.859; 95% confidence interval (CI): 0.802-0.925], and a cut-off value of 4.31 for LMR was associated with 81.68% sensitivity and 81.16% specificity (AUC: 0.853; 95% CI: 0.808-0.910) in predicting the high-risk group.</p><p><strong>Conclusions: </strong>Oxidative stress-inflammation parameters were higher in the high-risk group and positively correlated with Lp(a) levels. Furthermore, MHR and LMR could be used to detect high-risk patients.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 3","pages":"440-448"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Patent Foramen Ovale Anatomical Complexity on Fluoroscopy Time During Transcatheter Closure.","authors":"Ayşe İrem Demirtola, Duygu Inan, Anar Mammadli, Aslan Erdoğan, İhsan Demirtaş, Furkan Şen, Alev Kılıçgedik","doi":"10.6515/ACS.202605_42(3).20250904A","DOIUrl":"10.6515/ACS.202605_42(3).20250904A","url":null,"abstract":"<p><strong>Background: </strong>Complex patent foramen ovale (PFO) anatomical features can increase procedural difficulty during transcatheter closure, often leading to prolonged fluoroscopy time.</p><p><strong>Aim: </strong>This study aimed to evaluate the relationship between PFO anatomy, assessed via transesophageal echocardiography (TEE), and prolonged fluoroscopy time during transcatheter closure.</p><p><strong>Methods: </strong>This retrospective study analyzed 83 patients (median age: 45 years, 58% male) undergoing PFO closure for cryptogenic stroke. TEE measurements included key anatomical parameters related to PFO morphology and shunting dynamics. Patients were categorized into prolonged (≥ 80th percentile) and standard (< 80th percentile) fluoroscopy-time groups. Logistic regression, Pearson correlation analysis, and receiver operating characteristic (ROC) curve analyses were used to identify predictors of prolonged fluoroscopy time.</p><p><strong>Results: </strong>The prolonged fluoroscopy-time group had a significantly longer tunnel length (17.5 mm [interquartile range (IQR): 14.25-20.75] vs. 12.0 mm [IQR: 8.00-14.00], p < 0.01) and smaller aortic rim (3.0 mm [IQR: 2.0-3.75] vs. 6.0 mm [IQR: 5.0-8.0], p < 0.01). Fluoroscopy time correlated positively with tunnel length (r = 0.72, p < 0.001) and negatively with aortic rim length (r = -0.65, p < 0.001). Logistic regression identified tunnel length (odds ratio [OR] = 1.459; 95% confidence interval [CI]: 1.190-1.789) and aortic rim length (OR = 0.537; 95% CI: 0.378-0.764) as independent predictors. ROC curve analysis revealed a cut-off of 12.5 mm (area under the curve [AUC] = 0.770) for tunnel length and 5.5 mm (AUC = 0.798) for aortic rim in predicting prolonged fluoroscopy time.</p><p><strong>Conclusions: </strong>The findings of this study suggest that complex PFO anatomical features significantly impact fluoroscopy time, underscoring the need for detailed pre-procedural TEE assessments to optimize procedural planning and outcomes.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 3","pages":"360-370"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Procalcitonin/Albumin Ratio in Predicting Outcomes After Transcatheter Aortic Valve Implantation.","authors":"Funda Ozlem Pamuk, Esra Dönmez, Sevil Tuğrul Yavuz, Sevgi Özcan, Kadir Kasım Sahin, Duygu Inan, Emrah Bozbeyoglu, Hamdi Pusuroglu, Alev Kılıcgedik","doi":"10.6515/ACS.202605_42(3).20250930A","DOIUrl":"10.6515/ACS.202605_42(3).20250930A","url":null,"abstract":"<p><strong>Background: </strong>Transcatheter aortic valve implantation (TAVI) has emerged as preferred treatment for severe aortic stenosis in high-risk patients. Inflammatory and nutritional biomarkers have been increasingly investigated for their prognostic value. This study aimed to evaluate the utility of the procalcitonin/albumin ratio (PAR) in predicting 1-year mortality after TAVI.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on patients who underwent TAVI between June 2020 and January 2024. Pre-procedural serum procalcitonin and albumin levels were measured, and the PAR was calculated. Thirty-day and 1-year mortality and hospitalization for heart failure were defined as primary outcomes.</p><p><strong>Results: </strong>A total of 210 patients were included in the study. PAR was significantly higher in non-survivors compared to survivors (p < 0.0001). Receiver operating characteristic analysis demonstrated that the PAR had a moderate-to-good discriminatory ability for predicting 1-year mortality (area under the curve = 0.784 [95% confidence interval: 0.709-0.858]). In multivariate analysis, PAR was identified as an independent predictor of 30-day and 1-year mortality and hospitalization for heart failure.</p><p><strong>Conclusions: </strong>Our findings suggest that the PAR, as a combined marker of inflammation and nutritional status, may serve as a useful prognostic indicator in patients undergoing TAVI. The association between a higher PAR and increased mortality risk highlights the potential role of systemic inflammation and malnutrition in post-TAVI outcomes. The pre-procedural PAR appears to be a promising biomarker for predicting 1-year mortality after TAVI. Further prospective studies with larger cohorts are needed to validate these findings and explore potential clinical applications.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 3","pages":"429-439"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized Trial Comparing Radial and Ulnar Access in Single-Catheter Primary Coronary Intervention.","authors":"Luljeta Kurani Allaraj, Yusuf Can, Ibrahim Kocayiğit, Ömer Faruk Erkan, Emre Eynel, Havva KocayiğIt","doi":"10.6515/ACS.202605_42(3).20250922B","DOIUrl":"10.6515/ACS.202605_42(3).20250922B","url":null,"abstract":"<p><strong>Background: </strong>To compare the procedural success, complication rates, and clinical outcomes of transradial and transulnar arterial interventions in patients undergoing primary percutaneous coronary interventions (PCIs) due to acute ST elevation myocardial infarction (STEMI). The effectiveness of access routes was evaluated in procedures performed using a single catheter.</p><p><strong>Materials and methods: </strong>A total of 258 patients diagnosed with STEMI and who underwent primary PCI were included in the study. Eighteen patients were excluded for not meeting the study criteria, and the remaining 240 patients were randomized 1:1 into radial and ulnar groups. After excluding cross-overs, the remaining 231 patients underwent the procedure, including 113 via the radial route (Group R) and 118 via the ulnar route (Group U), and their data were analyzed. Procedural success, the number of arterial punctures, procedure duration, complication rates and clinical outcomes were prospectively compared.</p><p><strong>Results: </strong>No significant difference in procedural success was observed between the two groups. However, the number of arterial punctures was higher in the transulnar group (≥ 2 punctures: Group R: 24 [21.2%], Group U: 48 [40.7%]; p = 0.001), and the puncture duration was longer (Group R: 15 sec [10-20], Group U: 15 sec [10-30], p = 0.001). There were no significant differences in post-procedural hematoma formation or arterial occlusion rates between the two groups.</p><p><strong>Conclusions: </strong>Our results demonstrated that single-catheter transulnar access offers a similar procedural success rate and safety profile to transradial access. However, transulnar access was associated with a longer puncture duration and increased puncture attempts. Transulnar access may be considered a reliable alternative when transradial access is not feasible.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 3","pages":"403-412"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent Profile Analysis of Families Relocation Stress Prior to Transfer Out of Cardiac Surgery Intensive Care Unit Patients.","authors":"Lefei Sun, Jing Zheng, Shanshan Lv, Xianfeng Liu, Chuanni Wu, Li Liu","doi":"10.6515/ACS.202605_42(3).20251020B","DOIUrl":"10.6515/ACS.202605_42(3).20251020B","url":null,"abstract":"<p><strong>Background: </strong>Understanding the manifestations of stress in family members of postoperative cardiac patients after transfer from the cardiac surgical intensive care unit (CSICU) is important so that more targeted interventions can be applied.</p><p><strong>Objectives: </strong>The aim of the study was to explore the relationships among the level of family stress after relocation of patients after cardiac surgery, family members' uncertainty regarding the illness, and caregivers' readiness, thereby providing a theoretical basis for intervention.</p><p><strong>Methods: </strong>A general information questionnaire, the Family Relocation Stress Scale, Mishel Uncertainty in Illness Scale-Family Member Form, and Caregiver Preparedness Scale form were completed by 319 family members of patients in the CSICU of a tertiary hospital in Shandong Province from June 2024 to September 2024. The profiles of individuals experiencing family relocation stress were analyzed, and the influences of individual factors were analyzed.</p><p><strong>Results: </strong>Model 3 proved to be best suited for the analysis, with entropy = 0.865 and a bootstrap likelihood ratio p < 0.001. The factors that influenced family relocation stress included educational level, caregiving experience, place of residence, caregiver preparedness, and uncertainty about the illness (p < 0.05).</p><p><strong>Conclusions: </strong>In this study, three distinct patient classifications were identified: a high relocation stress group, a medium relocation stress group, and a low relocation stress group. There was significant heterogeneity in the levels of stress experienced by the families of patients in the CSICU before transfer. These results suggest that medical staff could implement targeted interventions to reduce the relocation stress experienced by family caregivers.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 3","pages":"371-380"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}