Acta Cardiologica Sinica最新文献

{"title":"The Effect of the Presence of Barrier during Resternotomy in Congenital Heart Surgery.","authors":"Onur Isik, Muhammet Akyuz, Gökcen Ozcifci, Gokmen Akkaya, Fatih Durak, Ayse Berna Anil","doi":"10.6515/ACS.202405_40(3).20231129A","DOIUrl":"10.6515/ACS.202405_40(3).20231129A","url":null,"abstract":"<p><strong>Background: </strong>Reoperation is an important cause of morbidity and mortality in congenital heart surgery. The aim of this study was to assess whether the presence of barrier during resternotomy affected the outcomes of infants and children who underwent congenital heart surgery.</p><p><strong>Methods: </strong>A total of 110 (7.6%) patients who underwent reoperations among 1445 consecutive patients between February 2018 and June 2023 were evaluated. The patients were divided into two groups: those with barrier (n = 72) and those without barrier (n = 38). Demographic, intraoperative and postoperative data were retrospectively analyzed.</p><p><strong>Results: </strong>Among the 110 patients, the age at reoperation was 10.1 ± 1.4 years in the group with barrier and 10.9 ± 2.8 years in the group without barrier. There were no statistically significant differences in the age at surgery, preoperative saturation, interval since preceding surgery (years), and aortic cross clamp time (minutes) between the groups. However, there were significantly higher rates of injuries during dissection (p = 0.001) and adverse events (p = 0.002) during dissection in the non-barrier group. One patient in the group without barrier underwent reoperation but subsequently died.</p><p><strong>Conclusions: </strong>The usage of any barrier in front of the right ventricle can decrease the incidence of adverse events, morbidity and mortality.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 3","pages":"275-280"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of D-Dimer in Patients with Acute Myocardial Infarction: A Retrospective Longitudinal Cohort Study in Taiwan.","authors":"Zong-Yu Yu, Po-Kai Chan, Tzu-Chiao Lin, Yuan Hung, Fang-Han Yu, Wei-Shiang Lin, Shu-Meng Cheng, Wen-Yu Lin","doi":"10.6515/ACS.202405_40(3).20240126A","DOIUrl":"10.6515/ACS.202405_40(3).20240126A","url":null,"abstract":"<p><strong>Background: </strong>Serum D-dimer level has been associated with worsening outcomes in patients with acute myocardial infarction. This study aimed to explore the association between serum D-dimer level and clinical outcomes in Taiwanese patients with acute myocardial infarction.</p><p><strong>Methods: </strong>We analyzed Tri-Service General Hospital-Coronary Heart Disease registry data related to patients with acute myocardial infarction who were admitted between January 2014 and December 2018. A total of 748 patients were enrolled and categorized into high (≥ 495 ng/ml) and low (< 495 ng/ml) D-dimer groups. The primary endpoint was in-hospital mortality, and secondary endpoints were post-discharge mortality and post-discharge major adverse cardiovascular events.</p><p><strong>Results: </strong>Overall, 139 patients died, with 77 from cardiovascular causes and 62 from non-cardiovascular causes. In-hospital mortality was higher in the high D-dimer group than in the low D-dimer group. Among the patients alive at discharge, those with a high D-dimer level had higher cardiovascular mortality and future major adverse cardiovascular events than those with a low D-dimer level. Multivariate Cox regression analysis revealed that higher serum D-dimer levels were significantly associated with higher risks of in-hospital mortality [hazard ratio (HR) = 1.11; 95% confidence interval (CI), 1.06-1.16, p < 0.001], subsequent cardiovascular mortality after discharge (HR = 1.15; 95% CI, 1.08-1.22, p < 0.001), and major adverse cardiovascular events (HR = 1.10; 95% CI, 1.04-1.16, p < 0.001).</p><p><strong>Conclusions: </strong>This is the first study in Taiwan to demonstrate that a higher baseline serum D-dimer level was independently associated with higher risks of in-hospital mortality, post-discharge mortality, and major adverse cardiovascular events in patients with acute myocardial infarction.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 3","pages":"300-311"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Systolic Pulmonary Artery Pressure and Contrast-Induced Nephropathy in Patients with ST-Segment Elevation Myocardial Infarction.","authors":"Mehmet Nail Bilen, Önder Demiröz, İlyas Çetin, Ömer Genç, Aslan Erdoğan, Zülfiye Kuzu, Ersin Yıldırım, Hamdi Püşüroğlu","doi":"10.6515/ACS.202405_40(3).20240129B","DOIUrl":"10.6515/ACS.202405_40(3).20240129B","url":null,"abstract":"<p><strong>Introduction: </strong>The objective of this study was to examine whether there is an elevated risk of developing contrast induced nephropathy (CIN) in patients with high systolic pulmonary artery pressure (SPAP) in ST-segment elevation myocardial infarction (STEMI).</p><p><strong>Methods: </strong>A total of 213 patients diagnosed with STEMI and who underwent primary percutaneous coronary intervention were enrolled in the study. The patients were stratified into two groups based on the presence of CIN. Comparisons between these groups included an assessment of demographic characteristics, laboratory findings, and risk factors. SPAP was calculated for each patient upon admission through echocardiography, and subsequent comparisons were performed between the groups.</p><p><strong>Results: </strong>The distribution of the study population was as follows: 33 (15.5%) were CIN(+) and 180 (84.5%) were CIN(-). SPAP [odds ratio (OR) = 1.295, 95% confidence interval (CI): 1.157-1.451, p < 0.001], and diabetes (OR = 1.241, 95% CI: 1.194-1.287, p = 0.013) were identified as independent factors associated with CIN development. In receiver operating characteristic curve analysis, SPAP above a cut-off level of 31.5 mmHg could determine the presence of CIN with a sensitivity of 91.0% and specificity of 90.0% (p < 0.001).</p><p><strong>Conclusions: </strong>SPAP on echocardiography is an independent predictor of the development of CIN in patients with STEMI. Its ease of calculation renders it a valuable tool for predicting CIN among STEMI patients.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 3","pages":"292-299"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141079915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidentally Detected Penile Cancer with Inguinal Metastasis Invading Femoral Vessels Following Atrial Fibrillation Radiofrequency Catheter Ablation.","authors":"Sung Soo Kim, Jum Suk Ko, Hyung Ki Jeong, Nam Ho Kim","doi":"10.6515/ACS.202405_40(3).20240226A","DOIUrl":"10.6515/ACS.202405_40(3).20240226A","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 3","pages":"349-352"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141079930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous Retrieval of a Peeled-off Fragment of a Hydrophilic Wire after a Cuffed Tunneled Hemodialysis Catheter Placement: A Case Report.","authors":"Hsiu-Ming Lee, Mingli Levin Li, Yun-Ting Lee, Yu-Hsuan Lien, Chiung-Ray Lu, Su Zi Chee","doi":"10.6515/ACS.202405_40(3).20240129D","DOIUrl":"10.6515/ACS.202405_40(3).20240129D","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 3","pages":"344-348"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional Benefits of Serum Oncostatin M Levels Compared to Cardiac Troponin in Non-ST Elevation Myocardial Infarction.","authors":"Murat Akarsu, Adem Atıcı, Şengül Yoldemir, Mustafa Özcan, Özgür Yıldırım, Harun Akarsu, Yücel Arman, Tufan Tükek","doi":"10.6515/ACS.202405_40(3).20240128A","DOIUrl":"10.6515/ACS.202405_40(3).20240128A","url":null,"abstract":"<p><strong>Background: </strong>The use of high-sensitivity troponin levels increases the sensitivity of the diagnosis of non-ST elevation myocardial infarction (NSTEMI). However, the inclusion of other factors in the differential diagnosis, apart from atherothrombosis causing myocardial injury, decreases the specificity of high-sensitivity troponin. In this study, we compared the efficacy of high-sensitivity troponin with serum oncostatin M in NSTEMI cases with elevated urea and creatinine.</p><p><strong>Methods: </strong>This study was performed with a prospective cross-sectional sample. Ninety participants with coronary angiography performed due to a preliminary diagnosis of NSTEMI were included. High-sensitivity troponin I, creatine kinase-MB, lactate dehydrogenase, serum transaminase and oncostatin M levels were quantitatively measured for the first 4-8 hours from the onset of symptoms. All participants had coronary angiography performed within the first 12 hours after attending the emergency service. Based on coronary angiography data, patients with significant coronary stenosis or occlusion detected during coronary angiography were defined as group A, and patients with no occlusion in the coronary artery and who did not require an additional interventional procedure were defined as group B. The SYNTAX 2 score was used to determine the severity of coronary artery disease.</p><p><strong>Results: </strong>Patients in both groups A and B had similar age, sex distribution and comorbidities. Group A had higher serum urea, creatinine, oncostatin M and high-sensitivity troponin I values than group B. With 585 pg/ml as the cut-off value, serum oncostatin M had a sensitivity of 88.6% and specificity of 85% for the diagnosis of NSTEMI. Logistic regression multivariate analysis showed that serum oncostatin M and high-sensitivity troponin I values had diagnostic efficacy for NSTEMI. Serum oncostatin M was found to be more effective than high-sensitivity troponin I in patients with elevated urea and creatinine.</p><p><strong>Conclusions: </strong>Serum oncostatin M had similar sensitivity and specificity for NSTEMI diagnosis as high-sensitivity troponin I. Serum OSM can especially be considered as a complementary diagnostic biomarker for NSTEMI in patients with renal dysfunction.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 3","pages":"281-291"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141079876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N6-Methyladenosine Demethylase ALKBH5 Promotes Pyroptosis by Modulating PTBP1 mRNA Stability in LPS-Induced Myocardial Dysfunction.","authors":"Min Liu, Xiyun Chen","doi":"10.6515/ACS.202405_40(3).20240127A","DOIUrl":"10.6515/ACS.202405_40(3).20240127A","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the mechanism by which alkB homolog 5 (ALKBH5) regulates polypyrimidine tract-binding protein 1 (PTBP1) to mediate cardiomyocyte pyroptosis in sepsis-induced myocardial injury.</p><p><strong>Methods: </strong>Lipopolysaccharide (LPS)-exposed H9C2 cell and rat models were established to mimic septic myocardial injury both <i>in vitro</i> and <i>in vivo</i>. The mRNA and protein levels of ALKBH5 and PTBP1 in the LPS-induced cell and septic rat models were detected. CCK-8 and flow cytometry were applied to detect cell viability and pyroptosis. H&E staining was used to observe myocardial tissue damage in rats, and immunohistochemistry to analyze the expression of pyroptosis and inflammation-related proteins in rat tissues.</p><p><strong>Results: </strong>Elevated expressions of both ALKBH5 and PTBP1 were found in the myocardial tissues of LPS-induced septic rats. ALKBH5 knockdown could restore the cell viability and cell pyroptosis inhibited by LPS, while ALKBH5 promoted PTBP1 mRNA stability by affecting its N6-methyladenosine (m6A) modification. <i>In vivo</i> experiments showed that PTBP1 knockdown could largely reverse the antiproliferative and pro-pyroptosis effects of ALKBH5 in LPS-exposed H9C2 cells. ALKBH5 knockdown in in vivo experiments was found to suppress the expressions of pyroptosis biomarkers and attenuate myocardial injury in septic rats.</p><p><strong>Conclusions: </strong>ALKBH5 promoted mRNA stability and the expression of PTBP1 through m6A modification to induce pyroptosis in cardiomyocytes and ultimately aggravate sepsis-induced myocardial dysfunction.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 3","pages":"312-321"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141079971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Rare Complications of Post Myocardial Infarction: A Case Report.","authors":"Mustafa Ucar, Muhammed Ikbal Sasmaz, Akkan Avci","doi":"10.6515/ACS.202405_40(3).20240129E","DOIUrl":"10.6515/ACS.202405_40(3).20240129E","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 3","pages":"359-361"},"PeriodicalIF":1.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11106628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor; Comment on \"Association between Premorbid Renin-Angiotensin-Aldosteron System Blockade and the Risk of Acute Kidney Injury in Critically Ill Patients\".","authors":"Ali Çoner","doi":"10.6515/ACS.202403_40(2).20231206A","DOIUrl":"10.6515/ACS.202403_40(2).20231206A","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 2","pages":"258-259"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10961631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Amount of Air Supplied to Radial Artery Compression Device Used after Transradial Procedure and Radial Artery Stenosis.","authors":"Yücel Kanal, Can Özkan","doi":"10.6515/ACS.202403_40(2).20231212A","DOIUrl":"10.6515/ACS.202403_40(2).20231212A","url":null,"abstract":"<p><strong>Background: </strong>Transradial access (TRA) is accepted as the safest route for coronary angiography (CAG) and percutaneous coronary intervention. Radial artery stenosis (RAS) prevents use of the radial artery in various clinical situations, even in cases without hand ischemia. In this context, this study aimed to investigate the relationship between the amount of air supplied to the radial artery compression device [transradial (TR) band] and RAS.</p><p><strong>Methods: </strong>The population in this single-center retrospective study consisted of patients who underwent CAG via TRA under elective conditions between March 1^st, 2020 and May 1^st, 2022. Of these patients, 111 who met the study inclusion criteria were included in the study.</p><p><strong>Results: </strong>The rate of RAS was significantly higher among the patients with a TR band inflated with 18 ml of air compared to those with a TR band inflated with 12 ml of air (19.6%-3.6%; p = 0.009). Univariable logistic regression analysis revealed that the mean corpuscular volume (MCV) and amount of air supplied to the TR band were significantly associated with RAS. Further analysis of these variables with multivariable logistic regression analysis indicated that both MCV and the amount of air supplied to the TR band were independent predictors of RAS (p < 0.05).</p><p><strong>Conclusions: </strong>The findings of the study revealed that the amount of air supplied to the TR band after CAG via TRA was an independent predictor for the development of RAS.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 2","pages":"200-207"},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10961642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}