The Impact of Insulin Resistance on the Development of Post-PCI Contrast-Induced Nephropathy in Non-Diabetic STEMI.

IF 1.8 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Acta Cardiologica Sinica Pub Date : 2025-01-01 DOI:10.6515/ACS.202501_41(1).20241018B

Aslıhan Mete Yıldırım, Adil Bayramoglu

{"title":"The Impact of Insulin Resistance on the Development of Post-PCI Contrast-Induced Nephropathy in Non-Diabetic STEMI.","authors":"Aslıhan Mete Yıldırım, Adil Bayramoglu","doi":"10.6515/ACS.202501_41(1).20241018B","DOIUrl":null,"url":null,"abstract":"Aims: Contrast-induced nephropathy (CIN) is a condition characterized by rapidly decreasing renal funciton following by the application of contrast material. Precutaneous coronary intervention (PCI) is a life-saving treatment method that should be applied under emergent conditions. Unfortunately, the incidence of CIN after PCI is common. Patients with insulin resistance or diabetes have a greater risk of developing CIN than most of the population. Therefore, studies on the predictive effects of insulin resistance indicators on CIN are gaining momentum. One of the most popular indicators is triglyceride/glucose-body mass index (TyG-BMI). In this study we aimed to evaluate the effect of TyG-BMI index on CIN.Materials and methods: A total of 960 patinets who underwent emergency PCI due to ST elevation myocardial infarction (STEMI) between 2020 and 2023 were included in the study. Laboratory and demographic parameters were compared between the patients who did and did not develop CIN.Results: While CIN developed in 120 of the 980 patients included in the study, it did not develop in 860 patients. There were significant differences between the groups in terms of age (p < 0.001), gender (p = 0.005), presence of hypertension (p = 0.021), heart rate (p = 0.049), amount of contrast material (p < 0.001), left ventricular ejection fraction (p < 0.001), stent length (p = 0.022), SYNTAX score (p < 0.001), fasting plasma glucose (p < 0.001), baseline creatinine (p < 0.001), glomerular filtration rate (p < 0.001), uric acid (p < 0.001), C reactive protein (CRP) (p < 0.001), baseline creatin kinase myocard band (CKMB) (p = 0.019), CKMB peak (p = 0.030), triglyceride (p = 0.017), and TyG-BMI (p < 0.001). CRP, creatinine, uric asid, amount of contrast material, and TyG-BMI were independent predictors for the development of CIN.Conclusions: TyG-BMI was a predictor of CIN in STEMI patient who underwent PCI under emergency conditions. In addition, the predicitive power of TyG-BMI was stronger than triglyceride-glucose index.","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 1","pages":"130-137"},"PeriodicalIF":1.8000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701499/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Cardiologica Sinica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.6515/ACS.202501_41(1).20241018B","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Aims: Contrast-induced nephropathy (CIN) is a condition characterized by rapidly decreasing renal funciton following by the application of contrast material. Precutaneous coronary intervention (PCI) is a life-saving treatment method that should be applied under emergent conditions. Unfortunately, the incidence of CIN after PCI is common. Patients with insulin resistance or diabetes have a greater risk of developing CIN than most of the population. Therefore, studies on the predictive effects of insulin resistance indicators on CIN are gaining momentum. One of the most popular indicators is triglyceride/glucose-body mass index (TyG-BMI). In this study we aimed to evaluate the effect of TyG-BMI index on CIN.

Materials and methods: A total of 960 patinets who underwent emergency PCI due to ST elevation myocardial infarction (STEMI) between 2020 and 2023 were included in the study. Laboratory and demographic parameters were compared between the patients who did and did not develop CIN.

Results: While CIN developed in 120 of the 980 patients included in the study, it did not develop in 860 patients. There were significant differences between the groups in terms of age (p < 0.001), gender (p = 0.005), presence of hypertension (p = 0.021), heart rate (p = 0.049), amount of contrast material (p < 0.001), left ventricular ejection fraction (p < 0.001), stent length (p = 0.022), SYNTAX score (p < 0.001), fasting plasma glucose (p < 0.001), baseline creatinine (p < 0.001), glomerular filtration rate (p < 0.001), uric acid (p < 0.001), C reactive protein (CRP) (p < 0.001), baseline creatin kinase myocard band (CKMB) (p = 0.019), CKMB peak (p = 0.030), triglyceride (p = 0.017), and TyG-BMI (p < 0.001). CRP, creatinine, uric asid, amount of contrast material, and TyG-BMI were independent predictors for the development of CIN.

Conclusions: TyG-BMI was a predictor of CIN in STEMI patient who underwent PCI under emergency conditions. In addition, the predicitive power of TyG-BMI was stronger than triglyceride-glucose index.

查看原文本刊更多论文

胰岛素抵抗对非糖尿病STEMI患者pci后造影剂肾病发展的影响

目的：造影剂肾病（CIN）是一种以应用造影剂后肾功能迅速下降为特征的疾病。经皮冠状动脉介入治疗（PCI）是一种紧急情况下应采用的救命治疗方法。不幸的是，PCI术后CIN的发生率很普遍。与大多数人群相比，胰岛素抵抗或糖尿病患者发生CIN的风险更高。因此，胰岛素抵抗指标对CIN的预测作用的研究越来越多。最流行的指标之一是甘油三酯/葡萄糖-体重指数（TyG-BMI）。本研究旨在评价TyG-BMI指数对CIN的影响。材料与方法：本研究纳入2020 - 2023年间960例因ST段抬高型心肌梗死（STEMI）行急诊PCI的患者。比较发生和未发生CIN的患者的实验室和人口学参数。结果：在纳入研究的980例患者中，120例发生CIN， 860例未发生CIN。有显著的年龄差异组(p < 0.001),性别(p = 0.005),高血压(p = 0.021),心率(p = 0.049),数量的对比材料(p < 0.001),左室射血分数(p < 0.001),支架长度(p = 0.022),语法得分(p < 0.001),空腹血糖(p < 0.001),基线肌酐(p < 0.001),肾小球滤过率(p < 0.001),尿酸(p < 0.001), C反应蛋白(CRP) (p < 0.001),基线肌激酶肌带（CKMB）（p = 0.019）、CKMB峰值（p = 0.030）、甘油三酯（p = 0.017）和TyG-BMI （p < 0.001）。CRP、肌酐、尿酸、造影剂量和TyG-BMI是CIN发展的独立预测因子。结论：TyG-BMI是急诊行PCI的STEMI患者CIN的预测因子。此外，TyG-BMI的预测能力强于甘油三酯-葡萄糖指数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta Cardiologica Sinica 医学-心血管系统

CiteScore

2.90

自引率

15.80%

发文量

144

审稿时长

>12 weeks

期刊介绍： Acta Cardiologica Sinica welcomes all the papers in the fields related to cardiovascular medicine including basic research, vascular biology, clinical pharmacology, clinical trial, critical care medicine, coronary artery disease, interventional cardiology, arrythmia and electrophysiology, atherosclerosis, hypertension, cardiomyopathy and heart failure, valvular and structure cardiac disease, pediatric cardiology, cardiovascular surgery, and so on. We received papers from more than 20 countries and areas of the world. Currently, 40% of the papers were submitted to Acta Cardiologica Sinica from Taiwan, 20% from China, and 20% from the other countries and areas in the world. The acceptance rate for publication was around 50% in general.