AAPS PharmSciTech最新文献_第10页

Investigations on the Impacts of Drugs or Excipients with Different Physicochemical and Compaction Properties on the Disintegration Behavior of Kollidon®SR-Based Binary Controlled Release Matrix Tablets 基于 Kollidon®SR 的二元控释基质片剂的崩解行为：不同理化性质和压实性质的药物或辅料的影响研究

IF 3.4 4区医学

AAPS PharmSciTech Pub Date : 2024-10-07 DOI: 10.1208/s12249-024-02933-4

Wasfy M. Obeidat, Shadi F. F. Gharaibeh

{"title":"Investigations on the Impacts of Drugs or Excipients with Different Physicochemical and Compaction Properties on the Disintegration Behavior of Kollidon®SR-Based Binary Controlled Release Matrix Tablets","authors":"Wasfy M. Obeidat, Shadi F. F. Gharaibeh","doi":"10.1208/s12249-024-02933-4","DOIUrl":"10.1208/s12249-024-02933-4","url":null,"abstract":"<div><p>The objective of this study was to examine the impact of the physicochemical properties of the loaded drug or excipient, the concentration of Kollidon®SR (KSR), and the mechanical characteristics of KSR compacts on their disintegration times. Using disintegration apparatus, a two-hour constraint was chosen as the process's end point. Lactose-KSR compacts subjected to the highest compression pressure and Microcrystalline cellulose-KSR compacts with KSR concentrations exceeding 30% exhibited disintegration times of less than ten minutes. Likewise, compacts containing Diltiazem HCl-KSR demonstrated brief disintegration times across all tested KSR concentrations and compression pressures. Compacts of Modafinil, Metformin HCl, and Ascorbic acid-KSR displayed disintegration times ranging from fast to moderate, contingent upon the levels of KSR and compression pressure applied. Compacts containing KSR with Aspirin, Salicylic acid, or Ibuprofen did not exhibit significant disintegration even at minimal amounts of KSR (0.5%). Theophylline-KSR tablets also showed prolonged dissolution times, even at very low concentrations of KSR. The disintegration times of Dic-KSR tablets were roughly close to an hour and were predominantly unaffected by varying KSR levels and only marginally influenced by compression pressures. It is possible to draw the conclusion that different drugs or excipients have different minimum KSR requirements to resist compacts’ disintegration process. Compounds that demonstrate low solubility in water can result in extended disintegration times for KSR compacts. The melting points of these compounds, in conjunction with the Py values of the compacts and their compaction properties, could affect the disintegration process, although a precise evaluation is necessary.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":6925,"journal":{"name":"AAPS PharmSciTech","volume":"25 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rosuvastatin Flexible Chitosomes: Development, In Vitro Evaluation and Enhancement of Anticancer Efficacy Against HepG2 and MCF7 Cell Lines 瑞舒伐他汀柔性壳质体：开发、体外评估和增强对 HepG2 和 MCF7 细胞株的抗癌功效

IF 3.4 4区医学

AAPS PharmSciTech Pub Date : 2024-10-07 DOI: 10.1208/s12249-024-02957-w

Nermin E. Eleraky, Abeer S. Hassan, Ghareb M. Soliman, Mohammed M. H. Al-Gayyar, Mohamed A. Safwat

{"title":"Rosuvastatin Flexible Chitosomes: Development, In Vitro Evaluation and Enhancement of Anticancer Efficacy Against HepG2 and MCF7 Cell Lines","authors":"Nermin E. Eleraky, Abeer S. Hassan, Ghareb M. Soliman, Mohammed M. H. Al-Gayyar, Mohamed A. Safwat","doi":"10.1208/s12249-024-02957-w","DOIUrl":"10.1208/s12249-024-02957-w","url":null,"abstract":"<div><p>Rosuvastatin (ROS), a statin drug with promising anticancer properties has a low bioavailability of approximately 20% due to lipophilicity and first-pass metabolism. This study aimed to enhance ROS anticancer efficacy through loading into flexible chitosomes. The chitosomes were prepared starting from negatively charged liposomes through electrostatic interactions with chitosan. The conversion of zeta potential from negative to positive confirmed the successful formation of chitosomes. The chitosan coating increased the particle size and zeta potential, which ranged from 202.0 ± 1.7 nm to 504.7 ± 25.0 nm and from − 44.9 ± 3.0 mV to 50.1 ± 2.6 mV, respectively. Chitosan and drug concentrations had an important influence on the chitosome properties. The optimum chitosome formulation was used to prepare ROS-loaded flexible chitosomes using different concentrations of four edge activators. The type and concentration of edge activator influenced the particle size, drug entrapment efficiency, and drug release rate of the flexible chitosomes. Flexible chitosomes significantly increased drug permeation through rat abdominal skin compared to control transferosomes and drug solution. The optimal ROS flexible chitosomes containing sodium deoxycholate as an edge activator had a 2.23-fold increase in ROS cytotoxic efficacy against MCF7 cells and a 1.84-fold increase against HepG2 cells. These results underscore the potential of flexible chitosomes for enhancing ROS anticancer efficacy.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":6925,"journal":{"name":"AAPS PharmSciTech","volume":"25 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Docetaxel-tethered di-Carboxylic Acid Derivatised Fullerenes: A Promising Drug Delivery Approach for Breast Cancer 多西他赛系链二羧酸衍生富勒烯：一种治疗乳腺癌的有效给药方法。

IF 3.4 4区医学

AAPS PharmSciTech Pub Date : 2024-10-02 DOI: 10.1208/s12249-024-02955-y

Charu Misra, Jasleen Kaur, Manish Kumar, Lokesh Kaushik, Deepak Chitkara, Simran Preet, Muhammad Wahajuddin, Kaisar Raza

{"title":"Docetaxel-tethered di-Carboxylic Acid Derivatised Fullerenes: A Promising Drug Delivery Approach for Breast Cancer","authors":"Charu Misra, Jasleen Kaur, Manish Kumar, Lokesh Kaushik, Deepak Chitkara, Simran Preet, Muhammad Wahajuddin, Kaisar Raza","doi":"10.1208/s12249-024-02955-y","DOIUrl":"10.1208/s12249-024-02955-y","url":null,"abstract":"<div><p>Docetaxel (DTX) has become widely accepted as a first-line treatment for metastatic breast cancer; however, the frequent development of resistance provides challenges in treating the disease.C<sub>60</sub> fullerene introduces a unique molecular form of carbon, exhibiting attractive chemical and physical properties. Our study aimed to develop dicarboxylic acid-derivatized C<sub>60</sub> fullerenes as a novel DTX delivery carrier. This study investigated the potential of water-soluble fullerenes to deliver the anti-cancer drug DTX through a hydrophilic linker. The synthesis was carried out using the Prato reaction. The spectroscopic analysis confirmed the successful conjugation of DTX molecules over fullerenes. The particle size of nanoconjugate was reported to be 122.13 ± 1.63 nm with a conjugation efficiency of 76.7 ± 0.14%. The designed conjugate offers pH-dependent release with significantly less plasma pH, ensuring maximum release at the target site. <i>In-vitro</i> cell viability studies demonstrated the enhanced cytotoxic nature of the developed nanoconjugate compared to DTX. These synthesized nanoscaffolds were highly compatible with erythrocytes, indicating the safer intravenous route administration. Pharmacokinetic studies confirmed the higher bioavailability (~ 6 times) and decreased drug clearance from the system <i>vis-à-vis</i> plain drug. The histological studies reveal that nanoconjugate-treated tumour cells exhibit similar morphology to normal cells. Therefore, it was concluded that this developed formulation would be a valuable option for clinical use.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":6925,"journal":{"name":"AAPS PharmSciTech","volume":"25 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Microbicidal Polymer Nanoparticles Containing Clotrimazole for Treatment of Vulvovaginal Candidiasis 更正：含克霉唑的杀菌聚合物纳米粒子用于治疗外阴阴道念珠菌病。

IF 3.4 4区医学

AAPS PharmSciTech Pub Date : 2024-10-02 DOI: 10.1208/s12249-024-02939-y

María del Rocío Lara-Sánchez, Adriana Ganem-Rondero, María Guadalupe Nava-Arzaluz, Andrea Angela Becerril-Osnaya, Laura Abril Pérez-Carranza, Sergio Alcalá-Alcalá, Néstor Mendoza-Muñoz, Elizabeth Piñón-Segundo

引用次数: 0

Correction: Synthesis of Quarternized Chitosans and Their Potential Applications in the Solubility Enhancement of Indomethacin by Solid Dispersion 更正：Quarternized Chitosans 的合成及其在通过固体分散提高吲哚美辛溶解度方面的潜在应用。

IF 3.4 4区医学

AAPS PharmSciTech Pub Date : 2024-10-02 DOI: 10.1208/s12249-024-02953-0

Sasikarn Sripetthong, Sirinporn Nalinbenjapun, Abdul Basit, Chitchamai Ovatlarnporn

引用次数: 0

Prolonged Skin Retention of Luliconazole from SLNs Based Topical Gel Formulation Contributing to Ameliorated Antifungal Activity 基于 SLNs 的局部凝胶制剂中的卢利康唑在皮肤上的长期滞留有助于增强抗真菌活性。

IF 3.4 4区医学

AAPS PharmSciTech Pub Date : 2024-10-01 DOI: 10.1208/s12249-024-02945-0

Manjot Kaur, Gurbir Singh, Riya Shivgotra, Manpreet Singh, Shubham Thakur, Subheet Kumar Jain

{"title":"Prolonged Skin Retention of Luliconazole from SLNs Based Topical Gel Formulation Contributing to Ameliorated Antifungal Activity","authors":"Manjot Kaur, Gurbir Singh, Riya Shivgotra, Manpreet Singh, Shubham Thakur, Subheet Kumar Jain","doi":"10.1208/s12249-024-02945-0","DOIUrl":"10.1208/s12249-024-02945-0","url":null,"abstract":"<div><p>The development of effective therapy is necessary because the patients have to contend with long-term therapy as skin fungal infections usually relapse and are hardly treated. Despite being a potent antifungal agent, luliconazole (LCZ) has certain shortcomings such as limited skin penetration, low solubility in aqueous medium, and poor skin retention. Solid Lipid Nanoparticles (SLNs) were developed using biodegradable lipids by solvent injection method and were embodied into the gel base for topical administration. After <i>in-vitro</i> characterizations of the formulations, molecular interactions of the drug with excipients were analyzed using <i>in-silico</i> studies. <i>Ex-vivo</i> release was determined in contrast to the pure LCZ and the commercial formulation followed by <i>in-vivo</i> skin localization, skin irritation index, and antifungal activity. The prepared SLNs have an average particle size of 290.7 nm with no aggregation of particles and homogenous gels containing SLNs with ideal rheology and smooth texture properties were successfully prepared. The <i>ex-vivo</i> LCZ release from the SLN gel was lower than the commercial formulation whereas its skin deposition and skin retention were higher as accessed by CLSM studies. The drug reaching the systemic circulation and the skin irritation potential were found to be negligible. The solubility and drug retention in the skin were both enhanced by the development of SLNs as a carrier. Thus, SLNs offer significant advantages by delivering long lasting concentrations of LCZ at the site of infection for a complete cure of the fungal load together with skin localization of the topical antifungal drug.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":6925,"journal":{"name":"AAPS PharmSciTech","volume":"25 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Exploration of Dissolution Tests for Inhalation Aerosols 吸入气溶胶溶解试验探索。

IF 3.4 4区医学

AAPS PharmSciTech Pub Date : 2024-10-01 DOI: 10.1208/s12249-024-02951-2

Min Wang, Zhaoying Fang, Kunhao Yang, Xiaowei Guo, Shangyang Li, Ali Liu

{"title":"An Exploration of Dissolution Tests for Inhalation Aerosols","authors":"Min Wang, Zhaoying Fang, Kunhao Yang, Xiaowei Guo, Shangyang Li, Ali Liu","doi":"10.1208/s12249-024-02951-2","DOIUrl":"10.1208/s12249-024-02951-2","url":null,"abstract":"<div><p>This study aimed to establish a feasible dissolution method for inhalation aerosols. A method of collecting fine particles was investigated to capture aerosol particles less than 4 μm in diameter for dissolution tests. This dose collection method enabled the aerosol particles to be uniformly distributed on the glass fiber filter, thus considerably reducing particle agglomeration. Budesonide was used as a model drug. The aerodynamic particle size distribution (APSD) of the meter-dose inhaler (MDI) was compared by replacing actuators with different orifice sizes. Dissolution tests were conducted on fine particle doses collected using various actuators, and the dissolution profiles were modeled. The fine particle dose decreased with an increasing orifice size of the actuator. Actuators with different orifice sizes would affect the dissolution behavior of inhaled drugs. This finding was supported by similarity factor f<sub>2</sub> analysis, suggesting the dissolution method has a discriminative capacity. The results of various model fits showed that the dissolution profiles produced by the different actuators could be fitted well using the Weibull mathematical model. The method employed in this study could offer a potential avenue for exploring the relationship between the orifice size of the actuator and the dissolution behavior of inhaled corticosteroids. This dissolution method was simple, reproducible, and suitable for determining the dissolution of inhalation aerosols.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":6925,"journal":{"name":"AAPS PharmSciTech","volume":"25 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

“Enhancing Oral Drug Absorption: Overcoming Physiological and Pharmaceutical Barriers for Improved Bioavailability” "加强口服药物吸收：克服生理和药物障碍，提高生物利用率"。

IF 3.4 4区医学

AAPS PharmSciTech Pub Date : 2024-10-01 DOI: 10.1208/s12249-024-02940-5

Rashmi Maurya, Akash Vikal, Preeti Patel, Raj Kumar Narang, Balak Das Kurmi

{"title":"“Enhancing Oral Drug Absorption: Overcoming Physiological and Pharmaceutical Barriers for Improved Bioavailability”","authors":"Rashmi Maurya, Akash Vikal, Preeti Patel, Raj Kumar Narang, Balak Das Kurmi","doi":"10.1208/s12249-024-02940-5","DOIUrl":"10.1208/s12249-024-02940-5","url":null,"abstract":"<div><p>The oral route stands out as the most commonly used method for drug administration, prized for its non-invasive nature, patient compliance, and easy administration. Several elements influence the absorption of oral medications, including their solubility, permeability across mucosal membranes, and stability within the gastrointestinal (GI) environment. Research has delved into comprehending physicochemical, biochemical, metabolic, and biological obstacles that impact the bioavailability of a drug. To improve oral drug absorption, several pharmaceutical technologies and delivery methods have been studied, including cyclodextrins, micelles, nanocarriers, and lipid-based carriers. This review examines both traditional and innovative drug delivery methods, as well as the physiological and pharmacological barriers influencing medication bioavailability when taken orally. Additionally, it describes the challenges and advancements in developing formulations suitable for oral use.</p><h3>Graphical abstract</h3><p>This graphical abstract summarizes the key elements of oral drug delivery systems. It depicts the human digestive system, highlighting the journey of orally administered drugs. The illustration focuses on different drug molecules, including nucleic acids, proteins, peptides, and small molecular drugs, and their delivery through platforms such as liposomes, hydrogels, bacteria, algae, and microneedles. It also identifies target regions in the gastrointestinal tract—stomach, small intestine, and colon—while emphasizing the physiological barriers that affect drug absorption, such as cellular permeability, digestive enzymes, and luminal pH variations.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":6925,"journal":{"name":"AAPS PharmSciTech","volume":"25 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naringenin Nanocrystals Mitigate Rotenone Neurotoxicity in SH-SY5Y Cell Line by Modulating Mitophagy and Oxidative Stress 柚皮苷纳米晶体通过调节丝裂吞噬和氧化应激减轻轮烯酮对 SH-SY5Y 细胞株的神经毒性

IF 3.4 4区医学

AAPS PharmSciTech Pub Date : 2024-09-30 DOI: 10.1208/s12249-024-02936-1

Vaibhavi Giradkar, Akshada Mhaske, Rahul Shukla

{"title":"Naringenin Nanocrystals Mitigate Rotenone Neurotoxicity in SH-SY5Y Cell Line by Modulating Mitophagy and Oxidative Stress","authors":"Vaibhavi Giradkar, Akshada Mhaske, Rahul Shukla","doi":"10.1208/s12249-024-02936-1","DOIUrl":"10.1208/s12249-024-02936-1","url":null,"abstract":"<div><p>Naringenin, a potent antioxidant with anti-apoptotic effects, holds potential in counteracting rotenone-induced neurotoxicity, a model for Parkinson's disease, by reducing oxidative stress and supporting mitochondrial function. Rotenone disrupts ATP production in SH-SY5Y cells through mitochondrial complex-I inhibition, leading to increased reactive oxygen species (ROS) and cellular damage. However, the therapeutic use of naringenin is limited by its poor solubility, low bioavailability, and stability concerns. Nano crystallization of naringenin (NCs), significantly improved its solubility, dissolution rates, and stability for targeted drug delivery. The developed NAR-NC and HSA-NAR-NC formulations exhibit particle sizes of 95.23 nm and 147.89 nm, with zeta potentials of -20.6 mV and -28.5 mV, respectively. These nanocrystals also maintain high drug content and show stability over time, confirming their pharmaceutical viability. In studies using the SH-SY5Y cell line, these modified nanocrystals effectively preserved mitochondrial membrane potential, sustained ATP production, and regulated ROS levels, counteracting the neurotoxic effects of rotenone. Naringenin nanocrystals offer a promising solution for improving the stability and bioavailability of naringenin, with potential therapeutic applications in neurodegenerative diseases.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":6925,"journal":{"name":"AAPS PharmSciTech","volume":"25 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HPMC-Zein Film-forming Gel Loaded with 5-Fluorouracil Coupled with CO2 Laser Dermabrasion for Managing Stable Vitiligo 含有 5-氟尿嘧啶的 HPMC-Zein 成膜凝胶与二氧化碳激光磨皮术用于治疗稳定期白癜风。

IF 3.4 4区医学

AAPS PharmSciTech Pub Date : 2024-09-26 DOI: 10.1208/s12249-024-02937-0

Heba A. Abou-Taleb, Mohamed S. Mohamed, Gamal M. Zayed, Lamiaa N. Abdelaty, Mahmoud A. Makki, Hazem L. Abdel-Aleem, Mohamed A. El-Mokhtar, Helal F. Hetta, Nidaa Abdullah, Mohammed S. Saddik

{"title":"HPMC-Zein Film-forming Gel Loaded with 5-Fluorouracil Coupled with CO2 Laser Dermabrasion for Managing Stable Vitiligo","authors":"Heba A. Abou-Taleb, Mohamed S. Mohamed, Gamal M. Zayed, Lamiaa N. Abdelaty, Mahmoud A. Makki, Hazem L. Abdel-Aleem, Mohamed A. El-Mokhtar, Helal F. Hetta, Nidaa Abdullah, Mohammed S. Saddik","doi":"10.1208/s12249-024-02937-0","DOIUrl":"10.1208/s12249-024-02937-0","url":null,"abstract":"<div><p>Vitiligo is a significant dermatological challenge affecting 0.5 to 2% of the global population. Despite the various existing medical approaches, current vitiligo treatments are far from ideal. The present study aimed to prepare and evaluate a film-forming gel of 5 fluorouracil (5FU) using different ratios of hydroxypropyl methylcellulose (HPMC) and Zein for treating vitiligo. The prepared film-forming gels were fully characterized in terms of morphology, Fourier-transform infrared spectroscopy, drug content, pH, drying time, <i>in-vitro</i> drug release, and clinical investigation. A 3<sup>2</sup>-full factorial design was used to study the impact of varying concentrations of HPMC (X1) and Zein (X2) on the percentage of 5FU released (Y1) from the prepared film-forming gels. Scanning electron microscopy (SEM) revealed a cross-linked network structure between polymers. An increase in HPMC concentration (2–4%) correlated with higher 5FU release, whereas increased Zein concentration (1–2%) resulted in reduced 5FU release. Furthermore, patients treated with 5FU film-forming gel after dermabrasion with fractional CO2 (FCO2) laser exhibited a significant decrease in JAK3 gene expression and higher effectiveness than those treated with FCO2 laser alone. Our results suggest that the film-forming gel of 5FU is promising as an effective formulation for treating vitiligo.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":6925,"journal":{"name":"AAPS PharmSciTech","volume":"25 7","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0