Acta Pharmaciae Indonesia : Acta Pharm Indo最新文献_第2页

Uji Aktivitas Antibakteri Ekstrak Metanol dan Akuades Daun Ganitri (Elaeocarpus ganitrus Roxb.) Terhadap Bakteri Streptococcus mutans 测试甲醇提取物和含水层甘草的抗菌活性。对抗链球菌

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2020-12-30 DOI: 10.20884/1.API.2020.8.2.3237

Naelaz Zukhruf Wakhidatul Kiromah, Wahyu Rahmatulloh

引用次数: 3

Effect of Ethanol Extract of Green Tea (Camellia Sinensis) to Lowering Iron Level in Ferrous Sulfate Induced Male Rats 绿茶乙醇提取物对硫酸亚铁诱导的雄性大鼠铁水平的影响

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2020-12-29 DOI: 10.20884/1.api.2020.8.2.3226

H. Wasito, H. Baroroh, Yossi Respa Sandiani

{"title":"Effect of Ethanol Extract of Green Tea (Camellia Sinensis) to Lowering Iron Level in Ferrous Sulfate Induced Male Rats","authors":"H. Wasito, H. Baroroh, Yossi Respa Sandiani","doi":"10.20884/1.api.2020.8.2.3226","DOIUrl":"https://doi.org/10.20884/1.api.2020.8.2.3226","url":null,"abstract":"Green tea (Camellia sinensis) has the potential to be developed as a natural agent for therapy of iron overload in thalassemia. The purpose of this research was to observe the ability of ethanol extract of green tea as a natural iron chelating agent in animal iron overload model. Ethanol extract of green tea leave (GTLE) was prepared by maceration using 70% ethanol. Sprague-Dawley male rats were divided into three groups (5 rats each), a normal control group (group I) received daily p.o. of deionized water, the iron overload group received 100 g/Kg BW (group II) of GTLE that given two hours before ferroussulfate0.5 g/Kg BW administrations and the last group (group III) received only 0.5 g/Kg BW of ferrous sulfate. GTLE and ferrous sulfate were given orally every day for 30 days. At the end of the experimental period, rat blood serum samples were collected. Iron content and alanine aminotransferase (ALT) levels were measured using a spectrophotometer followed by observing the histologic preparation of rat liver organ. The results showed that administration of green tea leaves ethanolic extract of 100 g/Kg BW was able to keep down iron and ALT levels in the rat blood to a normal level.","PeriodicalId":6923,"journal":{"name":"Acta Pharmaciae Indonesia : Acta Pharm Indo","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84711725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sistem Penghantaran Obat Transdermal Dissolving Microneedle (DMN) Serta Potensinya Sebagai Penghantaran Vaksin

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2020-03-31 DOI: 10.20884/1.api.2020.8.1.2591

Viviane Annisa

引用次数: 1

Hubungan Karakteristik Pasien dengan Kepatuhan Minum Obat dan Kualitas Hidup Pasien Rawat Jalan Strok Iskemik di RSUD Banyumas Banyumas区石斑病门诊病人的特点与服药依从性和生活质量有关

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2020-03-31 DOI: 10.20884/1.api.2020.8.1.2359

Nindita Rachmania, Nia Kurnia Sholihat, E. D. Utami

引用次数: 1

Molecular docking tangeretin and kaempferol compound against antiapoptotic Bcl-xL: in silico study 分子对接橘皮素和山奈酚化合物抗凋亡Bcl-xL的实验研究

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2019-09-30 DOI: 10.20884/1.API.2019.7.2.2455

Siska Febdian Nitami, Rifki Febriansah

引用次数: 1

Phytochemical Screening and Antibacterial Test of Leaf Extract of Canar Susu (Smilax macrocarpa Blume) Against Eschercihia coli, Pseudomonas aeruginosa, and Staphylococcus epidermidis 猕猴桃叶提取物对大肠埃希菌、铜绿假单胞菌和表皮葡萄球菌的植物化学筛选及抗菌试验

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2019-03-31 DOI: 10.20884/1.api.2019.7.1.2451

L. L. Khumaisah, V. Anggraeni, M. S. Fareza

{"title":"Phytochemical Screening and Antibacterial Test of Leaf Extract of Canar Susu (Smilax macrocarpa Blume) Against Eschercihia coli, Pseudomonas aeruginosa, and Staphylococcus epidermidis","authors":"L. L. Khumaisah, V. Anggraeni, M. S. Fareza","doi":"10.20884/1.api.2019.7.1.2451","DOIUrl":"https://doi.org/10.20884/1.api.2019.7.1.2451","url":null,"abstract":"Smilax is one of the genus Smilacaceae is widely used as a medicinal plant because it contains various secondary metabolites with some bioactivity, such as anti-inflammatory, antirheumatic, analgesic, antioxidant, anticancer and antibacterial. One species of Smilax that has not been studied and only grew in Indonesia is Smilax macrocarpa Blume (canar susu). Therefore, a preliminary study of phytochemicals and biological activities is required to encourage progress and novelty in science and to know its phylogenetics in Indonesia's biodiversity. The research was done by extraction method using maceration with methanol as a solvent. Simplicia characteristic, toxicity test with BSLT method, phytochemical screening according to Harborne method, and antibacterial activity test using microdilution against including Escherihia coli, Pseudomonas aeruginosa, and Staphylococcus epidermidis were performed to leaf extract of canar susu. The results obtained that methanol extract of canar susu leaves contains alkaloids, flavonoids, steroids, tannins, terpenoids, saponins, and glycosides. Water content, ash content, acid-soluble ash content, water sari content, and alcohol sari concentration 8.74%; 3.60%; 0.11%; 19.01% and 5.40% respectively. Toxicity results obtained LC50 680.07 ppm. Antibacterial activity test against E. coli has MIC 625 ppm, whereas in P. aeruginosa and S. epidermidis ATCC 12228 are 1.250 ppm. The MBC values for E. coli, P. aeruginosa, and S. epidermidis ATCC 12228 were 5,000 ppm. Based on this result known S. macrocarpa Blume is not potential as antibacterial, but potential as biopesticide according to toxicity result. ","PeriodicalId":6923,"journal":{"name":"Acta Pharmaciae Indonesia : Acta Pharm Indo","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81565775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pengobatan Berpotensi Tidak Tepat Berdasarkan Kriteria Beers 2015 Pada Pasien Geriatri di RSUD Prof. Dr. Margono Soekarjo 根据Margono Soekarjo博士住院的老年病人2015年医疗标准，这种潜在的治疗方法并不完全符合

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2019-03-31 DOI: 10.20884/1.api.2019.7.1.2412

Annisaa Ayu Nabilla, E. D. Utami, Ika Mustikaningtias

引用次数: 1

Aktivitas Antifungi Esktrak Etanol Daun Kamboja Merah (Plumeria rubra L.) Terhadap Pityrosporum ovale 柬埔寨红叶乙醇抗真菌活性。去Pityrosporum ovale

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2018-09-30 DOI: 10.20884/1.API.2018.6.2.2161

Rizki Akbar Ramadhan, Rehana Rehana, Muhamad Salman Fareza

引用次数: 0

Penapisan Senyawa Antikanker Dari Batang Brotowali (Tinospora Crispa L) Dan Uji Aktivitas Sitotoksik Pada Kultur Sel Widr

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2018-09-30 DOI: 10.5281/zenodo.3707213

Warsinah Warsinah, Harwoko Harwoko

{"title":"Penapisan Senyawa Antikanker Dari Batang Brotowali (Tinospora Crispa L) Dan Uji Aktivitas Sitotoksik Pada Kultur Sel Widr","authors":"Warsinah Warsinah, Harwoko Harwoko","doi":"10.5281/zenodo.3707213","DOIUrl":"https://doi.org/10.5281/zenodo.3707213","url":null,"abstract":"Penelitian ini bertujuan untuk melakukan penapisan profil senyawa, uji aktivitas sitotoksik, dan induksi apotosis dari ekstrak batang brotowali (Tinospora crispa L.). Ekstraksi dilakukan dengan maserasi menggunakan etanol 96% kemudian di fraksinasi dengan n-heksan, kloroform, etilasetat berdasarkan tingkat polaritas. Uji dilanjutkan kromatografi lapis tipis menggunakan fase diam silika gel GF 254 dan fase gerak campuran. Spot yang ada dilihat dibawah UV 254 nm dan 366 nm serta disemprot dengan reagen penampak noda. Ekstrak dan fraksi kemudian diuji aktivitas sitotosiknya dengan metode MTT, serta induksi apoptosis dengan metode double staining dan flowcytometri. Hasil penelitian menunjukkan bahwa ekstrak etanolik batang brotowali mengandung senyawa flavanoid, fenolik, dan terpenoid. Ekstrak mempunyai efek sitotoksik dengan IC50 sebesar 314 µg/ml dan fraksi F3 sebagai fraksi aktif mempunyai efek sitotoksik dengan IC50 sebesar 146 µg/ml. Pada konsentrasi 25 µg/ml, fraksi mampu menginduksi apoptosis sebesar 28,9 %, kontrol sel 17,90% dan doksorubisin 63,12%. Pemacuan apoptosis ditunjukkan dengan adanya warna orange dan terjadinya banyak badan apoptosis pada sel WiDr dengan perlakuan ekstrak yang lebih banyak dibandingkan dengan kontrol sel.","PeriodicalId":6923,"journal":{"name":"Acta Pharmaciae Indonesia : Acta Pharm Indo","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76000862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analisis Kualitatif Faktor-Faktor Pendukung Kepatuhan Pasien Infeksi dalam Menggunakan Antibiotik Sefiksim Setelah Masa Rawat Inap di Rumah Sakit Prof. Dr. Margono Soekarjo 定性分析是感染患者在住院后服用sesemsim抗生素的原因

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2018-09-30 DOI: 10.5281/ZENODO.3707223

Elisa Mahardika, Laksmi Maharani, M. W. Suryoputri

{"title":"Analisis Kualitatif Faktor-Faktor Pendukung Kepatuhan Pasien Infeksi dalam Menggunakan Antibiotik Sefiksim Setelah Masa Rawat Inap di Rumah Sakit Prof. Dr. Margono Soekarjo","authors":"Elisa Mahardika, Laksmi Maharani, M. W. Suryoputri","doi":"10.5281/ZENODO.3707223","DOIUrl":"https://doi.org/10.5281/ZENODO.3707223","url":null,"abstract":"Penggunaan antibiotik harus sesuai dengan regimen yang telah ditentukan dokter atau apoteker untuk mencegah resistensi. Pasien setelah masa rawat inap berpotensi pada masalah kepatuhan dalam penggunaan antibiotik. Penelitian ini bertujuan untuk mengeksplorasi faktor-faktor pendukung kepatuhan pasien infeksi dalam menggunakan antibiotik sefiksim setelah masa rawat inap di Rumah Sakit Prof. Dr. Margono Soekarjo. Penelitian dilakukan menggunakan metode non-experimental berdasarkan pada pendekatan kualitatif fenomenologis dengan cara wawancara mendalam (indepth interview). Wawancara dilakukan dua kali pada hari ke-7 setelah keluar dari rumah sakit dan satu minggu setelah wawancara pertama. Hasil wawancara dianalisis secara deskriptif dengan proses berfikir induktif. Hasil penelitian menunjukkan bahwa faktor-faktor pendukung kepatuhan pasien infeksi dalam meminum antibiotik sefiksim setelah masa rawat inap adalah keinginan untuk sembuh, informasi bahwa antibiotik harus dihabiskan, takut terjadi kekambuhan, diingatkan anggota keluarga, bentuk sediaan, kondisi kesehatan yang memburuk dan mengikuti saran dokter. Selain itu, didapatkan hasil bahwa pasien patuh meminum dan menghabiskan antibiotik sesuai aturan pakai. Pasien mendapat mendapat manfaat dari etiket yang membantunya dalam mengingat jam minum obat.","PeriodicalId":6923,"journal":{"name":"Acta Pharmaciae Indonesia : Acta Pharm Indo","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72755885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0