Molecular docking tangeretin and kaempferol compound against antiapoptotic Bcl-xL: in silico study

The plants that can be developed as a chemopreventive agent are orange peel (Citrus reticulata) and tea leaves (Camellia sinensis). This study aims to determine the chemopreventive agent of tangeretin and kaempferol in silico.  In silico test was performed molecular docking by using Vina Autodock Software by deprecating tangeretin and kaempferol compounds against target protein Bcl-xL. Tangeretin and kaempferol have an affinity to the protein with score -5,8 kkal/mol and -6,4 kkal/mol, respectively. Tangeretin has a high potency in inhibiting activity against Bcl-xL protein, while kaempferol has less potency in inhibition of Bcl-xL protein.