Acta Pharmaciae Indonesia : Acta Pharm Indo最新文献

Free Chlorine Determination in Disinfectant Product using Visible Spectrophotometry based on Prussian Blue Degradation 普鲁士蓝降解可见分光光度法测定消毒液中游离氯

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2022-02-02 DOI: 10.20884/1.api.2021.9.2.5371

H. Wasito, Defi Srium Siagian, M. S. Fareza

{"title":"Free Chlorine Determination in Disinfectant Product using Visible Spectrophotometry based on Prussian Blue Degradation","authors":"H. Wasito, Defi Srium Siagian, M. S. Fareza","doi":"10.20884/1.api.2021.9.2.5371","DOIUrl":"https://doi.org/10.20884/1.api.2021.9.2.5371","url":null,"abstract":"Disinfectant products with excessive chlorine could be dangerous for health and need quality control. It is important to develop an analytical method for monitoring product quality. The main objective of this work is to develop an alternative method and evaluate the analytical performance of visible spectrophotometry for determining free chlorine in disinfectant products based on the Prussian blue decomposition process. The capability of chlorine to oxidize ferrous to ferric ions makes the Prussian blue generated by ferrosulfate and potassium ferricyanide is decomposed and measured by spectrophotometer. The formation of Prussian blue was improved by optimizing some reaction conditions and assessing incubation time. Linearity, analytical concentration range, precision, accuracy, detection limit, and quantitation limit parameters were among the examined analytical parameters. The results showed that the optimum concentration of ferrosulfate, potassium ferysianide, and hydrochloric acid for Prussian blue formation was 2.0 mmol L-1, 3.0 mmol L-1, and 0.5 mol L-1, respectively, with 15 minutes incubation time after chlorine addition. Analytical performance parameters seemed appropriate for routine analysis purposes. The developed method can also be applied as an alternative analytical method to determine the free chlorine concentration of disinfection products in the market.","PeriodicalId":6923,"journal":{"name":"Acta Pharmaciae Indonesia : Acta Pharm Indo","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75035868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hubungan Tingkat Pengetahuan Terhadap Manajemen Diri Pasien Prolanis Diabetes Mellitus Tipe 2 di Puskesmas 1 Purwokerto Timur 普鲁士2型糖尿病患者的自我管理知识水平

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2022-02-02 DOI: 10.20884/1.api.2021.9.2.4250

Siti Rohimah Nurasyifa, V. Ru, Hening Pratiwi

引用次数: 0

ANALISIS TINGKAT PENGETAHUAN DAN SIKAP TENAGA KEFARMASIAN DALAM MENCEGAH OBAT RUSAK DAN KADARLUARSA DI RSUD TORA BELO 分析了托拉贝罗县抗坏药和保质期的知识水平和药效态度

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2022-02-02 DOI: 10.20884/1.api.2021.9.2.5135

Nurul Ambianti, Muhamad Rinaldhi Tandah, Khusnul Diana, R. Balqis

{"title":"ANALISIS TINGKAT PENGETAHUAN DAN SIKAP TENAGA KEFARMASIAN DALAM MENCEGAH OBAT RUSAK DAN KADARLUARSA DI RSUD TORA BELO","authors":"Nurul Ambianti, Muhamad Rinaldhi Tandah, Khusnul Diana, R. Balqis","doi":"10.20884/1.api.2021.9.2.5135","DOIUrl":"https://doi.org/10.20884/1.api.2021.9.2.5135","url":null,"abstract":"Abstrak \u0000Obat rusak dan kadaluarsa merupakan salah satu masalah yang dapat mencerminkan ketidaktepatan dan kurang baiknya manajemen pengelolaan obat di sebuah Instalasi Farmasi Rumah Sakit (IFRS). Penelitian ini dilakukan untuk mengetahui tingkat pengetahuan dan sikap tenaga kefarmasian dalam mencegah obat rusak dan kadaluarsa di Rumah Sakit Umum Daerah (RSUD) Tora Belo. Jenis penelitian ini adalah penelitian non-eksperimental dengan pengambilan data secara cross sectional. Data yang digunakan adalah data primer yang diperoleh dari hasil kuesioner yang telah diisi oleh tenaga kefarmasian di RSUD Tora Belo. Analisis yang digunakan pada penelitian ini adalah analisis korelasi menggunakan uji Spearman-Rho, untuk mengetahui hubungan tingkat pengetahuan dan sikap tenaga kefarmasian dalam mencegah obat rusak dan kadaluarsa. Jumlah sampel adalah 33 orang yang diambil secara total sampling. Waktu pengambilan data penelitian selama bulan Mei-Oktober 2020. Dari hasil penelitian dapat diperoleh pengetahuan tenaga kefarmasian dalam mencegah obat rusak dan kadaluarsa dikategorikan cukup yaitu sebanyak 17 orang (71,1%), sikap tenaga kefarmasian dalam mencegah obat rusak dan kadaluarsa dikategorikan sangat kuat yaitu sebanyak 18 orang (85,78%), serta hasil analisis korelasi tingkat pengetahuan dan sikap tenaga kefarmasian dalam mencegah obat rusak dan kadaluarsa diperoleh nilai signifikansi sebesar 0,021, sehingga dapat disimpulkan bahwa terdapat hubungan antara tingkat pengetahuan dan sikap tenaga kefarmasian dalam mencegah obat rusak dan kadaluarsa di RSUD Tora Belo. \u0000 ","PeriodicalId":6923,"journal":{"name":"Acta Pharmaciae Indonesia : Acta Pharm Indo","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86447054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gambaran Gambaran Pelayanan Swamedikasi Oleh Apoteker Di Kota Palu 这是帕劳镇药剂师的swamedication服务概述

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2022-02-02 DOI: 10.20884/1.api.2021.9.2.5144

Nurintan Kurnia Manikam, Amelia Rumi, Firdawati amir Parumpu

{"title":"Gambaran Gambaran Pelayanan Swamedikasi Oleh Apoteker Di Kota Palu","authors":"Nurintan Kurnia Manikam, Amelia Rumi, Firdawati amir Parumpu","doi":"10.20884/1.api.2021.9.2.5144","DOIUrl":"https://doi.org/10.20884/1.api.2021.9.2.5144","url":null,"abstract":"Pelayanan swamedikasi yang baik adalah swamedikasi yang dilakukan oleh tenaga ahli obat yaitu apoteker untuk mengoptimalkan penggunaan obat dan meningkatkan kesehatan. Pada saat yang bersamaan, apoteker juga diharapkan dapat memberikan konsultasi kepada pasien dan memantau setiap masalah yang mungkin terjadi selama penggunaan obat, yang disebut dengan masalah terkait obat (Medication error). Tujuan penelitian ini adalah untuk mengetahui gambaran pelayanan swamedikasi oleh apoteker di kota palu berdasarkan kategori penggalian informasi, pemilihan obat dan informasi obat. Metode penelitian yang digunakan adalah deskriptif kualitatif bersifat cross sectional dan metode pengambilan sampel adalah Purposive sampling. Kriteria responden yaitu apoteker yang memiliki SIPA aktif dan berpraktek di apotek serta bersedia menandatangani lembar Informed consent. Berdasarkan kriteria tersebut, diperoleh 86 sampel apoteker dalam apotek yang berada di Kota Palu. Instrumen yang digunakan yaitu menggunakan kuesioner dalam bentuk Google Form yang telah dilakukan uji validitas dan uji reliabilitas serta data yang diperolehdievaluasi secara deskriptif. Hasil penelitian menunjukkan bahwa apoteker dalam apotek di kota palu sudah melaksanakan pelayanan swamedikasi untuk penggalian informasi sebesar 83,60%, pemilihan obat sebesar 95,35% dan pemberian informasi obat sebesar 89,66%. Kesimpulan dari penelitian ini yaitu apoteker dalam apotek sudah melaksanakan pelayanan swamedikasi dengan baik sesuai variabel.","PeriodicalId":6923,"journal":{"name":"Acta Pharmaciae Indonesia : Acta Pharm Indo","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87527566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UJI AKTIVITAS ANTIINFLAMASI INFUSA BUNGA PUKUL EMPAT SECARA IN VITRO 在体外试验4小时内的抗炎症活性

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2021-06-29 DOI: 10.20884/1.api.2021.9.1.3683

Hidayatul Ihsan, I. Pratama, Nisa Isnaeni Hanifa

{"title":"UJI AKTIVITAS ANTIINFLAMASI INFUSA BUNGA PUKUL EMPAT SECARA IN VITRO","authors":"Hidayatul Ihsan, I. Pratama, Nisa Isnaeni Hanifa","doi":"10.20884/1.api.2021.9.1.3683","DOIUrl":"https://doi.org/10.20884/1.api.2021.9.1.3683","url":null,"abstract":"The stew of Mirabilis jalapa L. flower has been used traditionally as an anti-inflammatory. Phytochemical screening of Mirabilis jalapa L. flower showed flavonoid content which is known to have anti-inflammatory activity. This study aims to determine the anti-inflammatory activity of Mirabilis jalapa L. flower infusion using the red blood cell membrane stabilization method by inducing hypotonicity and heat. The test group consisted of Mirabilis jalapa L. flower infusion with a concentration of 2.5%; 5%; and 10% w / v, positive control (diclofenac sodium 0.01% w / v and aspirin 0.01% w / v), and negative control (distilled water). The anti-inflammatory activity of Mirabilis jalapa L. flower infusion was determined by the percentage of membrane stabilization and inhibition of red blood cell hemolysis. Data from the test results were statistically analyzed both parametric and nonparametric with SPSS. Mirabilis jalapa L. flower infusion contains flavonoids, tannins and terpenoids. The test results showed that the 10% concentration of Mirabilis jalapa L. flower infusion had the largest percentage of red blood cell hemolysis protection on hypotonicity induction, that is 99.50% (p>0.05) and the largest percentage of hemolysis inhibition on heat induction, that is 50.27% ( p≤0.05). From these results, it can be concluded that the Mirabilis jalapa L. flower infusion has potential as an anti-inflammatory by stabilizing the red blood cell membrane.","PeriodicalId":6923,"journal":{"name":"Acta Pharmaciae Indonesia : Acta Pharm Indo","volume":"113 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73423270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OPTIMASI SEDIAAN GEL EKSTRAK BUAH BELIMBING WULUH (Averrhoa bilimbi L.) DENGAN VARIASI BASIS KARBOPOL 940 DAN CMC-Na

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2021-06-29 DOI: 10.20884/1.api.2021.9.1.3669

N. Susianti, Yohanes Juliantoni, Nisa Isnaeni Hanifa

引用次数: 1

Optimasi Formula Sediaan Lotion Ekstrak Daun Jambu Biji (Psidium guajava L.) Dengan Variasi Konsentrasi Setil Alkohol dan Gliserin

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2021-06-28 DOI: 10.20884/1.api.2021.9.1.3408

Hardiyanti Dewi Azmi, Windah Anugrah Subaidah, Yohanes Juliantoni

{"title":"Optimasi Formula Sediaan Lotion Ekstrak Daun Jambu Biji (Psidium guajava L.) Dengan Variasi Konsentrasi Setil Alkohol dan Gliserin","authors":"Hardiyanti Dewi Azmi, Windah Anugrah Subaidah, Yohanes Juliantoni","doi":"10.20884/1.api.2021.9.1.3408","DOIUrl":"https://doi.org/10.20884/1.api.2021.9.1.3408","url":null,"abstract":"Daun jambu biji (Psidium guajava L.) mengandung senyawa flavonoid yang berpotensi sebagai antioksidan yang dapat mencegah terjadinya kerusakan kulit karena radikal bebas sehingga produk kosmetik sediaan topikal dengan zat aktif ekstrak daun jambu biji perlu dikembangkan. Tujuan dilakukannya penelitian ini untuk menentukan formula optimum sediaan lotion ekstrak daun jambu biji (Psidium guajava L.) dengan variasi setil alkohol dan gliserin serta menentukan sifat fisik formula optimumnya. Metode ekstraksi yang digunakan yaitu maserasi dengan pelarut etanol 96%. Nilai rendemen yang diperoleh yaitu 17,64%. Hasil skrining flavonoid menunjukkan hasil positif yang ditandai dengan terjadinya perubahan warna larutan menjadi merah. Optimasi formula dilakukan dengan metode Simplex Lattice Design yang diolah menggunakan software Design Expert dan sediaan lotion diformulasi dengan meleburkan bahan fase minyak (asam stearat, setil alkohol, propil paraben) dan fase air (trietanolamin, gliserin, metil paraben, aquades) secara terpisah pada suhu 70-75oC kemudian disatukan dan diaduk hingga homogen. Dari software tersebut diperoleh formula optimum dengan konsentrasi setil alkohol dan gliserin masing-masing sebesar 3,93% dan 13,07%. Hasil evaluasi sifat fisik formula optimum yaitu memilki warna hijau kecoklatan, bau khas daun jambu biji, konsistensi yang kental dan pH 7,942, daya sebar 6,350 cm dan daya lekat 0,975 detik.","PeriodicalId":6923,"journal":{"name":"Acta Pharmaciae Indonesia : Acta Pharm Indo","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75706175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Ethanol Extract of Green Tea (Camellia Sinensis) to Lowering Iron Level in Ferrous Sulfate Induced Male Rats 绿茶乙醇提取物对硫酸亚铁诱导的雄性大鼠铁水平的影响

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2020-12-29 DOI: 10.20884/1.api.2020.8.2.3226

H. Wasito, H. Baroroh, Yossi Respa Sandiani

{"title":"Effect of Ethanol Extract of Green Tea (Camellia Sinensis) to Lowering Iron Level in Ferrous Sulfate Induced Male Rats","authors":"H. Wasito, H. Baroroh, Yossi Respa Sandiani","doi":"10.20884/1.api.2020.8.2.3226","DOIUrl":"https://doi.org/10.20884/1.api.2020.8.2.3226","url":null,"abstract":"Green tea (Camellia sinensis) has the potential to be developed as a natural agent for therapy of iron overload in thalassemia. The purpose of this research was to observe the ability of ethanol extract of green tea as a natural iron chelating agent in animal iron overload model. Ethanol extract of green tea leave (GTLE) was prepared by maceration using 70% ethanol. Sprague-Dawley male rats were divided into three groups (5 rats each), a normal control group (group I) received daily p.o. of deionized water, the iron overload group received 100 g/Kg BW (group II) of GTLE that given two hours before ferroussulfate0.5 g/Kg BW administrations and the last group (group III) received only 0.5 g/Kg BW of ferrous sulfate. GTLE and ferrous sulfate were given orally every day for 30 days. At the end of the experimental period, rat blood serum samples were collected. Iron content and alanine aminotransferase (ALT) levels were measured using a spectrophotometer followed by observing the histologic preparation of rat liver organ. The results showed that administration of green tea leaves ethanolic extract of 100 g/Kg BW was able to keep down iron and ALT levels in the rat blood to a normal level.","PeriodicalId":6923,"journal":{"name":"Acta Pharmaciae Indonesia : Acta Pharm Indo","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84711725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sistem Penghantaran Obat Transdermal Dissolving Microneedle (DMN) Serta Potensinya Sebagai Penghantaran Vaksin

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2020-03-31 DOI: 10.20884/1.api.2020.8.1.2591

Viviane Annisa

引用次数: 1

Phytochemical Screening and Antibacterial Test of Leaf Extract of Canar Susu (Smilax macrocarpa Blume) Against Eschercihia coli, Pseudomonas aeruginosa, and Staphylococcus epidermidis 猕猴桃叶提取物对大肠埃希菌、铜绿假单胞菌和表皮葡萄球菌的植物化学筛选及抗菌试验

Acta Pharmaciae Indonesia : Acta Pharm Indo Pub Date : 2019-03-31 DOI: 10.20884/1.api.2019.7.1.2451

L. L. Khumaisah, V. Anggraeni, M. S. Fareza

{"title":"Phytochemical Screening and Antibacterial Test of Leaf Extract of Canar Susu (Smilax macrocarpa Blume) Against Eschercihia coli, Pseudomonas aeruginosa, and Staphylococcus epidermidis","authors":"L. L. Khumaisah, V. Anggraeni, M. S. Fareza","doi":"10.20884/1.api.2019.7.1.2451","DOIUrl":"https://doi.org/10.20884/1.api.2019.7.1.2451","url":null,"abstract":"Smilax is one of the genus Smilacaceae is widely used as a medicinal plant because it contains various secondary metabolites with some bioactivity, such as anti-inflammatory, antirheumatic, analgesic, antioxidant, anticancer and antibacterial. One species of Smilax that has not been studied and only grew in Indonesia is Smilax macrocarpa Blume (canar susu). Therefore, a preliminary study of phytochemicals and biological activities is required to encourage progress and novelty in science and to know its phylogenetics in Indonesia's biodiversity. The research was done by extraction method using maceration with methanol as a solvent. Simplicia characteristic, toxicity test with BSLT method, phytochemical screening according to Harborne method, and antibacterial activity test using microdilution against including Escherihia coli, Pseudomonas aeruginosa, and Staphylococcus epidermidis were performed to leaf extract of canar susu. The results obtained that methanol extract of canar susu leaves contains alkaloids, flavonoids, steroids, tannins, terpenoids, saponins, and glycosides. Water content, ash content, acid-soluble ash content, water sari content, and alcohol sari concentration 8.74%; 3.60%; 0.11%; 19.01% and 5.40% respectively. Toxicity results obtained LC50 680.07 ppm. Antibacterial activity test against E. coli has MIC 625 ppm, whereas in P. aeruginosa and S. epidermidis ATCC 12228 are 1.250 ppm. The MBC values for E. coli, P. aeruginosa, and S. epidermidis ATCC 12228 were 5,000 ppm. Based on this result known S. macrocarpa Blume is not potential as antibacterial, but potential as biopesticide according to toxicity result. ","PeriodicalId":6923,"journal":{"name":"Acta Pharmaciae Indonesia : Acta Pharm Indo","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81565775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0