中国医学科学院学报最新文献

{"title":"Current Status and Influencing Factors of Discharge Readiness of Patients With Special Positions After Ophthalmologic Surgery.","authors":"Yan-Ning Zhang, Ya-Fang Zhao, Dan Xie, Nan Wu, Jian-Jun Cui, Kun Quan, Qi Bing, Si-di Liu, Yue-Hui DU","doi":"10.3881/j.issn.1000-503X.16810","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16810","url":null,"abstract":"<p><p>Objective To investigate and discuss the current status of discharge readiness of patients with special positions after ophthalmologic surgery and analyze its influencing factors,thus providing more accurate,higher-quality,and humane perioperative nursing and guidance. Methods A cross-sectional study design was adopted,and the consecutive sampling method was used to select 200 pre-discharge patients in the ophthalmology ward of Peking Union Medical College Hospital from March 2024 to September 2024.The general data questionnaire,Readiness for Hospital Discharge Scale (RHDS),and Quality of Discharge Teaching Scale (QDTS) were used to explore the influencing factors through univariate analysis and multivariate linear regression analysis. Results The total score of discharge readiness of patients with special positions after silicone oil or gas filling was (103.44±15.30) points,with the average item score of (8.62±1.28) points.The results of one-way ANOVA showed that marital status,occupation,income level,degree of self-care,whether the medical resources in the place of residence could meet the needs of subsequent treatment,and postoperative visual acuity were influencing factors of discharge readiness (all <i>P</i><0.05).The results of multivariate linear regression analysis showed that the quality of discharge teaching,income level,and self-care degree of patients were independent factors influencing the discharge readiness of patients with special positions after silicone oil or gas filling.Pearson correlation analysis showed that the quality of discharge teaching was positively correlated with discharge readiness (<i>r</i>=0.482,<i>P</i><0.001). Conclusions Patients with special positions after silicone oil or gas filling had better outcomes of discharge readiness and quality of discharge teaching.However,the patients exhibited altered emotions after surgery and weak ability to understand the disease.The nursing staff should not only meet the life needs of the patients during the period of taking special positions in hospital but also pay attention to the emotional changes of the patients.At the same time,attention should be paid to personalized discharge teaching,which is both professional and practical,so that patients can obtain self-care knowledge and skills that are more valuable and more suitable for discharge and return home.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 3","pages":"489-497"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global,Regional,and National Burden Changes of Rheumatic Heart Disease From 1990 to 2021.","authors":"Dan-Ni Zhao, Yue Zhuo, Ming-Yao Luo, Zhou Zhou","doi":"10.3881/j.issn.1000-503X.16757","DOIUrl":"https://doi.org/10.3881/j.issn.1000-503X.16757","url":null,"abstract":"<p><p>Objective To systematically assess the global,regional,and national burdens of rheumatic heart disease (RHD) from 1990 to 2021 and to examine their associations with the sociodemographic index (SDI). Methods Data were obtained from the Global Burden of Disease Study 2021 (GBD 2021).We analyzed RHD-related deaths,prevalent cases,age-standardized death rates (ASDRs),and age-standardized prevalence rates (ASPRs),stratified by age,sex,region,and SDI.Estimated annual percentage changes (EAPCs) were calculated to evaluate temporal trends.Spearman correlation analysis was performed to explore the associations between EAPCs and baseline burden in 1990,as well as SDI in 2021.An autoregressive integrated moving average (ARIMA) model was employed to project the future trend of RHD through 2030. Results In 2021,the global ASDR and ASPR of RHD were estimated at 4.47 (95%<i>UI</i>:3.89-5.31) and 488.19 (95%<i>UI</i>:442.57-539.76) per 100 000 population,respectively.Females exhibited higher ASDR and ASPR than males,and the burden was more pronounced among older age groups.From 1990 to 2021,global deaths due to RHD declined by 10.8%,and ASDR decreased by 56.2%,with an EAPC of -2.71% (95%<i>CI</i>=-2.75--2.67).The ARIMA model projected a continued decline in both the number of deaths and ASDR through 2030.In contrast,the number of prevalent cases and ASPR increased by 69.4% and 12.6%,respectively.The highest absolute numbers of deaths and prevalent cases were observed in populous countries,notably India and China.From 1990 to 2021,ASDR and ASPR declined in most countries,while the disease burden in some countries in Africa,the Middle East,and South Asia experienced increasing trends.Both ASDR and ASPR were negatively correlated with SDI (<i>r</i>=-0.511 and -0.762,respectively,both <i>P</i><0.001).The EAPCs of ASDR and ASPR were associated with both baseline burden in 1990 and SDI in 2021.Countries with higher SDI experienced more substantial declines in RHD burden.However,the declines were limited in areas with high baseline prevalence,and some regions even showed upward trends. Conclusions Between 1990 and 2021,although the global mortality of RHD steadily declined,the prevalence slightly increased,with females and older adults bearing a disproportionate burden.Significant regional disparities in disease burden were observed.More pronounced declines occurred in countries with a high SDI,whereas some low-SDI and high-baseline-burden regions showed little or no decline,which suggested the need for sustained and targeted comprehensive prevention and control strategies in key areas.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 3","pages":"463-473"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Wnt1-Inducible Signaling Pathway Protein 1 in Human Cancer.","authors":"Ai-Hong Mao, Xiao-Xi Chen, Hui-Yan Pang, De-Ping Tang","doi":"10.3881/j.issn.1000-503X.16705","DOIUrl":"10.3881/j.issn.1000-503X.16705","url":null,"abstract":"<p><p>The Wnt1-inducible signaling pathway protein 1 (WISP1) is a highly conserved,cysteine-rich secreted protein that belongs to the cell communication network factor family.WISP1 is widely involved in cell proliferation,differentiation,apoptosis,adhesion,and metastasis,playing a critical role in various physiological and pathological processes.An increasing number of studies have demonstrated that dysregulated expression of WISP1 is associated with the development and progression of various human diseases,including cancer,fibrosis,metabolic disorders,and cardiovascular diseases.WISP1 can not only serve as a non-invasive diagnostic or prognostic biomarker but also holds great potential as a promising therapeutic target.To fully elucidate the potential application of WISP1 in cancer diagnosis and therapy,this review summarizes the structure,expression patterns,biological functions,and clinical correlations of WISP1 in human cancers,discusses its underlying molecular mechanisms,and highlights its translational clinical value.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"514-523"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147969406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Secondary Uterine Arteriovenous Fistula After Induced Abortion.","authors":"Chun-Ying Li, Yang Ye, Ping Peng, Yu-Han Liu, Xin-Yan Liu","doi":"10.3881/j.issn.1000-503X.17134","DOIUrl":"10.3881/j.issn.1000-503X.17134","url":null,"abstract":"<p><p>Objective To explore the risk factors for secondary uterine arteriovenous fistula (UAVF) after induced abortion. Methods A retrospective case-control study was conducted.Fifty-two patients with secondary UAVF after induced abortion in Peking Union Medical College Hospital between January 2013 and January 2025 were enrolled in the patient group.According to a 1∶3 ratio,patients who underwent the same method of abortion to terminate pregnancy within the same two weeks but did not develop UAVF post-surgery were selected and included in the control group (<i>n</i>=156).The basic information was compared between the two groups. Multivariate logistic regression analysis was performed to identify the risk factors for UAVF after induced abortion. Results Multivariate logistic regression analysis showed that residual pregnancy tissue in the uterus was an independent risk factor for the occurrence of UAVF (<i>OR</i>=16.02,<i>P</i>=0.037).The patients with residual pregnancy tissue after induced abortion had a 16 fold higher incidence of secondary UAVF than the control group. Conclusions Residual pregnancy tissue in the uterus is an independent risk factor for secondary UAVF after induced abortion.Avoiding residual pregnancy tissue may reduce the occurrence of UAVF.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"474-478"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser-Assisted Pulp Revascularization Therapy for Periapical Periodontitis in an Adult With an Immature Root:Report of One Case.","authors":"Zhen Li, Shan-Shan Ding, Yan Xie, Xiao-Wei Zhang, You-Jia Tang, Qian Li","doi":"10.3881/j.issn.1000-503X.16703","DOIUrl":"10.3881/j.issn.1000-503X.16703","url":null,"abstract":"<p><p>The conventional treatment for periapical periodontitis faces challenges,especially in the cases with immature roots.This article reports a case of periapical periodontitis in an adult permanent tooth with an immature root,where erbium-doped yttrium aluminum garnet(Er:YAG)laser-activated root canal disinfection was employed to induce apical bleeding and pulp revascularization.A 22-month postoperative follow-up showed healing of the periapical lesion,narrowing of the apical foramen,and positive pulp vitality test results.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"585-590"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in Adoptive Cell Therapy for Advanced Gastric Cancer.","authors":"Jia-Rang Liu, Shao-Qiu Dai, Ming-Yu Duan, Chen Huang, Zai Luo","doi":"10.3881/j.issn.1000-503X.16660","DOIUrl":"10.3881/j.issn.1000-503X.16660","url":null,"abstract":"<p><p>Although great progress has been achieved in radiotherapy,chemotherapy,and molecular targeted therapy for gastric cancer in recent years,the clinical benefits for patients with gastric cancer are very limited due to the high heterogeneity of gastric cancer.As the research on the immune microenvironment and the progression mechanism of solid cancers keeps advancing,accumulating evidence indicates that adoptive cell transfer therapy (ACT),as a novel precision therapy,holds important potential clinical applications in solid tumors such as gastric cancer.Chimeric antigen receptor T cell (CAR-T) therapy,T cell receptor-engineered T cell (TCR-T) therapy,natural killer (NK) cell therapy,etc.can inhibit the proliferation and metastasis of gastric cancer cells by conjugating specific antigen recognition components with T cells,genetically engineering T cells,and expanding and reinfusing NK cells <i>in vitro</i>.They exhibit particularly favorable therapeutic effects in patients with unresectable and metastatic gastric cancer.This article reviews the therapeutic principles,classification,main targets,and current treatment status of ACT and explores the opportunities and challenges it faces in the precision treatment of advanced gastric cancer,aiming to provide new ideas for the clinical treatment of gastric cancer.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"542-553"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147969508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Abnormal High-Density Lipoprotein in the Pathogenesis of Cardiovascular Diseases.","authors":"Ke-Han Li, Jian-Qiang Wu, Yue-Hong Zheng, Zai-Rong Wei","doi":"10.3881/j.issn.1000-503X.16681","DOIUrl":"10.3881/j.issn.1000-503X.16681","url":null,"abstract":"<p><p>High-density lipoprotein (HDL) has been regarded as a protective factor for cardiovascular health,with cholesterol transport-promoting,anti-inflammatory,and antioxidant effects,among others.However,recent studies have shown that HDL can undergo quantitative,structural,and functional abnormalities during the occurrence and progression of cardiovascular diseases.These abnormalities of HDL may promote the development of cardiovascular diseases by influencing cholesterol metabolism,inflammatory responses,oxidative stress,and endothelial function,among other pathways.This article summarizes the biological characteristics of abnormal HDL,its role in cardiovascular diseases,and potential underlying mechanisms,aiming to provide a theoretical foundation and clinical guidance for future research and to advance the exploration of new strategies for the prevention and treatment of cardiovascular diseases.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"561-567"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anesthetic Management for Epicardial Pacemaker Implantation in an Adult Patient With Uncorrected Functional Single Ventricle:Report of One Case.","authors":"Ai Hu, Xue Zhang, Le Shen","doi":"10.3881/j.issn.1000-503X.16870","DOIUrl":"10.3881/j.issn.1000-503X.16870","url":null,"abstract":"<p><p>Functional single ventricle (FSV) is a complex congenital heart defect characterized by a single functional ventricle responsible for supporting both systemic and pulmonary circulations.Patients with FSV may undergo non-cardiac surgeries at various stages of life,and their unique anatomical and physiological features present significant challenges to anesthetic management.This case report describes the perioperative anesthetic management of a patient with FSV who underwent epicardial pacemaker implantation.Particular attention is given to the preoperative evaluation and intraoperative strategies,providing clinical insights for the anesthetic care of patients with similar congenital cardiac anomalies.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"574-578"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148325321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Consistency and Application Value of Transabdominal Intestinal Ultrasound and Computed Tomography Enterography in the Diagnosis of Inflammatory Bowel Disease Complicated With Intestinal Stenosis.","authors":"Yan-Jia Gou, Kun Wang, Li-Xue Xu, Wei-Ming Kang, Dong Liu","doi":"10.3881/j.issn.1000-503X.17072","DOIUrl":"10.3881/j.issn.1000-503X.17072","url":null,"abstract":"<p><p>Objective To explore the consistency and clinical application value of transabdominal intestinal ultrasound (IUS) and computed tomography enterography (CTE) in the diagnosis of inflammatory bowel disease (IBD) complicated with intestinal stenosis. Methods A retrospective study was conducted on 115 patients diagnosed with IBD in Beijing Friendship Hospital,Capital Medical University from 2015 to 2024 and who underwent both IUS and CTE examinations during the same period.Clinical and imaging data were collected.Endoscopy was used as the gold standard to compare the detection,localization,and diagnostic efficacy of the two methods for intestinal stenosis and evaluate their consistency. Results A total of 115 patients (70 with Crohn's disease,22 with ulcerative colitis,and 23 with unclassified IBD) were included.In the diagnosis of stenosis among all the IBD patients,the sensitivity of IUS (86.2%) was higher than that of CTE (66.7%),while the specificity of CTE (57.1%) was better than that of IUS (35.7%).The two methods exhibited poor consistency in diagnosing intestinal stenosis (<i>κ</i>=0.056),while they were consistent in identifying pre-stenotic dilation (<i>κ</i>=0.614) and localizing the affected intestinal segments (<i>κ</i>=0.691).The intestinal wall thickness values measured by CTE were systematically higher than those by IUS. Conclusions IUS and CTE have complementary values in the diagnosis of IBD complicated with intestinal stenosis.IUS with higher sensitivity is suitable for screening and long-term follow-up,and CTE with better specificity is suitable for comprehensive anatomical assessment.Clinically,the appropriate choice and application should be made based on specific scenarios and IBD subtypes.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":" ","pages":"405-413"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Bibliometric Analysis of Chinese and English Articles on Freezing of Gait in Parkinson's Disease.","authors":"Jie Liu, Qiu-Qin Wang, Meng-Yuan Chen, Xin-Yue Zhang, Qing Wang, Heng Weng, Ju-Ping Chen, Gui-Hua Xu","doi":"10.3881/j.issn.1000-503X.16937","DOIUrl":"10.3881/j.issn.1000-503X.16937","url":null,"abstract":"<p><p>Objective To compare research hotspots and development trends regarding freezing of gait in Parkinson's disease between Chinese and English articles,thus providing reference for related studies in China. Methods The articles about freezing of gait in Parkinson's disease that were published from 2001 to 2025 was retrieved from the China National Knowledge Infrastructure,Wanfang Data,VIP,and Web of Science Core Collection.Visual analyses were conducted on the distribution of countries,authors,institutions,and keywords. Results A total of 177 Chinese articles and 1 095 English articles were included.The global annual number of published articles showed an overall upward trend with fluctuations.The articles in Chinese maintained steady growth while those in English slightly declined over the past three years.The United States led in the number of published articles,followed by China and Italy.The authors and institutions of Chinese articles exhibited greater independence than those of English articles.Current research hotspots on freezing of gait in Parkinson's disease focus on pathogenesis,assessment methods,and treatment strategies.Chinese articles emphasize clinical interventions,while English articles prioritize mechanism exploration and emerging physical therapies. Conclusions The research on freezing of gait in Parkinson's disease remains active,though differences exist in research focus between Chinese and English articles.Compared with Chinese articles,English articles reported early on freezing of gait in Parkinson's disease.In the future,China should deepen international exchanges and cooperation to actively draw on advanced findings and experience and work jointly to achieve breakthrough progress in both research and clinical practice,ultimately improving patients' quality of life.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 3","pages":"498-509"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}