Acta endocrinologica最新文献_第3页

Influence of Insulin on LH, Testosterone and SHBG in various PCOS Categories based on the Mode of Secretion of LH in relation to FSH Levels. 基于与FSH水平相关的LH分泌模式，胰岛素对不同PCOS类型的LH、睾酮和SHBG的影响

Acta endocrinologica Pub Date : 2021-01-01 DOI: 10.4183/aeb.2021.313

N. Malini, G. K. Roy

{"title":"Influence of Insulin on LH, Testosterone and SHBG in various PCOS Categories based on the Mode of Secretion of LH in relation to FSH Levels.","authors":"N. Malini, G. K. Roy","doi":"10.4183/aeb.2021.313","DOIUrl":"https://doi.org/10.4183/aeb.2021.313","url":null,"abstract":"Context Polycystic ovary syndrome (PCOS) or disease (PCOD) is one of the most common causes of female infertility. Objective The objective of this study was to find out the influence of insulin on LH, testosterone and SHBG in diffrent PCOS categories. Experimental design A total of 800 women who were subjected to infertility treatment at infertility clinics were selected. About 60 healthy females with regular menstrual cycles were considered as control. The data were collected from hospital records using subject's consent. Results Relationship of insulin to LH and testosterone was positive and significant (p<0.05) in the entire PCOS group and in five PCOS subcategories with increased LH rise (i.e. 1.3, 2, 3, 4 & 5 times of LH rise in relation to FSH levels in each group respectively). The correlation pattern showed an increasing trend from lower to increased rise of LH compared to FSH. The relationship between insulin and SHBG was negative and significant (p<0.05) in all PCOS subcategories, except for the group having similar LH and FSH levels and also in another group with FSH levels higher than LH levels. A strong positive correlation was established between insulin and SHBG in normal subjects. The percentage of negative correlation was strong in PCOD subcategories with elevated rises of LH. Conclusion This study established the influence of insulin on other marker hormones (LH, testosterone an SHBG) in various PCOS categories in view of their percentage of relationship.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"52 1","pages":"313-318"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78380136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Diazoxide-Induced Neutropenia and Long-Term Follow-up in a Patient with Hyperinsulinemia-Hyperammonemia due to GLUD1 Mutation. GLUD1突变引起的高胰岛素-高氨血症患者的二氮唑诱导中性粒细胞减少和长期随访。

Acta endocrinologica Pub Date : 2021-01-01 DOI: 10.4183/aeb.2021.383

D. Vurallı, S. Aytac Eyupoglu, N. Kandemir, A. Ozon, N. Gonc, A. Alikaşifoğlu

{"title":"Diazoxide-Induced Neutropenia and Long-Term Follow-up in a Patient with Hyperinsulinemia-Hyperammonemia due to GLUD1 Mutation.","authors":"D. Vurallı, S. Aytac Eyupoglu, N. Kandemir, A. Ozon, N. Gonc, A. Alikaşifoğlu","doi":"10.4183/aeb.2021.383","DOIUrl":"https://doi.org/10.4183/aeb.2021.383","url":null,"abstract":"Hyperinsulinism/hyperammonemia (HI/HA) syndrome is caused by activating mutations in GLUD1 gene, and causes fasting as well as protein sensitive symptomatic hypoglycemia, in addition to persistently elevated plasma ammonia levels. First-line treatment is diazoxide, and most patients respond well to this agent, however side effects may be observed. The most frequent side effect of diazoxide is fluid retention and hypertrichosis, while hyperuricemia and hematologic side effects are observed less often. Herein, we report a case who had a heterozygous mutation of GLUD1 gene and who developed diazoxide related neutropenia 8 years after the start of treatment. On follow-up, leucopenia and mild neutropenia persisted and the treatment was changed to somatostatin analogues. However, she developed persistent severe symptomatic hypoglycemia and required diazoxide retreatment. A lower dose of diazoxide (6 mg/kg/day) successfully controlled hypoglycemia and cell counts increased even though they were not normalized. Neutropenia in current case presented after a long period of time of diazoxide use and this period is the longest defined in the literature. Long-term endocrine and hematologic follow-up of this patient up to 18 years old will also be presented.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"13 1","pages":"383-387"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73273285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Actualities in Involvement of Estrogens in the Pathogenesis of Colorectal Cancer. 雌激素参与结直肠癌发病机制的现状。

Acta endocrinologica Pub Date : 2021-01-01 DOI: 10.4183/aeb.2021.400

R. Anghel, G. Serbanescu

引用次数: 0

Pseudo-hyperthyroidism: Biotin interference in a case with renal failure. 假性甲状腺机能亢进:生物素干扰肾衰竭1例。

Acta endocrinologica Pub Date : 2021-01-01 DOI: 10.4183/aeb.2021.319

M. Demiral, Z. K. Kıraz, I. Alatas, N. Çetin, B. Kırel

{"title":"Pseudo-hyperthyroidism: Biotin interference in a case with renal failure.","authors":"M. Demiral, Z. K. Kıraz, I. Alatas, N. Çetin, B. Kırel","doi":"10.4183/aeb.2021.319","DOIUrl":"https://doi.org/10.4183/aeb.2021.319","url":null,"abstract":"Introduction Biotin treatment causes false-low or false-high results in some immunoassays methods. This phenomenon is called as biotin interference. In the present article, a seven-month-old male, with renal failure and laboratory hyperthyroidism due to biotin interference is presented. Case report High free T4 (fT4), free T3 (fT3), anti-thyroid peroxidase antibody (anti-TPO), anti-thyroglobulin antibody (anti-TG) and low thyroid stimulating hormone (TSH) levels were detected in a seven-month-old male patient who has metabolic acidosis, renal failure, and suspected of metabolic disease. Anti-thyroid drug therapy was started. However, when he was re-evaluated due to the absence of euthyroidism with anti-thyroid therapy (methimazole 0.8 mg/kg /day), it was found that the patient had been given 20 mg/day biotin for acidosis for two months. Biotin interference was considered in hormone measurement. Thyroid function tests were found to be normal 12 days after discontinuation of biotin therapy. Conclusion Immunoassay measurements which use biotin should be done 2-7days after the last dose of biotin in patients under biotin treatment, but this time may need be much longer in renal failure patients. During this period or if the biotin therapy cannot be stopped, alternative methods should be preferred for analysis.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"13 1","pages":"319-322"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90946778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cerebrospinal Fluid Rhinorrhea Following Medical Treatment for an Invasive Macroprolactinoma. 侵袭性巨泌乳素瘤医学治疗后的脑脊液鼻漏。

Acta endocrinologica Pub Date : 2021-01-01 DOI: 10.4183/aeb.2021.412

N. Sandusadee, S. Prakkamakul, P. Boonchaya-anant, T. Snabboon

{"title":"Cerebrospinal Fluid Rhinorrhea Following Medical Treatment for an Invasive Macroprolactinoma.","authors":"N. Sandusadee, S. Prakkamakul, P. Boonchaya-anant, T. Snabboon","doi":"10.4183/aeb.2021.412","DOIUrl":"https://doi.org/10.4183/aeb.2021.412","url":null,"abstract":"*Correspondence to: Thiti Snabboon MD, Excellence Center in Diabetes, Hormone and Metabolism, BhumiSirimangalanusorn Bldg., 4C Fl., Division of Endocrinology and Metabolism, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Rama IV Road, Patumwan, Bangkok 10330, Thailand, E-mail: thiti.s@chula.ac.th A 38-year-old woman presented with a onemonth history of intermittent watery nasal discharge. Six months prior, she has been diagnosed with an invasive macroprolactinoma from her galactorrhea concurring with a prolactin (PRL) level of 2,715 ng/ mL. A magnetic resonance image (MRI) demonstrated a sellar lesion extending into the base of the skull (Fig. 1A). The tumor responded to bromocriptine 10 mg/d; her PRL level has dropped to 2.5 ng/mL and her 3-month follow-up MRI study has shown a dramatic decrease in the tumor size (Fig. 1B). Cerebrospinal fluid (CSF) rhinorrhea was diagnosed with a highresolution computerized tomography (HRCT) showing bony destruction of the floor of the sphenoid sinus (Fig. 1C). CSF rhinorrhea is an uncommon but well-recognized complication of head trauma or transsphenoidal surgery. However, CSF rhinorrhea following dopamine agonist (DA) therapy for prolactinoma is quite rare. It is presumed that the DA treatment results in tumor regression and then unplugs the eroded area at the base of the skull. The leakage is typically presented within the first month of treatment. This complication may lead to serious conditions including meningitis or brain abscess; however, the role of prophylactic antibiotics remains controversial. An investigation to differentiate CSF fluid from other types of nasal discharge is β-2 transferrin or β-trace protein test. HRCT should be performed to localize the bony defect. Contrast-enhanced imaging or radionuclide cisternography is considered in selected cases. Discontinuation of DA therapy followed by a surgical intervention to repair the skull base defect and simultaneous tumor removal are proposed as a treatment strategy. 1300","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"232 1","pages":"412"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76182091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

HORMONAL THERAPY IN WOMEN OF REPRODUCTIVE AGE WITH ENDOMETRIOSIS: AN UPDATE. 育龄妇女子宫内膜异位症的激素治疗:最新进展。

Acta endocrinologica Pub Date : 2019-04-01 DOI: 10.4183/AEB.2019.276

A. Gheorghisan-Galateanu, M. Gheorghiu

引用次数: 14

ABDOMINAL BIOELECTRIC IMPEDANCE FOR FOLLOW-UP OF DIETERS: A PROSPECTIVE STUDY. 腹部生物电阻抗用于节食者的随访:一项前瞻性研究。

Acta endocrinologica Pub Date : 2019-04-01 DOI: 10.4183/AEB.2019.145

Y. Bozkuş, U. Mousa, C. Demir, C. Anil, A. Kut, O. Iyidir, N. Kırnap, S. Fırat, A. Nar, N. B. Tütüncü

{"title":"ABDOMINAL BIOELECTRIC IMPEDANCE FOR FOLLOW-UP OF DIETERS: A PROSPECTIVE STUDY.","authors":"Y. Bozkuş, U. Mousa, C. Demir, C. Anil, A. Kut, O. Iyidir, N. Kırnap, S. Fırat, A. Nar, N. B. Tütüncü","doi":"10.4183/AEB.2019.145","DOIUrl":"https://doi.org/10.4183/AEB.2019.145","url":null,"abstract":"Context\u0000Visceral adipose tissue (VAT) is a strong predictor of carbohydrate metabolism disorders. Abdominal bioelectrical impedance analysis (A-BIA) is a simple method for the measurement of VAT and is a promising tool in screening and follow-up of abdominal obesity. However the role of A-BIA in dieting individuals has not been evaluated adequately in longitudinal follow-up studies.\u0000\u0000\u0000Objective\u0000The aim of this study is to determine the role of A-BIA in identifying the changes in metabolic predictors after diet and/or exercise therapy.\u0000\u0000\u0000Design\u0000All patients who sought weight loss treatment underwent baseline assessment and were prescribed a program of diet. After a mean follow-up of 3.2 months, data were analyzed.\u0000\u0000\u0000Subjects and Methods\u0000Ultimately, 103 participants who reported adhering to the diet, enrolled to the study. We tested associations between changes in body composition measures and changes in laboratory measures using correlations and multivariate linear regression analysis.\u0000\u0000\u0000Results\u0000Mean loss of body weight was 3.4±2.8 kg. All but waist-to-hip ratio, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels changed significantly (p<0.001). Decreases in body weight, body mass index (BMI), and VAT level significantly correlated with decreases in fasting blood glucose, fasting insulin level, and HOMA-IR score (r=0.230-0.371). In multiple linear regression analysis changes in BMI and VAT significantly correlated with change in HOMA-IR score (F(7.93)=2.283, p=0.034, R2=0.147).\u0000\u0000\u0000Conclusion\u0000Decreases in BMI and VAT, as determined by A-BIA, were predictors of changes in metabolic laboratory measures. A-BIA is useful for follow-up of patients receiving diet therapy for weight loss.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"4 1","pages":"145-152"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73598542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

EFFECTS OF EXENDIN-4 ON ENDOPLASMIC RETICULUM STRESS-MEDIATED INSULIN RESISTANCE IN 3T3-L1 ADIPOCYTES. exendin-4在内质网应激介导的3t3-l1脂肪细胞胰岛素抵抗中的作用。

Acta endocrinologica Pub Date : 2019-04-01 DOI: 10.4183/AEB.2019.158

Binbin Guan, Lin-xi Wang, L. Ma, Xiao-Hong Liu, Liang Liu

{"title":"EFFECTS OF EXENDIN-4 ON ENDOPLASMIC RETICULUM STRESS-MEDIATED INSULIN RESISTANCE IN 3T3-L1 ADIPOCYTES.","authors":"Binbin Guan, Lin-xi Wang, L. Ma, Xiao-Hong Liu, Liang Liu","doi":"10.4183/AEB.2019.158","DOIUrl":"https://doi.org/10.4183/AEB.2019.158","url":null,"abstract":"Objective\u0000Endoplasmic reticulum stress (ERS) is suspected as an important factor in the initiation of insulin resistance.\u0000\u0000\u0000Aim\u0000To explore the effects of exendin-4 (Ex-4) on the endoplasmic reticulum stress (ERS)-mediated insulin resistance in 3T3-L1 adipocytes. In our study, 3T3-L1 adipocytes were pre-treated with ERS inhibitors tauroursodeoxycholic acid (TUDCA), Ex-4 and an ERS inducer tunicamycin (TM) then induced insulin resistance. Glucose consumption of the adipocytes was measured. Western blots determined the protein levels of ERS markers and insulin signaling pathway.\u0000\u0000\u0000Results\u0000TM treatment reduced insulin-stimulated glucose consumption by 19.7% in 3T3-L1 adipocytes. This repression was blunted by 24h pre-treatment with TUDCA or Ex-4. Ex-4 augmented insulin-stimulated glucose consumption in adipocytes by 14.9%. Western blotting showed that TM treatment significantly increased the ER stress markers including p-IRE, p-JNK, p-PERK, p-eIF2a and ATF6 expression, whereas 24h pre-treatment of adipocytes with TUDCA or Ex-4 alleviated the ER stress. Ex-4 alleviates ERS-induced insulin resistance by upregulating the expression of phosphorylated Akt.\u0000\u0000\u0000Conclusion\u0000ERs mediates insulin resistance in 3T3-L1 adipocytes, and exendin-4 significantly improves this insulin resistance.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"12 1","pages":"158-164"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87712837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

THE EFFECT OF ANTITHYROID DRUGS ON OSTEOPONTIN AND OXIDATIVE STRESS IN GRAVES' DISEASE. 抗甲状腺药物对graves病骨桥蛋白及氧化应激的影响。

Acta endocrinologica Pub Date : 2019-04-01 DOI: 10.4183/AEB.2019.221

M. Koçak, E. Akarsu, H. Korkmaz, S. Taysı

{"title":"THE EFFECT OF ANTITHYROID DRUGS ON OSTEOPONTIN AND OXIDATIVE STRESS IN GRAVES' DISEASE.","authors":"M. Koçak, E. Akarsu, H. Korkmaz, S. Taysı","doi":"10.4183/AEB.2019.221","DOIUrl":"https://doi.org/10.4183/AEB.2019.221","url":null,"abstract":"Objective\u0000The aim of the present study is to evaluate the effects of methimazole (MTZ) and propylthiouracil (PTU) treatments on osteopontin (OPN) and oxidative stress in Graves' disease (GD).\u0000\u0000\u0000Material and Methods\u0000The study included 60 cases with GD in hyperthyroid state and taking no antithyroid treatment, and 30 healthy volunteers. GD patients were randomly separated into two groups; 30 of them took PTU, and the other 30 took MTZ treatments. Blood samples were taken from the patients with GD before the treatment, and three months after the treatment was begun, when they were in the euthyroid state; blood samples of the healthy control subjects were also taken at these times.\u0000\u0000\u0000Results\u0000TAS and OSI levels before treatment were significantly higher in the GD group, when compared to the control group (p<0.001, for each). GD subjects taking PTU treatment had significantly higher TAS levels (p=0.001), and significantly lower TOS and OSI levels (p=0.008 and p=0.001, respectively). TAS levels significantly decreased in the patients taking MTZ treatment (p=0.029), but TOS and OSI levels did not change significantly (p>0.05). Pretreatment OPN levels were significantly higher in GD patients, when compared to the control group (p=0.014). OPN level significantly decreased in the GD group taking PTU treatment; however OPN levels in the group taking MTZ treatment did not change significantly when compared to the pretreatment value.\u0000\u0000\u0000Conclusion\u0000PTU treatment is more effective in decreasing OPN and oxidative stress in GD patients, when compared to the MTZ treatment.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"22 1","pages":"221-224"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82628647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

NEONATAL SCREENING FOR CONGENITAL HYPOTHYROIDISM IN ROMANIA: DATA FROM MEDILOG MEDICAL INFORMATION REGISTRY. 罗马尼亚先天性甲状腺功能减退的新生儿筛查:来自medilog医学信息登记处的数据。

Acta endocrinologica Pub Date : 2019-04-01 DOI: 10.4183/AEB.2019.209

M. Nanu, I. Ardeleanu, F. Brezan, I. Nanu, A. Apostol, F. Moldovanu, H. Lăzărescu, M. Gheorghiu, A. Kozma

{"title":"NEONATAL SCREENING FOR CONGENITAL HYPOTHYROIDISM IN ROMANIA: DATA FROM MEDILOG MEDICAL INFORMATION REGISTRY.","authors":"M. Nanu, I. Ardeleanu, F. Brezan, I. Nanu, A. Apostol, F. Moldovanu, H. Lăzărescu, M. Gheorghiu, A. Kozma","doi":"10.4183/AEB.2019.209","DOIUrl":"https://doi.org/10.4183/AEB.2019.209","url":null,"abstract":"Objective\u0000Congenital hypothyroidism (CH) is one of the common preventable causes of intellectual disability in neonates, by early detection through neonatal screening. We present the 8-year experience of the National Institute for Mother and Child Health (INSMC) in using MEDILOG national registry for the neonatal screening of CH.\u0000\u0000\u0000Methods\u0000Neonatal screening for CH, done by TSH measurement in dried blood spot, is organized in 5 regional centers, each with a reference laboratory.\u0000\u0000\u0000Results\u0000In 2018 80% of all the newborns, from 80% of the maternity hospitals, were registered in MEDILOG. After re-testing of TSH and T4/FT4 from venous blood in positive cases, the incidence of confirmed CH in 2018 was 1/3576 - 1/ 4746. In INSMC center (which includes 26 counties and Bucharest, out of 41 counties), in 2018 the incidence of positive CH cases at screening was 1/2094 (TSH cut-off ≥17 mIU/L) and of confirmed CH cases 1/3576 newborns. For positive screening cases, the median duration from birth to the INSMC laboratory result was 19 days: median of 9 days between screening and laboratory registration and 6 days between registration and test result.\u0000\u0000\u0000Conclusion\u0000MEDILOG registry is a practical instrument for monitoring the steps of neonatal CH screening, the incidence of CH, the evolution of the diagnosed cases, for evaluation of iodine deficiency (by neonatal TSH), and also for research, with the aim of improving early disease detection and treatment.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"43 1","pages":"209-214"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75364980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8