Acta endocrinologica最新文献_第10页

Concentrations, metabolic clearance rates, production rates and plasma binding of cortisol in Antarctic phocid seals. 南极海豹中皮质醇的浓度、代谢清除率、生成率和血浆结合。

Acta endocrinologica Pub Date : 1993-10-01 DOI: 10.1530/acta.0.1290356

G C Liggins, J T France, R C Schneider, B S Knox, W M Zapol

{"title":"Concentrations, metabolic clearance rates, production rates and plasma binding of cortisol in Antarctic phocid seals.","authors":"G C Liggins, J T France, R C Schneider, B S Knox, W M Zapol","doi":"10.1530/acta.0.1290356","DOIUrl":"https://doi.org/10.1530/acta.0.1290356","url":null,"abstract":"We have reported previously that plasma of the Weddell seal, a member of the phocid family, contains a very high concentration of cortisol. The present study was undertaken to determine whether high cortisol levels were common to seals in the Antarctic environment, or to other phocidae, and to determine the mechanism of the hypercortisolaemia. High levels of cortisol (0.82-2.38 mumol/l) were found in 4 phocidae (Weddell, crabeater, leopard and Southern elephant seals), whereas levels in a member of the otariid family (Antarctic fur seal) were similar to human values. Metabolic clearance rates (MCR) and production rates (PR) of cortisol were determined in the field in Weddell (N = 1), crabeater (N = 3) and leopard (N = 3) seals following bolus injections of [3H] cortisol. The MCR and PR did not differ between the three phocids, but whereas the MCR of 410-590 1/day was twice that of human values, the PR of 460-1180 mumol.m-2 x d-1 was up to 40-fold greater. The binding capacity of corticosteroid-binding globulin (CBG) was equal to or greater than the plasma concentrations of cortisol, resulting in relatively low concentrations of free cortisol. We conclude that hypercortisolaemia is maintained in phocid seals mainly by a high production rate--the highest (corrected for surface area) reported in any species. The relatively low cortisol levels in otariid seals studied in the same environment suggest that the high PR in phocidae is unrelated to the harsh climatic conditions, but may be part of their adaptation for diving to extreme depths.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"129 4","pages":"356-9"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.1290356","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19226421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Insulin resistance caused by amylin in conscious rats is independent of induced hypocalcemia and fades during long-term exposure. 在清醒的大鼠中，胰淀素引起的胰岛素抵抗与诱导的低钙血症无关，并在长期暴露中消退。

Acta endocrinologica Pub Date : 1993-10-01 DOI: 10.1530/acta.0.1290360

C Fürnsinn, P Nowotny, M Roden, M Rohac, T Pieber, S Parzer, W Waldhäusl

{"title":"Insulin resistance caused by amylin in conscious rats is independent of induced hypocalcemia and fades during long-term exposure.","authors":"C Fürnsinn, P Nowotny, M Roden, M Rohac, T Pieber, S Parzer, W Waldhäusl","doi":"10.1530/acta.0.1290360","DOIUrl":"https://doi.org/10.1530/acta.0.1290360","url":null,"abstract":"To compare the effect of short- vs long-term amylin infusion on insulin sensitivity, glucose tolerance and serum calcemia, euglycemic-hyperinsulinemic clamp (26 pmol.kg-1 x min-1) and glucose tolerance tests (2.4 mmol/kg over 30 min) were performed in lean Zucker rats. Three infusion protocols were employed: control group: 24 h of i.v. saline; short-term amylin exposure: 22 h of i.v. saline followed by 2 h of i.v. amylin (20 micrograms/h); long-term amylin exposure: 24 h of iv amylin (20 micrograms/h). Insulin resistance was induced by short-term amylin infusion during euglycemic clamping, as shown by a 41% decrease in space-corrected glucose infusion rates (mumol.kg-1 x min-1; control group, 106.0 +/- 15.0; short-term i.v. amylin, 62.7 +/- 15.0; p < 0.005). After long-term amylin exposure, insulin sensitivity was identical to control values (109.9 +/- 6.7). This fading action of amylin was confirmed by data from the glucose tolerance test, demonstrating glucose intolerance after short- but not after long-term amylin exposure. Serum calcium concentration decreased during short-term (2 h) amylin infusion (from 2.52 +/- 0.15 to 2.09 +/- 0.12 mmol/l; p < 0.01) and hypocalcemia of a similar extent also was present after 22 h and 24 h of amylin exposure (2.10 +/- 0.09 and 2.04 +/- 0.14 mmol/l, respectively). The data demonstrate that short-term amylin infusion induces insulin resistance and glucose intolerance, both of which vanish during long-term (> 22 h) amylin exposure, being apparently independent of induced hypocalcemia.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"129 4","pages":"360-5"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.1290360","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19226422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Large somatostatin-insensitive thyrotrophin-secreting pituitary tumour responsive to D-thyroxine and dopamine agonists. 对d -甲状腺素和多巴胺激动剂有反应的大的生长抑素不敏感的分泌甲状腺激素的垂体瘤。

Acta endocrinologica Pub Date : 1993-10-01 DOI: 10.1530/acta.0.1290291

F A Karlsson, P Burman, O Kämpe, J E Westlin, L Wide

引用次数: 8

Adrenal imaging in Cushing's syndrome: morphology or function? 库欣综合征的肾上腺影像学:形态学还是功能?

Acta endocrinologica Pub Date : 1993-10-01 DOI: 10.1530/acta.0.1290281

X Bertagna

引用次数: 0

Hyperfunctioning unilateral adrenal macronodule in three patients with Cushing's disease: hormonal and imaging characterization. 库欣病3例单侧肾上腺大结节功能亢进:激素和影像学特征。

Acta endocrinologica Pub Date : 1993-10-01 DOI: 10.1530/acta.0.1290284

R Abs, F Nobels, J Verhelst, P Chanson, C Mahler, B Corthouts, P Blockx, A Beckers

{"title":"Hyperfunctioning unilateral adrenal macronodule in three patients with Cushing's disease: hormonal and imaging characterization.","authors":"R Abs, F Nobels, J Verhelst, P Chanson, C Mahler, B Corthouts, P Blockx, A Beckers","doi":"10.1530/acta.0.1290284","DOIUrl":"https://doi.org/10.1530/acta.0.1290284","url":null,"abstract":"We aimed to investigate the dynamics of adrenocorticotropin (ACTH) and cortisol secretion in pituitary-dependent Cushing's syndrome with bilateral macronodular adrenal hyperplasia presenting as a single adrenal macronodule, and to determine the imaging characteristics of this syndrome. Three female patients were studied. Plasma ACTH and serum cortisol secretion were studied by determining their rhythmicity and pulsatility and their responses to the administration of ovine corticotropin-releasing factor, thyrotropin-releasing hormone, metyrapone, tetracosactrin, insulin and dexamethasone. Techniques used to localize the anatomical lesion were bilateral simultaneous inferior petrosal sinus sampling, magnetic resonance examination of the pituitary, computed tomography (CT) scanning and [75Se]cholesterol scintigraphy of the adrenal glands. Plasma ACTH and serum cortisol levels were measured using a commercial radioimmunoassay and an immunoradiometric assay. The ACTH and cortisol pulse number and amplitude were calculated using established computer software. In all three patients ACTH and cortisol secretory dynamics fulfilled the requirements for diagnosis of pituitary-dependent Cushing's syndrome. A close relationship between ACTH and cortisol pulses also favored a pituitary dependency. Study of the amplitude of cortisol pulses classified two patients in the group of hypopulsatile Cushing's disease. Adrenal CT scanning demonstrated the presence of a large single nodule. [75Se]Cholesterol scintigraphy showed bilateral radionuclide uptake, although mostly localized over the adrenal nodule. All patients underwent successful trans-sphenoidal hypophysectomy. Over a period of 1 year, a slow shrinkage of the adrenal nodule was observed in two patients, while no change in volume was observed in one patient.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"129 4","pages":"284-90"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.1290284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19225828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Pentoxifylline inhibits the proliferation and glycosaminoglycan synthesis of cultured fibroblasts derived from patients with Graves' ophthalmopathy and pretibial myxoedema. 己酮茶碱抑制格雷夫斯眼病和胫前黏液水肿患者培养成纤维细胞的增殖和糖胺聚糖合成。

Acta endocrinologica Pub Date : 1993-10-01 DOI: 10.1530/acta.0.1290322

C C Chang, T C Chang, S C Kao, Y F Kuo, L F Chien

{"title":"Pentoxifylline inhibits the proliferation and glycosaminoglycan synthesis of cultured fibroblasts derived from patients with Graves' ophthalmopathy and pretibial myxoedema.","authors":"C C Chang, T C Chang, S C Kao, Y F Kuo, L F Chien","doi":"10.1530/acta.0.1290322","DOIUrl":"https://doi.org/10.1530/acta.0.1290322","url":null,"abstract":"Excessive amounts of glycosaminoglycans accumulate in the extraocular muscles of patients with Graves' ophthalmopathy and in the affected skin of patients with pretibial myxoedema. It is widely accepted that fibroblasts are the sources of glycosaminoglycan synthesis. Pentoxifylline, an analogue of the methylxanthine theobromine, inhibits the proliferation and certain biosynthetic activities of fibroblasts derived from normal human skin and from skin of patients with some fibrotic disorders. Our objective was to determine whether pentoxifylline has similar effects on fibroblasts derived from patients with Graves' ophthalmopathy and pretibial myxoedema and could serve as a candidate for the treatment of these manifestations. Fibroblasts from the extraocular muscles of two patients with Graves' ophthalmopathy and normal extraocular muscles of two subjects with strabismus, as well as the affected skin of two patients with pretibial myxoedema were cultured in vitro in the presence and absence of pentoxifylline to assay its effect on the proliferation of fibroblasts and their production of glycosaminoglycans. In subconfluent fibroblast cultures, pentoxifylline treatment caused a dose-dependent inhibition of serum-driven fibroblast proliferation. In confluent fibroblast cultures both in the presence and absence of serum, exposure to pentoxifylline similarly resulted in a dose-dependent inhibition of glycosaminoglycan synthesis for all these different kinds of fibroblasts. These findings may form the rationale for a clinical trial using pentoxifylline for the treatment of Graves' ophthalmopathy and pretibial myxoedema.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"129 4","pages":"322-7"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.1290322","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19226416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

Thyroid peroxidase: kinetics, pH optima and substrate dependency. 甲状腺过氧化物酶:动力学、最佳pH值和底物依赖性。

Acta endocrinologica Pub Date : 1993-10-01 DOI: 10.1530/acta.0.1290328

P R Kootstra, R Wever, J J de Vijlder

引用次数: 8

Amount of G-protein alpha-subunit in rat white adipocytes: lack of difference between subcutaneous and visceral fat. 大鼠白色脂肪细胞中g蛋白α亚基含量:皮下脂肪与内脏脂肪无差异。

Acta endocrinologica Pub Date : 1993-10-01 DOI: 10.1530/acta.0.1290366

G De Pergola, X Xu, P S Eriksson, B Carlsson, L X Fu, S Yang, S Edén, R Giorgino, P Björntorp

{"title":"Amount of G-protein alpha-subunit in rat white adipocytes: lack of difference between subcutaneous and visceral fat.","authors":"G De Pergola, X Xu, P S Eriksson, B Carlsson, L X Fu, S Yang, S Edén, R Giorgino, P Björntorp","doi":"10.1530/acta.0.1290366","DOIUrl":"https://doi.org/10.1530/acta.0.1290366","url":null,"abstract":"It has been the purpose of this study to examine possible differences in the amount of stimulatory (Gs) and inhibitory (Gi) G-protein alpha-subunits (measured with a quantitative enzyme-linked immunosorbent assay in fat cell membrane preparation) between subcutaneous and intra-abdominal regions in rats. The lipolytic response to isoproterenol and the number of beta-adrenergic binding sites were also examined. These parameters were all evaluated simultaneously in subcutaneous (inguinal), epididymal and perirenal fat samples collected from six male Sprague-Dawley rats. The membrane contents of the Gs and Gi alpha-subunits were similar in the three depots. Moreover, no difference was found among the different regions with regard to isoproterenol-stimulated glycerol release and beta-adrenoceptor number, expressed per cell number. In conclusion, the present study shows for the first time in rats that the abundance of inhibitory and stimulatory G-protein alpha-subunits is similar in subcutaneous and in visceral adipocytes. Moreover, the number of beta-adrenoceptors and the lipolytic response to isoproterenol do not show significant variations with the anatomical site. As the present results are apparently in contrast with those obtained previously in human adipocytes, there is a possibility that the different results observed in rat and in human fat cells could be explained by species differences.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"129 4","pages":"366-70"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1530/acta.0.1290366","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19227648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Hormonal status and clinical relevance of hirsutism in elderly women. 老年妇女多毛症的激素状况及其临床意义。

Acta endocrinologica Pub Date : 1993-10-01 DOI: 10.1097/00006254-199405000-00025

T. Pepersack, C. Rossi, F. Dupuis, A. Lefevre, M. Vanhaeverbeek, W. Dekoninck

{"title":"Hormonal status and clinical relevance of hirsutism in elderly women.","authors":"T. Pepersack, C. Rossi, F. Dupuis, A. Lefevre, M. Vanhaeverbeek, W. Dekoninck","doi":"10.1097/00006254-199405000-00025","DOIUrl":"https://doi.org/10.1097/00006254-199405000-00025","url":null,"abstract":"Hirsutism is a common condition of elderly women, but its aethiopathogeny and its clinical implications remain unclear. We therefore studied circulating androgen concentrations in elderly women. In addition, this study aims to define a possible relationship between hirsutism and anthropometric determinations, bone mass and serum lipids. Androgen levels were determined at basal state, after adrenocorticotrophin (ACTH) stimulation and after dexamethasone administration in 10 hirsute elderly women and compared to 10 age-matched non-hirsute women. Anthropometric determinations included measurements of skinfold thickness and body mass index. Spinal bone mass density was assessed using dual photon absorptiometry. Hirsute women presented significantly higher levels of testosterone than controls (1.49 +/- 0.38 vs 0.59 +/- 0.05 nmol/l, mean +/- SEM; p < 0.05) and dihydrotestosterone (0.54 +/- 0.07 vs 0.32 +/- 0.03; p < 0.02). 17-hydroxyprogesterone levels after ACTH stimulation tended to be higher in hirsute women than in controls. No differences were observed between the two groups in serum oestrogen concentrations, plasma lipid pattern or bone mineral density. Hirsute women had a lower body mass index and lower calculated percentage body fat than the control group. We conclude that: (i) hirsutism of elderly women is associated with increased androgen levels, probably from adrenal origin; (ii) in some cases, enhanced response in 17-hydroxyprogesterone after ACTH stimulation suggests a partial adrenal 21-hydroxylase deficiency; (iii) hirsute women present anthropometric characteristics compatible with the known anabolic effect of androgens on fat-free mass.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"75 1","pages":"307-10"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88004078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Unusual presentation of a TSH-secreting pituitary adenoma. 不寻常的tsh分泌垂体腺瘤。

Acta endocrinologica Pub Date : 1993-10-01 DOI: 10.1530/acta.0.1290283

P Beck-Peccoz

引用次数: 1