Acta endocrinologica最新文献

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GRANULYSIN PEPTIDE AND GENE POLYMORPHISM IN THE PATHOGENESIS OF HASHIMOTO THYROIDITIS. 桥本甲状腺炎发病机制中的颗粒蛋白肽和基因多态性。
Acta endocrinologica Pub Date : 2022-01-01 DOI: 10.4183/aeb.2022/288
G. C. Genc, S. Çelik, D. Arpaci, T. Aktaş, M. Can, T. Bayraktaroğlu, A. Dursun
{"title":"GRANULYSIN PEPTIDE AND GENE POLYMORPHISM IN THE PATHOGENESIS OF HASHIMOTO THYROIDITIS.","authors":"G. C. Genc, S. Çelik, D. Arpaci, T. Aktaş, M. Can, T. Bayraktaroğlu, A. Dursun","doi":"10.4183/aeb.2022/288","DOIUrl":"https://doi.org/10.4183/aeb.2022/288","url":null,"abstract":"Background Hashimoto thyroiditis (HT) is an autoimmune disease and the most common cause of hypothyroidism. The widespread lymphocyte infiltration in the thyroid gland and intolerance of the body against its thyroid antigens leads to the destruction of thyroid cells and impaired thyroid function. Granulysin (GNLY) is a cytolytic antimicrobial peptide that has been associated with a wide range of diseases such as various infections, cancer, transplantation, and skin problems. However, there are a few studies investigating the relationship between HT and granulysin. Aim Our study aims to investigate whether granulysin levels and GNLY gene polymorphism contribute to the damaged immune response leading to HT. Material and Methods 100 unrelated patients diagnosed with HT and 140 healthy individuals were included in our study. Frequencies of GNLY rs10180391 and rs7908 gene polymorphisms were determined using PCR- RFLP method and serum granulysin levels were determined using ELISA. Results There is no statistical significance between patient and control groups in terms of genotype and allele frequencies of GNLY gene polymorphisms and serum levels of granulysin. Conclusion In conclusion, granulysin and GNLY gene polymorphisms do not appear to relate to HT disease.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"76 1","pages":"288-293"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73957033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coronavirus as a Trigger Of Graves' Disease. 冠状病毒引发格雷夫斯病
Acta endocrinologica Pub Date : 2021-01-01 DOI: 10.4183/aeb.2021.413
A. Urbanovych, F. Laniush, M. Borovets, K. Kozlovska
{"title":"Coronavirus as a Trigger Of Graves' Disease.","authors":"A. Urbanovych, F. Laniush, M. Borovets, K. Kozlovska","doi":"10.4183/aeb.2021.413","DOIUrl":"https://doi.org/10.4183/aeb.2021.413","url":null,"abstract":"Context SARS-CoV-2 infection was declared a pandemic in 2020 and affected millions of people worldwide. Angiotensin-converting enzyme-2 receptors, through which coronavirus enters the cells of different organs, have been detected in the thyroid gland. The most common cause of thyrotoxicosis is Graves' disease in which thyroid-receptors antibodies (TRAb) stimulate the TSH receptor, increasing thyroid hormone production and release. Case presentation A 22-year-old woman had symptoms of palpitation, tremor, muscle weakness, anxiety and sleep disturbance. 3 weeks before the onset of these symptoms, the patient suffered from COVID-19, which lasted 14 days and was characterized by a course of moderate severity with fever up to 38°C, general weakness without shortness of breath. The patient had no pre-existing thyroid problems. Her TSH was <0.01 mU/L, FT4, FT3 and TRAb were increased. Antithyroid drugs, glucocorticosteroids and β-blockers were prescribed. During 3 months of treatment doses of methimazole, methylprednisolone and bisoprolol were gradually reduced due to the improvement of the patient's condition and thyroid tests normalization. Conclusions COVID-19 infection can cause Graves' disease and thyrotoxicosis. The onset of this disease after SARS-CoV-2 does not depend on the presence of pre-existing thyroid pathology and requires the appointment of glucocortisteroids.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"5 1","pages":"413-415"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87404879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Actualities in neonatal endocrine and metabolic screening. 新生儿内分泌和代谢筛查的现状。
Acta endocrinologica Pub Date : 2021-01-01 DOI: 10.4183/aeb.2021.394
V. Dima
{"title":"Actualities in neonatal endocrine and metabolic screening.","authors":"V. Dima","doi":"10.4183/aeb.2021.394","DOIUrl":"https://doi.org/10.4183/aeb.2021.394","url":null,"abstract":"Neonatal metabolic screening has proven to be an important tool for the early detection of innate metabolic errors. Despite the fact that simple and effective methods of testing for metabolic diseases have been identified since the middle of the twentieth century, no consensus has been reached so far on the content of neonatal metabolic screening panels. There are large differences between countries in the number of metabolic diseases identified through national metabolic screening programs, ranging from zero to several tens, the most common testing being for phenylketonuria and congenital hypothyroidism (including in Romania). Given the fact that rare but treatable diseases have been identified in recent decades, reducing the financial burden on the health system, it would be useful to include them in the national neonatal metabolic screening program.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"21 1","pages":"416-421"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73528699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Novel Variant in Triple A Syndrome. aaa综合征的一种新变异。
Acta endocrinologica Pub Date : 2021-01-01 DOI: 10.4183/aeb.2021.384
E. Demet Akbaş, Ö. Özalp Yüreğir, Ö. Anlaş, Z. Özçelik, O. Zerrin Tolunay
{"title":"A Novel Variant in Triple A Syndrome.","authors":"E. Demet Akbaş, Ö. Özalp Yüreğir, Ö. Anlaş, Z. Özçelik, O. Zerrin Tolunay","doi":"10.4183/aeb.2021.384","DOIUrl":"https://doi.org/10.4183/aeb.2021.384","url":null,"abstract":"Triple A syndrome is an autosomal recessive inherited multisystem disorder that was first described in 1978. Triple A syndrome has a high genotypic and phenotypic heterogeneity and has been linked with mutations in the AAAS gene, which has been identified on chromosome 12q13. A 14 years old male patient applied to outpatient clinic complaining of weakness and darkening of skin color since 4 months. On physical examination hyperpigmentation was observed on both the skin and mucosa. The morning cortisol level was 1.8 μg/dL and ACTH was >1250 ng/L. Schirmer test showed absence of tears. In the patient's esophagoscopy, mucosal paleness and stenosis of the cardia were observed. Molecular genetic analysis of AAAS gene confirmed the diagnosis of triple A syndrome caused by homozygous mutation: c.1368_1372delGCTCA (p.Gln456HisfsTer38). This variant is considered to be a possible pathogenic because it causes a frame shift that changes the protein structure. As a result of the genetic analysis of the patient's parents, the AAAS gene was detected as heterozygous in both parents for the c.1368_1372delGCTCA mutation. To the best of our knowledge, this is the first report of homozygous mutation: c.1368_1372delGCTCA (p.Gln456HisfsTer38).","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"12 1","pages":"399-401"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90102178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteomics of Tear in Inactive Thyroid-Associated Ophthalmopathy. 非活动性甲状腺相关性眼病中泪液的蛋白质组学研究。
Acta endocrinologica Pub Date : 2021-01-01 DOI: 10.4183/aeb.2021.291
L. Jiang, R. Wei, J. Diao, H. Ding, W. Wang, R. Ao
{"title":"Proteomics of Tear in Inactive Thyroid-Associated Ophthalmopathy.","authors":"L. Jiang, R. Wei, J. Diao, H. Ding, W. Wang, R. Ao","doi":"10.4183/aeb.2021.291","DOIUrl":"https://doi.org/10.4183/aeb.2021.291","url":null,"abstract":"Background Thyroid-associated ophthalmopathy (TAO), one of the most common orbital diseases in adults, seriously reduces patients' quality of life. Although human tear proteomics identified many abnormal expressed proteins and proposed several pathogeneses of TAO, most of these studies focused on the active stage or mixed types in TAO. In this study we identified significantly changed proteins and preliminary revealed the potential signalling pathways and mechanisms of TAO with the late, inactive stage. Patients and Methods Tears from TAO patients (n=6) with a CAS score < 3 and 6 control healthy subject were collected. The pooled tears were further fractionated using high pH reversed-phase chromatography, then submitted to LC-MS/MS and subsequent bioinformatic analysis. Results Proteomic profiling identified 107 significantly changed proteins between the inactive stage of TAO patients and healthy cases. Among these proteins, 62 were upregulated, and 45 were downregulated in TAO cases compared to healthy individuals. Enrichment analysis revealed that the immune system, cell cycle, metabolism (carbohydrate metabolism and metabolism of cofactors and vitamins), protein synthesis and degradation might play a vital role in the progress of inactive TAO. The present investigation represents the first proteomic tear study of TAO patients in the inactive stage. Conclusion The results shed light on the differences between inactive TAO patients and healthy cases, thus enabling us to understand better the molecular mechanisms and potential targets for the treatment of inactive TAO.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"10 1","pages":"291-303"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87493695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Gender Dsyphoria and Psychiatric Disorders in Children and Adolescents with Congenital Adrenal Hyperplasia. 先天性肾上腺增生儿童和青少年的性别失调和精神障碍。
Acta endocrinologica Pub Date : 2021-01-01 DOI: 10.4183/aeb.2021.365
H. Doktur, C. Tanıdır, H. Güneş, T. Aytemiz, G. Durcan, H. Önal, E. Kutlu
{"title":"Gender Dsyphoria and Psychiatric Disorders in Children and Adolescents with Congenital Adrenal Hyperplasia.","authors":"H. Doktur, C. Tanıdır, H. Güneş, T. Aytemiz, G. Durcan, H. Önal, E. Kutlu","doi":"10.4183/aeb.2021.365","DOIUrl":"https://doi.org/10.4183/aeb.2021.365","url":null,"abstract":"Context Gender identity, psychosexual function, psychiatric adjustment and quality of life have been investigated in congenital adrenal hyperplasia(CAH) patients. Objective We aimed to investigate gender identity problems and the psychiatric disorders and associated factors in children and adolescents with CAH patients. Subjects and methods Forty-five children and adolescents with CAH were included in the study. Psychiatric comorbidity was assessed using the Schedule for Affective Disorders and Schizophrenia for School Age Children - Present and Lifetime Version. Gender identity problems were investigated using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria. Results The mean age of the sample was 11.02 years (SD: 3.25, range: 6-18). 51.1% of the patients had at least one lifetime comorbid psychiatric disorder. The most common diagnoses were anxiety disorders, attention deficit hyperactivity disorder(ADHD), tic disorders and enuresis nocturna. Tic disorders and ADHD were higher in males but they were not statistically significant. Two female patients were diagnosed with gender dysphoria and 18.5% of females showed variably masculinized behaviors. The girls with gender identity problems expressed lower satisfaction with their sex than other girls and boys. Conclusions Children and adolescents with CAH had many psychiatric disorders, especially neurodevelopmental disorders. ADHD and tic disorders should be kept in mind during assessment especially in male patients. Gender dysphoria and masculine behaviors seem to be common in female patients with CAH so they should be carefully investigated.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"130 1","pages":"365-371"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89005755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effects of Testosterone Therapy Combined with Swimming Exercise on Adipose Tissue and Biochemical Parameters in Male Obese Wistar Rats. 睾酮治疗联合游泳运动对雄性肥胖Wistar大鼠脂肪组织及生化指标的影响。
Acta endocrinologica Pub Date : 2021-01-01 DOI: 10.4183/aeb.2021.304
D. G. de Lima, C. F. da Silva, A. G. Freitas, O. L. P. da Silva, F. M. A. de Souza, M. J. S. Bortolini, N. Penha-Silva, F. G. A. Santos, Y. K. de Carvalho, V. E. Valenti, R. P. M. Silva
{"title":"The Effects of Testosterone Therapy Combined with Swimming Exercise on Adipose Tissue and Biochemical Parameters in Male Obese Wistar Rats.","authors":"D. G. de Lima, C. F. da Silva, A. G. Freitas, O. L. P. da Silva, F. M. A. de Souza, M. J. S. Bortolini, N. Penha-Silva, F. G. A. Santos, Y. K. de Carvalho, V. E. Valenti, R. P. M. Silva","doi":"10.4183/aeb.2021.304","DOIUrl":"https://doi.org/10.4183/aeb.2021.304","url":null,"abstract":"Context Exercise and anabolic steroids are anticipated to promote fat mass reduction and so to decrease the number of comorbidities related to excessive weight. Objective The aim of this study was to verify the influence of aerobic exercise and the use of steroids on the accumulation of adipose tissue and on the biochemical limitations of Wistar rats nourished by a hypercaloric diet. Methods Forty, young male Wistar rats were split into four groups: obese control (n=10), obese under treatment (n=10), obese under aerobic exercise (n=10) and obese under aerobic exercise and treatment (n=10). All animals were fed with a hypercaloric diet and animals under treatment received intramuscular testosterone. Body (weight and visceral fat) and blood (lipidogram, glucose, and liver enzymes) parameters were assessed. Results The group treated with aerobic exercise and testosterone revealed a reduction in body weight and visceral, perirenal, retroperitoneal and epididymal fats, accompanied by the blood levels of glucose, lactate, LDL-cholesterol, HDL-cholesterol, and lactate dehydrogenase; following high-intensity physical activity. Conclusion The results support the theory that the combination of steroids and physical activity reduces the side-effects of androgenic-anabolic hormones and conveys benefits to some constraints.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"97 1","pages":"304-312"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85744105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Personalized nuclear imaging protocol in cases with nodular goiter and parathyroid adenoma. 结节性甲状腺肿和甲状旁腺瘤的个体化核成像方案。
Acta endocrinologica Pub Date : 2021-01-01 DOI: 10.4183/aeb.2021.393
W. Jalloul, R. Tibu, T. Ionescu, C. Stolniceanu, I. Grierosu, A. Ţarcă, L. Ionescu, M. C. Ungureanu, D. Ciobanu, V. Ghizdovat, C. Ștefănescu
{"title":"Personalized nuclear imaging protocol in cases with nodular goiter and parathyroid adenoma.","authors":"W. Jalloul, R. Tibu, T. Ionescu, C. Stolniceanu, I. Grierosu, A. Ţarcă, L. Ionescu, M. C. Ungureanu, D. Ciobanu, V. Ghizdovat, C. Ștefănescu","doi":"10.4183/aeb.2021.393","DOIUrl":"https://doi.org/10.4183/aeb.2021.393","url":null,"abstract":"A 62 years old woman was diagnosed with multinodular toxic goiter and primary hyperparathyroidism/left parathyroid adenoma by hormonal assessment, ultrasound and nuclear thyroid/parathyroid scans. Cervical ultrasound illustrated a multinodular aspect of the thyroid with solid nodules and cystic-component nodules; the larger one represented a multinodular complex with necrosis areas in the left thyroid lobe, ACR TI-RADS score 4 (moderately suspicious). Functional nuclear imaging was performed for accurate differential diagnosis between thyroid vs. parathyroid localization, between cold vs. hot nodules, and eventually, for guiding the choice of a subsequent Fine-Needle Aspiration Biopsy (FNAB). Scans described an early intense 99mTc-sestaMIBI uptake with no 99mTc-pertechnetate uptake in the left thyroid lobe larger nodule. Due to the suspicion of malignancy for this nodule, we performed an additional scan (1 hour before the classical 2 hours parathyroid delayed scan). The intense uptake persists in both delayed scans suggesting no malignant phenotype and which was confirmed after surgery by benign histology. In conclusion, using a 99mTc-sestaMIBI personalized protocol, related to the radiotracer cellular uptake mechanisms: 1 hour scan (supplementary image, corresponding to the maximum uptake pattern of 99mTc-sestaMIBI for cancer cells) and 2 hours scan (for parathyroid washout evaluation) may avoid unnecessary extensive thyroid surgery.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"35 1","pages":"393-398"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91114503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Recombinant human thyrotropin versus thyroid hormone withdrawal in differentiated thyroid carcinoma follow-up: a single center experience. 分化型甲状腺癌随访中重组人促甲状腺激素与甲状腺激素停药:单中心经验。
Acta endocrinologica Pub Date : 2021-01-01 DOI: 10.4183/aeb.2021.337
M. Şahin, B. I. Aydoğan, E. Özkan, R. Emral, S. Güllü, M. Erdoğan, D. Çorapçıoğlu
{"title":"Recombinant human thyrotropin versus thyroid hormone withdrawal in differentiated thyroid carcinoma follow-up: a single center experience.","authors":"M. Şahin, B. I. Aydoğan, E. Özkan, R. Emral, S. Güllü, M. Erdoğan, D. Çorapçıoğlu","doi":"10.4183/aeb.2021.337","DOIUrl":"https://doi.org/10.4183/aeb.2021.337","url":null,"abstract":"Introduction Our goal was to evaluate and compare the diagnostic utility of thyroid hormone withdrawal (THW) and recombinant thyroid-stimulating hormone (rhTSH) methods in detecting recurrence/persistence (R/PD) of differentiated thyroid carcinoma (DTC). Methods The study included 413 patients with DTC who underwent total thyroidectomy and had remnant ablation. DxWBS, s-Tg levels, R/PD were evaluated retrospectively. A s-Tg level≥2 ng/mL was considered as \"positive s-Tg\". Results DxWBS and s-Tg levels were evaluated with rhTSH in 116 and THW in 297 subjects, respectively. The sensitivity and specificity of \"positive s-Tg\" for R/PD in THW group were 77.3% and 92.7%, with 90.3% accuracy, respectively. The sensitivity and specificity of \"positive s-Tg\" for R/PD in rhTSH group were 58.8% and 100% with 93.9 % accuracy, respectively. An uptake outside thyroid bed at WBS showed a sensitivity of 17.1%, specificity of 100% for R/PD with 89.4% accuracy in THW group. An uptake outside thyroid bed at WBS showed a sensitivity of 7.7%, specificity of 100% for R/PD with 88.8% accuracy in rhTSH group. Conclusion Method of TSH stimulation did not influence the reliability of DxWBS. The \"positive s-Tg level\" had a higher sensitivity with THW when compared to rhTSH in detecting R/PD.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"11 1","pages":"337-345"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88719581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of COVID 19 infection on HCV-induced thyroid disease. COVID - 19感染对丙型肝炎所致甲状腺疾病的影响。
Acta endocrinologica Pub Date : 2021-01-01 DOI: 10.4183/aeb.2021.372
L. Toma, A. Zgura, T. Isac, A. Mercan-Stanciu, M. Dodot, L. Iliescu
{"title":"The impact of COVID 19 infection on HCV-induced thyroid disease.","authors":"L. Toma, A. Zgura, T. Isac, A. Mercan-Stanciu, M. Dodot, L. Iliescu","doi":"10.4183/aeb.2021.372","DOIUrl":"https://doi.org/10.4183/aeb.2021.372","url":null,"abstract":"Context As we progress into the COVID-19 pandemic, it has become apparent that this infection is associated with a multitude of systemic effects, some involving the thyroid gland. The thyroid is also frequently affected in the HCV chronic infection. Objective The objective of this study is to determine the effects of COVID-19 infection on the presence and severity of thyroid disorders associated with chronic HCV infection, at short and mid-term follow-up. Design We prospectively evaluated patients with documented HCV- associated thyroid disease (with sustained virologic response after antiviral therapy). Subjects and Methods The study group consisted of 42 patients with HCV- associated thyroid disease, diagnosed with COVID -19 infection between April and October 2020. We determined serum values of thyroid-stimulating hormone, freeT3, free T4, anti-thyroglobulin antibodies and anti-thyroid peroxidase antibodies at one and three months after resolution of infection and compared them to the baseline characteristics of the patient. We also evaluated the changes in thyroid substitution treatments or antithyroid drugs. Results At baseline, out of the 42 patients, 5 presented hypothyroidism under levothyroxine substitution therapy, while 2 presented hyperthyroidism under methimazole therapy; 37 patients had positive antithyroid antibodies. At one month follow-up, we note an increase in serum values of antibodies, with a decrease in TSH, freeT3 and freeT4 levels, correlated with the severity of COVID-19 infection. Two patients required discontinuation of levothyroxine. At 3 months follow-up, lower levels of antithyroid antibodies were recorded, with an increase in TSH levels. No medication doses were adjusted at this time. Conclusion Among the systemic effects of COVID-19, the impact of thyroid dysfunction should not be underestimated, especially in the presence of pre-existing conditions, such as HCV infection.","PeriodicalId":6910,"journal":{"name":"Acta endocrinologica","volume":"9 1","pages":"372-376"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88861133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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