THE EFFECT OF ANTITHYROID DRUGS ON OSTEOPONTIN AND OXIDATIVE STRESS IN GRAVES' DISEASE.

M. Koçak, E. Akarsu, H. Korkmaz, S. Taysı
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引用次数: 6

Abstract

Objective The aim of the present study is to evaluate the effects of methimazole (MTZ) and propylthiouracil (PTU) treatments on osteopontin (OPN) and oxidative stress in Graves' disease (GD). Material and Methods The study included 60 cases with GD in hyperthyroid state and taking no antithyroid treatment, and 30 healthy volunteers. GD patients were randomly separated into two groups; 30 of them took PTU, and the other 30 took MTZ treatments. Blood samples were taken from the patients with GD before the treatment, and three months after the treatment was begun, when they were in the euthyroid state; blood samples of the healthy control subjects were also taken at these times. Results TAS and OSI levels before treatment were significantly higher in the GD group, when compared to the control group (p<0.001, for each). GD subjects taking PTU treatment had significantly higher TAS levels (p=0.001), and significantly lower TOS and OSI levels (p=0.008 and p=0.001, respectively). TAS levels significantly decreased in the patients taking MTZ treatment (p=0.029), but TOS and OSI levels did not change significantly (p>0.05). Pretreatment OPN levels were significantly higher in GD patients, when compared to the control group (p=0.014). OPN level significantly decreased in the GD group taking PTU treatment; however OPN levels in the group taking MTZ treatment did not change significantly when compared to the pretreatment value. Conclusion PTU treatment is more effective in decreasing OPN and oxidative stress in GD patients, when compared to the MTZ treatment.
抗甲状腺药物对graves病骨桥蛋白及氧化应激的影响。
目的探讨甲巯咪唑(MTZ)和丙硫脲嘧啶(PTU)对Graves病(GD)骨桥蛋白(OPN)和氧化应激的影响。材料与方法选择未接受抗甲状腺药物治疗的甲状腺机能亢进患者60例,健康志愿者30例。GD患者随机分为两组;30例采用PTU治疗,30例采用MTZ治疗。GD患者在治疗前和治疗开始3个月后处于甲状腺功能正常状态时分别采血;同时还采集了健康对照者的血液样本。结果GD组治疗前stas、OSI水平显著高于对照组(p0.05)。GD患者预处理后的OPN水平明显高于对照组(p=0.014)。服用PTU治疗的GD组OPN水平明显降低;而MTZ治疗组的OPN水平与治疗前相比无明显变化。结论与MTZ治疗相比,ptu治疗能更有效地降低GD患者的OPN和氧化应激。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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