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Acta leprologica最新文献

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Global warming and performance of therapeutic agents against leprosy. 全球变暖与麻风病治疗剂的性能。
Acta leprologica Pub Date : 1999-01-01
S C Arya
{"title":"Global warming and performance of therapeutic agents against leprosy.","authors":"S C Arya","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"11 3","pages":"79-81"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21406605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pathogenic agent and host response]. [病原与宿主反应]。
Acta leprologica Pub Date : 1999-01-01
{"title":"[Pathogenic agent and host response].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"11 2","pages":"49-57"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40039134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Profile of leprosy in New Caledonia. Evolution from 1983-1998]. [新喀里多尼亚麻风病概况。从1983年到1998年的演变]。
Acta leprologica Pub Date : 1999-01-01
M Crouzat
{"title":"[Profile of leprosy in New Caledonia. Evolution from 1983-1998].","authors":"M Crouzat","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors report the results of a retrospective study on the evolution of leprosy in New-Caledonia, French island in Oceania, between 1983, time of the onset of polychemotherapy (PCT), and 1998. Since 1996, the prevalence is and remains less than 1/10,000. The annual rate detection fall from 15.6 in 1983 to 2.48/100,000 in 1998. Less than 10 new cases are detected annually since 1994. During this period, the number of new patients less than 15-years old decreased and the percentage of multibacillary patients increased, assessing a priori the improvement of the endemicity. One case of relapse was detected in a MB patients treated for 2 years among the 231 new patients.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"11 4","pages":"139-44"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21822011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Potential applications of molecular biology to leprosy research]. [分子生物学在麻风研究中的潜在应用]。
Acta leprologica Pub Date : 1999-01-01
T P Gillis
{"title":"[Potential applications of molecular biology to leprosy research].","authors":"T P Gillis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"11 2","pages":"43-4"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40039132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Disabilities observed in new cases of leprosy diagnosed in the Bamako district (Mali) in 1994]. [1994年在马里巴马科区诊断的麻风病新病例中观察到残疾]。
Acta leprologica Pub Date : 1999-01-01
S O Sow, A Tiendrebeogo, B Hamed Oould, C Lienhart, J M Ponnighaus
{"title":"[Disabilities observed in new cases of leprosy diagnosed in the Bamako district (Mali) in 1994].","authors":"S O Sow,&nbsp;A Tiendrebeogo,&nbsp;B Hamed Oould,&nbsp;C Lienhart,&nbsp;J M Ponnighaus","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Our study concerns 244 new cases of leprosy diagnosed in the Bamako district in 1994. 154/244 patients could be contacted and were examined in the Leprosy Department of the Marchoux Institute in Bamako. Results showed that the presence of leprosy induced physical disabilities was associated with male gender (59%), advanced age (68%) and multibacillary disease (68%). Disabilities were also more frequent among patients having a rural or manual occupation at the time of screening or afterwards. There was a significant increase (p < 0.001) in the prevalence of disabilities when comparing patients at the time of diagnosis (29%) and thereafter (48%). This means that in 40% of disability cases, lesions developed during or after the treatment. Disabilities were predominantly observed in hands (33%) and feet (29%) with more frequent lesions in lateral popliteal, superior ulnar and posterior tibial nerves. Our results seem to demonstrate the inadequacy of preventive measures and management. This stresses the need for adequate prevention and therapy of leprosy induced disabilities in order to obtain proper eradication of leprosy induced health problems.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"11 4","pages":"161-70"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21822014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of treatment on PCR positivity in multibacillary leprosy patients treated with conventional and newer drugs ofloxacin and minocycline. 氧氟沙星和米诺环素治疗对多菌性麻风患者PCR阳性的影响。
Acta leprologica Pub Date : 1999-01-01
H B Singh, K Katoch, M Natrajan, R K Sharma, U D Gupta, V D Sharma, D Singh, D S Chauhan, K Srivastava, V M Katoch
{"title":"Effect of treatment on PCR positivity in multibacillary leprosy patients treated with conventional and newer drugs ofloxacin and minocycline.","authors":"H B Singh,&nbsp;K Katoch,&nbsp;M Natrajan,&nbsp;R K Sharma,&nbsp;U D Gupta,&nbsp;V D Sharma,&nbsp;D Singh,&nbsp;D S Chauhan,&nbsp;K Srivastava,&nbsp;V M Katoch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to develop objective criteria to monitor trends of therapeutic responses positivity of PCR signals and ATP assay methods has been compared in multibacillary (MB) leprosy patients. Biopsies from lesions of 95 BL/LL patients before and after one year of treatment with a new drug regimen comprising of conventional and newer drugs ofloxacin and minocycline have been studied. These biopsies were processed for bacillary ATP assay and PCR positivity for a 36 kDa gene target by earlier published methods. In the untreated patients bacillary ATP levels were detectable in all specimens and ranged from 0.02 to more than 36 pg/millions organisms. After one year of treatment ATP levels were not detectable in any of the 57 biopsies specimens available for analysis. However, PCR signals were detectable in 3 out of 57 biopsies. In two specimens signals were very weak detectable only by hybridization. It may be concluded that DNA based PCR assay may be useful in monitoring the trends of therapeutic responses in MB patients under treatment.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"11 4","pages":"179-82"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21822016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparative study on the Mitsuda type response to antigens of chemoautotrophic nocardioform bacteria and to standard lepromin in leprosy patients. 麻风患者三田型对趋化自养型诺心样细菌抗原和标准麻风素反应的比较研究。
Acta leprologica Pub Date : 1999-01-01
A N Chakrabarty, S G Dastidar, A K Chandra, M Mukherjee, S K Chaudhuri
{"title":"A comparative study on the Mitsuda type response to antigens of chemoautotrophic nocardioform bacteria and to standard lepromin in leprosy patients.","authors":"A N Chakrabarty,&nbsp;S G Dastidar,&nbsp;A K Chandra,&nbsp;M Mukherjee,&nbsp;S K Chaudhuri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Anergy, or contrarily, Mitsuda-type responses towards 4 chemoautotrophic nocardioform antigens (CAN-Ags) and a control standard lepromin were tested in 73 LL, TT and borderline cases of leprosy. The antigens injected per patient varied from a maximum of 5 to a minimum of 2. Complete anergy to CAN-Ags was seen in 92/92 instances tested on 24 LL cases. The anergy was weakly modified or unmodified in 3 other LL cases which had been vaccinated before. Concurrent studies with the same antigens tested on 33 TT cases showed clear-cut, dose-dependent, Mitsuda-type late responses in 80/81 instances. The CAN bacteria, therefore, despite their origin from different unrelated leprous human, mouse footpad (MFP) and armadillo tissues, appeared to be identical with each other and also probably related to the leprosy bacillus, on the basis of these parameters.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"11 3","pages":"105-12"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21406022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The study of the genome of Mycobacterium leprae]. 麻风分枝杆菌基因组的研究。
Acta leprologica Pub Date : 1999-01-01
S T Cole
{"title":"[The study of the genome of Mycobacterium leprae].","authors":"S T Cole","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"11 2","pages":"41-2"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40039131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dapsone induced pulmonary eosinophilia without cutaneous allergic manifestations--an unusual encounter--a case report. 氨苯砜诱导肺嗜酸性粒细胞增多，无皮肤过敏表现-罕见的遭遇-一个病例报告。
Acta leprologica Pub Date : 1998-01-01
S Arunthathi, S Raju
{"title":"Dapsone induced pulmonary eosinophilia without cutaneous allergic manifestations--an unusual encounter--a case report.","authors":"S Arunthathi,&nbsp;S Raju","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dapsone is a drug of choice in the treatment of leprosy. In addition it is very useful in the treatment of many other dermatological conditions. The \"dapsone-induced hypersensitivity\" is not unknown. However, to the best of our knowledge, pulmonary eosinophilia induced by dapsone without any cutaneous allergic manifestation has not been reported in leprosy patients. Pulmonary eosinophilia (Loeffler's syndrome) induced by dapsone without cutaneous manifestation has been reported in a non leprosy patient by Janier et al. We report a case of pulmonary eosinophilia associated with dapsone therapy in a patient with lepromatous leprosy without allergic cutaneous manifestations and our experience in the management of this patient.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"11 1","pages":"3-5"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20609359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Results of surgical decompression of ulnar nerve in leprosy. 麻风病尺神经减压术的效果。
Acta leprologica Pub Date : 1998-01-01
S Husain, B Mishra, V Prakash, G N Malaviya
{"title":"Results of surgical decompression of ulnar nerve in leprosy.","authors":"S Husain,&nbsp;B Mishra,&nbsp;V Prakash,&nbsp;G N Malaviya","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ulnar neurolysis in 279 cases of leprosy was performed with objectives of relief in neuritic pain and impending/ existing sensory motor loss of varying extent. Of the above, 193 could be followed between 3-10 years. Neuritic pain was first to disappear. 48.7% of the 193 cases showed sensory recovery. Motor power gain and/or further fall in muscle power was prevented as a result of preventive neurolysis in 173 (89.6%) cases. In this series benefits of appropriate and timely surgical intervention have been observed.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"11 1","pages":"17-20"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20609361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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