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Acta leprologica最新文献

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[Evaluation of the elimination of leprosy in Burkina Faso]. [对布基纳法索消灭麻风病的评估]。
Acta leprologica Pub Date : 1998-01-01
A Tiendrebeogo, S O Sow, O Sawadogo, M S Dembele, K Ouedraogo, L Bide, J Millan
{"title":"[Evaluation of the elimination of leprosy in Burkina Faso].","authors":"A Tiendrebeogo,&nbsp;S O Sow,&nbsp;O Sawadogo,&nbsp;M S Dembele,&nbsp;K Ouedraogo,&nbsp;L Bide,&nbsp;J Millan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>During May and June 1997, we conducted a rapid survey on leprosy prevalence in 30 villages. It was to assess reaching of the leprosy elimination threshold (one case per 10,000 inhabitants) in Burkina Faso. We drew lots for the villages in ten provinces among which five had the highest prevalence rates of leprosy in 1996 and five had the lowest prevalence rates. We added a leprosy elimination monitoring to the survey. This monitoring consisted of visits to the health centers covering the 30 villages. We interviewed and clinically examined 33 cases of leprosy in treatment in those health centers. We found fifty-one patients of leprosy in visited villages. The prevalence rate of leprosy (6.74 per 10,000 inhabitants) was twice higher than the prevalence rate registered in the same villages. We detected 28 new cases of leprosy during the survey. Proportion of hidden cases of leprosy were 54.9%. We estimated geographical coverage of MDT at 75% in the 10 provinces. Eight of the 27 visited health centers (29.6%) did not get sufficient supply. The cure rate has fallen from 93 to 73 per cent between 1992 and 1997. Our results show that leprosy elimination threshold is not reached in Burkina Faso. Leprosy control activities that were declining during the last five years need to be reinforced.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"11 1","pages":"7-16"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20609360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progression of bone lesions in cured leprosy patients. 麻风病治愈患者骨骼病变的进展。
Acta leprologica Pub Date : 1998-01-01
P Carpintero, C Logroño, A Carreto, A Carrascal, C Lluch
{"title":"Progression of bone lesions in cured leprosy patients.","authors":"P Carpintero,&nbsp;C Logroño,&nbsp;A Carreto,&nbsp;A Carrascal,&nbsp;C Lluch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A group of 52 patients deemed to be cured of Hansen's disease were examined in order to determine the appearance or aggravation of bone lesions after cure. A study was made of X-rays performed both at the moment these patients were considered to be cured and a minimum of 2 years later. During the elapsing interval, new lesions had appeared in 8 patients, and existing lesions had worsened in 12 patients. Factors associated with the progression of lesions were: impaired sensitivity, physical activity and appearance of plantar ulcers. The authors feel that leprosy patients, even when considered to be bacteriologically cured, should undergo regular checkups. Factors which might aggravate bone lesions should be borne in mind.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"11 1","pages":"21-4"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20609362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of operational factors for the interpretation of indicators in the Hansen's disease endemic in Brazil. 业务因素对解释巴西汉森病流行指标的重要性。
Acta leprologica Pub Date : 1997-01-01
V Andrade, M D Militao de Albuquerque, P Chagastelles Sabroza
{"title":"The importance of operational factors for the interpretation of indicators in the Hansen's disease endemic in Brazil.","authors":"V Andrade,&nbsp;M D Militao de Albuquerque,&nbsp;P Chagastelles Sabroza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In Brazil, an increase has been recorded in recent years in the magnitude of detection coefficients for new cases of Hansen's disease, which is frequently interpreted as evidence of the endemic's expansion. The objective of this work is the determine the role of operational factors for interpreting the trend displayed by the morbidity coefficients for Hansen's disease from 1982 to 1995 in the country. We observed a strong correlation between the adjusted detection coefficients and the number of technicians trained (r = 0.80), a decrease in the proportion of new cases with disabilities at the time of diagnosis (r = 0.86), and a downward trend in tuberculoid forms (r = -0.70). Patient time on the active register is correlated negatively with MDT-WHO coverage (r = -0.95) and the percentage of patients discharged from treatment due to cure (r = -0.91). These results suggest that the increase in the potential for detection of new cases of Hansen's disease resulting from new strategies adopted by the program, i.e., mainly extensive training of health personnel, could be a coherent explanation for the increase in detection coefficients for new cases observed in Brazil in the last ten years.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"10 3","pages":"131-9"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20201718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Leprosy and infection by the human immunodeficiency virus (HIV)]. [麻风病与人类免疫缺陷病毒(HIV)感染]。
Acta leprologica Pub Date : 1997-01-01
B Flageul
{"title":"[Leprosy and infection by the human immunodeficiency virus (HIV)].","authors":"B Flageul","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"10 3","pages":"129-30"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20222875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New WHO recommendations for the treatment of leprosy]. [世卫组织关于治疗麻风病的新建议]。
Acta leprologica Pub Date : 1997-01-01
{"title":"[New WHO recommendations for the treatment of leprosy].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"10 4","pages":"189"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20450021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rifampicin and isoniazid in the treatment of leprous nerve abscesses. 利福平与异烟肼治疗麻风神经脓肿。
Acta leprologica Pub Date : 1997-01-01
S Husain, B Mishra, G N Malaviya
{"title":"Rifampicin and isoniazid in the treatment of leprous nerve abscesses.","authors":"S Husain,&nbsp;B Mishra,&nbsp;G N Malaviya","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thirty nine cases of borderline tuberculoid leprosy having nerve abscesses (15 with sinuses) were treated with daily dose of rifampicin and isoniazid for six months along with standard multidrug therapy. The patients were followed up for three to five years. No recurrence of abscess or sinus was observed. Observations indicate that medical approach is required at times to supplement surgical intervention for management of these cases.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"10 3","pages":"147-50"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20201098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skin smears in leprosy: is reduction in number of sites justified? 麻风病皮肤涂片:减少麻风病皮肤涂片的数量是否合理?
Acta leprologica Pub Date : 1997-01-01
S Sujai, K Vilvanathan, K Nisha, S Arunthathi
{"title":"Skin smears in leprosy: is reduction in number of sites justified?","authors":"S Sujai,&nbsp;K Vilvanathan,&nbsp;K Nisha,&nbsp;S Arunthathi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An analysis of 377 sets of positive skin smears of leprosy patients was done to determine the minimum sites needed to detect all smear positive leprosy patients. A combination of earlobe and a selective site could pick up 95.5% of the patients. An additional smear from the forehead increased the sensitivity of 97.7%. The results suggest that the sites for skin smears may be reduced to a combination of the earlobe and one selective site smear from a skin lesion to be able to detect most smear positive leprosy patients.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"10 4","pages":"191-4"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20373762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ability of lymphokine-activated killer cells to lyse mycobacteria-infected cells. 淋巴因子激活的杀伤细胞裂解分枝杆菌感染细胞的能力。
Acta leprologica Pub Date : 1997-01-01
S V Chiplunkar, M A Deshmukh, J A Kode, S G Gangal, M G Deo
{"title":"Ability of lymphokine-activated killer cells to lyse mycobacteria-infected cells.","authors":"S V Chiplunkar,&nbsp;M A Deshmukh,&nbsp;J A Kode,&nbsp;S G Gangal,&nbsp;M G Deo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lymphokine-activated killer (LAK) cells were generated by interleukin-2 activation of peripheral blood lymphocytes obtained from lepromatous leprosy (LL) patients and healthy individuals. The ability of LAK cells to lyse targets (macrophages and T-24, a bladder carcinoma cell line) infected with mycobacteria (Mycobacterium leprae and mycobacterial strain ICRC) was assessed in a 51 chromium-release assay. It was observed that LAK cells generated from LL patients and healthy individuals could preferentially lyse M. leprae or ICRC-pulsed macrophages and T-24 cells, compared to non-pulsed targets. The ability of LAK cells to kill intracellular mycobacteria was demonstrated in colony forming assays. These results indicate a promising role for LAK cells in immunotherapy of leprosy.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"10 4","pages":"203-8"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20373764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Atypical presentations of leprosy: apropos of 2 cases]. [麻风病的不典型表现:关于2例]。
Acta leprologica Pub Date : 1997-01-01
L Benzekri, B Hassam
{"title":"[Atypical presentations of leprosy: apropos of 2 cases].","authors":"L Benzekri,&nbsp;B Hassam","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This report describes two atypical cases of leprosy. A 48 year old male patient presented laryngeal dyspnea with adhesions of the oropharynx of which the biopsies were inconclusive. The patient was cachectic with hyperesthesia of the extremities and two subcutaneous nodules. The biopsy of one nodule evoked thesaurismosis or dyslipoidosis while the bacilloscopy was positive in nasal smears. A 14 year old female patient suffered from bullae which appeared spontaneously on erythematous skin on the legs and upper arms. Upon examination those areas were found to be hypoaesthetic, as was a very large hamartoma on the left half of the body. A biopsy of healthy skin evoked the diagnosis of leprosy. The patient then developed BT leprosy and episodes of hysteria. The first observation led to several diagnoses: while laryngeal dyspnea is unusual in LL and while cutaneous histology of regressive LL contrasted with the abundance of the bacilloscopy. The diagnosis of the second case is that of indeterminate leprosy with premonitory neurological signs associated with pathomania and evolution to a multibacillary form.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"10 4","pages":"195-8"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20450022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microdensitometric scanning procedure for quantitative assessment of hybridization of rRNA targeting probes in leprosy. 麻风病中rRNA靶向探针杂交定量评估的微密度扫描程序。
Acta leprologica Pub Date : 1997-01-01
R K Sharma, C T Shirannavar, K Katoch, V D Sharma, M Natrajan, N Saxena, V M Katoch
{"title":"Microdensitometric scanning procedure for quantitative assessment of hybridization of rRNA targeting probes in leprosy.","authors":"R K Sharma,&nbsp;C T Shirannavar,&nbsp;K Katoch,&nbsp;V D Sharma,&nbsp;M Natrajan,&nbsp;N Saxena,&nbsp;V M Katoch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to develop an objective criteria of grading of positivity of hybridization signals of gene probes targeting rRNA, a microdensitometric scanning procedure was standardised. Ribosomal RNA was extracted from the bacilli harvested from biopsies of leprosy cases across the spectrum and blotted on nitro-cellulose membranes. M. leprae specific rRNA targeting oligonucleotide probes were end-labelled and hybridization was done by the technique standardised and published earlier. The autoradiographs were developed and microdensitometric scanning was done by altering different parameters. Positivity was graded in 5 grades and compared with visual positivity. Microdensitometric scanning procedure and 5 grade system appear to be useful and reproducible. Signals in paucibacillary specimens were in 2+ to 3+ grading range whereas those in multibacillary specimens varied in grades from 2+ to 5+. This approach appears to have potential usefulness for assessing the bacillary load (possibly viable) in the clinical specimens from leprosy cases.</p>","PeriodicalId":6905,"journal":{"name":"Acta leprologica","volume":"10 4","pages":"213-7"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20373638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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