Chemical Society Reviews最新文献

{"title":"Peptide design to control protein–protein interactions","authors":"Suzanne P. van Wier and Andrew M. Beekman","doi":"10.1039/D4CS00243A","DOIUrl":"10.1039/D4CS00243A","url":null,"abstract":"<p >Targeting of protein–protein interactions has become of huge interest in every aspect of medicinal and biological sciences. The control of protein interactions selectively offers the opportunity to control biological processes while limiting off target effects. This interest has massively increased with the development of cryo-EM and protein structure prediction with tools such as RosettaFold and AlphaFold. When designing molecules to control protein interactions, either inhibition or stabilisation, a starting point is commonly peptide design. This tutorial review describes that process, highlighting the selection of an initial sequence with and without structural information. Subsequently, methods for how the sequence can be analysed for key residues and how this information can be used to optimise the ligand efficiency are highlighted. Finally a discussion on how peptides can be further modified to increase their affinity and cell permeability, improving their drug-like properties, is presented.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 4","pages":" 1684-1698"},"PeriodicalIF":40.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/cs/d4cs00243a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translational nanorobotics breaking through biological membranes","authors":"Alzbeta Ressnerova, Zbynek Heger and Martin Pumera","doi":"10.1039/D4CS00483C","DOIUrl":"10.1039/D4CS00483C","url":null,"abstract":"<p >In the dynamic realm of translational nanorobotics, the endeavor to develop nanorobots carrying therapeutics in rational <em>in vivo</em> applications necessitates a profound understanding of the biological landscape of the human body and its complexity. Within this landscape, biological membranes stand as critical barriers to the successful delivery of therapeutic cargo to the target site. Their crossing is not only a challenge for nanorobotics but also a pivotal criterion for the clinical success of therapeutic-carrying nanorobots. Nevertheless, despite their urgency, strategies for membrane crossing in translational nanorobotics remain relatively underrepresented in the scientific literature, signaling an opportunity for further research and innovation. This review focuses on nanorobots with various propulsion mechanisms from chemical and physical to hybrid mechanisms, and it identifies and describes four essential biological membranes that represent the barriers needed to be crossed in the therapeutic journey of nanorobots in <em>in vivo</em> applications. First is the entry point into the blood stream, which is the skin or mucosa or intravenous injection; next is the exit from the bloodstream across the endothelium to the target site; further is the entry to the cell through the plasma membrane and, finally, the escape from the lysosome, which otherwise destroys the cargo. The review also discusses design challenges inherent in translating nanorobot technologies to real-world applications and provides a critical overview of documented membrane crossings. The aim is to underscore the need for further interdisciplinary collaborations between chemists, materials scientists and chemical biologists in this vital domain of translational nanorobotics that has the potential to revolutionize the field of precision medicine.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 4","pages":" 1924-1956"},"PeriodicalIF":40.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142975507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steady state and transient absorption spectroscopy in metal halide perovskites","authors":"Mehri Ghasemi, Junlin Lu, Baohua Jia and Xiaoming Wen","doi":"10.1039/D4CS00985A","DOIUrl":"10.1039/D4CS00985A","url":null,"abstract":"<p >Metal halide perovskites (MHPs) have emerged as the most promising materials due to superior optoelectronic properties and great applications spanning from photovoltaics to photonics. Absorption spectroscopy provides a broad and deep insight into the carrier dynamics of MHPs, and is a critical complement to fluorescence and scattering spectroscopy. However, absorption spectroscopy is often misunderstood or underestimated, being seen as UV-vis spectroscopy only, which can lead to various misinterpretations. In fact, absorption spectroscopy is one of the most important branches of spectroscopic techniques (others including fluorescence and scattering), which plays a critical role in understanding the electronic structure and optoelectrical dynamics of MHPs. In this tutorial, the basic principles of various types of absorption spectroscopy as well as their recent developments and applications in MHP materials and devices are summarized, covering comprehensive advances in steady state and transient absorption spectroscopy. Given the significance of absorption spectroscopy in directing the design of different optoelectronic applications of MHPs, this tutorial will comprehensively discuss absorption spectroscopy, covering wavelengths from optical to terahertz (THz) and microwave, and timescales from femtoseconds to hours, and it specifically focuses on time-dependent steady-state and transient absorption spectroscopy under light illumination bias to study MHP materials and devices, allowing researchers to select suitable characterization techniques.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 4","pages":" 1644-1683"},"PeriodicalIF":40.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental applications of metal–organic framework-based three-dimensional macrostructures: a review","authors":"Cheng Chen, Liguo Shen, Boya Wang, Xinchun Lu, Saleem Raza, Jiujing Xu, Bisheng Li, Hongjun Lin, Banglin Chen","doi":"10.1039/d4cs00435c","DOIUrl":"https://doi.org/10.1039/d4cs00435c","url":null,"abstract":"Metal–organic frameworks (MOFs) hold considerable promise for environmental remediation owing to their exceptional performance and distinctive structure. Nonetheless, the practical implementation of MOFs encounters persistent technical hurdles, notably susceptibility to loss, challenging recovery, and potential environmental toxicity arising from the fragility, insolubility, and poor processability of MOFs. MOF-based three-dimensional macrostructures (3DMs) inherit the advantageous attributes of the original MOFs, such as ultra-high specific surface area, tunable pore size, and customizable structure, while also incorporating the intriguing characteristics of bulk materials, including hierarchical structure, facile manipulation, and structural flexibility. Consequently, they exhibit rapid mass transfer and exceptional practicality, offering extensive potential applications in environmental remediation. This review presents a comprehensive overview of recent advancements in utilizing MOF-based 3DMs for environmental remediation, encompassing their fascinating characteristics, preparation strategies, and characterization methods, and highlighting their exceptional performance in pollutant adsorption, catalysis, and detection. Furthermore, existing challenges and prospects are presented to advance the utilization of MOF-based materials across various domains, particularly in environmental remediation.","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":"41 1","pages":""},"PeriodicalIF":46.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142940524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From photocatalysis to photon–phonon co-driven catalysis for methanol reforming to hydrogen and valuable by-products","authors":"Hui Wang, Eleana Harkou, Achilleas Constantinou, Sultan M. Al-Salemc, George Manos, Junwang Tang","doi":"10.1039/d4cs00551a","DOIUrl":"https://doi.org/10.1039/d4cs00551a","url":null,"abstract":"Hydrogen energy will play a dominant role in energy transition from fossil fuel to low carbon processes, while economical, efficient, and safe hydrogen storage and transportation technology has become one of the main bottlenecks that currently hinder the application of the hydrogen energy scale. Methanol has widely been regarded as a primary liquid H<small>₂</small> storage medium due to its high hydrogen content, easy storage and transportation and relatively low toxicity. Hydrogen release from methanol using photocatalysis has thus been the focus of intense research and recent years have witnessed its fast progress and drawbacks. This review offers a comprehensive overview of methanol-based hydrogen production <em>via</em> photocatalysis, spotlighting recent developments in photocatalysts referring to thermal catalysts, including efficient semiconductors and cocatalysts, followed by the discussion of mechanistic investigation <em>via</em> advanced techniques and their disadvantages. Beyond this, particular focus has been placed on the discussion of co-driven processes involving coupling of photons (photocatalysis) with phonons (thermal catalysis) – the concept of photon–phonon co-driven catalysis – for methanol reforming and cutting-edge reactor design strategies, in order to enhance the overall process efficiency and applicability. Concluding with forward-looking insights, this review aims to provide valuable guidance for future research on hydrogen release through methanol reforming.","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":"68 1","pages":""},"PeriodicalIF":46.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal–organic frameworks for the separation of xylene isomers","authors":"Ming Xu, Wen-Qi Tang, Sha-Sha Meng and Zhi-Yuan Gu","doi":"10.1039/D4CS00796D","DOIUrl":"10.1039/D4CS00796D","url":null,"abstract":"<p >Xylene isomers, including <em>para</em>-xylene (<em>p</em>X), <em>meta</em>-xylene (<em>m</em>X), <em>ortho</em>-xylene (<em>o</em>X), and ethyl benzene (EB), are important raw materials in industry. The separation of xylene isomers has been recognized as one of the “seven chemical separations to change the world”. However, because of their similar physicochemical properties, totally separating four xylene isomers has remained a big challenge until now. Metal–organic frameworks (MOFs) have emerged as promising separators to achieve this goal because MOFs synergistically provide multiple mechanisms at the molecular scale. In this review, we summarize the recent progress of MOFs as separators for the separation of xylenes based on four main separation mechanisms: the molecular sieving effect, gating mechanism, thermodynamic interactions, and kinetic diffusion. We concentrate on the applications of MOFs in the field of chromatography, single-component vapor adsorption, liquid-phase competitive adsorption, breakthrough, and membrane separation. Finally, we conclude with the possible direction for designing high-performance MOF separators and briefly discuss the existing challenges in this area.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 3","pages":" 1613-1633"},"PeriodicalIF":40.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfacial fluid manipulation with bioinspired strategies: special wettability and asymmetric structures†","authors":"Haoyu Bai, Tianhong Zhao and Moyuan Cao","doi":"10.1039/D4CS01073F","DOIUrl":"10.1039/D4CS01073F","url":null,"abstract":"<p >The inspirations from nature always enlighten us to develop advanced science and technology. To survive in complicated and harsh environments, plants and animals have evolved remarkable capabilities to control fluid transfer <em>via</em> sophisticated designs such as wettability contrast, oriented micro-/nano-structures, and geometry gradients. Based on the bioinspired structures, the on-surface fluid manipulation exhibits spontaneous, continuous, smart, and integrated performances, which can promote the applications in the fields of heat transfer, microfluidics, heterogeneous catalysis, water harvesting, <em>etc.</em> Although fluid manipulating interfaces (FMIs) have provided plenty of ideas to optimize the current systems, a comprehensive review of history, classification, fabrication, and integration focusing on their interfacial chemistry and asymmetric structure is highly required. In this review, we systematically introduce development and highlight the state-of-the-art progress of bioinspired FMIs. Firstly, the biological prototype and development timeline are presented, and the underlying mechanism of on-surface fluid control on versatile structures is analyzed. Secondly, the definition and classification of FMIs as well as the strategy for controlling fluid/interface interaction are discussed. Thirdly, emergent applications of FMIs in practical scenarios including fog/vapor collection, fluid diodes, interfacial catalysis, <em>etc.</em> are presented. Furthermore, the challenges and prospects of interfacial liquid manipulation are concluded. We envision that this review should provide guidance for the incorporation of FMIs into suitable situations, which enlightens interdisciplinary research and practical applications in the fields of interface chemistry, materials design, bionic science, fluid dynamics, <em>etc.</em></p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 4","pages":" 1733-1784"},"PeriodicalIF":40.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular insights into the composition, sources, and aging of atmospheric brown carbon","authors":"Alexander Laskin, Christopher P. West and Anusha P. S. Hettiyadura","doi":"10.1039/D3CS00609C","DOIUrl":"10.1039/D3CS00609C","url":null,"abstract":"<p >The light-absorbing chemical components of atmospheric organic aerosols are commonly referred to as Brown Carbon (BrC), reflecting the characteristic yellowish to brown appearance of aerosol. BrC is a highly complex mixture of organic compounds with diverse compositions and variable optical properties of its individual chromophores. BrC significantly influences the radiative budget of the climate and contributes to adverse air pollution effects such as reduced visibility and the presence of inhalable pollutants and irritants. However, a fundamental understanding of the sources, formation, and transformation (aging effects) of BrC remains incomplete. This gap in knowledge necessitates advanced chemical characterization of individual aerosol components and the correlation of their composition with optical properties. Over the past decade, a multi-modal analytical platform composed of high-performance liquid chromatography with a photodiode array UV-vis detector and high-resolution mass spectrometry has been extensively used for the untargeted analysis of BrC components in complex mixtures of atmospheric organic aerosols and their laboratory proxies. This method separates solvent-extractable BrC compounds into distinct fractions, each characterized by specific retention times, UV-vis absorption spectra, and elemental compositions, offering comprehensive molecular insights into BrC components. In this review, we highlight the application of this platform in analyzing both real-world aerosol samples and laboratory-generated proxies. These studies have identified composition-specific sources and transformations of BrC, advancing our understanding of these complex atmospheric mixtures. Atmospheric humic-like substances (HULIS), formed through cloud processing of wildfire smoke and the oligomerization of water-soluble organics, are key contributors to BrC. Additional HULIS originate from fossil fuel combustion, biogenic, and marine emissions. Key BrC chromophores include nitroaromatics, imidazoles, N-heterocycles, polyaromatic hydrocarbons, quinones, and others. Aging processes, including photolysis and multiphase reactions, can significantly alter BrC optical properties by generating new chromophores or degrading existing ones. The fundamental knowledge gained from these investigations is essential for assessing BrC optical properties. Additionally, it provides practical composition metrics necessary to inform and improve future atmospheric models, enabling more accurate predictions of BrC behavior and its impact on climate and air quality.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 3","pages":" 1583-1612"},"PeriodicalIF":40.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/cs/d3cs00609c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracellular metal ion-based chemistry for programmed cell death","authors":"Yawen You, Zhaochen Guo, Tyler Wolter and Quanyin Hu","doi":"10.1039/D4CS00930D","DOIUrl":"10.1039/D4CS00930D","url":null,"abstract":"<p >Intracellular metal ions play essential roles in multiple physiological processes, including catalytic action, diverse cellular processes, intracellular signaling, and electron transfer. It is crucial to maintain intracellular metal ion homeostasis which is achieved by the subtle balance of storage and release of metal ions intracellularly along with the influx and efflux of metal ions at the interface of the cell membrane. Dysregulation of intracellular metal ions has been identified as a key mechanism in triggering programmed cell death (PCD). Despite the importance of metal ions in initiating PCD, the molecular mechanisms of intracellular metal ions within these processes are infrequently discussed. An in-depth understanding and review of the role of metal ions in triggering PCD may better uncover novel tools for cancer diagnosis and therapy. Specifically, the essential roles of calcium (Ca<small>²⁺</small>), iron (Fe<small>^2+/3+</small>), copper (Cu<small>^+/2+</small>), and zinc (Zn<small>²⁺</small>) ions in triggering PCD are primarily explored in this review, and other ions like manganese (Mn<small>^2+/3+/4+</small>), cobalt (Co<small>^2+/3+</small>) and magnesium ions (Mg<small>²⁺</small>) are briefly discussed. Further, this review elaborates on the underlying chemical mechanisms and summarizes these metal ions triggering PCD in cancer therapy. This review bridges chemistry, immunology, and biology to foster the rational regulation of metal ions to induce PCD for cancer therapy.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 3","pages":" 1552-1582"},"PeriodicalIF":40.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the transitional window for organic semiconductor single crystals towards practical integration: from materials, crystallization, and technologies to real-world applications","authors":"Xianshuo Wu, Xiaoting Zhu, Lingjie Sun, Shihan Zhang, Yiwen Ren, Zhaofeng Wang, Xiaotao Zhang, Fangxu Yang, Hao-Li Zhang and Wenping Hu","doi":"10.1039/D4CS00987H","DOIUrl":"10.1039/D4CS00987H","url":null,"abstract":"<p >Organic semiconductor single crystals (OSSCs), which possess the inherent merits of long-range order, low defect density, high mobility, structural tunability and good flexibility, have garnered significant attention in the organic optoelectronic community. Past decades have witnessed the explosive growth of OSSCs. Despite numerous conceptual demonstrations, OSSCs remain in the early stages of implementation for applications that require high integration and multifunctionality. The commercialization trend of organic optoelectronic devices is driving the development of highly integrated OSSCs. Therefore, timely tracking of material requirements, crystallization demands, and key technologies for high integration, along with exploring their limitations and potential pathways, will provide critical guidance during this pivotal transition period. From the perspective of materials properties, multifunctional materials, such as ambipolar charge transport materials, high mobility emission materials and others, aiming at high integration, deserve our attention, and the material design rules are carefully discussed in the first section. Following this, we delve into the controllable growth of large-scale OSSCs based on crystallization thermodynamics and kinetics. Key technologies for achieving high integration are then discussed, with an emphasis on methods for growing wafer-scale organic single crystals and patterning single crystalline arrays. Subsequently, we outline the cutting-edge optoelectronic applications based on OSSCs, including organic logic circuits, electroluminescent displays, and image sensors. Moreover, explicitly recognizing as yet limitations and prospects on the road to ‘lab-to-fab’ transitions for OSSCs is crucial. Thus, we conclude by offering an objective assessment of key limitations and potential, encompassing aspects such as uniformity, integration density, stability, and driving capability, providing an instructive projection for future advancements.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 4","pages":" 1699-1732"},"PeriodicalIF":40.4,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}