Macromolecular Research最新文献

{"title":"High-stability flexible body motion monitoring sensor based on waterborne polyurethane-coated conductive warp-knitted fabric","authors":"Xinyan Yue,&nbsp;Xiaohu Wang,&nbsp;Xiao Han,&nbsp;Jianhan Hong","doi":"10.1007/s13233-024-00258-6","DOIUrl":"10.1007/s13233-024-00258-6","url":null,"abstract":"<div><p>To prepare a high-stability flexible sensor for body motion monitoring, a conductive warp-knitted fabric (CWKF) with a two-bar tricot structure coated with polyaniline(PANI) was prepared by in situ polymerization, and then a waterborne polyurethane-coated conductive warp-knitted fabric (WPU/CWKF) was prepared using a simple dip-and-dry method. The structure and properties of both CWKF and WPU/CWKF were analyzed, their strain-resistance sensing properties were investigated, and their application in body motion monitoring was discussed. The results indicate that conductive treatment of in situ polymerization can give the polyester warp-knitted fabric good electrical conductivity, with a resistivity of approximately 5 Ω cm. After coating with WPU, the resistivity of the WPU/CKWF increased to approximately 40 Ω cm. Both CKWF and WPU/CKWF showed good strain-resistance sensing performance, but CWKF was more sensitive than WPU/CKWF, whereas WPU/CKWF was more stable than CWKF. Both the CWKF and WPU/CKWF sensors could monitor body motion in real time. Similar to their base materials, the CWKF sensor demonstrated a higher sensitivity for human movement monitoring, whereas the WPU/CKWF sensor exhibited higher stability.</p><h3>Graphic abstract</h3><p>Conductive warp-knitted fabric (CWKF) with a two-bar tricot warp-knitted structure coated with polyaniline (PANI) was prepared by in situ polymerisation. After repeated reciprocal stretching, the structure of the PANI conductive layer on the CWKF surface broke down and its conductivity changed, especially under large strains. CWKF sensors enable real-time human motion monitoring with high sensitivity\u0000</p><div><figure><div><div><picture><img></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 7","pages":"641 - 652"},"PeriodicalIF":2.8,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modification of rice hull powder by in situ generation of silver nanoparticales for antibacterial composite filler applications","authors":"A. Ganesh Babu,&nbsp;S. S. Saravanakumar,&nbsp;B. Balavairavan,&nbsp;P. Senthamaraikannan","doi":"10.1007/s13233-024-00257-7","DOIUrl":"10.1007/s13233-024-00257-7","url":null,"abstract":"<div><p>It is important to reduce environmental problems caused by biowaste materials. The large amount of biowaste generated causes serious problems on a global scale. The majority of waste produced is recycled, disposed of, or left untreated in landfills. Methane gas produced by organic waste in landfills contributes to the greenhouse impact and creates issues with leachate and odor. Furthermore, as these organic wastes decompose in landfills, toxic substances that produce unpleasant aromas and contaminate soil and aquatic habitats are discharged. The shortcomings of the traditional approach have put pressure on the waste management, farming, and industrial sectors to develop environmentally friendly ways to handle these biodegradable wastes with less pollution. According to the latest survey, the most generated biowaste was rice hull. Rice hull powder (RHP) needs some modifications for extensive applications as filler materials. By using a one-step hydrothermal process, the silver nanoparticles (AgNPs) were generated and mixed with rice hull powder. The modified rice hull powder (MRHP) was characterized by FTIR, XRD, FESEM, EDX, and thermal analysis. Through the FESEM image, the presence of small spherical-shaped particles clarifies the presence of in-situ generated AgNPs. FTIR study reveals that there is no chemical interaction between silver nanoparticles and RHP observed while generation of MRHP. The Xrd image signifies the presence of a broad hump along with a few sharp peaks clarifies that the semi-crystalline nature of MRHP. The MRHP records a slight increase in maximum inflection temperature at 365 °C due to the addition of thermally stable silver nanoparticles with 28.5 percent of the remaining residual mass. The addition of silver nanoparticles makes the MRHP has significantly improved the diameter of the zone of inhibition by 27.6 mm to 30.7 mm. This impressive change in properties suggests that the MRHP can be utilized as filler along with polymer matrices for high thermal applications.</p><h3>Graphical abstract</h3><p>In situ generation of silver nanoparticles on rice hull powder</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 7","pages":"653 - 661"},"PeriodicalIF":2.8,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140302691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and characterization of a chitosan/TiO2 nanocomposite hydrogel intended for the photocatalytic degradation of pollutants","authors":"Hafida Sehil,&nbsp;Mohamed Badaoui,&nbsp;Abdelkader Chougui,&nbsp;Larbi Bouhadjar,&nbsp;Wissame Aoun,&nbsp;Lamia Belkhier","doi":"10.1007/s13233-024-00254-w","DOIUrl":"10.1007/s13233-024-00254-w","url":null,"abstract":"<div><p>Nanocomposite chitosan-based hydrogels (chitosan-co-polycrotonic acid), with and without TiO₂, were prepared via chemical cross-linking of chitosan using sodium trimetaphosphate (STMP), followed by free radical polymerization. The structural and morphological properties of the synthesized composites were investigated and analyzed using X-ray diffraction, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and diffuse reflectance spectroscopy (DRS) techniques, as well as by determining the swelling rate and the pH at the point of zero charge (pH_pzc). The results of these analyses showed that the cross-linking of chitosan by STMP and the distribution of TiO₂ nanoparticles on the surface of the gel were both successfully achieved. In addition, the incorporation of TiO₂ particles into the hydrogel led to an increase in the swelling rate but a reduction in the band gap of titanium dioxide. These findings allowed concluding that the prepared material can be used for the efficient photocatalytic degradation of pollutants.</p><h3>Graphical Abstract</h3><p>The nanocomposite chitosan-based hydrogels prepared via chemical cross-linking of chitosan using sodium trimetaphosphate (STMP) with and without TiO₂ can be used for the efficient photocatalytic degradation of pollutants</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 7","pages":"673 - 684"},"PeriodicalIF":2.8,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140199066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Based on Eudragit® encapsulated ionic polymer IR775@nido-carborane strategy: release, bioactivity and tumor cell imaging studies in simulated gastrointestinal environment","authors":"Shuo Wang,&nbsp;Ying Liu,&nbsp;Meng Zhou,&nbsp;Jiankang Feng,&nbsp;Tiantian Chai,&nbsp;Jingnan Hu,&nbsp;Qingxia Chu,&nbsp;Shihe Shao,&nbsp;Chichong Lu,&nbsp;Guofan Jin","doi":"10.1007/s13233-024-00250-0","DOIUrl":"10.1007/s13233-024-00250-0","url":null,"abstract":"<div><p>To enhance the bioavailability of carborane as a potential pharmacophore for BNCT, we labeled the modified <i>o</i>-carborane with the near-infrared dye IR775 and encapsulated it using two types of Eudragit^® (pH-sensitive and osmotic). Consequently, four separate fluorescent complexes containing carborane were acquired. To confirm the nido-carborane presence within these complexes, the distinct peak at 2510 cm⁻¹ was detected using infrared spectroscopy as a first step. The photophysical properties were observed in phosphate buffer with different pH. The UV and fluorescence spectra of the four fluorescent complexes were very similar, with the maximum absorption wavelengths centered in the range of 773–789 nm and the emission wavelengths centered in the range of 796–811 nm. Subsequently, a stable and releasing complex L100-C-IR775 was screened through zeta potential testing and simulated release experiments in the gastrointestinal environment, and spherical shape was observed by transmission electron microscopy. AFM imaging showed a relatively smooth surface with a uniform distribution of protrusions. The L100-C-IR775 was then applied to tumor cell imaging, and it was observed that it could enter into three kinds of tumor cells, A549, HCT116 and HeLa, and distribute around the nucleus. Finally, it was shown by a cell proliferation toxicity assay (CCK8) that the compound inhibited HeLa and PC-3 cells by 50 and 51% at concentrations up to 10 µg/mL. In conclusion, the carborane fluorescent complexes prepared in this paper have good biocompatibility and demonstrate toxicity toward tumor cell proliferation. Furthermore, they have the potential to serve as a carbon borane anti-tumor prodrug.</p><h3>Graphical abstract</h3><p>\u0000An acrylic encapsulated ionic polymer IR775@nido-carborane simulates release in the gastrointestinal environment, tumor cells imaging, and schematics of therapeutic mechanisms.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 6","pages":"525 - 540"},"PeriodicalIF":2.8,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140199148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilayered porous composite scaffolds for enhanced treatment of bone cancer through chemo-photothermal combination therapy","authors":"Jae Woo Kim,&nbsp;Jung Hun Kwon,&nbsp;Ki Hong Kim,&nbsp;Young-Jin Kim","doi":"10.1007/s13233-024-00256-8","DOIUrl":"10.1007/s13233-024-00256-8","url":null,"abstract":"<div><p>The combination of therapeutic materials and biocompatible scaffolds to create multifunctional scaffolds with therapeutic and restorative functions has been investigated as a new therapeutic modality for bone cancers because the integration of multi-modal therapies into one platform can exhibit significant potential in overcoming the drawbacks of conventional therapy in bone cancers. In this study, we develop an IR780- and epigallocatechin gallate (EGCG)-loaded multifunctional polylactic acid (PLA) (E-PLMH780) composite scaffold for chemo-photothermal combination therapy without cytotoxicity. This bilayered E-PLMH780 scaffold is prepared using a layer of EGCG-loaded PLA monolith and a three-dimensionally printed PLA composite scaffold, followed by coating with IR780-loaded Mg-HA nanoparticles. The monolith layer in the composite scaffold exhibits a three-dimensional porous structure and a uniform morphology featuring small leaf-like units, whereas the three-dimensionally printed layer exhibits a uniform porous structure with a hierarchical architecture. The results of the chemo-photothermal combination therapy and cytotoxicity assays showed that the E-PLMH780 scaffold effectively inhibited bone cancer cell proliferation but did not cause cytotoxicity in normal osteoblastic cells. Therefore, chemo-photothermal combination therapy using IR780- and EGCG-loaded E-PLMH780 scaffolds can potentially provide a new generation of therapeutic modality for the improved treatment of bone cancers and repair of bone defects.</p><h3>Graphical abstract</h3><p>\u0000Schematic diagram of the fabrication of IR780- and EGCG-loaded E-PLMH780 scaffolds and their therapeutic efficacy on cancer cells</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 7","pages":"685 - 701"},"PeriodicalIF":2.8,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140100230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-dimensional culture system model for hippocampal NSCs on PLLA microwell pattern","authors":"Donghuo Zhong,&nbsp;Wenxu Wang,&nbsp;Sizhe Tang,&nbsp;Tao Ling,&nbsp;Shikai Qi,&nbsp;Xingnuan Li,&nbsp;Zhongping Wang","doi":"10.1007/s13233-024-00255-9","DOIUrl":"10.1007/s13233-024-00255-9","url":null,"abstract":"<div><p>Poly-L-lactic acid (PLLA) microwell patterns were fabricated using a lithography-based replica molding method to develop neural stem cell-based assays. Hippocampal neural stem cells (NSCs) were cultured on microwell patterns to construct a multi-dimensional culture system model in which cells within the microwells were mainly cultured with three-dimensional cellular aggregates (MW-3D cells), and cells on the top surfaces were mainly cultured with two-dimensional single-layer adherent cultures (TS-2D cells). It was found that self-renewal and MW-3D cell-directed migration and transformation regulate the construction of this model. Patterns without channel connections occurred earlier in the construction of this model than those with channel connections, due to the tendency of NSCs to extend to both sides along the direction of the channels. Self-renewal and stemness maintenance of NSCs within the microwells were promoted by the patterns with the channel connections as a suitable microenvironment for a prolonged period of time, and can be used to build quasi-one-dimensional neural networks within the microwells. This will become a practical model for studying the functional behavior of NSCs, with different culture systems dynamically assembled on the same platform for stem cell research and the development of stem cell-based assays.</p><h3>Graphical abstract</h3><p>Multi-dimensional culture system model of the hippocampal NSCs on microwell patterns. (a-b) Hippocampal NSCs were stained with Nestin and DAPI after 7 days on the (a) 100–0 μm and (b) 120–40 μm patterns. Images were obtained by multi-slice scanning with CLSM, volume rendering of the image sequence, and overlaying of the confocal fluorescence images with phase-contrast micrographs. (c-d) Cross-sectional views of the 3D reconstructed confocal microscopic images of DAPI and Nestin were used to analyze the distribution of cells inside the microwells.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 7","pages":"717 - 725"},"PeriodicalIF":2.8,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140076398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of biomimetic three-dimensional scaffolds in bone tissue repairing","authors":"Zhiqiang Zhang,&nbsp;Xiaonan Qiu,&nbsp;Chunmin Deng","doi":"10.1007/s13233-024-00253-x","DOIUrl":"10.1007/s13233-024-00253-x","url":null,"abstract":"<div><p>Bone defects and fractures represent common health concerns, with bone repair posing a challenging physiological process. This reparative process is often complicated with the presence of bacterial toxins, inflammation, and oxidative stress. Furthermore, bone tissue, being highly metabolic, requires a substantial amount of nutrients during the healing process. These factors collectively contribute to the difficulty in spontaneous or timely bone tissue regeneration. Currently, the conventional approach to facilitate bone defect healing involves surgically implanting the patient’s autologous tissue graft at the defect sites. However, this method necessitates surgical intervention, presents challenges in deformity correction, exhibits limited plasticity, and has constrained availability, thus increasing the likelihood of associated complications. Clinically, an ideal scaffolds should exhibit attributes such as cost-effectiveness, ease of preparation, minimal invasiveness, and compatibility with the surrounding bone tissue to facilitate nutrient transportation and the formation of blood vessels. This review critically examines the merits and demerits of the two most widely employed three-dimensional (3D) biomimetic scaffolds for bone tissue repairing. Furthermore, it delves into the fundamental prerequisites and prospective advancements of 3D biomimetic porous scaffolds, emphasizing their potential future development trends.</p><h3>Graphical abstract</h3><p>Schematic of the process of bone fracture healing process.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 6","pages":"493 - 504"},"PeriodicalIF":2.8,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140073296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy storage enabled by cross-linked multilayer films using block copolymer-modified nanocapsules and chitosan biopolymers","authors":"Li Xu,&nbsp;Yinzhao Li,&nbsp;Tingwei Cai,&nbsp;Jianhua Zhang,&nbsp;Lang He,&nbsp;Raymond Cai,&nbsp;Chunyin Zhu,&nbsp;Haifeng Shi,&nbsp;Zihan Chu,&nbsp;Xiaochen Shen","doi":"10.1007/s13233-024-00246-w","DOIUrl":"10.1007/s13233-024-00246-w","url":null,"abstract":"<div><p>The silica nanocapsules were functionalized with poly(methacrylic acid)-<i>block</i>-poly(2-acrylamido-2-methylpropanesulfonic acid) (PMAA-<i>b</i>-PAMPS) and assembled with chitosan (CHI) by layer-by-layer deposition and cross-linking to develop lithium electrolyte nanocomposites in the presence of concentrated alkaline solutions. The inorganic/organic nanocapsules and the assembled CHI chains endowed the multilayer films with well-defined structure, great temperature tolerance, and comparable mechanical properties. The films possessed a high loading capacity of alkaline electrolytes. The entrapment of a concentrated alkaline solution in the film matrix led to high ionic conductivity (~ 0.73 mS cm⁻¹ at 25 °C) and outstanding temperature-tolerated capacity. The films maintained a constant ionic conductivity and physical strength against mechanical deformations. For the first time, the impact of molecular weight of block copolymers on electrochemical properties of electrolyte-loaded multilayer films was investigated. The lithium-ion batteries built by flexible alkaline electrolytes of nanocapsule-based multilayer films demonstrated excellent ionic conductivity and electrochemical sustainability, possessing discharge capacity of 163.5 mA h g⁻¹ and retaining 97.53% of the original capacity after 120 cycles. This work demonstrates the first proof-of-concept platform of polymer/nanocapsule composite-incorporated multilayer films with well-defined internal structure and high loading capacity for energy storage. The multilayer films could be adopted as the reliable electrolyte in lithium-ion batteries and introduce enhanced cycling ability and high rate charge–discharge performance.</p><h3>Graphical abstract</h3><p>We describe the structure, surface morphology, and electrochemical properties of multilayer films of block copolymer-functionalized silica nanocapsules and chitosan biopolymers via layer-by-layer deposition and cross-linking. The structure and property of the films could be manipulated by controlling the chain length of the block copolymers. In addition, the films could efficiently entrap alkaline solution, demonstrating excellent ionic conductivity and electrochemical sustainability.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 5","pages":"453 - 465"},"PeriodicalIF":2.8,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140073295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the combustion hazards of polyacrylonitrile-based stabilizing fiber insulation with cellulose adhesive","authors":"Kil Song Jeon,&nbsp;Jae Ung Sim,&nbsp;Eun Mi Ryu,&nbsp;In Hwan Yeo,&nbsp;Kyung Suk Cho","doi":"10.1007/s13233-024-00249-7","DOIUrl":"10.1007/s13233-024-00249-7","url":null,"abstract":"<div><p>Numerous studies are exploring methodologies to enhance flame resistance and minimize the emission of toxic gases and chemicals from building materials in the event of a fire, aiming to mitigate risks and save lives. To that end, this study produced an insulation material using stabilized fiber based on polyacrylonitrile (PAN). Stabilized fiber provides flame retardancy by forming aromatic bonds in existing PAN fiber through heat treatment. To manufacture an insulation material with fiber, a separate adhesive is needed to maintain the shape, and cellulose was selected as the adhesive. Cellulose is an environmentally friendly material that can be obtained from natural sources and has the additional advantages of excellent stability and heat resistance. For this study, PAN-based stabilizing fiber (PSF) insulation was prepared and further processed using cellulose adhesive (PSF-C). Combustion experiments and gas analysis were performed to assess the combustion risks of the developed PSF insulation, and the contents of the hazardous gases and smoke generated were measured. The hazardous gases and smoke released during combustion were considerably reduced, and the heat resistance of the insulation was improved. Furthermore, the pyrolysis reaction and thermal stability were investigated. The results demonstrated a substantial reduction in the combustion hazards associated with the PSF when cellulose was used, i.e., PSF-C was used. The findings of this study are expected to substantially contribute to advancing the practical applicability of PSF-C insulating materials and the development of safe building and fire prevention systems.</p><h3>Graphical abstract</h3><p>\u0000We developed PAN-based stabilized fiber insulation to enhance fire safety and minimize human casualties. We utilized an eco-friendly cellulose adhesive for structural integrity and studied its fire-safety properties, including HCN emissions. The developed insulation with cellulose adhesive (PSF-C) significantly reduced HCN emissions compared with a PAN insulator alone (PSF). PSF-C reduces human casualties</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 6","pages":"515 - 523"},"PeriodicalIF":2.8,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140073014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic properties and enzyme inhibition potentials of some natural compounds on hyaluronidase, collagenase, and elastase with molecular docking studies","authors":"Yanyan Wang,&nbsp;Yang Yu,&nbsp;Yu Zhang","doi":"10.1007/s13233-023-00242-6","DOIUrl":"10.1007/s13233-023-00242-6","url":null,"abstract":"<div><p>In this study, isobavachalcone and bavachalcone molecules obtained excellent to good inhibitory against hyaluronidase, collagenase, and elastase enzymes with IC₅₀ values of 16.65, 4.18, and 0.79 µM for isobavachalcone and 7.31, 19.38, and 10.56 µM for bavachalcone. The chemical activities of these compounds against hyaluronidase, collagenase enzyme, and elastase were evaluated utilizing the molecular modeling study. Molecular docking was used to investigate the chemical activities of isobavachalcone and bavachalcone against hyaluronidase, collagenase, and elastase. The compounds’ anti-cancer activities were tested against MDA-MB-468, Hs 281.T, AU565, CAMA-1, MCF7, NMU, SK-BR-3, and RBA cell lines. Molecular docking calculations were used to evaluate the chemical activities of isobavachalcone and bavachalcone against some of the expressed surface receptor proteins (folate receptor, EGFR, HER2, progesterone receptor, estrogen Receptor, CD47, androgen receptor, and CD44) in the mentioned cell lines. The findings revealed the most likely interactions and their properties at the atomic level. The docking values revealed that the molecules have a high affinity for enzymes. Furthermore, these molecules made direct contact with the receptors and enzymes. As a result, these chemical molecules may have the potential to inhibit cancer cells and enzymes. Furthermore, even at low doses, these compounds significantly reduced breast cancer cell viability. Furthermore, a 100 M dose of all molecules resulted in significant reductions in breast cancer cell viability.</p><h3>Graphical abstract</h3><p>Therapeutic Properties and Enzyme Inhibition Potentials of Some Natural Compounds on Hyaluronidase, Collagenase, and Elastase With Molecular Docking Studies.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"32 5","pages":"475 - 491"},"PeriodicalIF":2.8,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139987721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}