Macromolecular Research最新文献_第7页

FGF-7 treatment accelerates wound healing in concentration-dependent manner by regulating TGF-β1 and VEGF expression FGF-7治疗通过调节TGF-β1和VEGF表达，呈浓度依赖性促进创面愈合

IF 2.8 4区工程技术

Macromolecular Research Pub Date : 2025-01-09 DOI: 10.1007/s13233-024-00358-3

Young-Sik Kim, Gun-Jae Jeong, Jung Soo Lee, Ju Woong Jang, Sae Hyun Kim, Heung Jae Chun, Dae Hyeok Yang

{"title":"FGF-7 treatment accelerates wound healing in concentration-dependent manner by regulating TGF-β1 and VEGF expression","authors":"Young-Sik Kim, Gun-Jae Jeong, Jung Soo Lee, Ju Woong Jang, Sae Hyun Kim, Heung Jae Chun, Dae Hyeok Yang","doi":"10.1007/s13233-024-00358-3","DOIUrl":"10.1007/s13233-024-00358-3","url":null,"abstract":"<div><p>In this study, we report the effects of fibroblast growth factor-7 (FGF-7) concentration on wound healing, which has been less extensively studied compared to other growth factors. Assessment of the concentration-dependent effects of FGF-7 in an in vitro cell scratch assay showed that FGF-7 promoted human HaCaT keratinocyte migration into the wound area. In an in vivo animal test, local treatment with FGF-7 (up to 100 μg) resulted in no toxicity. In addition, we found that when 100 μg of FGF-7 was administered, transforming growth factor-beta 1 (TGF-β1), vascular endothelial growth factor (VEGF), and hydroxyproline, which are all related to wound healing, were significantly upregulated, followed by accelerated wound healing. All our results demonstrated that the FGF-7 concentration affects wound healing, and a dose of 100 μg of FGF-7 exhibited the most pronounced wound healing effect.</p><h3>Graphical abstract</h3><p>Increased wound recovery effect according to increased FGF-7 concentration in an in vivo wound model\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 5","pages":"655 - 665"},"PeriodicalIF":2.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advancements in polyethyleneimine (PEI)-grafted materials and composites as versatile adsorbents for water detoxification 聚乙烯亚胺（PEI）接枝材料及其复合材料的多用途水解毒吸附剂研究进展

IF 2.8 4区工程技术

Macromolecular Research Pub Date : 2025-01-08 DOI: 10.1007/s13233-024-00356-5

Shambhuraj A. Kapase, Pranoti H. Patil, Sushilkumar A. Jadhav

{"title":"Recent advancements in polyethyleneimine (PEI)-grafted materials and composites as versatile adsorbents for water detoxification","authors":"Shambhuraj A. Kapase, Pranoti H. Patil, Sushilkumar A. Jadhav","doi":"10.1007/s13233-024-00356-5","DOIUrl":"10.1007/s13233-024-00356-5","url":null,"abstract":"<div><p>The linear and branched polyethyleneimine (PEI)-based materials have shown their potential applications in various fields including water purification technologies. Due to several primary, secondary, and tertiary amine groups in their structure, PEIs as such and PEI-based copolymers, hybrid materials, and nanocomposites are capable of entrapment or adsorption of contaminants from different categories such as dyes, heavy metal ions, pharmaceuticals, and oils. The latest interesting reports in the literature about PEIs-based materials have proved the continued interest and significant advancements in these materials for developing new and highly efficient adsorbents. This review provides important basic information about PEI and its structure, a glimpse of its various applications, and, collective information with an analysis of the latest works on PEI-based materials developed to be used as adsorbents for the adsorption removal of pollutants from water. The latest advancements are discussed with the main results while the interesting data about types of materials developed, pH, adsorption time, etc. is reported in tabular format. The report concludes with the study’s main findings and future prospectus regarding synthetic polymer chemistry challenges in PEIs and PEI-based materials.</p><h3>Graphical abstract</h3><p>Schematic representation of the adsorption of various pollutants onto linear and branched polyethylenimine (PEI). </p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 3","pages":"249 - 270"},"PeriodicalIF":2.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyacrylamide-based nanocomposite hydrogel prepared by synergistic solar light-induced polymerization 太阳能光诱导协同聚合制备聚丙烯酰胺基纳米复合水凝胶

IF 2.8 4区工程技术

Macromolecular Research Pub Date : 2025-01-08 DOI: 10.1007/s13233-024-00344-9

Nery M. Aguilar, Brenda L. Sanchez-Gaytan, Guillermo Soriano-Moro

引用次数: 0

Effect of glyoxal concentration and nanoparticles reinforcement on the functional properties of composite hydrogel for biomedical applications 乙二醛浓度和纳米颗粒增强对生物医用复合水凝胶功能性能的影响

IF 2.8 4区工程技术

Macromolecular Research Pub Date : 2025-01-08 DOI: 10.1007/s13233-024-00361-8

Devara Venkata Krishna, Mamilla Ravi Sankar, Thopireddy Nagendra Reddy

{"title":"Effect of glyoxal concentration and nanoparticles reinforcement on the functional properties of composite hydrogel for biomedical applications","authors":"Devara Venkata Krishna, Mamilla Ravi Sankar, Thopireddy Nagendra Reddy","doi":"10.1007/s13233-024-00361-8","DOIUrl":"10.1007/s13233-024-00361-8","url":null,"abstract":"<div><p>Hydrogels are widely used in tissue engineering applications due to their supportive structure to the proliferation of cells. In recent years, much work has gone into improving these hydrogels’ mechanical qualities using various combinations of natural and synthetic polymer types, adjusting the molecular cross-linking type, and combining these techniques to create interpenetrating polymer network hydrogels. The present study investigates the preparation of composite hydrogels from polyvinyl alcohol (PVA), gelatin (GLTN), and guar gum (GG) supplemented with copper nanoparticles. The composite hydrogels’ static and dynamic mechanical behavior were tested by considering the effect of cross-linking density. The increased cross-linking density enhances storage modulus and tensile strength. <i>G</i><sup>′</sup> upsurges from 69.298 to 87.289 kPa at 628 rad/s. With the incorporation of the CuNPs, further enhancement of 28.211 kPa was observed in the <i>G</i><sup>′</sup> at the 628 rad/s. Hydrogel with a higher amount of glyoxal and copper nanoparticles exhibited the lowest creep deformation of 0.49%, and the amount of stress relaxed by the hydrogels within the timeframe was 42.28%. An increase in the tensile strength of ~ 31.58 kPa was perceived for the CMH4 compared with the CMH1 due to decreased porosity by 11.79% with the combined effect of glyoxal concentration and nanoparticle reinforcement. All the developed composite hydrogels exhibited better blood compatibility, antibacterial, pH, and thermo-sensitive swelling behavior.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div><div><p>Schematic representation of key research insights involved in the current work</p></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 5","pages":"569 - 592"},"PeriodicalIF":2.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of shear yield stress and apparent viscosity of xanthan gum solutions: application of rheological models and analytical study 黄原胶溶液的剪切屈服应力和表观粘度的评价：流变模型的应用和分析研究

IF 2.8 4区工程技术

Macromolecular Research Pub Date : 2024-12-24 DOI: 10.1007/s13233-024-00346-7

Kaci Chalah, Dalila Hammiche, Imed Bennnoui, Abdelbaki Benmounah

{"title":"Evaluation of shear yield stress and apparent viscosity of xanthan gum solutions: application of rheological models and analytical study","authors":"Kaci Chalah, Dalila Hammiche, Imed Bennnoui, Abdelbaki Benmounah","doi":"10.1007/s13233-024-00346-7","DOIUrl":"10.1007/s13233-024-00346-7","url":null,"abstract":"<div><p>The use of xanthan gum (XG) in various fields is of significant interest due to its exceptional rheological properties, including viscosity, yield stress, and thixotropy. This article reports on the dependencies of steady shear stress and apparent viscosity on both shear rate and XG concentration based on experimentally obtained data using continuous shear. Three plastic models are used to analyze steady shear flow behavior and estimate yield stress. Additionally, the apparent viscosity is thoroughly discussed using the Ostwald–de Waele model. The results indicate that the aqueous XG solutions showed viscoplastic behavior. It was found that the experimental data fit better with the Herschel–Bulkley model, with high correlation coefficient (<i>R</i><sup>2</sup> ˃ 0.909). XG concentration did not have a significant effect on apparent viscosity at high shear rates, ranging from 300 to 700 1/s. A mathematical model was developed to assess yield stress across a wide range of XG concentrations, from 0.01 to 4 wt%. Furthermore, a multiple regression model was created to evaluate the apparent viscosity as a function of XG concentration (ranging from 0.025 to 3 wt%) and shear rate.</p><h3>Graphic Abstract</h3><p>The apparent viscosity and yield stress of xanthan gum solutions were deeply investigated.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 4","pages":"423 - 437"},"PeriodicalIF":2.8,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile, reproducible, and high-throughput production of human dermal fibroblast spheroids 人类真皮成纤维细胞球体的快速、可重复和高通量生产

IF 2.8 4区工程技术

Macromolecular Research Pub Date : 2024-12-13 DOI: 10.1007/s13233-024-00348-5

A. Aslihan Gokaltun

{"title":"Facile, reproducible, and high-throughput production of human dermal fibroblast spheroids","authors":"A. Aslihan Gokaltun","doi":"10.1007/s13233-024-00348-5","DOIUrl":"10.1007/s13233-024-00348-5","url":null,"abstract":"<div><p>Spheroids offer a three-dimensional environment that more closely mimics physiologic conditions than traditional two-dimensional cultures. However, conventional spheroid formation methods are often time-consuming, labor-intensive, and struggle to produce high-throughput and uniform-sized spheroids. This work demonstrated an efficient, high-throughput method for generating human dermal fibroblast (HDF) spheroids (up to 1,200 spheroids/well) within 24 h using AggreWell™ plates. Spheroid formation was evaluated over 14 days using two initial seeding densities (100 and 300 cells per microwell). Larger spheroids, ranging from 127–142 µm in diameter, were observed with the higher seeding density, compared to 88–108 µm at the lower seeding density. The spheroids exhibited consistent and uniform size distributions, with a coefficient of variation under 11% on day 1 for both conditions. Key morphological parameters, including perimeter, circularity, spheroid area, and aspect ratio, were assessed on days 1, 7, and 14, revealing stable values, with circularity and aspect ratio remaining above 0.86 and 0.90, respectively. Cell viability exceeded 90% by day 7 and remained above 85% on day 14 for both seeding densities. These results highlight the scalability and reproducibility of HDF spheroid formation for drug screening, tissue engineering, and regenerative medicine.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 3","pages":"355 - 366"},"PeriodicalIF":2.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical sensor for the detection of mercury in seawater using carbon dots–carboxymethyl chitosan hydrogel 碳点-羧甲基壳聚糖水凝胶电化学传感器检测海水中汞

IF 2.8 4区工程技术

Macromolecular Research Pub Date : 2024-12-13 DOI: 10.1007/s13233-024-00354-7

S. Arundhathi, R. Gopika, P. Muhamed Ashraf, P. K. Binsi

{"title":"Electrochemical sensor for the detection of mercury in seawater using carbon dots–carboxymethyl chitosan hydrogel","authors":"S. Arundhathi, R. Gopika, P. Muhamed Ashraf, P. K. Binsi","doi":"10.1007/s13233-024-00354-7","DOIUrl":"10.1007/s13233-024-00354-7","url":null,"abstract":"<p>The study aimed to develop a rapid electrochemical sensor for selective sensing of mercury ions in saline environments to ensure the safety of aquatic life and human consumption. A sulfopropyl methacrylate-based hydrogel composite, synthesised by incorporating carbon dot derived from fish skin and carboxy methyl chitosan (CMCS), was used as sensing probe for mercury in aquatic environments with varying salinity. The synthesized composite was formed by interacting the carbon dot with CMCS hydrogel through C–N, conjugated C=C double bonds, and carboxyl groups, as evidenced by Fourier transform infrared spectroscopy. Electrochemical sensing through cyclic voltammetry and electrochemical impedance spectroscopy of varied concentrations of Hg<sup>2+</sup> exhibited excellent linear relationships between concentration and current/ real or imaginary impedance. The Hg<sup>2+</sup> interacted with the amino, hydroxyl, and sulfhydryl groups of the hydrogel composite, leading to significant structural changes or bond shifts, which resulted in a strong current signal. An excellent sensing response was demonstrated at varied salinity levels, including natural seawater, as well as with the use of interdigitated electrodes. The sensor is capable of detecting low concentrations of mercury in water under varying salinity conditions, making it suitable for applications in marine and aquaculture environments.</p><p>Synthesis of carbon dot-carboxy methyl chitosan mercury sensor </p>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 5","pages":"611 - 623"},"PeriodicalIF":2.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimized activated carbon pellets for effective cobalt ion adsorption 用于有效吸附钴离子的优化活性炭颗粒

IF 2.8 4区工程技术

Macromolecular Research Pub Date : 2024-12-13 DOI: 10.1007/s13233-024-00340-z

Minji Park, Yeonjin Lee, Jaehyeok Kyung, Chang-Min Yoon, Seulki Song

{"title":"Optimized activated carbon pellets for effective cobalt ion adsorption","authors":"Minji Park, Yeonjin Lee, Jaehyeok Kyung, Chang-Min Yoon, Seulki Song","doi":"10.1007/s13233-024-00340-z","DOIUrl":"10.1007/s13233-024-00340-z","url":null,"abstract":"<div><p>Technologies for treating and removing the radioactive element cobalt, released during nuclear decommissioning, are necessary to address the health risks it poses to humans. A pelletized activated carbon material is considered the best option for effectively eliminating dissolved cobalt in water, addressing the physical constraints of traditional activated carbon. This study involved producing optimized activated carbon pellets by combining activated carbon with a polymer binder and a triethylenediamine (TEDA) attachment agent. The activated carbon pellets incorporating the TEDA attachment agent and polymer binder were used as adsorbents to observe the Co<sup>2+</sup> adsorption characteristics based on attachment concentration, leading to the development of a combination of pellets with optimized adsorption capacity. It was confirmed that the C–N amine functional groups introduced by TEDA help to enhance interactions within the chemical adsorption environment with Co<sup>2+</sup> ions. In experiments, the removal rates were 99.1% and 93.4% for AC@PU@0.2T with 20 wt% TEDA when treating Co<sup>2+</sup> concentrations of 50 and 100 mg L<sup>−1</sup>, respectively. It was confirmed that the pores inside the activated carbon were significantly reduced during the pelletization process, and high adsorption performance was maintained even after pelletization due to the chemical adsorption ability of TEDA added at the optimal ratio. It was identified that both physical and chemical adsorption mechanisms operate simultaneously, allowing effective adsorption of Co<sup>2+</sup> ions while maintaining the physical properties of the pellets.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 4","pages":"523 - 531"},"PeriodicalIF":2.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping the photocurrent and photovoltage of hybrid perovskite thin films under concentrated sunlight 聚光条件下杂化钙钛矿薄膜的光电流和光电压映射

IF 2.8 4区工程技术

Macromolecular Research Pub Date : 2024-12-13 DOI: 10.1007/s13233-024-00349-4

Chandra Shakher Pathak

引用次数: 0

Unveiling novel grub-style pentacene crystals driven by hierarchical self-assembled crystallization 揭示由分层自组装结晶驱动的新型蛴螬型并五苯晶体

IF 2.8 4区工程技术

Macromolecular Research Pub Date : 2024-12-13 DOI: 10.1007/s13233-024-00355-6

Jungyoon Seo, Taehoon Hwang, Jisu Park, Yumin Kim, Hwa Sung Lee

{"title":"Unveiling novel grub-style pentacene crystals driven by hierarchical self-assembled crystallization","authors":"Jungyoon Seo, Taehoon Hwang, Jisu Park, Yumin Kim, Hwa Sung Lee","doi":"10.1007/s13233-024-00355-6","DOIUrl":"10.1007/s13233-024-00355-6","url":null,"abstract":"<div><p>Organic–semiconductor-based electronic devices have become a pivotal area of research, particularly owing to their promising applications in cost-effective and flexible electronics. Refinement of the crystalline structure of organic semiconductors is one of the most important strategies for improving device performance. Herein, we aim to expand our knowledge of single-crystalline organic semiconductors and elucidate the crystallization mechanism and growth dynamics of novel grub-shaped pentacene single crystals synthesized via a solvent-assisted drying technique. These crystals exhibit a unique grub-like morphology, distinct from the planar or ribbon-like structures typically reported for high-solubility organic semiconductors. The findings reveal that pentacene molecules, self-assembled through <i>π</i>–<i>π</i> interactions, form numerous small sub-grub crystals, which subsequently coalesce into larger, well-defined crystals. This hypothesis was supported by the presence of a hierarchical structure combined with sub-grub-like crystals on the grub-shaped pentacene crystal surface. Electrical evaluations demonstrated substantial current densities in the low-drain-voltage regime, underscoring the potential of these crystals for advanced organic electronic applications. This study offers significant insight into the unique crystallization behavior of low-solubility organic semiconductors and highlights their potential for use in high-performance electronics.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":688,"journal":{"name":"Macromolecular Research","volume":"33 5","pages":"625 - 631"},"PeriodicalIF":2.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0