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Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry最新文献

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Electrochemical reduction of a 5H-2,3-benzodiazepine. 5h -2,3-苯二氮卓类化合物的电化学还原。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1988-01-01 DOI: 10.3891/acta.chem.scand.42b-0052
R Fuhlendorff, H Lund
{"title":"Electrochemical reduction of a 5H-2,3-benzodiazepine.","authors":"R Fuhlendorff, H Lund","doi":"10.3891/acta.chem.scand.42b-0052","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.42b-0052","url":null,"abstract":"","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"42 1","pages":"52-4"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14490033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
ATP-stimulated polymerase activity involving DNA polymerase I and a recB-dependent factor in extracts of Escherichia coli cells. 在大肠杆菌细胞提取物中，atp刺激的聚合酶活性涉及DNA聚合酶I和recb依赖因子。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-12-08 DOI: 10.1002/CHIN.198749349
J. Syväoja
{"title":"ATP-stimulated polymerase activity involving DNA polymerase I and a recB-dependent factor in extracts of Escherichia coli cells.","authors":"J. Syväoja","doi":"10.1002/CHIN.198749349","DOIUrl":"https://doi.org/10.1002/CHIN.198749349","url":null,"abstract":"ATP-stimulated DNA polymerase activity involving DNA polymerase I has been found to be present in cell extracts from wild type and recC mutant strains of Escherichia coli, but not in extracts from recB strain. The activity has been separated from recBC DNase by DEAE-cellulose ion exchange. It is suggested that recB-dependent factor is involved in the ATP-stimulation of polymerase. Evidence is provided that this stimulation may be due to the interaction of recB-dependent factor with DNA polymerase I.","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"1 1","pages":"332-5"},"PeriodicalIF":0.0,"publicationDate":"1987-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89046624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
An import factor in reticulocyte lysates which stimulates processing of several precursors destined for the rat liver mitochondrial inner membrane. 网状细胞裂解物中的一种重要因子，它刺激通往大鼠肝脏线粒体内膜的几种前体的加工。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-11-01 DOI: 10.3891/acta.chem.scand.41b-0770
V Joste, J M Berrez, N Latruffe, B D Nelson
{"title":"An import factor in reticulocyte lysates which stimulates processing of several precursors destined for the rat liver mitochondrial inner membrane.","authors":"V Joste, J M Berrez, N Latruffe, B D Nelson","doi":"10.3891/acta.chem.scand.41b-0770","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0770","url":null,"abstract":"","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 10","pages":"770-2"},"PeriodicalIF":0.0,"publicationDate":"1987-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14454802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Preparative electrochemical reduction of 2-amino-6-chloropurine and synthesis of 6-deoxyacyclovir, a fluorescent substrate of xanthine oxidase and a prodrug of acyclovir. 2-氨基-6-氯嘌呤的电化学还原制备及黄嘌呤氧化酶荧光底物和阿昔洛韦前药6-脱氧阿昔洛韦的合成。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-11-01 DOI: 10.3891/acta.chem.scand.41b-0701
J T Kusmierek, B Czochralska, N G Johansson, D Shugar
{"title":"Preparative electrochemical reduction of 2-amino-6-chloropurine and synthesis of 6-deoxyacyclovir, a fluorescent substrate of xanthine oxidase and a prodrug of acyclovir.","authors":"J T Kusmierek,&nbsp;B Czochralska,&nbsp;N G Johansson,&nbsp;D Shugar","doi":"10.3891/acta.chem.scand.41b-0701","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0701","url":null,"abstract":"<p><p>D.c. polarography of 2-amino-6-chloropurine in aqueous medium over a broad pH range revealed two diffusion waves, the first of which corresponds to reduction of the C(6)-Cl bond, leading to formation of 2-aminopurine in high yield. Condensation of the sodium salt of 2-aminopurine with (2-acetoxyethoxy)methyl chloride led to the two isomeric 9- and 7-(2-hydroxyethoxymethyl)-2-aminopurines. The 9- isomer, 6-deoxyacyclovir, a prodrug of acyclovir previously synthesized by another route, was readily converted to the latter by xanthine oxidase; the 7-isomer was not a substrate. The intense fluorescence of 6-deoxyacyclovir makes it a convenient fluorescent substrate for xanthine oxidase, although less sensitive than xanthine; it is shown that 2-aminopurine would be a very sensitive fluorescent substrate. The polarographic behaviour of the riboside of 2-amino-6-chloropurine was virtually identical with that of the parent purine, leading to a simple procedure for conversion of 2-amino-6-chloropurine nucleosides and acyclonucleosides to the corresponding 2-aminopurine congeners.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 10","pages":"701-7"},"PeriodicalIF":0.0,"publicationDate":"1987-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13970470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Polypeptide composition of human macrophage gelatinase. 人巨噬细胞明胶酶的多肽组成。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-11-01 DOI: 10.3891/acta.chem.scand.41b-0754
T Vartio, T Hovi
{"title":"Polypeptide composition of human macrophage gelatinase.","authors":"T Vartio,&nbsp;T Hovi","doi":"10.3891/acta.chem.scand.41b-0754","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0754","url":null,"abstract":"","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 10","pages":"754-6"},"PeriodicalIF":0.0,"publicationDate":"1987-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13970471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Effects of depolarizing agents and Na+-channel inhibitors on ligand binding to muscarinic receptors from rat cerebral cortex. 去极化剂和Na+通道抑制剂对大鼠大脑皮层毒蕈碱受体配体结合的影响。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-10-01 DOI: 10.3891/acta.chem.scand.41b-0686
B Hedlund
{"title":"Effects of depolarizing agents and Na+-channel inhibitors on ligand binding to muscarinic receptors from rat cerebral cortex.","authors":"B Hedlund","doi":"10.3891/acta.chem.scand.41b-0686","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0686","url":null,"abstract":"<p><p>In a vesicle preparation from rat cerebral cortex, carbachol recognizes a high-affinity and a low-affinity muscarinic agonist binding site. A number of agents, including veratridine (10 microM), gramicidin (10 microM) and valinomycin (10 microM), which depolarize the vesicles also appear to block the high-affinity muscarinic agonist binding site. Lowering [Na+] (from 137 to 80 mM) or raising [K+] (from 5 to 50 mM) produced effects similar to those of the depolarizing agents. Agents such as tetrodotoxin (1 microM), which block the Na+-channel, also appear to block the high-affinity agonist binding site or to convert it into a low-affinity agonist binding form.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 9","pages":"686-93"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13596714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Crystal and molecular structures of the isomeric dipeptides alpha-L-aspartyl-L-alanine and beta-L-aspartyl-L-alanine. - l-天冬氨酸- l-丙氨酸和- l-天冬氨酸- l-丙氨酸异构体二肽的晶体和分子结构。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-10-01 DOI: 10.3891/acta.chem.scand.41b-0679
C H Görbitz
{"title":"Crystal and molecular structures of the isomeric dipeptides alpha-L-aspartyl-L-alanine and beta-L-aspartyl-L-alanine.","authors":"C H Görbitz","doi":"10.3891/acta.chem.scand.41b-0679","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0679","url":null,"abstract":"<p><p>The crystal and molecular structures of the alpha- and beta-L-Asp isomers of L-aspartyl-L-alanine have been determined at 120 K using 1226 and 1609 reflections (I greater than 2.5 sigma I), respectively. The space group for the alpha-isomer is P2(1), with cell parameters a = 4.788(1), b = 16.943(4), c = 5.807(1) A and beta = 107.55(2) degrees; final R factor 0.042. The space group for the beta-isomer is P2(1)2(1)2(1) with a = 4.845(1), b = 9.409(2) and c = 19.170(3) A; final R-factor 0.047. The two peptides crystallize as zwitterions with the side-chain acidic groups ionized. Each molecule adopts a trans configuration at the peptide bond with both carboxyl groups situated on the same side of the peptide plane. The geometries of the aspartyl moieties do, however, differ in the two structures. The peptide bond is significantly longer in the beta-isomer than in the alpha-isomer, with C-N 1.344(3) and 1.328(4) A, respectively. A very short intermolecular carboxyl...carboxyl hydrogen bond (O...O = 2.502(4) A) is observed in the crystals of the alpha-isomer.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 9","pages":"679-85"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14566854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
The substrate specificity of the enzyme amyloglucosidase (AMG). Part I. Deoxy derivatives. 淀粉糖苷酶(amyloglucosidase, AMG)的底物特异性。第一部分:脱氧衍生物。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-09-01 DOI: 10.3891/acta.chem.scand.41b-0617
K Bock, H Pedersen
{"title":"The substrate specificity of the enzyme amyloglucosidase (AMG). Part I. Deoxy derivatives.","authors":"K Bock,&nbsp;H Pedersen","doi":"10.3891/acta.chem.scand.41b-0617","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0617","url":null,"abstract":"<p><p>The eight possible monodeoxy derivatives of methyl beta-maltoside and two bisdeoxy derivatives have been synthesized. The unprotected glycosides have all been investigated by NMR (1H and 13C) spectroscopy in order to confirm their structures and to obtain supporting information about their preferred solution conformations. The compounds have all been tested as substrates toward the hydrolase, amyloglucosidase (AMG) and it has been demonstrated that three hydroxy groups (3, 4' and 6') are essential for the compounds to act as substrate for the enzyme. The kinetic parameters KM (Michaelis-Menten constant) and VM (maximum rate for the reaction) have been determined using 1H NMR spectroscopy at 500 MHz.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 8","pages":"617-28"},"PeriodicalIF":0.0,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14252850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Active site ionizations of papaya proteinase A. 木瓜蛋白酶A的活性位点电离。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-09-01 DOI: 10.3891/acta.chem.scand.41b-0629
N C Kaarsholm
{"title":"Active site ionizations of papaya proteinase A.","authors":"N C Kaarsholm","doi":"10.3891/acta.chem.scand.41b-0629","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0629","url":null,"abstract":"","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 8","pages":"629-32"},"PeriodicalIF":0.0,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14548076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Crystal structure of a 1,4-dihydropyridine with enantiomers showing opposite effects on calcium channels: structural features of calcium channel agonists and antagonists. 对钙通道具有相反作用的1,4-二氢吡啶及其对映体的晶体结构:钙通道激动剂和拮抗剂的结构特征。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-09-01 DOI: 10.3891/acta.chem.scand.41b-0581
R Fossheim
{"title":"Crystal structure of a 1,4-dihydropyridine with enantiomers showing opposite effects on calcium channels: structural features of calcium channel agonists and antagonists.","authors":"R Fossheim","doi":"10.3891/acta.chem.scand.41b-0581","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0581","url":null,"abstract":"<p><p>The structure of the calcium channel modulator isopropyl 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-5-nitro- 3-pyridinecarboxylate has been determined by X-ray analysis. Structural and stereochemical features are discussed in relation to previously determined structures of calcium agonists and antagonists of the 1,4-dihydropyridine type, and in relation to a newly proposed model for the dihydropyridine binding site.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 8","pages":"581-8"},"PeriodicalIF":0.0,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13592658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
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