Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry最新文献_第4页

The pKa and pH dependence of the formation of nitroxide radicals from some drug substances with an aliphatic secondary amino group by oxidation with hydrogen peroxide. An Electron Spin Resonance (ESR) Study. 一些含有脂肪族仲氨基的原料药在过氧化氢氧化作用下生成一氧化氮自由基的pKa和pH依赖性。电子自旋共振(ESR)研究。

Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-08-01 DOI: 10.3891/acta.chem.scand.41b-0526

C Lagercrantz

{"title":"The pKa and pH dependence of the formation of nitroxide radicals from some drug substances with an aliphatic secondary amino group by oxidation with hydrogen peroxide. An Electron Spin Resonance (ESR) Study.","authors":"C Lagercrantz","doi":"10.3891/acta.chem.scand.41b-0526","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0526","url":null,"abstract":"The pKa and pH dependence of the formation of nitroxide radicals from the following drugs that contain an aliphatic secondary amino group, by oxidation with hydrogen peroxide, have been studied by ESR spectroscopy: Ephedrine, (1R,2S)-1-phenyl-2-methyl-aminopropanol, timolol, (S)-1-(tert-butyl-amino)-3-[(4-morpholino-1,2,3-thiadiazol-3-yl)ox y]-2- propanol, metoprolol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol and terodiline, N-tert-butyl-3,3-diphenyl-1-methylpropylamine. Radicals were formed from the non-ionized base only. Therefore, the pKa value of the amine and the pH of the reaction mixture is of crucial importance for the yield of nitroxide radical. At 37 degrees C the pKa values of 1-3 are about 9.2, and of 4 about 9.6, which means that 1.5% of 1-3, and 0.6% of 4, are present in the reactive base form at the physiological pH of 7.4. Horse-radish peroxidase was found both to enhance radical production and to decrease the life-time of the radicals formed in the reaction with hydrogen peroxide.","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 7","pages":"526-35"},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13967499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Asymmetric synthesis of L-2-amino[3-11C]butyric acid, L-[3-11C]norvaline and L-[3-11C]valine. L-2-氨基[3-11C]丁酸、L-[3-11C]正缬氨酸和L-[3-11C]缬氨酸的不对称合成。

Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-08-01 DOI: 10.3891/acta.chem.scand.41b-0511

G Antoni, B Långström

引用次数: 17

Solid phase synthesis of a 31-residue fragment of human glucose-dependent insulinotropic polypeptide (GIP) by the continuous flow polyamide method. 连续流聚酰胺法固相合成人葡萄糖依赖性胰岛素多肽(GIP) 31残基片段。

Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-08-01 DOI: 10.3891/acta.chem.scand.41b-0494

M Carlquist

引用次数: 9

The effects of DNA polymerase I and nucleotides on ligation of hydrogen-bonded lambda DNA circles by Escherichia coli DNA ligase. DNA聚合酶I和核苷酸对大肠杆菌DNA连接酶连接氢键λ DNA环的影响。

Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-08-01 DOI: 10.3891/acta.chem.scand.41b-0551

J E Syväoja

引用次数: 1

Anion effects on the kinetics of yeast phosphoglycerate kinase. 阴离子对酵母磷酸甘油酸激酶动力学的影响。

Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-05-01 DOI: 10.3891/acta.chem.scand.41b-0348

M M Khamis, M Larsson-Raźnikiewicz

{"title":"Anion effects on the kinetics of yeast phosphoglycerate kinase.","authors":"M M Khamis, M Larsson-Raźnikiewicz","doi":"10.3891/acta.chem.scand.41b-0348","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0348","url":null,"abstract":"(A) The effects of phosphate, chloride, nitrate, pyruvate, malate, succinate and glutamate ions on the kinetics of yeast phosphoglycerate kinase (ATP: 3-phospho-D-glycerate 1-phosphotransferase, EC 2.7.2.3) were studied with MgATP2- and 3-P-glycerate as variable substrates. Three types of patterns were obtained: (1) Nitrate, succinate, malate and glutamate ions, strictly noncompetitive versus both the substrates. (2) Phosphate and chloride ions, noncompetitive versus MgATP2- and mixed versus 3-P-glycerate. (3) Pyruvate ions, being very weak inhibitors, competitive with MgATP2- and noncompetitive with 3-P-glycerate. (B) Based on experiments with simultaneous inhibition by various combinations of two anions the following suggestions were made: The type 1 anions presumably bind to a site outside the active centre. These ions appear to bind to the enzyme independently of type 2. The latter also appears to include sulfate ions, which are competitive versus both the substrates as well as versus the phosphate and chloride ions. Sulfate and phosphate ions are electronically similar, but show different inhibition patterns, presumably due to various effects on the protein conformation. Type 3 inhibition exerted by pyruvate ions was shown earlier for 1-anilino-8-naphthalenesulfonate and salicylate ions, but as these two anions are supposed to bind to the adenine binding pocket of the catalytic centre, the results indicate that pyruvate ions might preferably compete with the nucleotide substrate for the polyphosphate binding site.","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 5","pages":"348-55"},"PeriodicalIF":0.0,"publicationDate":"1987-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14442532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Syntheses of (S)-(+)-trihexyphenidyl hydrochloride and (S)-(+)-procyclidine hydrochloride, two anticholinergics, using (S)-(-)-3-cyclohexyl-3-hydroxy-3-phenylpropanoic acid as chiral synthon. 以(S)-(-)-3-环己基-3-羟基-3-苯基丙烷酸为手性合成两种抗胆碱能药物(S)-(+)-三己苯基盐酸盐和(S)-(+)-丙环吡啶盐酸盐。

Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-05-01 DOI: 10.3891/acta.chem.scand.41b-0356

L Schjelderup, O Harbitz, P Groth, A J Aasen

引用次数: 7

ATP-stimulated polymerase activity involving DNA polymerase I and a recB-dependent factor in extracts of Escherichia coli cells. 在大肠杆菌细胞提取物中，atp刺激的聚合酶活性涉及DNA聚合酶I和recb依赖因子。

Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-05-01 DOI: 10.3891/acta.chem.scand.41b-0332

J E Syväoja

引用次数: 3

Animal carotenoids. 31. Structure elucidation of a sponge metabolite via mesylate elimination. 动物的类胡萝卜素。31. 海绵代谢物甲磺酸消除的结构解析。

Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-04-01 DOI: 10.3891/acta.chem.scand.41b-0245

H R Sliwka, O W Nøkleby, S Liaaen-Jensen

引用次数: 5

Modulation of the substrate specificity of purified human protein kinase C by its activators. 纯化的人蛋白激酶C的激活剂对底物特异性的调节。

Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-03-01 DOI: 10.3891/acta.chem.scand.41b-0174

A Hansson, M Ingelman-Sundberg

引用次数: 4

Kinetic resolution in the oxidation of iminium ion to lactam catalysed by aldehyde oxidase. 醛氧化酶催化亚胺离子氧化制内酰胺的动力学分解。

Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-03-01 DOI: 10.3891/acta.chem.scand.41b-0198

J Bielawski, S Brandänge, B Rodriguez

引用次数: 4