Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry最新文献

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Determination of thermodynamic constants for agonist binding to muscarinic receptors from rat cerebral cortex. 激动剂与大鼠大脑皮层毒蕈碱受体结合的热力学常数测定。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-03-01 DOI: 10.3891/acta.chem.scand.41b-0225
B Hedlund, T Bartfai
{"title":"Determination of thermodynamic constants for agonist binding to muscarinic receptors from rat cerebral cortex.","authors":"B Hedlund, T Bartfai","doi":"10.3891/acta.chem.scand.41b-0225","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0225","url":null,"abstract":"","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 3","pages":"225-7"},"PeriodicalIF":0.0,"publicationDate":"1987-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14751562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Crystal and molecular structure of aspartame X HCl X 2H2O. 阿斯巴甜X HCl X 2H2O的晶体和分子结构。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-02-01 DOI: 10.3891/acta.chem.scand.41b-0087
C H Görbitz
{"title":"Crystal and molecular structure of aspartame X HCl X 2H2O.","authors":"C H Görbitz","doi":"10.3891/acta.chem.scand.41b-0087","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0087","url":null,"abstract":"<p><p>The crystal and molecular structure of the hydrochloride salt of the peptide sweetener aspartame (alpha-L-Asp-L-Phe methyl ester) has been determined at 120 K using 3877 reflections with I greater than 2.5 sigma I. Space group P2(1)2(1)2(1), cell dimensions a = 6.768(1), b = 9.796(1) and c = 26.520(3) A; final R factor 0.033. While the N-terminal L-Asp group in the structure of aspartame itself forms a six-membered ring with an intramolecular hydrogen bond between the carboxylate and the protonated amino terminus, the corresponding group in the hydrochloride adopts a completely different conformation with a weak intramolecular hydrogen bond between the carboxyl group and the N atom of the L-Phe residue. The L-Phe methyl ester moiety is rather similar in the two structures. Of the many possible conformations of aspartame, only one may be expected to function as a substrate at the receptor site for sweet taste, and a proposal is made for this active conformation.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 2","pages":"87-92"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14726949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Similarities between soluble inorganic pyrophosphatase from yeast and some nucleotide-binding polypeptides. 酵母菌可溶性无机焦磷酸酶与某些核苷酸结合多肽的相似性。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-02-01 DOI: 10.3891/acta.chem.scand.41b-0106
H Baltscheffsky, M Alauddin, G Falk, M Lundin
{"title":"Similarities between soluble inorganic pyrophosphatase from yeast and some nucleotide-binding polypeptides.","authors":"H Baltscheffsky,&nbsp;M Alauddin,&nbsp;G Falk,&nbsp;M Lundin","doi":"10.3891/acta.chem.scand.41b-0106","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0106","url":null,"abstract":"","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 2","pages":"106-7"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14170074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Age-dependent changes in the levels of dolichol and dolichyl phosphates in human brain. 人类大脑中多酚和多酚磷酸酯水平的年龄依赖性变化。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-02-01 DOI: 10.3891/acta.chem.scand.41b-0144
M Andersson, E L Appelkvist, K Kristensson, G Dallner
{"title":"Age-dependent changes in the levels of dolichol and dolichyl phosphates in human brain.","authors":"M Andersson,&nbsp;E L Appelkvist,&nbsp;K Kristensson,&nbsp;G Dallner","doi":"10.3891/acta.chem.scand.41b-0144","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0144","url":null,"abstract":"","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 2","pages":"144-6"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14726947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Non-respiring rat liver mitochondria do not have a Ca2+/2H+ antiporter. 非呼吸大鼠肝脏线粒体不具有Ca2+/2H+反转运蛋白。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-02-01 DOI: 10.3891/acta.chem.scand.41b-0079
N E Saris
{"title":"Non-respiring rat liver mitochondria do not have a Ca2+/2H+ antiporter.","authors":"N E Saris","doi":"10.3891/acta.chem.scand.41b-0079","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0079","url":null,"abstract":"<p><p>Liver mitochondria take up Ca2+ by the Ca2+ uniporter, whereas at steady state efflux is believed to occur mainly by means of a ruthenium red-insensitive Ca2+/2H+ antiporter. The latter activity was studied in respiration-inhibited mitochondria in the presence of ruthenium red and was measured as Ca2+ uptake following acidification of the matrix by addition of nigericin, which catalyzes K+/H+ exchange. Ca2+ uptake was stimulated by protonophorous uncoupling agents and inhibited by increasing the concentration of ruthenium red. However, the rates were always smaller than those obtained by addition of valinomycin instead of nigericin. This indicates that under these conditions, Ca2+ fluxes are not mediated by a Ca2+/2H+ antiporter but by residual uniporter activity.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 2","pages":"79-82"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14726948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Biosynthesis of ubiquinone in rat liver. 大鼠肝脏中泛醌的生物合成。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-01-01 DOI: 10.3891/acta.chem.scand.41b-0070
A Kalén, E L Appelkvist, G Dallner
{"title":"Biosynthesis of ubiquinone in rat liver.","authors":"A Kalén,&nbsp;E L Appelkvist,&nbsp;G Dallner","doi":"10.3891/acta.chem.scand.41b-0070","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0070","url":null,"abstract":"","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 1","pages":"70-2"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14700238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Dolichol biosynthesis in rat liver peroxisomes. 大鼠肝脏过氧化物酶体的醇类生物合成。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-01-01 DOI: 10.3891/acta.chem.scand.41b-0073
E L Appelkvist
{"title":"Dolichol biosynthesis in rat liver peroxisomes.","authors":"E L Appelkvist","doi":"10.3891/acta.chem.scand.41b-0073","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0073","url":null,"abstract":"","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 1","pages":"73-5"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14238485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Biosynthesis of sterols and dolichol in human hepatomas. 人肝癌中甾醇和醇的生物合成。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1987-01-01 DOI: 10.3891/acta.chem.scand.41b-0067
I Eggens
{"title":"Biosynthesis of sterols and dolichol in human hepatomas.","authors":"I Eggens","doi":"10.3891/acta.chem.scand.41b-0067","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.41b-0067","url":null,"abstract":"","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"41 1","pages":"67-9"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14166689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Synthesis of O2'-methyluridine, O2'-methylcytidine, N4,O2'-dimethylcytidine and N4,N4,O2'-trimethylcytidine from a common intermediate. 共同中间体合成O2′-甲基尿苷、O2′-甲基胞苷、N4,O2′-二甲基胞苷和N4,N4,O2′-三甲基胞苷。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1986-11-01 DOI: 10.3891/acta.chem.scand.40b-0826
A Nyilas, J Chattopadhyaya
{"title":"Synthesis of O2'-methyluridine, O2'-methylcytidine, N4,O2'-dimethylcytidine and N4,N4,O2'-trimethylcytidine from a common intermediate.","authors":"A Nyilas,&nbsp;J Chattopadhyaya","doi":"10.3891/acta.chem.scand.40b-0826","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.40b-0826","url":null,"abstract":"<p><p>A facile synthesis of the title compounds from a readily accessible precursor, 3',5'-O-bis-protected O4-(2-nitrophenyl)uridine, is described.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"40 10","pages":"826-30"},"PeriodicalIF":0.0,"publicationDate":"1986-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14687264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Synthesis of an mRNA fragment of alanyl-tRNA synthetase gene in Escherichia coli using the 6-methyl-3-pyridyl group for protection of the imide functions of uridine and guanosine. 利用6-甲基-3-吡啶基在大肠杆菌中合成丙氨酰trna合成酶基因mRNA片段,保护尿苷和鸟苷的亚胺功能。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1986-11-01 DOI: 10.3891/acta.chem.scand.40b-0817
C J Welch, X X Zhou, J Chattopadhyaya
{"title":"Synthesis of an mRNA fragment of alanyl-tRNA synthetase gene in Escherichia coli using the 6-methyl-3-pyridyl group for protection of the imide functions of uridine and guanosine.","authors":"C J Welch,&nbsp;X X Zhou,&nbsp;J Chattopadhyaya","doi":"10.3891/acta.chem.scand.40b-0817","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.40b-0817","url":null,"abstract":"<p><p>The synthesis of 5'-GpGpUpGpU-3' is reported to demonstrate the synthetic use of the 6-methyl-3-pyridyl group for the protection of the O-4 and O-6 imide functions of uridine and guanosine, respectively. The 2'- and 5'-hydroxyl functions of the key intermediates were protected with two acid-labile groups: 3-methoxy-1,5-dicarbomethoxypentane-3-yl (MDMP) and 9-(4-octadecyloxyphenyl)xanthen-9-yl (C18Px), respectively. The internucleotide phosphotriesters were protected with 2-chlorophenyl and the 9-fluorenylmethyl group was employed for 3'-terminal phosphate protection.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"40 10","pages":"817-25"},"PeriodicalIF":0.0,"publicationDate":"1986-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13583069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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