Thanh Nguyen-Duc, He Zhao, Jianfei Cai, Dinh Q. Phung
{"title":"MED-TEX: Transfer and Explain Knowledge with Less Data from Pretrained Medical Imaging Models","authors":"Thanh Nguyen-Duc, He Zhao, Jianfei Cai, Dinh Q. Phung","doi":"10.1109/ISBI52829.2022.9761709","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761709","url":null,"abstract":"Deep learning methods usually require a large amount of training data and lack interpretability. In this paper, we pro-pose a novel knowledge distillation and model interpretation framework for medical image classification that jointly solves the above two issues. Specifically, to address the data-hungry issue, a small student model is learned with less data by distilling knowledge from a cumbersome pretrained teacher model. To interpret the teacher model and assist the learning of the student, an explainer module is introduced to highlight the regions of an input that are important for the predictions of the teacher model. Furthermore, the joint framework is trained by a principled way derived from the information-theoretic perspective. Our framework outperforms on the knowledge distillation and model interpretation tasks com-pared to state-of-the-art methods on a fundus dataset.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"53 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82166860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Neuropathological Hub Identification for Alzheimer’s Disease Via joint Analysis of Topological Structure and Neuropathological Burden","authors":"Defu Yang, Wenchao Li, Jingwen Zhang, Hui Shen, Minghan Chen, Wentao Zhu, Guorong Wu","doi":"10.1109/ISBI52829.2022.9761444","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761444","url":null,"abstract":"Mounting evidence shows that the neuropathological burden associated with Alzheimer’s disease spreads along the network pathway and is often selectively accumulated at certain critical hub regions, resulting in a higher level of amyloid burden than their topological neighbors. However, current approaches for hub identification only focus on the topological structure of brain networks without considering the spatial distribution pattern of neuropathological burden residing within networks. In this work, we proposed a novel method for identifying neuropathological hubs that integrates both the neuropathological and topological information of brain networks based on multimodal neuroimages, where the removal of hubs will result in a maximum decomposition in brain networks as well as a minimum variation in neuropathological burdens. Experimental results on real datasets demonstrated that regions identified as neuropathological hubs suffer a greater risk of neuropathological damage than those of conventional approaches, supporting the consensus distribution between hub nodes and neuropathological burdens.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"26 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84157157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manna E. Philip, Ana Ferrieira, Aishani Tomar, Sparsh Chawla, A. Welsh, G. Stevenson, A. Sowmya
{"title":"A Machine Learning Framework for Fully Automatic 3D Fetal Cardiac Ultrasound Evaluation","authors":"Manna E. Philip, Ana Ferrieira, Aishani Tomar, Sparsh Chawla, A. Welsh, G. Stevenson, A. Sowmya","doi":"10.1109/ISBI52829.2022.9761613","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761613","url":null,"abstract":"Fetal cardiac ultrasound (US) is an understudied but important area of medical image analysis. In this work, we identify sources of error and obstacles that may render artificial intelligence (AI) models ineffective in this particular setting. We then present an efficient AI segmentation pipeline for the fetal heart using raw 3D-US volume data with no prior processing. We applied our work on a dataset consisting of 30 3D-US volumes from 26 participants, acquired using 3 different probes on 2 different ultrasound machines. Using an appropriate data enhancement schema, performance of fetal cardiac segmentation improves using state-of-the-art deep learning (DL) methods. We obtained a 19% increase in the Dice Similarity Coefficient (DSC) for convolutional neural networks (CNN). A 16% increase was observed for transformer based networks. The machine learning framework focuses on the data rather than the method, and is able to achieve good performance in spite of the numerous variations in the dataset.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"100 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84636512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Multi-Scale Self-Attention Network to Discriminate Pulmonary Nodules","authors":"A. Moreno, A. Rueda, F. Martínez","doi":"10.1109/ISBI52829.2022.9761574","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761574","url":null,"abstract":"Lung cancer is the main cause of cancer-related deaths. Pulmonary nodules are the principal disease indicator, whose malignancy is mainly related with textural and geometrical patterns. Different computational alternatives have been proposed so far in the literature to support lung nodule characterization, however, they remain limited to properly capture the geometrical signatures that discriminate between each malignant class. This work introduces a multi-scale self-attention (MSA) network that accurately recovers geometrical and textural nodule maps. At each hierarchical level is recovered a set of saliency nodule maps that find non-local nodule correlations, properly representing radiological finding patterns. Validation was performed on the LICD-IDRI dataset, obtaining classification percentages that outperform the state of the art: 95.56% in accuracy, and 98.67% in AUC.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"31 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85482569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gasper Podobnik, B. Ibragimov, P. Strojan, P. Peterlin, T. Vrtovec
{"title":"Segmentation of Organs-At-Risk from Ct and Mr Images of the Head and Neck: Baseline Results","authors":"Gasper Podobnik, B. Ibragimov, P. Strojan, P. Peterlin, T. Vrtovec","doi":"10.1109/ISBI52829.2022.9761433","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761433","url":null,"abstract":"For the head and neck (HaN) cancer, radiotherapy is a mainstay treatment modality that aims to deliver a high radiation dose to the targeted cancerous cells while sparing the nearby healthy organs-at-risk (OARs). A precise three-dimensional segmentation of OARs from computed tomography (CT) images is required for optimal radiation dose distribution calculation, however, so far there has been no evaluation about the impact of the combined analysis of multiple imaging modalities, such as CT and magnetic resonance (MR). For this purpose, we have devised a database of 56 CT and MR images of the same patients with 31 manually delineated OARs, and in this paper we present the baseline segmentation results that were obtained by applying the nnU-Net framework. The resulting average Dice coefficient of 68% and average 95-percentile Hausdorff distance of 8.2mm on a subset of 14 images indicate that nnU-Net serves as a solid baseline method.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"82 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80546782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haorui He, Abhirup Banerjee, M. Beetz, R. Choudhury, V. Grau
{"title":"Semi-Supervised Coronary Vessels Segmentation from Invasive Coronary Angiography with Connectivity-Preserving Loss Function","authors":"Haorui He, Abhirup Banerjee, M. Beetz, R. Choudhury, V. Grau","doi":"10.1109/ISBI52829.2022.9761695","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761695","url":null,"abstract":"The segmentation of arteries in invasive coronary angiography is necessary to build quantitative models and eventually improve the diagnosis of cardiovascular diseases. Standard segmentation algorithms suffer due to the lack of fully annotated datasets and tend to return disconnected vessels. Thus, we explore a semi-supervised segmentation framework to address these issues. Specifically, we use a student model and a teacher model as the main framework with Nested U-Nets (UNet++) as their backbones. The student model learns by minimizing a segmentation loss between the output and the ground truth, and a consistency loss guided by the uncertainty information. Additionally, a special loss function based on elastic interaction is used to improve the connectivity of arterial branches. We demonstrate the effectiveness of our proposed techniques over 42 labeled and 60 unlabeled samples and find relative improvement of 5.59% for Dice score and 69.99% for Betti number compared to a U-Net.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"5 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83235078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Locally Structured Low-Rank MR Image Reconstruction using Submatrix Constraints","authors":"X. Chen, Wenchuan Wu, M. Chiew","doi":"10.1109/ISBI52829.2022.9761692","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761692","url":null,"abstract":"Image reconstruction methods based on structured low-rank matrix completion have drawn growing interest in magnetic resonance imaging. In this work, we propose a locally structured low-rank image reconstruction method which imposes low-rank constraints on submatrices of the Hankel structured k-space data matrix. Simulation experiments based on numerical phantoms and experimental data demonstrated that the proposed method achieves robust and significant improvements over the conventional, global structured low-rank methods across a variety of structured matrix constructions, sampling patterns and noise levels, at the cost of slower convergence speed only.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"55 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81482532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhiwen Wang, Bowen Li, Wenjun Xia, Chenyu Shen, Mingzheng Hou, Hu Chen, Y. Liu, Jiliu Zhou, Yi Zhang
{"title":"Leaders: Learnable Deep Radial Subsampling for Mri Reconstruction","authors":"Zhiwen Wang, Bowen Li, Wenjun Xia, Chenyu Shen, Mingzheng Hou, Hu Chen, Y. Liu, Jiliu Zhou, Yi Zhang","doi":"10.1109/ISBI52829.2022.9761544","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761544","url":null,"abstract":"Recently, deep learning approaches have shown great promise in learning MRI subsampling. The majority of existing works have focused on optimizing Cartesian or equipment-constrained Gaussian-like subsampling, ignoring the question of learning radial subsampling. This paper proposes a simple learnable radial subsampling technique for compressed sensing MRI. The proposed approach exploits a radial subsampling for direct estimation of all radial spokes’ weights from radial sampling space. The proposed Learnable Deep Radial Subsampling (LEADERS) method can be easily integrated with any deep learning-based reconstruction algorithm. This method can provide reliable estimates in a deep learning manner. The effectiveness of the generated radial subsampling patterns is verified on two deep learning-based reconstruction models, with a large-scale, publicly available brain MRI datasets for two downsampling factors (R = 4 and 8). The numerical and visual experiments demonstrate that the learned radial subsampling patterns can be applied for different deep learning reconstruction models with different subsampling rates, and shows more efficient and effective results than the ones reconstructed using existing handcrafted radial subsampling patterns.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"5 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87866312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cats: Complementary CNN and Transformer Encoders for Segmentation","authors":"Hao Li, Dewei Hu, Han Liu, Jiacheng Wang, I. Oguz","doi":"10.1109/ISBI52829.2022.9761596","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761596","url":null,"abstract":"Recently, deep learning methods have achieved state-of-the-art performance in many medical image segmentation tasks. Many of these are based on convolutional neural networks (CNNs). For such methods, the encoder is the key part for global and local information extraction from input images; the extracted features are then passed to the decoder for predicting the segmentations. In contrast, several recent works show a superior performance with the use of transformers, which can better model long-range spatial dependencies and capture low-level details. However, transformer as sole encoder underperforms for some tasks where it cannot efficiently replace the convolution based encoder. In this paper, we propose a model with double encoders for 3D biomedical image segmentation. Our model is a U-shaped CNN augmented with an independent transformer encoder. We fuse the information from the convolutional encoder and the transformer, and pass it to the decoder to obtain the results. We evaluate our methods on three public datasets from three different challenges: BTCV, MoDA and Decathlon. Compared to the state-of-theart models with and without transformers on each task, our proposed method obtains higher Dice scores across the board.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"15 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89004030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving the Detection of The Prostrate in Ultrasound Images Using Machine Learning Based Image Processing","authors":"Tao Peng, Yiyun Wu, Jing Cai","doi":"10.1109/ISBI52829.2022.9761639","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761639","url":null,"abstract":"This work aims to develop a method for accurate prostate segmentation in transrectal ultrasound (TRUS) images. However, accurate prostate segmentation remains a challenging task for many reasons, such as the missing/ambiguous boundary between the prostate and surrounding organs, the presence of shadow artifacts, and intra-prostate intensity heterogeneity. This work proposes a three-cascaded prostate segmentation framework, using only a few manually delineated points as a prior, including (1) an improved principal curve-based model is used to obtain the data sequences consisting of data points and projection indexes; (2) an improved differential evolution-based artificial neural network is used for training to decrease the model error; and (3) the artificial neural network’s parameters are used to explain the smooth mathematical description of the prostate contour. Experimental results show that our proposed method achieves superior segmentation performance in prostate TRUS images than state-of-the-art methods.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"62 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78696979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}