乳腺癌(英文)最新文献

{"title":"Predictors for Metachronous Metastases in Early Breast Cancer: A Single Institution Study","authors":"H. Fayed, Mohamed Ali Abdalla Billel, G. Abouelnagah, G. Khedr","doi":"10.4236/abcr.2021.103007","DOIUrl":"https://doi.org/10.4236/abcr.2021.103007","url":null,"abstract":"Background: Breast cancer (BC) is considered the most common women cancer worldwide. The main clinicopathological prognostic \u0000factors are tumor size, lymph node status and estrogen/progesterone (ER/PR) \u0000receptor status. In addition, some \u0000factors are both prognostic and predictive as ER/PR receptors and HER2/neu \u0000overexpression. Axillary lymph node status is the most important \u0000prognostic factor for breast cancer. Node negative breast cancer patients had \u0000the best 5-year overall survival (OS) of 82.8% compared to 73%, 45.7%, and \u000028.4% for patients with 1 - 3, 4 - 12, and \u0000≥13 positive nodes, respectively. The aim of \u0000this study was to determine the association between different \u0000clinicopathological features and development of metastasis in a group of Egyptian women with early breast cancer, also, to assess patients’ \u0000Relapse-free survival (DFS) and OS and their correlation with different \u0000clinicopathological features. Patients and Methods: We retrospectively \u0000reviewed the files of breast cancer patients who were treated and followed-up at the clinical oncology department \u0000and surgical oncology unit, Alexandria Main University Hospital during the \u0000period from January 2014 to December 2017. A total of 1848 breast cancer cases \u0000were presented during this period of time. \u0000141 out of the 1848 patients developed metastasis from breast cancer during \u0000follow-up. Among the 141 patients, only 102 had adequate clinical, pathological, \u0000treatment and follow-up data enough for \u0000analysis and were included in our study. Results: The number of patients \u0000who developed distant metastasis from breast cancer during the study period \u0000(metachronous metastasis) ranges from 17 - 31 \u0000cases/year. All the study patients had documented metastatic disease \u0000constituting 102 out of 1848 collected patients representing about 5.5%. The \u0000median time for development of metastasis \u0000from the initial diagnosis among the 102 studied patients was 17.88 months. \u0000Seventy-two out of 102 cases had distant recurrence. There was a significant correlation between DFS and \u0000tumor size, grade, number of lymph nodes involved and hormone receptor (ER and PR) status. Age, tumor grade, tumor \u0000size and Her2 status had a significant impact on the OS. Conclusion: The \u0000clinicopathological characteristics of the primary tumor are important for \u0000predicting the risk of metastasis among early breast cancer patients and \u0000determining their prognosis.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48579250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits of Radiotherapy with Indigenous Tools Aiding Deep Inspiration Breath Holding Technique Compared to Free Breathing Technique among Breast Cancer Patients in Bangladesh","authors":"Md Arifur Rahman, R. Balakrishnan, Md. Salim Reza, Q. Chowdhury","doi":"10.4236/abcr.2021.103006","DOIUrl":"https://doi.org/10.4236/abcr.2021.103006","url":null,"abstract":"Background: Post-operative breast radiotherapy is used to \u0000reduce recurrence. The aim of this \u0000study was to investigate the outcomes of Deep Inspiration Breath-Hold (DIBH) technique with indigenous breath holding indicator scale in 3DCRT for \u0000breast cancer radiotherapy over Free Breathing (FB) technique. Methods: An observational study conducted at the Department of Radiation \u0000Oncology at National Institute of Cancer Research and Hospital, Dhaka and Square Hospital Limited, \u0000Dhaka, Bangladesh from June 2015 to May 2016. A total of 60 confirmed breast cancer patients who underwent \u0000adjuvant radiotherapy were included. An indigenous reproducible plastic tool (Perspex) \u0000was used as breath holding indicator \u0000scale with DIBH technique in 3DCRT. Paired \u0000sample t-test was used to compare with FB technique. Results: The mean age of patients was 47.32 (SD ± 8.33) years. In FB technique, Mean Heart Dose \u0000(MHD) was 413.27 cGy while in DIBH technique, it was 254.91 cGy (P and V30 were 5.5%, 4.37% in FB and 3.13%, 2.36% in DIBH \u0000respectively. In FB technique LADMD, LAD 0.2 cm3, ILMD and ILV20 were 1698.17 cGy, 2852.53 cGy, 1155.31 \u0000cGy and 28.62% while in DIBH technique, it was reduced to 1164.01 cGy, \u00002132.24 cGy, 1007.98 cGy and 23.39% respectively. Similarly, the lung-CLMD and \u0000breast-CLMD were reduced \u0000from 38.37 cGy and 55.18 cGy to 24.64 cGy and 33.82 cGy respectively (P Conclusion: The use \u0000of indigenous breath holding indicator \u0000scale with DIBH had better outcomes on breast cancer radiotherapy.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46463220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Adjuvant Radiation Planning Outcomes in Patients with Synchronous Bilateral Breast Cancer","authors":"M. Alhefny, Hany S. Attallah, Mahmoud Abdallah, A. Yassin, Khaled M. El-Shahat, A. Obaya","doi":"10.4236/abcr.2021.103009","DOIUrl":"https://doi.org/10.4236/abcr.2021.103009","url":null,"abstract":"Background: Breast cancer is the most common cancer diagnosed \u0000worldwide, synchronous bilateral breast cancer accounts for unique entity of the disease, particularly \u0000post-operative radiotherapy for Synchronous Bilateral Breast Cancer (SBBC) is \u0000challenging with lack of evidence about \u0000the best irradiation technique. In this study, we tried to explore the optimum radiotherapy \u0000technique regarding the dosimetric parameters. Methods: We recruited 15 \u0000SBBC patients in whom post-operative radiotherapy was indicated and we established three plans for each patient \u0000using 3DCRT, IMRT and VMAT, and then we \u0000compared the three plans as regard target volume coverage parameters and organs \u0000at risk (OAR) doses. Results: We found that PTV coverage parameter was \u0000superior with IMRT compared with 3DCRT and VMAT in terms of Dmean (p = 0.001), \u0000D95% (p = 0.001), Dmax (p = 0.0001), conformity index (p = 0.0001) and \u0000HI (p = 0.0001). Doses to OAR were not significantly different between the three \u0000techniques in cardiac dose and LAD \u0000maximum dose, but 3DCRT was superior in LAD mean dose (p = 0.03) and lung \u0000volume receiving 20 Gy (V20) and 10 Gy (V10) (p = 0.0001), but this difference \u0000was non-significant between 3DCRT and IMRT (p = 0.4 and 0.06 respectively), \u0000while VMAT led to the highest doses to LAD and lung. Conclusions: IMRT \u0000showed the best target coverage parameters in post-operative radiotherapy for \u0000SBBC compared with 3DCRT and VMAT. For OAR doses IMRT showed comparable results \u0000with 3DCRT, while VMAT delivered a \u0000significantly higher dose to OAR.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44064987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Silico Identification of Anticancer Compounds; Ligand-Based Pharmacophore Approach against EGFR Involved in Breast Cancer","authors":"Irum Khalid, T. H. Jafar, Ahsanullah Unar, R. Rasool, Ayesha Sahar, H. Rashid","doi":"10.4236/abcr.2021.103010","DOIUrl":"https://doi.org/10.4236/abcr.2021.103010","url":null,"abstract":"Objective: Breast cancer is a public health challenge on a global scale that is \u0000caused by environmental or genetic factors. Breast cancer is affecting both \u0000males and females, but there is still a lack of effective drugs with improved \u0000potency and admissibility against breast cancer as many of the breast cancer \u0000drugs have severe side effects. Methods: The docking approach has been \u0000used to find a new compound for breast \u0000cancer with more efficacy and tolerance and with lesser side effects. A \u0000ligand-based pharmacophore approach has been generated for 39 anticancer \u0000compounds with significance for the development of new drugs. Result: Through docking, the approach found new lead compounds for breast \u0000cancer. The proposed pharmacophore model in this study contains two HBAs and \u0000one HYD, one \u0000hydrophobic domain and two Aromatic rings and the estimated distance range is minimum \u0000to maximum of derived pharmacophore \u0000features. Conclusion: Based on \u0000this research, it is proposed that these two lead compounds may be able to be \u0000used against EGFR in breast cancer. New compounds can be identified based on \u0000common features in the Pharmacophore model. 3D pharmacophore triangle could be \u0000used for further studies because this pharmacophore has better merging and in \u0000the future for more studies can suggest the same distance range of pharmacophore features as this pharmacophore.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48589898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological, Diagnosis, Therapeutic and Evolving Profile of Triple Negative Breast Cancer in Senegal","authors":"P. Gaye, Mouhamed Diouf, M. Bâ, D. Diouf, F. Sarr, M. Mane, M. Sarr, M. Dieng, Sidy Ka, A. Dem","doi":"10.4236/abcr.2021.103008","DOIUrl":"https://doi.org/10.4236/abcr.2021.103008","url":null,"abstract":"Objective: Describe the epidemiological, diagnostic, therapeutic and evolutionary \u0000profile of triple negative breast cancer at the Dakar Cancer Institute in \u0000Senegal. Patients and Methods: This was a retrospective study between \u0000January 1, 2011 and December 31, 2014. All patients with a triple negative \u0000molecular profile were included. The data were collected from the medical \u0000records of the patients. The data were entered and analyzed with SPSS edition \u000016 software under Windows 7. Results: Two hundred and twenty-five patients were selected. The \u0000mean age was 47.9 ± 12.5 years with extremes of 25 and 90 years. The main \u0000reason for consultation was dominated by the finding of a breast lump. The mean \u0000clinical tumor size was 8, 54 cm with a large majority of T3-T4 tumors 26% and 63% respectively, \u0000lymph node involvement in one hundred and seventy-two cases (76.4%); twenty \u0000eight patients (12.4%) were metastatic from the outset. Non-specific invasive \u0000carcinoma was the most common histologic type (78.2%), and more than half of \u0000the patients (53.3%) had an aggressive tumor (Scarff-Bloom-Richardson grading \u0000III). Neoadjuvant chemotherapy was performed in 65.78% of cases. We noted 27.7% \u0000total response and 41.7% partial response in patients who have received this \u0000neoadjuvant chemotherapy. The surgery was radical in 77% of cases, conservative \u0000in 14% and cleanliness surgery for palliative purposes in 9% of cases. Adjuvant \u0000radiotherapy is performed in 58.6% of operated patients. The mean time to \u0000follow-up was 20.63 months with extremes of 1 and 53 months. Overall survival \u0000was 69.8% at one year, 41.6% at two years and 25.6% at three years. Conclusion: The descriptive analysis of these results confirms the high frequency of \u0000triple-negative breast cancer in Senegal and its poor prognosis.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48462690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and Clinical Significance of PIK3CA, c-MET and c-KIT Mutations in Saudi Breast Cancer Patients","authors":"R. Nassir, G. Esheba, H. M. A. Elmoneim, Ahlam S. Altowairqi, G. Nouman","doi":"10.4236/abcr.2021.103005","DOIUrl":"https://doi.org/10.4236/abcr.2021.103005","url":null,"abstract":"Objective: PIK3CA is \u0000the most common pathway affected by mutations in breast cancer. PIK3CA/PTEN pathway is under \u0000intense investigation as a possible target for molecular therapy. Dysregulation PIK3CA/PTEN \u0000pathway is a substantial mechanism for the development of resistance to \u0000anti-HER2 therapy. Therefore, we aimed to study the PIK3CA/PTEN in breast cancer \u0000patients in Saudi population. Methods: We applied PTEN \u0000immunohistochemistry on 98 patients. Then, we applied next-generation \u0000sequencing to determine the genetic variations associated with the development \u0000of breast cancer and their correlations with clinicopathological variables. Results: PTEN expression was \u0000significantly correlated with lymph node metastasis (LNM), tumor stage, \u0000lymphovascular invasion (LVI) and triple negative breast cancer (TNBC). The \u0000prevalence of the PIK3CA mutation was 33.3% of cases and it was significantly associated with LNM, tumor \u0000stage, and with PTEN expression. c-MET mutation was identified in 41.7% of cases and it was associated with tumor \u0000stage and with TNBC, while c-KIT mutation was detected in 20.8% \u0000of cases, and it was significantly associated with TNBC only. Patients with \u0000positive PTEN expression had a significantly better overall survival (OS); on \u0000the contrary, patients with PIK3CA and c-MET had a significantly worse OS. Conclusion: Our study confirms the importance of PIK3CA/PTEN pathway in breast cancer \u0000patients. A high frequency of PIK3CA and c-MET mutations was detected and was associated with poor prognosis. \u0000Both c-MET and c-KIT genes have significant roles in developing \u0000TNBC. These findings should be expanded to a larger group study to improve the \u0000clinical outcomes and individualizing treatment.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44404541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Whole-Course and Multidisciplinary Nutrition Management Model for Breast Cancer: A Typical Case Report","authors":"Yuanzheng Luo, Li Shi, Linfei Liu, Rong Chen, Huiting Zhang","doi":"10.4236/abcr.2021.104015","DOIUrl":"https://doi.org/10.4236/abcr.2021.104015","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An AAS Dependent Method for Quantitative Essential Elements Analysis of Pakistani Female Breast Cancer Blood and Serum Samples","authors":"G. Chanihoon, Ahsanullah Unar, A. Memon, T. H. Jafar, Huma Shaikh, A. Sani, Raj Kumar, Sanam Soomro, Muqaddas Qureshi","doi":"10.4236/abcr.2021.103004","DOIUrl":"https://doi.org/10.4236/abcr.2021.103004","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization Diagnosis of Breast Cancer Vertebral Metastases","authors":"Dinara Zhoobasarova, A. Sadykova, Z. Muratov, Feruza Abdraeva, Ainisa Aitieva, Zhyldyz Aitieva, Dilaram Zheenbekova, F. Ismailova, Umutai Tazhibaeva, Asel Murzabek Kyzy, Zhypargul D. Abdullaeva, Zhanangul Kochkorbaeva, Tazhibaev Maksatbek, B. Keneshbaev, Meerzhan Kadyrberdieva, Nurilia Sherieva","doi":"10.4236/abcr.2021.104013","DOIUrl":"https://doi.org/10.4236/abcr.2021.104013","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Disparities in Breast Cancer Incidence-Mortality Rates of Black-White Women in the U.S.: 2000-2016","authors":"I. Aftab, A. Ahmed, S. Mumu, Tonima Fairooz Mouly, Drishti Sharad Commar","doi":"10.4236/abcr.2021.104017","DOIUrl":"https://doi.org/10.4236/abcr.2021.104017","url":null,"abstract":"Introduction: Female Breast cancer is the second leading cause of can-cer-related deaths in the U.S. While the incidence rate is lower in Hispan-ic-Black, the mortality rate is higher compared to Non-Hispanic White. This study investigates the trends of incidence and mortality rate of breast cancer in the U.S.: 2000-2016. It further explores the racial disparities between these two races. Method: Data for four age groups (15 - 39 yrs, 40 - 64 yrs, 65 - 74 yrs, 75+ yrs) of Hispanic-Black and Non-Hispanic White women for breast cancer were extracted from SEER; age-adjusted rate (U.S. 2000 standard pop-ulation). Primary trend analysis was done with PyCharm 2020.3.3. (line charts) and regression models to check any significant increase or decrease over the years were done with JoinPoint 4.8.0.1 (APC, 95% CI, significant p-value: <0.05). Result: Incidence rate is higher in Non-Hispanic White women, whereas mortality rate is higher in Hispanic Black. The 40 - 64 yrs age groups showed an increase in incidence rate for Hispanic Black women, whereas an decrease for White women. The least vulnerable group, 15 - 39 yrs age showed an increase in incidence rate in Non-Hispanic White women. The mortality rate was declining overall for both races. Conclusion: Disparities in oncologic healthcare, insurance system and socio-economic factors are possibly responsible for the higher mortality in Black American women. Improvements in these factors may reduce racial differences.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}