乳腺癌(英文)最新文献

{"title":"Diagnostic and Therapeutic Options of Breast Cancer Patients in Yaounde, Cameroon","authors":"J. D. Ngowa, Hortense Jeanne Fouedjio, Annaïk Morelle Tchami, J. L. N. Likeng, C. Noche, Brigitte Wandji Djouonang, F. F. Ymele, P. Foumane, E. Mboudou, P. Tebeu","doi":"10.4236/abcr.2022.111003","DOIUrl":"https://doi.org/10.4236/abcr.2022.111003","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70477096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preservation of the Intercostobrachial Nerve during Axillary Dissection for Breast Cancer at the Surgical Oncology Unit of Cancer Department of Dakar University","authors":"Sidy Ka, M. Mouelle, Mohammed Ezzet Charfi, J. Thiam, S. Dieng, S. Baldé, M. Dieng, A. Dem","doi":"10.4236/abcr.2022.111004","DOIUrl":"https://doi.org/10.4236/abcr.2022.111004","url":null,"abstract":"The intercostobrachial nerve (ICBN) is responsible for the sensory innervation of a part of the inner side of the arm. Injury of the intercostobrachial nerve is a complication of axillary dissection during lymph node dissection. Objective: This study aimed to determine the effect of preservation of the intercostobrachial nerve on postoperative sensory disturbances. Methods: This is a prospective, single-center study which was carried out in 90 patients followed in the oncology department of the Aristide Le Dantec hospital in Dakar, suffering from breast cancer and having undergone breast surgery associated with axillary dissection, for a period of 6 months. The patients were divided into two groups depending on whether the intercostobrachial nerve (ICBN) was preserved or not. The two groups were compared in terms of the incidence of sensory disturbances. Results: Sixty patients without nerve preservation and 30 patients with nerve preservation were included in the study, i.e., 90 patients in total. ICBN was injured in 60 patients of which 41 patients (83.7%) developed numbness in the inner arm. While in the preserved group, only 8 patients suffered from numbness (16.3%) with a significant P value of 0.002; however, for other variables such as the incidence of neuropathic pain and hypoesthesia-like sensory deficit, there was no significant difference. Conclusion: Preservation of the intercostobrachial nerve during axillary dissection for breast cancer reduces the incidence of sensory disturbances on the upper limb.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in the Tracer Technology Used for Sentinel Lymph Node Biopsy in Breast Cancer","authors":"Jiali Li, Hongxue Zhang, D. Hu","doi":"10.4236/abcr.2022.112009","DOIUrl":"https://doi.org/10.4236/abcr.2022.112009","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Metastasis and Axillary Lymph Node Tuberculosis in Breast Cancer: Clinical Case and Review of the Literature","authors":"Seydou Pamateck, B. Sidibé, I. Diakite, Z. Saye, Iriss A. Darar, A. Doumbia, A. Togo","doi":"10.4236/abcr.2022.112008","DOIUrl":"https://doi.org/10.4236/abcr.2022.112008","url":null,"abstract":"The coexistence of tuberculosis with axillary lymph node metastases in breast carcinoma is rare. Axillary lymph node metastasis is the most important fac-tor in the staging of breast carcinoma, and the number of axillary lymph nodes metastasizing changes the stage. Since tuberculosis also produces lymph node enlargement, this can mimic or complicate the staging of a ma-lignant disease. Dual organ pathology can lead to interpretation difficulties and inappropriate treatment of tuberculosis as well as breast carcinoma. Ad-ditionally, fine needle aspiration cytology (FNAC) of such cases can be mis-leading if only one of the diseases is detected. We report two cases of infiltrating carcinoma of the nonspecific type of the breast in two women aged 35 and 55 where tuberculosis was found in the axillary lymph nodes in addition to metastases. As the present case led to the fortuitous discovery of tuberculosis with tumor metastasis, it reinforces the possibility of a coexisting lesion in the minds of pathologists, especially in areas endemic to tuberculosis.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epithelial-Mesenchymal Transition and Breast Cancer Stem Cells in Breast Cancer Progression","authors":"Wanyue Han, Qingshan Li, Qing Zhang, Fan Xu","doi":"10.4236/abcr.2022.112012","DOIUrl":"https://doi.org/10.4236/abcr.2022.112012","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex Cystic Breast Masses: An Ultrasound Imaging Review","authors":"N. Chotai, Harold Yim, E. C. Fok, Siu Cheng Loke, Hollie Mei Yeen Lim","doi":"10.4236/abcr.2022.111002","DOIUrl":"https://doi.org/10.4236/abcr.2022.111002","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70477031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Expression and Prognostic Significance of Major MicroRNA Genes in Breast Cancer Based on Bioinformatics Analysis","authors":"Qiong Wang, Jiuli Hu, Junwei Liang, Lanfang Liu, Shuoyang Xiao, Rui Wang, Chanchan Hu","doi":"10.4236/abcr.2022.111001","DOIUrl":"https://doi.org/10.4236/abcr.2022.111001","url":null,"abstract":"Objective: Breast Cancer (BC) is characterized by high complexity and heterogeneity, and microRNA (miRNA) is bound up with the occurrence and development of BC. In this study, we evaluated the prognostic value of miRNA in BC. Background: Breast ductal and lobular cancers are the most common types of Breast Carcinomas (BC) and indicate the high complexity heterogeneity in this disease. Each BC patient has unique morphological and molecular features. MicroRNAs (miRNAs) play a critical role in human oncogenesis, progression, and prognosis. Our study aimed to identify potential prognostic biomarkers of breast ductal and lobular cancers to predict the overall survival outcome. Methods: All analyzed miRNA sequencing and clinical data were obtained from the Genomic Data Commons Data Porta. edgeR package in R software was used to analyze the differential miRNA expression profiles. Complete survival information and differentially expressed miRNA expression were obtained and the Caret package was used for random division of the samples along with their profiles into two groups (training group and test group). We performed univariate Cox regression analyses for miRNAs in the training group. We utilized three different web-based tools to identify the target genes of miRNAs and used the Perl language to evaluate the target genes for miRNA signature. STRING database was used to assess PPIs. Results: A total of 304 differentially expressed miRNAs were identified (213 were upregulated and 91 were downregulated). Among these, nine (hsa-miR-204-5p, by Cox regression analysis and miRNA signature risk score built. And then we performed the model of BC patients for three years survival risk, the AUCs of ROC were 0.804, 0.667, and 0.739 in the training, test, and entire groups, respectively. miRNAs were differentially expressed in tumor-related biological processes and pathways by functional enrichment and bioinformatic analysis. Conclusion: The current study provided novel insights into the mi-RNA-based mRNA network in BC. The nine miRNA and ten hub genes may be independent prognostic signatures for survival prediction in BC patients.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasosinus Metastases from Breast Cancer: A Review of Two Cases","authors":"P. Gaye, M. Bâ, F. Sarr, F. Niang, M. Mane, Franck Chouamou Aurélien Chemega","doi":"10.4236/abcr.2021.104011","DOIUrl":"https://doi.org/10.4236/abcr.2021.104011","url":null,"abstract":"Context: Breast cancer affects more than 2 million women a year worldwide. \u0000Improved treatments have made it possible to increase survival rates with more and more patients having time to develop \u0000secondary locations. Nasosinus metastases from this cancer are rare. Two \u0000recently treated breast cancer patients developed metastases to the sphenoidal \u0000and maxillary sinuses. These cases gave rise to an examination of the incidence \u0000of this disease, its diagnosis, the therapeutic means envisaged and the fate of \u0000these patients. Method: We report the diagnostic and therapeutic data of \u0000two patients suffering from breast cancer and presenting metastases at the \u0000nasosinus level, with a focus on the interest of radiotherapy in palliative \u0000care. Results: The two patients aged 56 and 60 presented in the course \u0000of their breast cancer secondary localizations in the sphenoidal and maxillary \u0000sinus confirmed by endoscopy and histology. All the cases presented massive \u0000lesions associated with other secondary bone locations in particular. After \u0000local radiotherapy and systemic chemotherapy treatment, one patient died 5 \u0000months after her diagnosis and the other was alive 16 months later. Conclusion: Nasal and sinus metastases from breast cancer are rare and have a poor \u0000prognosis as disseminated disease, they do not respond well to conventional \u0000systemic therapies even if palliative radiotherapy allows local control.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47802188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Predictive Model for Pathologic Complete Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy Using Machine Learning","authors":"Isaac Kim, Kwanbum Lee, Seung Ah Lee, Yeon-Hee Park, S. K. Kim","doi":"10.4236/abcr.2021.104012","DOIUrl":"https://doi.org/10.4236/abcr.2021.104012","url":null,"abstract":"Background: In patients with breast cancer after Neoadjuvant Chemotherapy (NAC), pathological \u0000Complete Response (pCR) was associated with better long-term outcomes. We here attempted to predict pCR using machine learning. Patients and Methods: From 2008 to 2017, 1308 breast \u0000cancer patients underwent NAC before surgery, of whom 377 patients underwent \u0000Cancer SCANTM for gene data. Of 377, 238 were analyzed here, with 139 excluded due to \u0000incomplete medical data. Results: The pCR (-) vs. (+) group had 200 vs. 38 patients. In our predictive model with \u0000gene data, the Area Under the Curve (AUC) of \u0000the Receiver Operating Characteristic (ROC) curve was 0.909 and accuracy \u0000was 0.875. In another model without gene data, the AUC of ROC curve was 0.743 \u0000and accuracy was 0.800. We also conducted internal validation with 72 patients \u0000undergoing NAC and Cancer SCANTM during July 2017 and April 2018. When we applied a 0.4 \u0000threshold value, accuracy was 0.806 and \u00000.778 in the predictive model with vs. without gene profiles, respectively. Conclusion: The \u0000present predictive model may be a useful and easy-to-access tool for pCR-prediction in breast cancer \u0000patients treated with NAC.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46228603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contrast-Enhanced Mammogram: A New Game-Changer in Breast Imaging. Indications with Case-Based Experience","authors":"Chotai Niketa, L. Cheng, T. Yu","doi":"10.4236/abcr.2021.104016","DOIUrl":"https://doi.org/10.4236/abcr.2021.104016","url":null,"abstract":"Mammograms \u0000are the mainstay of diagnostic breast imaging and cancer screening. Despite advances in technology such as Full Field Digital \u0000Mammography (FFDM) and Digital Breast Tomosynthesis (DBT), these imaging \u0000techniques are purely structural, and are unable to overcome shortcomings in \u0000mammography posed by dense breast \u0000parenchyma. Magnetic Resonance Imaging (MRI) is the most sensitive modality in breast imaging, due to its functional aspects in \u0000addition to structural imaging with this modality. The use of MRI is however \u0000constrained by cost and availability. The utilization of intravenous contrast with mammograms introduces a \u0000functional element to imaging. This greatly \u0000improves the sensitivity of the examination, approaching sensitivity \u0000levels of Magnetic Resonance Imaging (MRI) in the detection of primary breast \u0000cancer. With increased sensitivity afforded \u0000by assessment of tumor neo-vascularity, as well as its low \u0000cost, low energy imaging that is \u0000more readily available than MRI, Contrast-Enhanced \u0000Mammography (CEM) if more readily available than MRI, this imaging modality is \u0000a potential game-changer in breast imaging. In this article, we share our experience in \u0000the use of CEM, for indications previously reserved for MRI, with the literature review of these indications. In resonance with prior studies, \u0000we echo the ease of performing and reporting of CEM as well as greater patient \u0000comfort as the distinct advantages of CEM. In spite of slightly higher \u0000radiation dose and some risks related to contrast media, functional \u0000results at a significantly lower cost may change how we practice breast imaging in the future using CEM.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47862851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}