乳腺癌(英文)最新文献

{"title":"Cancer Susceptibility for Male Breast Cancer Assessed by SNP-A Analysis and Risk Alleles of TP53, MDM2, VEGF, VEGFR1, HIF1A and BRCA1","authors":"Sarika Sharma, V. Sambyal, K. Guleria, R. Kapahi, N. Singh, M. Manjari","doi":"10.4236/abcr.2021.104018","DOIUrl":"https://doi.org/10.4236/abcr.2021.104018","url":null,"abstract":"Male Breast Cancer (MBC) has a familial component thus identification of polymorphic risk alleles of candidate genes and/or cytogenetic anomalies may help to predict the risk for the offspring of MBC patients. The conventional metaphase cytogenetics can indicate loci that are hotspots while analysis by single nucleotide polymorphism arrays (SNP-A) can identify chromosomal defects which may play a role in the etiology of cancer. A cumulative genotype risk due to each allele of candidate genes of the signaling pathways regulating c-MYC, HIF1A, TP53 and BRCA1 may be a factor facilitating cancer development. Cancer risk was assessed in a 35-year-old healthy son of a 60-year-old MBC patient with a family history of cancer by metaphase cytogenetics, SNP-A and analysis of 25 polymorphisms in six genes TP53, MDM2, VEGF, VEGFR1, HIF1A, and BRCA1. The risk genotype GG-TT of MDM2 309T > G and VEGF-417C/T polymorphisms along with chromosomal instability shown by cytogenetic analysis and SNP-A, rare de novo duplication Yp, deletion in 7q pericentromeric region indicate an increased risk of cancer in the healthy son of an MBC patient.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inverted T-Shaped Flap Nursing after the Reverse Double V-Shaped Mastoconstriction Suspension for Breast Cancer","authors":"Linfei Liu, Lijuan Zhang, Yuanzheng Luo, Xuehui Zeng, Rong Chen","doi":"10.4236/abcr.2021.104014","DOIUrl":"https://doi.org/10.4236/abcr.2021.104014","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70476279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Profile of Carcinoma Breast Patients Treated with Trastuzumab: A Single Centre Study","authors":"S. B. Jayappa, B. Lalkota, V. Mani, Reshma Elsa Jenny, K. P. Krishnamurthi, V. Sarathy, S. Thineshwaran, B. Nithin, Sumithra Martinovic, A. Ram, S. Patil, R. Naik","doi":"10.4236/ABCR.2020.94009","DOIUrl":"https://doi.org/10.4236/ABCR.2020.94009","url":null,"abstract":"Introduction: Breast cancer is the most common \u0000female cancer in India and accounting for almost 1 in 4 cancer cases \u0000in women worldwide. According to GLOBOCAN 2018: breast cancer incidence is \u0000increased to 162,468 in 2018 compared to 144,937 in \u00002012. Biosimilar drugs allow expanding access to the therapies in the form of \u0000cost savings and leading to better overall health outcomes. Our study evaluates \u0000the efficacy and safety of Trastuzumab biosimilars and assesses overall \u0000survival in the study population. Materials & Methods: This prospective study was conducted in Healthcare Global Enterprises \u0000Ltd., Bengaluru, India, and all female patients diagnosed with Her2 positive, \u0000metastatic (mBC) and Locally advanced breast cancer (LABC), between March 2013 \u0000and November 2014, with at least 4 years of post-treatment follow up. Results: A total of 65 patients diagnosed with Her2 positive breast cancer and satisfied \u0000the selection criteria were included for the study. Partial Response (PR) was \u0000observed in 42 (64.6%) patients, Stable Disease (SD) in 11 (16.9%) patients and \u0000Progressive Disease (PD) in 12 (18.5%) patients. The overall response rates \u0000were 46.1% PR, 30% SD, 23.8% PD in metastatic population and 76% PR, 7.2% SD, \u000015% PD observed in locally advanced disease. The mean overall survival of the \u0000study population was 20.75 ± 15.20 months in metastatic and 29.2 ± 17.06 months in locally advanced patients. Conclusion: This \u0000prospective study shows the effectiveness of Trastuzumab for HER2-positive in \u0000locally advanced and metastatic breast cancer. The response rates, survival and \u0000toxicity correlate with other global studies. The response and survival are as same as either generic or original Trastuzumab.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45589325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Cancer: Knowledge, Attitudes on Risk Factors and Means of Screening by Medical Students from Lomé, Togo","authors":"T. Darré, Mazamaesso Tchaou, T. Djiwa, Essossinam L. Tcharié, L. Brun, F. Gbeasor-Komlanvi, B. N'timon, A. Amadou, P. Simgban, D. Ekouevi, G. Napo-koura","doi":"10.4236/abcr.2020.94011","DOIUrl":"https://doi.org/10.4236/abcr.2020.94011","url":null,"abstract":"Background: Breast cancer is the leading cause of cancer-related death in women \u0000around the world. The objective of this study was to assess knowledge and \u0000attitudes about breast cancer screening among students in the Faculty of Health \u0000Sciences at the University of Lome. Methods: This was a prospective \u0000descriptive transversal study conducted among students enrolled in the Faculty \u0000of Health Sciences (FSS) of the University of Lome (UL) in the 2019 school year \u0000account 2020. The purpose of this study was to assess the knowledge and \u0000attitudes of medical students about breast cancer screening. Results: In \u0000total, the questionnaire was completed by 934 students, for a response rate of \u000057.1%. The most frequently mentioned risk \u0000factors were the presence of a family history of breast cancer (n = 799, \u000085.55%) and the use of oral or injectable contraceptives (n = 606, 64.88%). \u0000There is a statistically significant link between the participants’ knowledge \u0000of the self-examination and clinical examination of the breasts and certain \u0000socio-demographic characteristics, namely age (OR = 0.2, 95% CI [0.11 - 0.75], p-value 0.0001), the level of study (OR = 1.5, 95% CI [0.55 - 2.46], p-value = 0.0054), the follow-up of a course on breast cancer (OR \u0000= 2.63, 95% CI [0.32 - 4.33], p-value = 0.009) and the effectiveness of an \u0000internship in a gynecology-obstetrics department (OR = 0.77, \u000095% CI [0.49 - 2.56], p-value 0.0001). \u0000Similarly, there is a statistically significant link between participants’ \u0000knowledge of mammography and certain socio-demographic characteristics, namely \u0000age (OR = 0.75, 95% CI [0.50 - 0.84], p-value = 0.0005), \u0000the level of study (OR = 1.92, 95% CI [1.11 - 3.46], \u0000p-value 0.0001), the follow-up of a course or training on breast cancer (OR = 2.44, 95% \u0000CI [0.08 - 3.91], p-value 0.0001) and \u0000the effectiveness of an internship in a gynecology-obstetrics department (OR = 0.62, \u000095% CI [0.33 - 0.85], p-value Conclusion: Knowledge and attitudes related to breast cancer screening \u0000have been found to be generally satisfactory to medical students. Active \u0000measures are needed to develop educational programs for health personnel, which \u0000could enable them to disseminate knowledge and positively influence patient \u0000attitudes.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43260016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Up to Date Management of DCIS and Future Directions","authors":"R. Arrangóiz, F. Cordera, E. Moreno, E. Luque-de-León, M. Múñoz","doi":"10.4236/abcr.2020.93007","DOIUrl":"https://doi.org/10.4236/abcr.2020.93007","url":null,"abstract":"Ductal carcinoma in situ (DCIS) \u0000is a non-invasive malignancy confined within the basement membrane of the breast ductal system. There is a lot of \u0000disparity in the natural history of DCIS with an estimated incidence of \u0000progression to invasive ductal carcinoma \u0000between 20% to 53% over ten or more years after initial diagnosis. The surgical and \u0000adjuvant management of DCIS has advanced significantly in the last couple of \u0000decades. Nonetheless, surgeons, medical oncologists, and radiation oncologists, along with their patients, still depend on \u0000conventional clinical and pathologic risk \u0000factors to make management decisions. Irrespective of the management strategy, \u0000long-term survival is excellent. The debate around DCIS relates to \u0000preventing either under-treatment or over-treatment. In this paper, we will \u0000review the incidence and management options \u0000of DCIS. Additionally, we will focus on several current disputes related to the management of DCIS, including breast conserving surgery, the role of radiation \u0000in breast conservation surgery, sentinel node biopsy in DCIS, hormonal therapy, \u0000various risk stratification schemes, and the option of active surveillance for \u0000low-risk DCIS.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44931851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Breast Cancer in the City of Douala: A Case Control Study","authors":"Engbang Ndamba Jean Paul, E. Henri, M. Valère, Sukam Noutadjeu Diane Sara, Mboudou Emile","doi":"10.4236/abcr.2020.93006","DOIUrl":"https://doi.org/10.4236/abcr.2020.93006","url":null,"abstract":"Background: The breast cancer is an abnormal proliferation of \u0000mammary gland cells. This condition as well as other cancers is globally \u0000increasing in the world. It is the most frequent malignancy of women in the \u0000world and is a public health problem. Generally in Africa and central Africa in \u0000particular, few studies have been realized in search of risk factors of breast \u0000cancer. It’s all in this optical we began the study to determine the risk \u0000factors of this disease in the city of Douala. Patients and Methods: We conducted \u0000a case-control study, gave retrospectives \u0000collect on five years and prospectives collect on seven months. The \u0000studied population was all women aged 18 years and above with breast cancer \u0000diagnostic on histological plan for cases; and women from 18 years or more with normal physical examination and \u0000mammography. We have done our research \u0000in three reference hospitals of the city of Douala and two laboratories \u0000of pathological anatomy. The data were collected at the search files and the patients where interviewed. \u0000The parameters studied were: socio-demographic profile, clinic and Para clinic \u0000parameters, and the histological type. Results: At the end of this \u0000study, breast cancer is predominantly on young women in the city of Douala with \u0000a middle age of 44.08 ± 2.6 years. The most significant risk factors were age, \u0000age of the first birth ≥ 30 years, age of the first sexual act ≤ 18 years, low \u0000economic level, tobacco, hormonal contraceptive, parity. Conclusion: Finally, \u0000the malignancy of the breast takes a primordial place within the feminine \u0000population of Douala with many risk factors likes causes.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49032634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Safety with High Cumulative Dose of Pegylated Liposomal Doxorubicin in Patients with Metastatic Breast Cancer Previously Treated with Conventional Anthracyclines","authors":"A. Refaat, Dalia O. Mohamed, E. M. Ali, S. Khallaf","doi":"10.4236/abcr.2020.93005","DOIUrl":"https://doi.org/10.4236/abcr.2020.93005","url":null,"abstract":"Introduction: The treatment of metastatic breast cancer (MBC) is still challenging. Many \u0000studies documented the efficacy of pegylated \u0000liposomal doxorubicin (PLD) in patients with MBC, but there is a limited data \u0000about the cardiac safety with high cumulative dose (HCD) of PLD. Aim of the \u0000work: We conducted this trial to outline the cardiac \u0000safety of HCD of PLD in patients with \u0000MBC who previously received conventional anthracyclines. Methods: During the period of nine years (January 2011 to \u0000December 2019). We extracted the data of the patients with MBC receiving \u0000PLD at Medical Oncology Department, South Egypt Cancer Institute, Assiut \u0000University. These included patients’ demographics and therapeutic data \u0000including the full data of PLD, prior conventional anthracyclines, prior \u0000trastuzumab, and prior radiotherapy. Also, data about comorbidities as well as \u0000cardiac and other toxicities of PLD were obtained. The data was analysed using \u0000SPSS v. 21. Results: For all 81 eligible patients, the mean age was 43.9 \u0000years (±standard deviation (SD) 13.2). The mean cumulative dose of PLD was \u0000378.4 mg/m2 (± SD of 250.2) and a range of 100 - 1200 \u0000mg/m2. About thirty-one (38.3%) patients received high cumulative dose (400 mg/m2 or more), \u0000while the remaining 50 patients did not. The decline in left \u0000ventricular ejection fraction (LVEF) was relatively rare; and of low grade. Grade 2 decline in LVEF occurred in only two patients who \u0000received high cumulative dose of PLD, and only one patient who did not reach \u0000HCD (p = 0.555). Grade 3 or 4 decline in LVEF did not occur in patients either with \u0000or without HCD. Regarding other toxicities, there was a significant increase in \u0000incidence of all grades palmar plantar erythrodysesthesia (PPE) in patients who received HCD of PLD when compared to those who did not reach the HCD (38.7% versus 16% respectively; p = 0.021). Conclusion: Our study concluded that the use of \u0000PLD seems to be a justified agent in the treatment of MBC who previously \u0000treated by conventional anthracyclines in the adjuvant, metastatic or both settings, \u0000even in patients reaching the cumulative dose of conventional anthracycline.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44655252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"List of Contributors","authors":"S. Suman, Garima Suman, Sanjay M. Mishra","doi":"10.2174/9789811451447120010003","DOIUrl":"https://doi.org/10.2174/9789811451447120010003","url":null,"abstract":"","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83164001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Morphometry in Senegalese Women: Study on a Sample of 118 Subjects","authors":"N. Mar, A. Ndiaye, A. Ndiaye, Karim Yacouba Garba, M. Gaye, S. Thiam, I. Seck, R. Wade, J. Ndoye, M. Diop, A. Ndiaye","doi":"10.4236/abcr.2020.92002","DOIUrl":"https://doi.org/10.4236/abcr.2020.92002","url":null,"abstract":"Nowadays, women are more and more resorting to breast surgery for the purposes of isolated esthetics or within the framework of a mammectomy for tumor with its cohort of psychological problems post mutilation often requiring reconstruction. In context of breast cancer increase in Senegal, we have carried out breast morphology in female subjects of the Sahelian type in order to contribute to the development of a morphological database for reconstruction, reduction or breast augmentation. It was a prospective study on 118 female subjects received at Cancer Institute for screening. They were divided into two groups (age ≤ 40 years and age > 40 years). Subjects’ morphometric variables were collected in anatomical position and correlated with age, parity, obesity and genital activity using. Fifty six subjects (47.5%) were over 40 years of age. There were 40 multiparous (33.9%). Fifteen subjects (12.7%) and six subjects (5%) were obese and morbidly obese, respectively. Subjects in genital activity were 34 (29%). The overall average size of the areola was 4.3 ± 1.5 cm. The nipple was low located with an average of 7.2 ± 3.5 cm. The diameters mentioned above increased significantly with age and body mass index, for p-values  0.05, with the exception of the vertical diameter. Breast diameters were greater in postmenopausal women. Morphometry of Sahelian-type women’s breast is strongly influenced by socio-demographic data, hence the need to take it into account during reconstruction, reduction or breast augmentation surgeries in Senegal.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48242265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey on the Consciousness of Japanese Women Regarding Dense Breasts on Mammography","authors":"Ikumi Kataoka, Ryuko Kawashima, Yumiko Tsubota, Yumiko Fukkoshi, H. Kawashima, H. Fukuta, I. Kashiwakura","doi":"10.4236/abcr.2019.84010","DOIUrl":"https://doi.org/10.4236/abcr.2019.84010","url":null,"abstract":"Patients with dense breasts on mammography have a higher risk of developing breast cancer and missing a tumor mass than those with non-dense breasts. Whether examinees who have dense breasts should be notified is currently under consideration in Japan; however, there is concern about the low level of understanding regarding dense breasts. A questionnaire survey on the degree of comprehension regarding dense breasts was conducted among 409 general women of >20 years of age in Hachinohe city in October 2017 and 2018. The results showed that the degree of comprehension was extremely low, as only 35 people (8.5%) responded with, “I know the meaning”; however, 32 of them (91.5%) stated that they would like to be notified in they had dense breasts. In addition, the degree of comprehension regarding dense breasts was significantly greater among those who had a breast cancer screening history (OR = 6.4; 95% CI = 2.0 - 19.8; P = 0.001) and a self-examination history than among those with no such history (OR = 2.5; 95% CI = 1.1 - 5.8; P = 0.03). However, the degree of comprehension did not differ between participants of years of age or between participants with and without a breast cancer sufferer among their close blood relatives. The present findings to reflect a low understanding of dense breasts on mammography screening and suggest that the degree of comprehension is influenced by the presence or absence of a consultation history and a self-examination history.","PeriodicalId":67095,"journal":{"name":"乳腺癌(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45440613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}