Yi-Chien Wu, T. Santra, Ting-Hsiang Wu, D. Clemens, Bai‐Yu Lee, Ximiao Wen, M. Horwitz, M. Teitell, P. Chiou
{"title":"Photothermal nanoblades for delivery of large-sized cargo into mammalian cells at high throughput","authors":"Yi-Chien Wu, T. Santra, Ting-Hsiang Wu, D. Clemens, Bai‐Yu Lee, Ximiao Wen, M. Horwitz, M. Teitell, P. Chiou","doi":"10.1109/NANO.2016.7751307","DOIUrl":"https://doi.org/10.1109/NANO.2016.7751307","url":null,"abstract":"Technologies for transferring large-sized cargo into mammalian cells are needed to advance key applications in cell engineering. However, reliable methodologies for introducing large-sized cargo into mammalian cells are nearly completely lacking. This talk will present two new technologies, photothermal nanoblade and BLAST, that overcome the size limitation of cargo delivery into mammalian cells.","PeriodicalId":6646,"journal":{"name":"2016 IEEE 16th International Conference on Nanotechnology (IEEE-NANO)","volume":"53 1","pages":"47-50"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78164209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dielectrophoresis-induced cell patterning using a new PLA scaffold made by 3D printing","authors":"Zhijie Huan, H. Chu, Jie Yang, Dong Sun","doi":"10.1109/NANO.2016.7751549","DOIUrl":"https://doi.org/10.1109/NANO.2016.7751549","url":null,"abstract":"This paper presents a new technique of fabricating 3D-printed scaffolds that can utilizes dielectrophoresis (DEP) for cell patterning. The scaffold was first fabricated using a 3D printer with a biodegradable polymer, polylactic acid (PLA). The electrical conductivity of the polymeric scaffold was enhanced through sputtering a thin layer of gold. When a voltage was supplied to the scaffold, non-uniform electric fields were generated so that cells were polarized and patterned onto the scaffold. Experiments were conducted to demonstrate that the gold-coated PLA scaffold could be used for rapid patterning MC3T3-E1 cells via DEP. Cell proliferation was assessed by (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) MTT method and the result confirms the DEP cell patterning mechanism is not cytotoxic.","PeriodicalId":6646,"journal":{"name":"2016 IEEE 16th International Conference on Nanotechnology (IEEE-NANO)","volume":"602 1","pages":"853-856"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77389951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Niclosamide loaded cationic Solid Lipid Nanoparticles for treatment of Cancer","authors":"N. Jain, R. Srivastava, V. Naidu","doi":"10.1109/NANO.2016.7751439","DOIUrl":"https://doi.org/10.1109/NANO.2016.7751439","url":null,"abstract":"Niclosamide (NIC), an anthelminthic drug exhibits poor oral bioavailability due to hydrophobic nature which limits its in vivo application. In recent times, NIC has been reported to exhibit anticancer activity against wide range of tumors. Solid Lipid Nanoparticles (SLNs) of NIC were prepared using solid lipid Glyceryl monostearate, charge modifier stearyl amine, soya lecithin, and tween 80 by emulsion solvent evaporation technique. The SLNs were characterized for their size and zeta potential using Zetasizer. Whereas, the morphology was studied using TEM analysis. The results suggested the formation of positively charged SLNs with a size range of 197.3±18.08nm and zeta potential of +10±3.43 mV. The interaction of the excipients with the drug was studied using FTIR which suggested their compatibility with NIC. The entrapment efficiency and loading efficiency was determined and found to be 75.64±8.49% and 8.16±0.31% respectively. The results of the drug release study indicated the prolonged and sustained release of NIC over a period of 24h. Hence, the NIC loaded solid lipid nanoparticles can deliver the drug for sustained period of time which can be used in the treatment of Cancer.","PeriodicalId":6646,"journal":{"name":"2016 IEEE 16th International Conference on Nanotechnology (IEEE-NANO)","volume":"31 1","pages":"245-248"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77556727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular wire for quantum biomimetic electronic nose","authors":"Ashlesha Patil, D. Saha, S. Ganguly","doi":"10.1109/NANO.2016.7751334","DOIUrl":"https://doi.org/10.1109/NANO.2016.7751334","url":null,"abstract":"We study the molecular wire connected to leads as the fundamental unit of a quantum biomimetic electronic nose - a chemical sensor inspired by the vibration theory of olfaction. This is based upon inelastic tunneling transport in the molecular wire, which is treated using the Non-Equilibrium Green Function within the self-consistent Born approximation.","PeriodicalId":6646,"journal":{"name":"2016 IEEE 16th International Conference on Nanotechnology (IEEE-NANO)","volume":"34 1","pages":"12-14"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82165440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Bhattacharyya, Kyongwan Kim, H. Nakazawa, M. Umetsu, W. Teizer
{"title":"Altering the microtubule kinesin nanomechanics in the presence of metallic ions","authors":"S. Bhattacharyya, Kyongwan Kim, H. Nakazawa, M. Umetsu, W. Teizer","doi":"10.1109/NANO.2016.7751410","DOIUrl":"https://doi.org/10.1109/NANO.2016.7751410","url":null,"abstract":"Microtubules play an important role in intraneuronal communication. A barrier to microtubule mediated neuronal transport can initiate dementia. The nanoscale modeling of these biological events is expected to be useful for healthcare applications and auxiliary biosensor based diagnostics. Here, we report a model system by using an in vitro bio-motility assay to predict events related to dementia at excess metal ion concentration. We demonstrate how metal ions (calcium, iron, zinc) at pathophysiologically relevant concentrations have the ability to affect the gliding motion of microtubules on kinesin. The addition of the neurotransmitter (acetyl choline) has no apparent effect on MT gliding. Therefore, the reagents that can stabilize the bio-motility system have potential to regulate dementia.","PeriodicalId":6646,"journal":{"name":"2016 IEEE 16th International Conference on Nanotechnology (IEEE-NANO)","volume":"1 1","pages":"79-81"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79139761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
En-Tzu Lee, S. Noda, W. Mizubayashi, K. Endo, S. Samukawa
{"title":"Defect-free germanium etching for 3D Fin MOSFET using neutral beam etching","authors":"En-Tzu Lee, S. Noda, W. Mizubayashi, K. Endo, S. Samukawa","doi":"10.1109/NANO.2016.7751453","DOIUrl":"https://doi.org/10.1109/NANO.2016.7751453","url":null,"abstract":"Several-ten nanometer-width Ge Fin structure with defect-free, vertical and smooth sidewall were successively delineated by a neutral beam etching method using pure Cl2 gas chemistry for developing three dimensional channel FETs. The cross-sectional profile of the Ge Fins tended to have bottom tails without undercuts beneath etching masks in the best etching conditions. The bottom tails were eliminated by increasing Cl neutral beam energy and increasing substrate temperature. Very precise dimension control became possible by adjusting those two conditions. High resolution TEM observations revealed that the Ge Fin sidewalls, which were supposed to be FET channels, etched by the neutral beam seemed very smooth in a substantially atomic level while those ones etched in a plasma had relatively rough surfaces due to plasma damages.","PeriodicalId":6646,"journal":{"name":"2016 IEEE 16th International Conference on Nanotechnology (IEEE-NANO)","volume":"80 3 1","pages":"816-818"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83151652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Direct formation of thermochromic composite films of VO2 nanoparticles in SiO2 hosts","authors":"Yuxia Ji, G. Niklasson, C. Granqvist","doi":"10.1109/NANO.2016.7751395","DOIUrl":"https://doi.org/10.1109/NANO.2016.7751395","url":null,"abstract":"Vanadium dioxide (VO<sub>2</sub>) is a key material for modern thermochromic energy-efficient window coatings. Nanocomposite VO<sub>2</sub>-SiO<sub>2</sub> films were fabricated by reactive magnetron sputtering. VO<sub>2</sub> nanoparticles with grain sizes of about 100 nm were distributed uniformly in the SiO<sub>2</sub> host, and the composite film showed excellent thermochromic properties with plasmonic effect.","PeriodicalId":6646,"journal":{"name":"2016 IEEE 16th International Conference on Nanotechnology (IEEE-NANO)","volume":"124 1","pages":"823-825"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77334835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Zinn, R. Stoltenberg, Jerome Chang, Y. Tseng, Shannon M. Clark
{"title":"Nanocopper as a soldering alternative: Solder-free assembly","authors":"A. Zinn, R. Stoltenberg, Jerome Chang, Y. Tseng, Shannon M. Clark","doi":"10.1109/NANO.2016.7751572","DOIUrl":"https://doi.org/10.1109/NANO.2016.7751572","url":null,"abstract":"A nanocopper-based interconnect material was developed as a robust, high-performance alternative to solder. This new solder-free nanocopper material overcomes an inherent limitation of traditional solders wherein the operating temperature is limited by the processing temperature. For the first time, an interconnect material is capable of operating at temperatures not only equal to but even far above its original processing temperature. Being pure copper, the material can form contacts with 5-10× the thermal and electrical conductivity of typical solder systems. The material rheology can be tuned for drop-in replacement of solder on standard PCB assembly lines and other industrial paste dispensing equipment. Such nanoparticle based interconnects can exhibit improved creep resistance and enhanced reliability in low- and high-temperature operating environments. The nanocopper material is obtained by reducing a copper salt with sodium borohydride in the presence of an amine surfactant mixture that controls particle size and protects the nanoparticles from oxidation. The manufacturing process has proven readily scalable with a 1 kg pilot plant currently in operation and a path to a continuous low-cost manufacturing process. For the present work, a readily dispensable nanocopper paste was formulated to bond commercial LEDs to a thermal heat sink. To evaluate the quality of the formed bulk copper interconnects, a large number of test samples was fabricated to measure mechanical strength. Shear strengths exceeding 70 MPa have been achieved.","PeriodicalId":6646,"journal":{"name":"2016 IEEE 16th International Conference on Nanotechnology (IEEE-NANO)","volume":"28 1","pages":"367-370"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85220024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structural and gas sensing characteristics of ZnO nanorods grown on different substrates","authors":"Fang-Hsing Wang, Chih-En Tsai","doi":"10.1109/NANO.2016.7751362","DOIUrl":"https://doi.org/10.1109/NANO.2016.7751362","url":null,"abstract":"ZnO nanorod arrays were grown by hydrothermal method on flat glass substrates and patterned sapphire substrates. Different growth times and concentrations of zinc acetate solution were performed for ZnO nanorod growth to investigate the structural and CO gas sensing properties. The highest gas sensing response was obtained with the growth time of 60 min and zinc acetate concentration of 0.03 M for both types of substrates. The sensing responses under different temperature and gas concentration were also measured. The highest responses was 1.85 and 1.75 for the flat glass substrates and the patterned sapphire substrates, respectively, under the temperature of 300 °C and the CO gas concentration of 2000 ppm. The response times of 200 and 110 s were achieved for the flat glass substrates and the patterned sapphire substrates, respectively.","PeriodicalId":6646,"journal":{"name":"2016 IEEE 16th International Conference on Nanotechnology (IEEE-NANO)","volume":"48 1","pages":"206-209"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85588820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current status and prospects of nanoimprint technology","authors":"S. Matsui","doi":"10.1109/NANO.2016.7751312","DOIUrl":"https://doi.org/10.1109/NANO.2016.7751312","url":null,"abstract":"Nanoimprint is an emerging lithographic technology that promises high-throughput patterning of nanostructures. Based on the mechanical embossing principle, nanoimprint technique can achieve pattern resolutions beyond the limitations set by the light diffractions or beam scatterings in other conventional techniques. Nanoimprint can be applied to optical device, magnetic device, LSI device and so on.","PeriodicalId":6646,"journal":{"name":"2016 IEEE 16th International Conference on Nanotechnology (IEEE-NANO)","volume":"48 1","pages":"706-709"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76982904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}