世界移植杂志最新文献

{"title":"Lesson learnt from 60 years of liver transplantation: Advancements, challenges, and future directions.","authors":"Eyad Gadour","doi":"10.5500/wjt.v15.i1.93253","DOIUrl":"10.5500/wjt.v15.i1.93253","url":null,"abstract":"<p><p>Over the past six decades, liver transplantation (LT) has evolved from an experimental procedure into a standardized and life-saving intervention, reshaping the landscape of organ transplantation. Driven by pioneering breakthroughs, technological advancements, and a deepened understanding of immunology, LT has seen remarkable progress. Some of the most notable breakthroughs in the field include advances in immunosuppression, a revised model for end-stage liver disease, and artificial intelligence (AI)-integrated imaging modalities serving diagnostic and therapeutic roles in LT, paired with ever-evolving technological advances. Additionally, the refinement of transplantation procedures, resulting in the introduction of alternative transplantation methods, such as living donor LT, split LT, and the use of marginal grafts, has addressed the challenge of organ shortage. Moreover, precision medicine, guiding personalized immunosuppressive strategies, has significantly improved patient and graft survival rates while addressing emergent issues, such as short-term complications and early allograft dysfunction, leading to a more refined strategy and enhanced post-operative recovery. Looking ahead, ongoing research explores regenerative medicine, diagnostic tools, and AI to optimize organ allocation and post-transplantation car. In summary, the past six decades have marked a transformative journey in LT with a commitment to advancing science, medicine, and patient-centered care, offering hope and extending life to individuals worldwide.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"15 1","pages":"93253"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future of non-invasive graft evaluation: A systematic review of proteomics in kidney transplantation.","authors":"Eleni Avramidou, Konstantina Psatha, Kallisti St John, Georgios Tsoulfas, Michalis Aivaliotis","doi":"10.5500/wjt.v15.i1.96025","DOIUrl":"10.5500/wjt.v15.i1.96025","url":null,"abstract":"<p><strong>Background: </strong>Despite the developments in the field of kidney transplantation, the already existing diagnostic techniques for patient monitoring are considered insufficient. Protein biomarkers that can be derived from modern approaches of proteomic analysis of liquid biopsies (serum, urine) represent a promising innovation in the monitoring of kidney transplant recipients.</p><p><strong>Aim: </strong>To investigate the diagnostic utility of protein biomarkers derived from proteomics approaches in renal allograft assessment.</p><p><strong>Methods: </strong>A systematic review was conducted in accordance with PRISMA guidelines, based on research results from the PubMed and Scopus databases. The primary focus was on evaluating the role of biomarkers in the non-invasive diagnosis of transplant-related complications. Eligibility criteria included protein biomarkers and urine and blood samples, while exclusion criteria were language other than English and the use of low resolution and sensitivity methods. The selected research articles, were categorized based on the biological sample, condition and methodology and the significantly and reproducibly differentiated proteins were manually selected and extracted. Functional and network analysis of the selected proteins was performed.</p><p><strong>Results: </strong>In 17 included studies, 58 proteins were studied, with the cytokine CXCL10 being the most investigated. Biological pathways related to immune response and fibrosis have shown to be enriched. Applications of biomarkers for the assessment of renal damage as well as the prediction of short-term and long-term function of the graft were reported. Overall, all studies have shown satisfactory diagnostic accuracy of proteins alone or in combination with conventional methods, as far as renal graft assessment is concerned.</p><p><strong>Conclusion: </strong>Our review suggests that protein biomarkers, evaluated in specific biological fluids, can make a significant contribution to the timely, valid and non-invasive assessment of kidney graft.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"15 1","pages":"96025"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiology and health assessment, risk balance, and model for end-stage liver disease scores: Postoperative outcome of liver transplantation.","authors":"Raquel Hohenreuther, Andresa Thomé Silveira, Edison Moraes Rodrigues Filho, Anderson Garcez, Bruna Goularth Lacerda, Sabrina Alves Fernandes, Claudio Augusto Marroni","doi":"10.5500/wjt.v15.i1.95899","DOIUrl":"10.5500/wjt.v15.i1.95899","url":null,"abstract":"<p><strong>Background: </strong>Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of life. The number of organs available for transplantation is lower than the demand. To provide fair organ distribution, predictive mortality scores have been developed.</p><p><strong>Aim: </strong>To compare the Acute Physiology and Chronic Health Evaluation IV (APACHE IV), balance of risk (BAR), and model for end-stage liver disease (MELD) scores as predictors of mortality.</p><p><strong>Methods: </strong>Retrospective cohort study, which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to 2018.</p><p><strong>Results: </strong>The transplant recipients were mainly male, with a mean age of 58.1 years. Donors were mostly male, with a mean age of 41.6 years. The median cold ischemia time was 3.1 hours, and the median intensive care unit stay was 5 days. For APACHE IV, a mean of 59.6 was found, BAR 10.7, and MELD 24.2. The 28-day mortality rate was 9.5%, and at 90 days, it was 3.5%. The 28-day mortality prediction for APACHE IV was very good [area under the curve (AUC): 0.85, <i>P</i> < 0.001, 95%CI: 0.76-0.94], <i>P</i> < 0.001, BAR (AUC: 0.70, <i>P</i> < 0.001, 95%CI: 0.58-0.81), and MELD (AUC: 0.66, <i>P</i> < 0.006, 95%CI: 0.55-0.78), <i>P</i> < 0.008. At 90 days, the data for APACHE IV were very good (AUC: 0.80, <i>P</i> < 0.001, 95%CI: 0.71-0.90) and moderate for BAR and MELD, respectively, (AUC: 0.66, <i>P</i> < 0.004, 95%CI: 0.55-0.77), (AUC: 0.62, <i>P</i> < 0.026, 95%CI: 0.51-0.72). All showed good discrimination between deaths and survivors. As for the best value for liver transplantation, it was significant only for APACHE IV (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>The APACHE IV assessment score was more accurate than BAR and MELD in predicting mortality in deceased donor liver transplant recipients.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"15 1","pages":"95899"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Literature study on traditional Chinese medicine syndromes after renal transplantation.","authors":"Yun-Peng Guo, Ling-Xue Bao, Yu-Yang Wang, Quan Wen, Gai Hang, Bo Chen","doi":"10.5500/wjt.v15.i1.96870","DOIUrl":"10.5500/wjt.v15.i1.96870","url":null,"abstract":"<p><strong>Background: </strong>Kidney transplantation is the most effective means to treat patients with renal failure, but its postoperative problems such as rejection reactions, immunosuppressant poisoning, chronic transplant kidney nephropathy, <i>etc.</i> still have not been effectively solved. This study searched for literature on traditional Chinese medicine (TCM) syndromes after kidney transplantation in China, conducted statistical analysis of the results, and sought to identify the underlying patterns.</p><p><strong>Aim: </strong>To understand the TCM syndromes after renal transplantation and associated rules and provide a theoretical basis for further clinical research.</p><p><strong>Methods: </strong>The literature pertaining to TCM syndromes in renal transplantation, published in the China National Knowledge Infrastructure, Wanfang database, and WIP database from 1970 to 2021, was meticulously searched and comprehensively and statistically analyzed.</p><p><strong>Results: </strong>Following the established inclusion and exclusion criteria, 13 studies were selected for analysis. Post-renal transplantation, no significant discrepancy was noted among the groups based on the location of TCM viscera. However, when categorized according to TCM pathogenic factors, the groups with spleen and kidney yang deficiency, as well as liver and kidney yin deficiency, exhibited a statistically significant difference in the frequency.</p><p><strong>Conclusion: </strong>Currently, the research on TCM syndromes pertaining to renal transplantation is in its nascent phase. It is imperative to conduct a multicentric, large-scale survey of TCM syndromes subsequent to renal transplantation in the ensuing years.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"15 1","pages":"96870"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of living donor kidney transplants: Right <i>vs</i> left.","authors":"Taqi Khan, Nadeem Ahmad, Qaisar Iqbal, Muneeb Hassan, Lajward Asnath, Naveed Khan, Sajid Shakeel","doi":"10.5500/wjt.v15.i1.97598","DOIUrl":"10.5500/wjt.v15.i1.97598","url":null,"abstract":"<p><strong>Background: </strong>Transplant teams often hesitate to use the right kidney (RK) in living donor (LD) transplants due to the complexities of anastomosing the short, thin-walled right renal veins, which can potentially lead to graft loss or graft dysfunction. Nevertheless, circumstances may arise where selecting the RK over the left kidney (LK) is unavoidable. Consequently, it is crucial to thoroughly examine the implications of such a choice on the overall transplant outcome.</p><p><strong>Aim: </strong>To compare transplant outcomes between recipients of RK and LK while examining the factors that influence these outcomes.</p><p><strong>Methods: </strong>We retrospectively analyzed data from adult patients who received LD kidney transplants involving meticulous patient selection and surgical techniques at our center from January 2020 to December 2023. We included all kidney donors who were over 18, fit to donate, and had undergone diethylenetriamine pentaacetic acid split function and/or computed tomography based volumetry. The variables examined comprised donor and recipient demographics, and outcome measures included technical graft loss (TGL), delayed or slow graft function (SGF), and post-transplant serum creatinine (SC) trends. We used a logistic regression model to assess the likelihood of adverse outcomes considering the donor kidney side.</p><p><strong>Results: </strong>Of the 250 transplants performed during the period, 56 (22%) were RKs. The recipient demographics and transplant factors were comparable for the right and LKs, except that the donor warm and cold ischemia time were shorter for RKs. TGL and SGF each occurred in 2% (<i>n</i> = 1) of RKs and 0.5% (<i>n</i> = 1) of LKs, the difference being insignificant. These complications, however, were not related to the venous anastomosis. One RK (2%) developed delayed graft function after 48 hours, which was attributable to postoperative hypoxia rather than the surgical technique. The post-transplant SC trend and mean SC at the last follow-up were similar across both kidney sides.</p><p><strong>Conclusion: </strong>The donor kidney side has little impact on post-transplant adverse events and graft function in LD transplants, provided that careful patient selection and precise surgical techniques are employed.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"15 1","pages":"97598"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular carcinoma recurrence after liver transplant: An Australian single-centre study.","authors":"Matthew G Garas, Luis Calzadilla-Bertot, Briohny W Smith, Luc Delriviere, Byron Jaques, Lingjun Mou, Leon A Adams, Gerry C MacQuillan, George Garas, Gary P Jeffrey, Michael C Wallace","doi":"10.5500/wjt.v15.i1.99004","DOIUrl":"10.5500/wjt.v15.i1.99004","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. Liver transplantation (LT) offers the most effective treatment. HCC recurrence is the strongest risk factor that decreases post-LT survival in patients transplanted for HCC. The rate of HCC recurrence is generally reported as 8%-20% in the literature. Many predictors of HCC have already been researched, however, to our knowledge there are no published studies on this topic using Australian data.</p><p><strong>Aim: </strong>To determine the rate and identify predictors of HCC recurrence in a contemporary Western Australian LT cohort.</p><p><strong>Methods: </strong>We performed a retrospective cohort study of all liver transplants in patients with HCC at Sir Charles Gairdner Hospital between 2006 and 2021. Data was collected from various health record databases and included recipient demographics, serum biochemistry, radiology, operation notes, explant histopathology and details of recurrence. Overall survival of HCC patients post-LT, stratified for recurrence, was calculated by Kaplan Meier analysis. Univariate and multivariate Cox regression was used to determine predictors of HCC recurrence post-LT.</p><p><strong>Results: </strong>Between 1/1/2006 and 12/31/2021, 119 patients were transplanted with HCC. 8.4% of subjects developed recurrent HCC after LT with median follow-up time of 5.4 years. The median time to recurrence was 2.9 years ± 0.75 years. When comparing baseline characteristics, a greater proportion of subjects with recurrence had common characteristics on explant histopathology, including > 3 viable nodules (<i>P</i> = 0.001), vascular invasion (<i>P</i> = 0.003) and poorly differentiated HCC (<i>P</i> = 0.03). Unadjusted survival curves showed lower 1-year, 3-year, 5-year and 10-year survival rates in subjects with HCC recurrence compared to those without HCC recurrence (90% <i>vs</i> 92%, 70% <i>vs</i> 88%, 42% <i>vs</i> 80%, 14% <i>vs</i> 76%, respectively; log rank <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>HCC recurrence was low at 8.4% in this contemporary Australian cohort, however it significantly impacted post-LT survival. Further studies are required to confirm predictors of recurrence and improve recipient outcomes.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"15 1","pages":"99004"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large-for-size syndrome prophylaxis in infant liver recipients with low body mass.","authors":"Konstantin Semash, Timur Dzhanbekov","doi":"10.5500/wjt.v15.i1.99452","DOIUrl":"10.5500/wjt.v15.i1.99452","url":null,"abstract":"<p><p>Transplantation of the left lateral section (LLS) of the liver is now an established practice for treating advanced diffuse and unresectable focal liver diseases in children, with variants of the LLS primarily used in infants. However, the surgical challenge of matching the size of an adult donor's graft to the volume of a child's abdomen remains significant. This review explores historical developments, various approaches to measuring the required functional liver mass, and techniques to prevent complications associated with large-for-size grafts in infants.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"15 1","pages":"99452"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding role of antibodies in kidney transplantation.","authors":"Khawar Abbas, Muhammed Mubarak","doi":"10.5500/wjt.v15.i1.99220","DOIUrl":"10.5500/wjt.v15.i1.99220","url":null,"abstract":"<p><p>The role of antibodies in kidney transplant (KT) has evolved significantly over the past few decades. This role of antibodies in KT is multifaceted, encompassing both the challenges they pose in terms of antibody-mediated rejection (AMR) and the opportunities for improving transplant outcomes through better detection, prevention, and treatment strategies. As our understanding of the immunological mechanisms continues to evolve, so too will the approaches to managing and harnessing the power of antibodies in KT, ultimately leading to improved patient and graft survival. This narrative review explores the multifaceted roles of antibodies in KT, including their involvement in rejection mechanisms, advancements in desensitization protocols, AMR treatments, and their potential role in monitoring and improving graft survival.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"15 1","pages":"99220"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial dysfunction in the kidney transplant population: Current evidence and management strategies.","authors":"Arun Prabhahar, Akshey Batta, Juniali Hatwal, Vivek Kumar, Raja Ramachandran, Akash Batta","doi":"10.5500/wjt.v15.i1.97458","DOIUrl":"10.5500/wjt.v15.i1.97458","url":null,"abstract":"<p><p>The endothelium modulates vascular homeostasis owing to a variety of vasoconstrictors and vasodilators. Endothelial dysfunction (ED), characterized by impaired vasodilation, inflammation, and thrombosis, triggers future cardiovascular (CV) diseases. Chronic kidney disease, a state of chronic inflammation caused by oxidative stress, metabolic abnormalities, infection, and uremic toxins damages the endothelium. ED is also associated with a decline in estimated glomerular filtration rate. After kidney transplantation, endothelial functions undergo immediate but partial restoration, promising graft longevity and enhanced CV health. However, the anticipated CV outcomes do not happen due to various transplant-related and unrelated risk factors for ED, culminating in poor CV health and graft survival. ED in kidney transplant recipients is an under-recognized and poorly studied entity. CV diseases are the leading cause of death among kidney transplant candidates with functioning grafts. ED contributes to the pathogenesis of many of the CV diseases. Various biomarkers and vasoreactivity tests are available to study endothelial functions. With an increasing number of transplants happening every year, and improved graft rejection rates due to the availability of effective immunosuppressants, the focus has now shifted to endothelial protection for the prevention, early recognition, and treatment of CV diseases.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"15 1","pages":"97458"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global transplantation: Lessons from organ transplantation organizations worldwide.","authors":"Solonas Symeou, Eleni Avramidou, Vassilios Papalois, Georgios Tsoulfas","doi":"10.5500/wjt.v15.i1.99683","DOIUrl":"10.5500/wjt.v15.i1.99683","url":null,"abstract":"<p><p>Although national transplant organizations share common visions and goals, the creation of a unified global organization remains impractical. Differences in ethnicity, culture, religion, and education shape local practices and infrastructure, making the establishment of a single global entity unfeasible. Even with these social disparities aside, logistical factors such as time and distance between organ procurement and transplantation sites pose significant challenges. While technological advancements have extended organ preservation times, they have yet to support the demands of transcontinental transplantations effectively. This review presents a comparative analysis of the structures, operational frameworks, policies, and legislation governing various transplant organizations around the world. Key differences pertain to the administration of these organizations, trends in organ donation, and organ allocation policies, which reflect the financial, cultural, and religious diversity across different regions. While a global transplant organization may be out of reach, agreeing on best practices for the benefit of patients is essential.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"15 1","pages":"99683"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}