世界移植杂志最新文献

{"title":"Letter to the Editor: Response to outcomes of \"right <i>vs</i> left kidney\".","authors":"Taqi Khan, Qaisar Iqbal, Muneeb Hassan, Sajid Shakeel, Naveed Khan, Lajward Asnath","doi":"10.5500/wjt.v16.i2.115987","DOIUrl":"10.5500/wjt.v16.i2.115987","url":null,"abstract":"<p><p>We read the comments by Favi and Morabito, published in the recent issue of the <i>World Journal of Transplantation</i>, about our recently published paper and am concerned that our paper is being misrepresented as a debate on donor nephrectomy techniques. Ours is a surgical paper, in which we discussed selection criteria for right kidneys and how to best utilize the vein, because it is the vein length that causes serious technical complications. Despite limitations of our healthcare resources, the excellent donor and recipient outcomes in right kidneys have validated our current donation and transplant techniques.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"16 2","pages":"115987"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13248514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiological spectrum and probability of transmission of infection from ocular tissues of enucleated eyes harvested from septicemic donors.","authors":"Aditi Dubey, Priyanka, Deepak Soni, Deepti Chaurasia, Brindha Periasamy, Nikhila C Jain, Deepayan Sarkar, Mamta Singh, Srishti Khullar, Kavita Kumar, Pragyil Chaturvedi, Bhavana Sharma","doi":"10.5500/wjt.v16.i2.118357","DOIUrl":"10.5500/wjt.v16.i2.118357","url":null,"abstract":"<p><strong>Background: </strong>Tissues from septicemic donor are considered contraindication for transplantation. However, a definite evidence is lacking to link these corneas as a potential source of post-transplantation infection.</p><p><strong>Aim: </strong>To assess corneal tissue microbiology in septicemic donors and correlate postmortem blood cultures with ocular isolates to determine transplant suitability.</p><p><strong>Methods: </strong>A bicentric cross-sectional study evaluated 264 eyes from 136 septicemic and non-septicemic donors at two eye banks of tertiary eye centers. Culture report of tissue samples (conjunctival swab, aqueous and vitreous tap, cornea, sclera, and post- mortem blood sample) was compared with the culture results of post-mortem blood samples. Additionally, correlation if any was evaluated between culture positivity of harvested tissue with death to retrieval time. Statistical results were analyzed using Pearson <i>χ</i> ² and Fisher's exact tests.</p><p><strong>Results: </strong>Among 21 septicemic donors, microbial growth was observed in 28.6%, 7.1%, 9.5%, 4.8%, and 2.4% of non-utilized conjunctival, corneal, scleral, aqueous, and vitreous samples respectively as opposed to 16.7 [odds ratio (OR) = 10.6, 95% confidence interval (CI): 0.938-4.263, <i>P</i> = 0.058], 9.0 (OR = 0.777, 95%CI: 0.141-2.815, <i>P</i> = 0.485), 10.8 (OR = 0.868, 95%CI: 0.207-2.739, <i>P</i> = 0.530), 2.2 (OR = 2.162, 95%CI: 0.199-13.78, <i>P</i> = 0.308) and 1.3% (OR = 1.776, 95%CI: 0.033-22.74, <i>P</i> = 0.502) of 115 non-septicemic donors. Only one tissue of cornea and sclera, yielded the same organism as the blood culture. The microbiological spectrum of pathogens from culture-positive tissues was reflective of commensal pathogens. A strong positive correlation was seen between death to retrieval time in relation to microbial growth.</p><p><strong>Conclusion: </strong>These findings suggest that sepsis does not significantly impact ocular tissue sterility. Thus, current transplantation guidelines may benefit from further review, particularly in light of the potential to increase the availability of transplantable tissue, consequent to reduced rejection and wastage.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"16 2","pages":"118357"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C3 glomerulopathy in transplant \"like yet unlike native\": Pathophysiology, recent advances in therapeutics and evolving paradigms.","authors":"Arun Chutani, Sayna Norouzi, Edgar V Lerma","doi":"10.5500/wjt.v16.i2.117138","DOIUrl":"10.5500/wjt.v16.i2.117138","url":null,"abstract":"<p><p>This review provides an in-depth examination of the recurrence and management of glomerular diseases after kidney transplantation, with particular emphasis on C3 glomerulopathy (C3G). Among post-transplant glomerular diseases, C3G exhibits the highest recurrence rates, reported between 30% and 89% across studies. The review outlines the complex pathophysiology of C3G, driven by dysregulation of the complement system - whether from genetic variants, autoantibodies, monoclonal gammopathy, or other acquired factors. It highlights the diagnostic challenges posed by overlapping features with hemolytic uremic syndrome and membranoproliferative glomerulonephritis, as well as the difficulty in distinguishing complement overactivation from true regulatory failure. Key mechanisms of complement activation and the role of regulatory proteins are discussed, along with operative and clinical risk factors such as ischemia-reperfusion injury, delayed graft function, viral infections, and monoclonal gammopathy. The review describes the histopathologic spectrum of C3G in the allograft and underscores the importance of early protocol biopsies for timely detection. Management strategies include conservative measures, nonspecific immunosuppression, and emerging complement-targeted therapies. Recent Food and Drug Administration approvals of iptacopan and pegcetacoplan represents major advances. The review concludes by emphasizing personalized medicine, improved biomarkers, comprehensive genetic and autoantibody testing, and continued research to refine surveillance and treatment strategies for transplant recipients with C3G.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"16 2","pages":"117138"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor heart injury caused by liver needle biopsy during multi-organ procurement surgery: A case report.","authors":"Yuriko Terada, Tsuyoshi Takahashi, Michael K Pasque, Daniel Kreisel, Amit Pawale","doi":"10.5500/wjt.v16.i2.119012","DOIUrl":"10.5500/wjt.v16.i2.119012","url":null,"abstract":"<p><strong>Background: </strong>Thoracic organ procurement procedures have been standardized for decades, and serious organ injury during procurement is considered rare. However, when injuries do occur, they may result in irreversible loss of transplantable organs.</p><p><strong>Case summary: </strong>We report a rare case of unintentional donor heart injury caused by transdiaphragmatic liver core needle biopsy using a Tru-Cut-type device during multi-organ procurement. Two puncture injuries were identified on the inferior wall of the heart adjacent to the posterior descending coronary artery. Although there was no active bleeding and gross ventricular function appeared preserved, the proximity to a coronary branch raised concern for potential coronary injury and re-bleeding following systemic heparinization. After multidisciplinary discussion among the cardiac procurement team, recipient transplant team, and the organ procurement organization, the donor heart was declined intraoperatively.</p><p><strong>Conclusion: </strong>This case highlights a preventable mechanism of procurement-related cardiac injury and underscores the importance of coordination, timing, and situational awareness among procurement teams to minimize avoidable donor organ loss.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"16 2","pages":"119012"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphocele after renal transplant: Prevention and management.","authors":"Mahendra Singh, Jaideep Singh Soni, Manali Jain, Deepak P Bhirud, Shiv C Navriya, Gautam R Choudhary, Arjun S Sandhu","doi":"10.5500/wjt.v16.i2.114224","DOIUrl":"10.5500/wjt.v16.i2.114224","url":null,"abstract":"<p><p>Lymphocele is a common postoperative complication following renal transplantation, with reported incidence ranging from 0.6% to 38%. Symptomatic lymphoceles, occurring in 5%-10% of recipients, may cause graft dysfunction through ureteric or vascular compression. This minireview provides a comprehensive synthesis of the epidemiology, pathophysiology, risk factors, prevention, diagnosis, and management of post-transplant lymphoceles. Prevention strategies include meticulous surgical ligation of lymphatics, prophylactic peritoneal fenestration, and delaying the use of mammalian target of rapamycin inhibitors in the early post-transplant period. Diagnosis is best achieved using ultrasound, with computed tomography or magnetic resonance imaging reserved for complex cases. Management follows a stepwise approach: Conservative observation for small asymptomatic collections, percutaneous drainage with or without sclerotherapy for symptomatic cases, and laparoscopic marsupialization for refractory or complicated lymphoceles. Novel techniques, including intraoperative lymphangiography and bioengineered sealants, represent promising future strategies for addressing these challenges. This minireview highlights the importance of integrating surgical refinement, tailored immunosuppression, and emerging technologies to optimize outcomes in renal transplant recipients.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"16 2","pages":"114224"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Informing national policy: Healthcare workers' readiness for a deceased donor kidney transplant program in Brunei Darussalam.","authors":"Nor Islya Emma Othman, Chiao Yuen Lim, Lubna Razak, Musuriani Yusuf, Dalinatul Ahmed, Fazean Idris, Nayan Joshi, Muhammad Abdul Mabood Khalil, Minh Cuong Duong, Jackson Tan","doi":"10.5500/wjt.v16.i2.117585","DOIUrl":"10.5500/wjt.v16.i2.117585","url":null,"abstract":"<p><strong>Background: </strong>Brunei Darussalam currently lacks a deceased donor kidney transplant (DDKT) program, and its establishment in a small population poses challenges related to limited expertise and community misconceptions. Healthcare workers (HCWs), as the operational backbone of any transplant service, are central to translating policy into practice and guiding patient understanding. Assessing their perceptions is essential for gauging system readiness and informing strategies for future program development.</p><p><strong>Aim: </strong>To explore HCWs' views on initiating a DDKT program, with specific focus on knowledge of kidney disease and attitudes toward deceased organ donation, opt-in donor card policy and transplant commercialization.</p><p><strong>Methods: </strong>This was a questionnaire-based knowledge, attitude and practice study conducted at the main tertiary hospital in Brunei Darussalam. Statistical analyses included bivariate tests for categorical variables and multivariable logistic regression to identify factors associated with supportive or non-supportive attitudes towards DDKT.</p><p><strong>Results: </strong>A total of 370 HCWs participated in the study, with a female predominance (76%), comprising 58 doctors, 271 nurses, and 41 allied health professionals. Overall, 61% of respondents demonstrated high knowledge, while 39% had low knowledge. Regarding attitudes toward DDKT, 44% agreed, 12% disagreed, and 45% remained neutral. An opt-in donor card system was favored by 54%, while 35% were neutral and 11% disagreed. Attitudes towards transplant commercialization showed little variation, with 21% expressing acceptance, 45% neutrality, and 33% disagreement. Islamic religion, Malay ethnicity, nursing profession, lower knowledge level, female sex, and unawareness of fatwa were significantly associated with disagreement towards both DDKT and the donor card system (all <i>P</i> < 0.05). In multivariable logistic regression analysis, profession [adjusted odds ratio (aOR) = 4.54], religion (aOR = 7.34), education level (aOR = 4.11) and knowledge status (aOR = 1.88) remained independently associated with disapproval of DDKT.</p><p><strong>Conclusion: </strong>Among HCWs in Brunei Darussalam, support for a DDKT program outweighs opposition, although a sizeable proportion remain undecided. Notably, some view commercialized transplantation as a potential means to address donor shortages, signaling ethical and policy concerns. These findings underscore the need to address knowledge gaps, enhance educational exposure, and clarify contextual issues to inform the development of a national DDKT program.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"16 2","pages":"117585"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13248161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-like peptide-1 agonists usage to widen the living donor pool for liver transplantation: A novel metabolic strategy.","authors":"Amr Alnagar, Muhammad U Khan, Muhammad S Ahmad, Mahmoud Mersal, Mohamed Ayyad, Rana Hassan, Mohamed Saleem Noormohamed","doi":"10.5500/wjt.v16.i2.118702","DOIUrl":"10.5500/wjt.v16.i2.118702","url":null,"abstract":"<p><p>Glucagon-like peptide-1 (GLP-1)/glucose-dependent insulinotropic polypeptide receptor agonists' use as a weight loss tool is gradually expanding. They can be used as bridging therapies to reduce weight in potential living donors for liver transplantation and improve graft quality. A living donor with high body mass index is likely to be declined in most living donor programs due to concerns about donor safety and graft function. Reducing weight before surgical procedures can improve outcomes and lower the incidence of morbidity and mortality. Growing clinical evidence supports the advantage of GLP-1 receptor agonists as well as GLP-1/glucose-dependent insulinotropic polypeptide receptor agonists as bridging therapies to minimize perioperative complications. However, these agents should be used with caution due to concerns about side effects, particularly delayed gastric emptying and the risk of aspiration. This article summarizes the available evidence about the promising use of new weight-reducing agents to expand graft pool by including higher body mass index donors after weight optimization.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"16 2","pages":"118702"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13248179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking procurement biopsy in donors with normal renal function: A barrier to kidney utilization without survival benefit.","authors":"Lena Sibulesky, Daniel M Kaufman, Ramasamy Bakthavatsalam, Nicolae Leca, James D Perkins","doi":"10.5500/wjt.v16.i2.118088","DOIUrl":"10.5500/wjt.v16.i2.118088","url":null,"abstract":"<p><strong>Background: </strong>Procurement biopsy remains widely used in deceased donor kidney transplantation, yet its value is uncertain in kidneys with preserved renal function. Concerns persist regarding sampling error, interpretive variability, and the potential for biopsy findings to contribute directly to organ discard. Whether procurement biopsy improves decision-making or graft outcomes in donors with normal renal function is not known.</p><p><strong>Aim: </strong>To investigate whether biopsy adds clinical value or causes delay, misclassification without improving outcomes in donors with preserved renal function.</p><p><strong>Methods: </strong>Using national Organ Procurement and Transplantation Network data (2014-2024), we evaluated deceased donor kidneys with terminal epidermal growth factor receptor ≥ 60. Donor, recipient, and transplant variables were linked at the center level to reflect clinical decision pathways. Propensity-score matching (1:1 nearest neighbor, caliper 0.2 SD) generated balanced biopsy and non-biopsy cohorts. Center-clustered Cox models estimated the association between biopsy and death-censored graft failure. Mediation through cold ischemia time and delayed graft function was examined using sequential attenuation, with robustness assessed <i>via E</i>-values, restricted mean survival time, and decision curve analysis.</p><p><strong>Results: </strong>Of 158365 recovered kidneys, 46.6% underwent biopsy and were over six times more likely to be discarded (28.2% <i>vs</i> 4.4%), including 5.9% discarded solely due to biopsy findings, more than half with only mild abnormalities. The matched cohort comprised 52094 transplants with excellent covariate balance. Center-clustered Cox models showed biopsy was associated with higher graft-failure risk (hazard ratio = 1.12, 95% confidence interval: 1.05-1.19). Biopsy prolonged cold ischemia time by 42 minutes, mediating approximately half of its adverse survival association. Restricted mean survival time demonstrated a small but significant absolute reduction in five-year survival (-0.03 years). Decision curve analysis showed no meaningful improvement in clinical benefit from biopsy beyond standard clinical variables.</p><p><strong>Conclusion: </strong>In deceased donors with normal renal function, procurement biopsy adds no prognostic value, increases discard and ischemic delay, and may hinder optimal utilization of otherwise transplantable kidneys.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"16 2","pages":"118088"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of islet purity on the proportion of smaller islets and graft outcomes in clinical transplantation.","authors":"Praveen Kumar Ravi, Sipra Rout, Pravash R Mishra, Appakalai N Balamurugan","doi":"10.5500/wjt.v16.i2.116413","DOIUrl":"10.5500/wjt.v16.i2.116413","url":null,"abstract":"<p><p>The outcome of clinical islet transplantation has been influenced by various factors, including the volume of islet transplanted (IEQ), frequency of transplantation, islet size, and purity. Most studies have compared the outcomes with these factors individually. This review attempts to comprehend the key factors that influence the outcome of clinical islet transplantation by understanding and analyzing the relationship between them. The purity of the islet preparation is often overlooked, as it is often believed to have a higher level of purity associated with better clinical outcome. However, a recent study documented long-term outcome of transplantation is better when purity less than 50%. Various studies have documented the decrease in the proportion of small islets with an increase in purity. Poor clinical outcomes have been documented when the transplanted islet preparation contains a lower proportion of small islets. This is not only because small islets survive better with diffusion, but also the higher proportion of large islets is prone to producing overestimation in IEQ calculation, leading to inadequate transplantation volume. Vigorous purification processes may remove the potential stem cells or progenitor cells present in pancreas and lack the paracrine effect that supports the viability and function of transplanted islets.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"16 2","pages":"116413"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifaceted role of histopathology in liver transplantation for hepatocellular carcinoma: A narrative review towards precision prognosis.","authors":"Marcelo Fabián Amante, María Fernanda Vargas Wille, María L Pestalardo","doi":"10.5500/wjt.v16.i2.115879","DOIUrl":"10.5500/wjt.v16.i2.115879","url":null,"abstract":"<p><p>Hepatocellular carcinoma is a leading cause of cancer mortality globally. Liver transplantation is considered the best curative treatment for selected patients, as it removes the tumor and restores hepatic function. However, organ scarcity requires precise prognostic stratification. Histopathology is the essential bridge between morphology and biology, offering unique insights into tumor aggressiveness that imaging cannot capture. Öztürk <i>et al</i> recently published a study in the <i>World Journal of Transplantation</i>, analyzing a large United States transplant cohort analysis, which reveals clear differences in the risk profiles of macrovascular invasion and microvascular invasion. A central prognostic factor is macrovascular invasion. Macrovascular invasion indicates a poor prognosis, whereas microvascular invasion, detectable only histologically, defines an intermediate risk, highlighting the need for meticulous and standardized pathological examination. Prognostic accuracy is further refined by factors such as histological grading and specific subtypes (<i>e.g</i>., macrotrabecular-massive). Histopathological data guide clinical decision-making throughout the transplant process, from candidate selection to individualized surveillance. The incorporation of microvascular invasion or poor differentiation into predictive models improves patient management. In the future, digital pathology and artificial intelligence will automate the detection of prognostic markers, while molecular profiling will deepen our understanding of tumors at the morpho-molecular level. Within this integrated framework, histopathology has evolved into a dynamic science that is essential for the implementation of precision medicine for liver transplantation in cases of hepatocellular carcinoma. The liver explant has become a valuable repository of biological information that informs risk, guides therapy, and expands the field of transplant oncology.</p>","PeriodicalId":65557,"journal":{"name":"世界移植杂志","volume":"16 2","pages":"115879"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13248513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148229365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}