Analytical Methods最新文献_第3页

Multiplexed centrifugal microfluidic system for rapid and non-invasive detection of myocardial fibrosis. 用于快速无创检测心肌纤维化的多重离心微流控系统。

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-12-16 DOI: 10.1039/d4ay01703j

Luhai Wang, Jiaze Sun, Siwei Dai, Pengfei Zhang, Yefei Zhu, Yu Zhang

{"title":"Multiplexed centrifugal microfluidic system for rapid and non-invasive detection of myocardial fibrosis.","authors":"Luhai Wang, Jiaze Sun, Siwei Dai, Pengfei Zhang, Yefei Zhu, Yu Zhang","doi":"10.1039/d4ay01703j","DOIUrl":"https://doi.org/10.1039/d4ay01703j","url":null,"abstract":"Myocardial fibrosis is a pathological condition characterized by the excessive accumulation of extracellular matrix proteins, primarily collagen, within the myocardium. Early symptoms of myocardial fibrosis are often subtle, leading to late detection. As the disease progresses, it is often associated with life-threatening complications. Therefore, myocardial fibrosis urgently demands a diagnostic system that is rapid, effective, and preferably non-invasive. In this study, we developed a highly sensitive microfluidic light-initiated chemiluminescent assay (LICA) for the simultaneous detection of cTnI, NT-proBNP, HA, LN, PICP, and PIIINP, the key biomarkers involved in the occurrence and development of myocardial fibrosis. The system is highly integrated and compact, incorporating reagent lyophilization and whole blood separation technologies, and is suitable for point-of-care testing. By combining advantages of centrifugal microfluidics and LICA, the system effectively shortens the detection time for key biomarkers associated with MACEs. Moreover, the system provides optimal analytical performance, with LoDs of 0.0018 ng mL-1, 0.0127 ng mL-1, 3.52 ng mL-1, 6.88 ng mL-1, 4.68 ng mL-1, and 0.072 ng mL-1 for cTnI, NT-proBNP, HA, LN, PIIINP and PICP, respectively. Ultimately, the system can achieve an AUC of 0.548, 0.670, 0.772, 0.752, 0.833 and 0.713 for cTnI, NT-proBNP, HA, LN, PIIINP, and PICP, respectively, and an overall combined ROC of 0.946 for the detection of myocardial fibrosis, indicating its excellent efficacy and potential for widespread clinical applications.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research and application discussion on new technology for detecting cadmium ions based on a near-red light carbon dot fluorescence quenching method. 基于近红光碳点荧光淬灭法的镉离子检测新技术的研究与应用探讨。

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-12-16 DOI: 10.1039/d4ay01760a

Runfeng Tian, Shifang Zhan, Guanlong He, Zixuan Wang, Zheng Zhang, Xiaoyan Wang

{"title":"Research and application discussion on new technology for detecting cadmium ions based on a near-red light carbon dot fluorescence quenching method.","authors":"Runfeng Tian, Shifang Zhan, Guanlong He, Zixuan Wang, Zheng Zhang, Xiaoyan Wang","doi":"10.1039/d4ay01760a","DOIUrl":"https://doi.org/10.1039/d4ay01760a","url":null,"abstract":"Cadmium ions are considered one of the most dangerous heavy metal pollutants. The human body does not require cadmium for growth and development, yet continuous intake of cadmium ions due to environmental pollution can lead to their accumulation in the body. This accumulation can result in damage to the urinary system and, in severe cases, pose life-threatening risks. The current conventional methods for analyzing heavy metals in the environment primarily include inductively coupled plasma mass spectrometry (ICP-MS), atomic absorption spectrometry (AAS), and inductively coupled plasma atomic emission spectrometry (ICP-AES). These methods are known for their drawbacks such as complex testing procedures, as well as expensive instrumentation and equipment. In this study, a novel technique for detecting cadmium ions using the near-red light carbon spot fluorescence burst method was developed. The near-infrared carbon dots (NIR-CDs) exhibited vibrant deep red fluorescence ranging from 625 to 710 nm, with a prominent peak at 685 nm. At a pH of 7 and a concentration of 0.1805 g L-1, the linear detection range for Cd2+ was determined to be 0.15-0.75 μM. The CDs demonstrated selectivity for Cd2+ detection, boasting an impressive detection limit of 0.397 nM. Mechanistic studies indicated that the interaction between red carbon dots and cadmium ions involved dynamic bursting of the ions. The practical application of the near-red light carbon spot fluorescence burst method for detecting cadmium ions could be further explored through the establishment of a Cd2+ recovery detection system.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous analysis of residual prohibited doping substances in foods using gas chromatography-tandem mass spectrometry. 利用气相色谱-串联质谱法同时分析食品中的残留禁用兴奋剂。

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-12-16 DOI: 10.1039/d4ay01606h

Yejin Lee, Yoeseph Cho, Seongeun Jeon, Yinglan Xu, Kang Mi Lee, Ho Jun Kim, Dong-Woo Lee, Junghyun Son

{"title":"Simultaneous analysis of residual prohibited doping substances in foods using gas chromatography-tandem mass spectrometry.","authors":"Yejin Lee, Yoeseph Cho, Seongeun Jeon, Yinglan Xu, Kang Mi Lee, Ho Jun Kim, Dong-Woo Lee, Junghyun Son","doi":"10.1039/d4ay01606h","DOIUrl":"https://doi.org/10.1039/d4ay01606h","url":null,"abstract":"The continuous consumption of various foods increases the risk of unintentional exposure to residual contaminants. Thus, improving premonitoring procedures to ensure food safety is critical. Herein, a rapid and efficient assay was developed to monitor residual contaminants in food, with a focus on banned doping substances. First, 73 doping compounds, including anabolic agents that can be ingested from food were selected, after which a gas chromatography-tandem mass spectrometry (GC-MS/MS) method was developed for their simultaneous screening. Based on the GC-MS/MS-determined food-matrix characteristics and types, a sample-preparation module was developed to optimize the sample-preparation method. Thereafter, the developed analytical method was validated using representative food matrices, and the results confirmed that the developed method obtained good recoveries (80-123% (limit of quantification: 0.01-20 μg kg-1)). To monitor residual doping substances in commercially available foods, the established method was applied to the analysis of 40 food samples, including meat. Notably, endogenous hormones, such as testosterone, nandrolone, 19-norandrosterone, and 19-noretiocholanolone, were detected in the meat samples, although they did not exceed the maximum residue limits. This approach enables the assessment of potential exposure levels to food-borne endogenous hormones, thereby supporting food safety and preventing unintentional doping incidents in athletes.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bimetallic metal-organic framework based dispersive solid phase extraction followed by using a carbon dot solution as the elution solvent; application in the extraction of imidacloprid and acetamiprid from pepper samples. 基于双金属金属有机框架的分散固相萃取，然后使用碳点溶液作为洗脱溶剂；应用于从辣椒样品中萃取吡虫啉和啶虫脒。

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-12-13 DOI: 10.1039/d4ay01564a

Sarina Beiramzadeh, Mir Ali Farazjadeh, Ali Akbar Fathi, Mohammad Reza Afshar Mogaddam, Jafar Abolhasani

{"title":"Bimetallic metal-organic framework based dispersive solid phase extraction followed by using a carbon dot solution as the elution solvent; application in the extraction of imidacloprid and acetamiprid from pepper samples.","authors":"Sarina Beiramzadeh, Mir Ali Farazjadeh, Ali Akbar Fathi, Mohammad Reza Afshar Mogaddam, Jafar Abolhasani","doi":"10.1039/d4ay01564a","DOIUrl":"https://doi.org/10.1039/d4ay01564a","url":null,"abstract":"This study focuses on the dispersive solid phase extraction technique for the efficient extraction and enrichment of imidacloprid and acetamiprid from pepper samples. A synthesized sorbent was used for this purpose. Once the target analytes were adsorbed, the sorbent was separated using a centrifuge and the analytes were desorbed using a carbon dot solution. After centrifugation, a portion of the eluent was injected into a high-performance liquid chromatography-tandem mass spectrometry system for analysis of the analytes. Several parameters affecting the performance of the method were investigated, such as the amount of sorbent, the type and volume of elution solvent, pH, and so on. By optimizing these parameters, the method showed favorable results under the following conditions: a sample solution volume of 5 mL, a sorbent amount of 10 mg, vortexing for 2 min, 150 μL of carbon dot solution as the elution solvent, a pH of 10, and 3 min of agitation during the desorption step. Notably, this optimized method exhibited high extraction recoveries ranging from 67% to 78% as well as low detection limits (0.44 μg L-1 and 0.32 μg L-1) and quantification limits (1.4 μg L-1 and 1.0 μg L-1) for imidacloprid and acetamiprid, respectively. To validate the effectiveness of the method, four pepper samples were successfully analyzed and no analyte was detected in any of them using this approach. Overall, the developed DSPE method represents a reliable and sensitive technique for the extraction and analysis of the studied pesticides in pepper samples.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent poly(tannic acid)-based nanoprobes for selective and sensitive detection of bismuth ions. 基于荧光聚（单宁酸）的纳米探针，用于选择性灵敏检测铋离子。

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-12-13 DOI: 10.1039/d4ay01478b

Changchang Chen, Yuqing Yang, Chenyang Ji, Yasi Shui, Xiaoyan Jiang, Renyong Liu, Chenggen Xie, Lijuan Chen

{"title":"Fluorescent poly(tannic acid)-based nanoprobes for selective and sensitive detection of bismuth ions.","authors":"Changchang Chen, Yuqing Yang, Chenyang Ji, Yasi Shui, Xiaoyan Jiang, Renyong Liu, Chenggen Xie, Lijuan Chen","doi":"10.1039/d4ay01478b","DOIUrl":"https://doi.org/10.1039/d4ay01478b","url":null,"abstract":"Herein, blue luminescent fluorescent poly(tannic acid) nanoparticles (FPTA NPs) were fabricated through chemical degradation of poly(tannic acid) large particles using H2O2, and the obtained FPTA NPs exhibited excellent water dispersibility, great fluorescence stability, and relatively high quantum yield. More importantly, based on the dynamic quenching and chelation enhanced quenching effect between FPTA NPs and bismuth ions (Bi3+), a fluorescence method for the rapid identification and detection of Bi3+ was developed. With the increase of Bi3+, the fluorescence of FPTA NPs could be quenched gradually; the linear range was 0.2-80 μM, R2 was 0.997, the detection limit was 13.54 nM, and the response time was as short as 10 s. The FPTA NP based nanoprobe was successfully applied for the determination of Bi3+ in water samples, and the recovery rate ranged from 98.18% to 105.89%, with a relative standard deviation of less than 3.48%, thereby confirming the feasibility of using FPTA NPs for detecting Bi3+ in real water samples.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterisation of the phytochemical and bioactivity profiles of raw tea, stale-aroma, and betelnut-aroma type of Liupao tea through GC/LC-MS-based metabolomics. 基于GC/LC-MS的代谢组学分析六堡茶（生茶、陈瘤和槟榔瘤）的植物化学成分和生物活性特征。

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-12-13 DOI: 10.1039/d4ay01672f

Xuancheng Wang, Zhiyong She, Hailin Zhou, Tingting An, Jianwen Teng, Ning Xia, Pingchuan Zhu, Wenhui Liu, Huanxiao Dong, Limin Tang, Shulan You, Lu Wei, Kongying Li, Lingli Wang, Li Huang, Qisong Zhang

{"title":"Characterisation of the phytochemical and bioactivity profiles of raw tea, stale-aroma, and betelnut-aroma type of Liupao tea through GC/LC-MS-based metabolomics.","authors":"Xuancheng Wang, Zhiyong She, Hailin Zhou, Tingting An, Jianwen Teng, Ning Xia, Pingchuan Zhu, Wenhui Liu, Huanxiao Dong, Limin Tang, Shulan You, Lu Wei, Kongying Li, Lingli Wang, Li Huang, Qisong Zhang","doi":"10.1039/d4ay01672f","DOIUrl":"https://doi.org/10.1039/d4ay01672f","url":null,"abstract":"Liupao tea (LPT) is a Chinese dark tea known to possess a unique flavour. Microbial fermentation plays a crucial role in flavour development and enrichment. Currently, the phytochemical profiles and bioactivities of LPT with and without fermentation are not fully known. In this study, we compared the chemical composition of raw tea (SF), stale-aroma (SA), and betelnut-aroma (BA) type LPT through the application of GC/LC-MS-based metabolomics, and experimentally investigated their bioactivities via antioxidant, anti-inflammatory, hypolipidemic, and hypoglycemic assays in vitro. The results indicated that fermentation enhanced the flavour of LPT as evidenced by the sweetness-producing substances, decreased bitterness and astringency-related compounds and enriched abundance of aroma-generating compounds. Two and four volatiles were detected to be major contributors to the aroma in SA and BA, respectively. Fatty acids and phosphatidylcholines were the primary lipids, among which the lysing diacylglycerol trimethyl homoserines were found to be a new class of lipids in LPT. Notably, the fermentation resulted in the degradation of compounds, particularly glycerophospholipids and saccharolipids. SF had the highest level of bioactivity, followed by BA and SA. These findings expand the present understanding regarding the development of flavour, nutrition, and medicinal value of LPT. Moreover, they provide a theoretical basis for the identification of BA and SA and serve as a reference value for consumers in their selection of LPT products.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A highly sensitive facile plasmonic scheme for assessment of melamine in raw milk.

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-12-12 DOI: 10.1039/d4ay01764a

Upama Das, Abhilash Gayan, Rajib Biswas

引用次数: 0

Efficient extraction and determination of Au(III) ions from acid mine drainage and water samples using silica gel immobilized with Brevibacillus borstelensis.

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-12-11 DOI: 10.1039/d4ay01950d

Aslihan Yilmaz Camoglu, Celal Duran, Duygu Ozdes, Aleyna Nalcaoglu, Kadriye Inan Bektas, Ali Osman Belduz

{"title":"Efficient extraction and determination of Au(III) ions from acid mine drainage and water samples using silica gel immobilized with Brevibacillus borstelensis.","authors":"Aslihan Yilmaz Camoglu, Celal Duran, Duygu Ozdes, Aleyna Nalcaoglu, Kadriye Inan Bektas, Ali Osman Belduz","doi":"10.1039/d4ay01950d","DOIUrl":"https://doi.org/10.1039/d4ay01950d","url":null,"abstract":"The analysis of gold, which is a precious metal with limited resources, in environmental samples is crucial for the sustainable utilization of natural resources. Therefore, in the present research we have aimed to develop a novel and environmentally friendly bioadsorbent, Brevibacillus borstelensis loaded on silica gel (BB@Si), with outstanding adsorptive properties that can be implemented for quantitative recovery of Au(III) ions via the solid phase extraction (SPE) technique. After characterizing the developed adsorbent using FTIR and SEM techniques, we conducted a detailed investigation of the critical parameters that influence the extraction performance of Au(III) ions. Optimum parameters were observed as follows: pH 3.0, adsorption contact time 30 min, eluent type 0.1% (w/v) thiourea in 0.5 M HNO3, elution time 60 min, BB@Si amount 1.0 g L-1, and sample volume 400 mL. Some of the well-known isotherm and kinetic models were applied to the results observed from the adsorption studies. Equilibrium adsorption capacity of BB@Si was estimated to be 66.2 mg g-1 utilizing the Langmuir isotherm model while the limit of detection (LOD) and relative standard deviation (RSD%) were established as 0.99 μg L-1 and 3.7%, respectively. The developed method was utilized smoothly for the quantification of Au(III) ions in mining wastewater, acid mine drainage (AMD), streams and seawater.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid determination of chemical losses in a microplate bioassay using fluorescence spectroscopy.

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-12-10 DOI: 10.1039/d4ay01980f

Juliana M Huizenga, Lisa Truong, Lewis Semprini

{"title":"Rapid determination of chemical losses in a microplate bioassay using fluorescence spectroscopy.","authors":"Juliana M Huizenga, Lisa Truong, Lewis Semprini","doi":"10.1039/d4ay01980f","DOIUrl":"https://doi.org/10.1039/d4ay01980f","url":null,"abstract":"The increase in production and innovation of chemicals that humans interface with has enhanced the need for rapid toxicity testing of new and existing chemicals. This need, along with efforts to reduce animal testing, has led to the development of high-throughput bioassays typically conducted in microplates. These bioassays offer time and resource advantages over traditional animal models; however, significant chemical losses can occur in microplates. Current methods for measuring chemical losses in microplates require extensive sample preparation and highly sensitive instruments. We propose the use of fluorescence spectroscopy to measure chemical losses in high-throughput bioassays as a low resource alternative to the existing methods. A fluorescent plate reader was used to develop methods for quantifying the aqueous concentrations of two chemicals, 2-hydroxynaphthalene and acridine, in microwells of a 96-well microplate. A high-throughput, 5 day embryonic zebrafish bioassay was used as the model bioassay for method development. Chemical losses were attributed to a combination of photodegradation, sorption, and uptake by the zebrafish embryos, kinetics of which were derived from a pseudo-first order model. Chemical uptake amount was calculated to be approximately 50% and 21% of the total chemical amount added for 2-hydroxynaphthalene and acridine, respectively. Unexpected cranial deformities were observed in the embryonic zebrafish, suggesting further investigation of potential additive toxicity of the ultraviolet radiation exposure from fluorescence measurements and chemical exposure is needed. Nonetheless, this novel method provides a rapid, low resource approach to measuring chemical losses in microplates that can be extended to a variety of autofluorescent chemicals and microplate-based bioassays.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a fluorescent probe for detecting superoxide anions for monitoring the progression and treatment of acute spondylitis.

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-12-10 DOI: 10.1039/d4ay01626b

Xiaoming Chen, Peng Li, Guiqing Wang

{"title":"Development of a fluorescent probe for detecting superoxide anions for monitoring the progression and treatment of acute spondylitis.","authors":"Xiaoming Chen, Peng Li, Guiqing Wang","doi":"10.1039/d4ay01626b","DOIUrl":"https://doi.org/10.1039/d4ay01626b","url":null,"abstract":"The superoxide anion (O2˙-) is a vital reactive oxygen species (ROS) and participates in various physiological and pathological processes in organisms. The outbreak of O2˙- in the endoplasmic reticulum (ER) is believed to be closely related to many inflammatory diseases. In this work, a turn-on type ER-targeting fluorescent probe ERO was rationally designed for sensitive and selective detection of O2˙-. The minimum detection limit concentration for O2˙- was about 3.3 × 10-7 M in aqueous solution. More importantly, the probe ERO has minimal biological toxicity and can effectively target the ER and detect O2˙- in macrophage cells. Resveratrol is a natural drug closely related to anti-inflammatory effects. Through fluorescence monitoring of the probe ERO, it was found that there was an outbreak of O2˙- in the ER in acute spondylitis in mice and resveratrol reversed this increase. Thus, the probe ERO has the potential to become a favorable diagnostic tool to visualize the mouse spine during inflammation and the therapeutic effect of resveratrol.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0