Jiehao Huang, Hongwu Chen, Yimin Xu, Cong Huang, Rui Lin, Zhongjing Su, Jie Wu
{"title":"Liposome modification THP boosts glioma ferroptosis and immunogenic cell death through reinforcement of mitochondrial dysfunction and mitophagy","authors":"Jiehao Huang, Hongwu Chen, Yimin Xu, Cong Huang, Rui Lin, Zhongjing Su, Jie Wu","doi":"10.1007/s10853-025-11491-4","DOIUrl":"10.1007/s10853-025-11491-4","url":null,"abstract":"<div><p>Glioblastoma multiforme (GBM) is the most lethal tumor of the central nervous system, for which effective therapeutic options remain unavailable. Ferroptosis was a programmed cell death mechanism driven by lethal lipid peroxide accumulation, which emerged as a strategic target for glioma management. In this study, we show that phytochemical levo-tetrahydropalmatine (THP) activates ferroptosis and immunogenic cell death (ICD) though inducing mitochondrial dysfunction and augmented mitophagy. The significant improvement of the anti-tumor therapy efficacy for glioma through liposome modification THP (Lpo@THP NPs), delivering drugs through the blood-brain barrier (BBB). Lpo@THP NPs markedly suppressed GBM cell growth and impeded both migration and invasion in the murine glioma cell line GL261 as well as the human glioma cell line U87. Moreover, Lpo@THP NPs induced mitochondrial dysfunction and autophagy and further exerts its anti-GBM effects through lipid peroxidation and ferroptosis. Furthermore, ferroptosis initiation facilitates the release of damage-associated molecular patterns (DAMPs), thereby promoting ICD and enhancing the infiltration of cytotoxic T lymphocytes. In addition, both in vitro and in vivo studies confirmed that Lpo@THP NPs effectively suppressed GBM progression. Collectively, our findings establish immunomodulation of the tumor immune microenvironment (iTME) as a viable therapeutic approach to potentiate immunotherapy efficacy in glioma.</p></div>","PeriodicalId":645,"journal":{"name":"Journal of Materials Science","volume":"60 38","pages":"17531 - 17547"},"PeriodicalIF":3.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145143241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond current limits: a simulation study of 31.02% efficient tandem photovoltaics with novel oriented CsPbI3 and Ag2BeSnSe4","authors":"Mohamed Ait oufakir, Younes Chrafih, Habib Rozale, Khalid Rahmani, Omar Bajjou","doi":"10.1007/s10853-025-11469-2","DOIUrl":"10.1007/s10853-025-11469-2","url":null,"abstract":"<div><p>The importance of crystal orientation in CsPbI<sub>3</sub> perovskites, recognized for their outstanding optoelectronic properties, including high absorption coefficients and tunable bandgaps, is investigated within a tandem perovskite solar cell structure featuring an ITO/ZnSe/CsPbI<sub>3</sub> top cell and an ITO/ZnSe/Ag<sub>2</sub>BeSnSe<sub>4</sub> bottom cell. Among the studied orientations, through numerical simulations, we demonstrate that the orthogonal (010) configuration achieves the highest power conversion efficiency (PCE) of 21.88%. In contrast, the cubic (100) orientation exhibits the lowest PCE of 20.40%, highlighting the significance of structural anisotropy in photovoltaic performance. The tandem architecture, designed to exceed the Shockley–Queisser limit, demonstrates a remarkable PCE of 31.02%, with an open-circuit voltage (<i>V</i><sub>oc</sub>) of 2.006 V, a short-circuit current density (<i>J</i><sub>sc</sub>) of 17.5 mA/cm<sup>2</sup>, and a fill factor (FF) of 88.3%. Analysis of the individual sub-cells reveals PCEs of 16% for the top CsPbI3 cell and 23.32% for the bottom Ag<sub>2</sub>BeSnSe<sub>4</sub> cell, elucidating their contributions to the overall tandem efficiency. Furthermore, the study examines temperature-dependent performance, observing efficiency declines with rising temperatures and underscoring the importance of thermal management for device stability.</p></div>","PeriodicalId":645,"journal":{"name":"Journal of Materials Science","volume":"60 36","pages":"16163 - 16180"},"PeriodicalIF":3.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of fungal endophthalmitis with controlled-release voriconazole using a pH-responsive zeolitic-imidazolate-framework-based drug delivery system","authors":"Jiaojiao Wei, Jian Yu, Huan Xu, Yuan Zong, Chunhui Jiang","doi":"10.1007/s10853-025-11299-2","DOIUrl":"10.1007/s10853-025-11299-2","url":null,"abstract":"<div><p>Fungal endophthalmitis is a severe infectious disease that can result in permanent vision loss. Its poor visual prognosis is associated with the short half-lives of current antifungal medications and the formation of fungal biofilms. In this study, we designed and synthesized a pH-sensitive, positively charged antifungal nanocarrier based on a metal–organic framework, voriconazole-inbuilt zeolitic imidazolate framework-8 (VCZ@ZIF-8), as an efficient therapy for fungal infections and the eradication of biofilm during fungal endophthalmitis. With its strategic design, the injected VCZ@ZIF-8 arrived at and penetrated the fungal biofilm after its positively charged exterior interacted with the negative charge on the fungal cell surface. It then decomposed in response to the acid environment of the biofilm. The basic characteristics of VCZ@ZIF-8 were evaluated, including its biocompatibility, toxicity, the rate of cargo release, and thermal stability. Its antifungal effects and antibiofilm properties in fungal endophthalmitis were also investigated. In vitro, VCZ@ZIF-8 exerted significant antifungal effects and excellent biofilm penetration against <i>Candida albicans</i>. In an in vivo endophthalmitis model, VCZ@ZIF-8 showed better eradication of intraocular infections induced by <i>Candida albicans</i> than voriconazole, with negligible retinal toxicity or adverse effects on other organs. Our findings demonstrate that VCZ@ZIF-8 offers a safe and effective option for the treatment of fungal endophthalmitis.</p></div>","PeriodicalId":645,"journal":{"name":"Journal of Materials Science","volume":"60 36","pages":"16311 - 16327"},"PeriodicalIF":3.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Photochromic and luminescent modulation behaviors in K0.5Na0.5NbO3-based ferroelectric transparent ceramics","authors":"Chunxiao Lu, Ye Zhao, Qiwei Zhang, Shuai Li, Pengyu Li, Yu Guo, Yong Li, Liwen Zhang, Xihong Hao","doi":"10.1007/s10853-025-11410-7","DOIUrl":"10.1007/s10853-025-11410-7","url":null,"abstract":"<div><p>Transparent ferroelectric ceramics, emerging as innovative photoelectric multifunctional coupling material, demonstrate significant potential for applications in optical storage and smart windows. However, achieving high transparency via manipulation of the preparation process, microstructure, and phase structure poses a considerable challenge. Here, we employ multiple strategies, including the fabrication technology regulation and donor doping of La<sup>3+</sup> and Tb<sup>3+</sup> at the A-site of K<sub>0.5</sub>Na<sub>0.5</sub>NbO<sub>3</sub> to fabricate exceptional transparent ceramics coupled with multi-mode reversible modulations of transparency, photochromism, and photoluminescence. This research offers a novel perspective on the design of transparent multifunctional materials.</p></div>","PeriodicalId":645,"journal":{"name":"Journal of Materials Science","volume":"60 37","pages":"16779 - 16789"},"PeriodicalIF":3.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145128714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Y, Al doping on the microstructure and properties of h-BN fibers with low oxygen content","authors":"Huihui Zhao, Min Ge, Wen Xiao, Weigang Zhang","doi":"10.1007/s10853-025-11402-7","DOIUrl":"10.1007/s10853-025-11402-7","url":null,"abstract":"<div><p>Hexagonal boron nitride (h-BN) particles present significant challenges in sintering and crystallization processes, necessitating the use of specific aid reagents. While Y or Al containing compounds are extensively utilized as additives in the hot-press sintering of monolithic h-BN ceramics to enhance density and strength, their application in the production of continuous h-BN fibers remains under-explored. In this study, polymer-derived h-BN fibers doped with Y and Al elements were prepared and systematically investigated. The effects of these additives on the crystallization and properties of the derived ceramic fiber were analyzed. The results demonstrate that Y, Al, and Y/Al doping promote the growth of h-BN grains. Additionally, the formation of borate and yttrium aluminate in the Y and Al co-doped fibers, which melt at high temperatures, creates a liquid phase that aids in the bonding of BN layers. This liquid phase promotes the closure of micropores and densifies the structure. Conversely, it was observed that the introduction of Y/Al hindered the formation of excessively large h-BN grains, with an Lc of only 11 nm and a La of 27 nm when treated at 2000 °C. Furthermore, the tensile strength of the Y/Al-doped fibers was found to peak at 860 MPa upon treatment at 2000 °C, while Young’s modulus reached its maximum value of 110 GPa at the comparatively lower temperature of 1800 °C. These findings underscore the pivotal role of Y and Al doping in optimizing the microstructure and mechanical properties of h-BN fibers, thereby establishing them as promising candidates for advanced applications.</p></div>","PeriodicalId":645,"journal":{"name":"Journal of Materials Science","volume":"60 36","pages":"16015 - 16032"},"PeriodicalIF":3.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhengnan Lu, Yi Wang, Peng Zhang, Yang Sheng, Yixin Sun, Mark Bradley, Rong Zhang
{"title":"Design and in vitro photodynamic evaluation of self-illuminating nanospheres loaded with polyurethane containing protoporphyrin IX for anticancer and antibacterial applications","authors":"Zhengnan Lu, Yi Wang, Peng Zhang, Yang Sheng, Yixin Sun, Mark Bradley, Rong Zhang","doi":"10.1007/s10853-025-11465-6","DOIUrl":"10.1007/s10853-025-11465-6","url":null,"abstract":"<div><p>Locally induced photodynamic therapy (PDT) with internally generated light could offer opportunities for the efficient treatment of deep tissue tumors and bacteria hidden in places where external light cannot reach. To achieve this, luminol acrylamide was synthesized and used to prepare nanospheres that were loaded with a polyurethane photosensitizer and the enzyme horseradish peroxidase. With H<sub>2</sub>O<sub>2</sub> the nanoparticles were self-illuminating and showed good antibacterial abilities and also anticancer effects via a PDT mechanism indicating efficient self-luminous functionality. The self-luminating nanospheres could potentially be used in sterilization and for cancer depression.</p></div>","PeriodicalId":645,"journal":{"name":"Journal of Materials Science","volume":"60 36","pages":"16351 - 16363"},"PeriodicalIF":3.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multi-layered composite for custom production: integrating 3D-printed core with fiber-reinforced composites","authors":"Jakub Szary, Marcin Barburski, Jacek Świniarski","doi":"10.1007/s10853-025-11481-6","DOIUrl":"10.1007/s10853-025-11481-6","url":null,"abstract":"<div><p>This study investigates a novel hybrid multi-layer composite (MLC) that integrates a 3D-printed (3DP) core with technical fiber reinforcement and epoxy resin for custom-made applications, such as personalized knee braces. This approach aims to enhance the mechanical performance of 3DP components while eliminating the need for rigid molds. The MLC was fabricated by producing a flat PA12 3DP core via powder bed fusion, applying unidirectional glass fibers using tailored fiber placement (TFP), and encasing it in a braided biaxial carbon fiber sleeve. Flexural and tensile tests were performed. Micro-computed tomography (micro-CT) was used to analyze the internal structure. The mechanical behavior of the textile-reinforced composite layer was modeled using the Chamis model and classical laminate theory (CLT), with predictions compared to experimental results. The MLC exhibited a tensile strength of approximately 300 MPa, a modulus of 20 GPa, and a low average density of 1.4 g/cm<sup>3</sup>, resulting in a specific modulus comparable to that of aluminum alloys, thereby confirming its suitability for Lightweight structural applications. Both the Chamis and CLT models showed good agreement with experimental data, demonstrating their effectiveness in predicting and optimizing reinforcement structures. This study highlights the potential of utilizing 3D-printed cores as structural frames for fiber reinforcement. When combined with non-rigid molds, such as those used in infusion techniques, this novel approach eliminates the need for expensive production tools, significantly improving the cost-effectiveness of composite manufacturing. The proof of concept confirms the feasibility of MLCs for medical applications, such as lightweight, customized knee orthoses.</p></div>","PeriodicalId":645,"journal":{"name":"Journal of Materials Science","volume":"60 37","pages":"16934 - 16951"},"PeriodicalIF":3.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10853-025-11481-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145128561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pompa Saha, Sujit Kumer Shil, Probal Roy, Rajon Saha Auntu, Nazrul Islam Khan, S. S. Sikder
{"title":"Exploring the structural, magnetic, dielectric and electrical properties of solid state method synthesized Mn3+ substituted Co–Zn ferrites","authors":"Pompa Saha, Sujit Kumer Shil, Probal Roy, Rajon Saha Auntu, Nazrul Islam Khan, S. S. Sikder","doi":"10.1007/s10853-025-11449-6","DOIUrl":"10.1007/s10853-025-11449-6","url":null,"abstract":"<div><p>Co–Zn ferrites have already been familiar for their outstanding properties, including large saturation magnetization and high permeability over a broad frequency range. Herein, Co–Zn ferrites with the partial substitution of Mn in place of Fe have been prepared by solid state method for sintering temperature 1200 °C in air for 3 h and their structural, magnetic, dielectric and electrical properties have been investigated. The synthesized Mn-free and Mn-doped Co–Zn ferrites show a single phase with cubic spinel structure. The lattice parameter exhibited an increasing trend whereas the grain size showed an opposite manner with the increase in Mn substitutions in place of Fe. An enhanced saturation magnetization is noted after substituting 1 wt% Mn for Fe. Additionally, all the ferrite samples showed low coercivity (~ 12–40 Oe) values, indicating they belong to the family of soft ferrites. The permeability values are observed to decline gradually with the substitution of Mn, which can be attributed to the decrease in grain size as well as bulk density. The quality factor showed a gradual reduction with Mn substitution, however shifted toward higher frequencies. The dielectric dispersion exhibited a rapid decrease in the lower frequency range before practically remaining constant in the high frequency region beyond that a random nature. The explored dielectric behavior is an usual characteristics of ferrite materials, which can be realized by the Maxwell–Wagner interfacial polarization and Koop’s theory. The AC resistivity is obtained in the order of ~ 10<sup>5</sup>–10<sup>6</sup> Ω-m at low frequency region, indicating a semiconducting nature of the samples. Overall investigations suggest that Mn-substituted Co–Zn ferrites can be a good candidate to use in modern electromagnetic devices operating for high frequency regions.</p></div>","PeriodicalId":645,"journal":{"name":"Journal of Materials Science","volume":"60 37","pages":"17051 - 17064"},"PeriodicalIF":3.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145128756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tempo-oxidize cellulose nanofibers based Zn–BTC composite for high-efficiency Cd2+ and Ni2+ removal","authors":"Zilong Deng, Zixuan Wu, Zhongqi Zhao, Haoyu Gong, Yan Zhao, Donglu Fang, Hongcai Zhang","doi":"10.1007/s10853-025-11476-3","DOIUrl":"10.1007/s10853-025-11476-3","url":null,"abstract":"<div><p>Aiming at severe heavy metal pollution in wastewater, a novel nFe<sub>3</sub>O<sub>4</sub>&Zn–BTC@TOCNF was synthesized under ambient conditions for high-efficiency adsorption of Cd<sup>2+</sup> and Ni<sup>2+</sup>. SEM, FTIR, XRD, XPS and N<sub>2</sub>-adsorption/desorption were conducted and the removal performance of Cd<sup>2+</sup> and Ni<sup>2+</sup> were discussed in aqueous phase under different conditions. TOCNF loading elevated the crystallinity for the construction of more rigid scaffold. Meanwhile, the physical entanglement, electrostatic attractions, hydrogen and coordination bonds further improved the porosity and stability of nFe<sub>3</sub>O<sub>4</sub>&Zn–BTC@TOCNF. The composite exhibited maximum adsorption capacities of 230 mg/g and 67 mg/g for Cd<sup>2</sup>⁺ and Ni<sup>2</sup>⁺, respectively. Adsorption kinetics and isothermal adsorption suggested that the quasi-second-order kinetic model was more suitable to describe the adsorption than the quasi-first-order kinetic model. Furthermore, the adsorption process could be well described by Langmuir model, during which, both Cd<sup>2+</sup> and Ni<sup>2+</sup> were adsorbed at surface through monolayer adsorption. In addition, all R<sub>L</sub> values were in the range of 0–1, indicating favorable adsorption of Cd<sup>2+</sup> and Ni<sup>2+</sup> of the composite. Therefore, nFe<sub>3</sub>O<sub>4</sub>&Zn–BTC@TOCNF showed great prospects for the enhancement of water quality polluted by heavy metal.</p></div>","PeriodicalId":645,"journal":{"name":"Journal of Materials Science","volume":"60 37","pages":"16921 - 16933"},"PeriodicalIF":3.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145128759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Perspectives on the driving factors of accelerated tin whisker growth","authors":"Bo Wang, Zhenglin Zou, Jinshuai Xie, Shuang Tian, Yundeng Zhang, Jiacheng Liu, Wei Liu, Wei Zheng, Chenghuan Huang, Jianxiang Ding","doi":"10.1007/s10853-025-11387-3","DOIUrl":"10.1007/s10853-025-11387-3","url":null,"abstract":"<div><p>Tin (Sn) whiskers have long posed a serious threat to the reliability of electronic devices. This issue has become particularly prominent in the context of lead-free soldering, where the elimination of Pb (previously effective in suppressing Sn whisker growth) has reintroduced substantial risks to the long-term service of electronic components. To gain deeper insights into the whisker growth mechanism, establish effective mitigation strategies, and assess growth propensity, the development of controllable whisker acceleration methods has emerged as a critical research direction. This review systematically summarizes recent advances in whisker acceleration techniques, including the well-established stress-driven approaches, emerging mechanisms based on active atoms, as well as other methods such as electric field and irradiation. On this basis, a focused comparison is conducted between the stress-induced and active atom mechanisms in terms of driving forces, formation conditions, and acceleration efficacy. This multidimensional analysis aims to elucidate the factors behind rapid Sn whisker growth and to provide a theoretical foundation for optimizing acceleration methods and constructing reliable Sn whisker growth propensity evaluation strategies.</p></div>","PeriodicalId":645,"journal":{"name":"Journal of Materials Science","volume":"60 36","pages":"15955 - 15973"},"PeriodicalIF":3.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}