Journal of Nutritional Oncology最新文献

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The Association of Diet-Modulated Gut Microbiota on Development and Treatment of Colorectal Cancer 饮食调节肠道微生物群与结直肠癌发展和治疗的关系
Journal of Nutritional Oncology Pub Date : 2021-11-15 DOI: 10.34175/jno202104001
Elizabeth Clinger, Lei Hao
{"title":"The Association of Diet-Modulated Gut Microbiota on Development and Treatment of Colorectal Cancer","authors":"Elizabeth Clinger, Lei Hao","doi":"10.34175/jno202104001","DOIUrl":"https://doi.org/10.34175/jno202104001","url":null,"abstract":"Abstract: Colorectal cancer is the third most common cancer worldwide. Etiology of colon cancer continues to be investigated with research findings ranging from environment to diet to inherited gene mutations. Risk factors associated with colon cancer include familial history of colon cancer and inflammatory bowel disease, as well as lifestyle-related modifiable influences like diet, weight, and exercise. Recent findings point to the connection between diet and gut microbiota, which is highly affected by changes in diet promoting either an environment of beneficial bacteria or dysbiosis. Dietary effects on the microbiome can impact health outcomes, including an increased risk for colorectal cancer. Although the mechanisms behind the effect of gut microbiota on the development of colorectal cancer continues to evolve, its effect on both inflammation and immune response may play a key role. Further, after development of colorectal cancer diagnosis, the changes to gut microbiota have a potential to continue to influence the effectiveness of therapy and treatment. This review presents the current knowledge around the diet-modulated gut microbiome and its association with, risk for, development of, and treatment of colorectal cancer. Overall, further research on dietary elements that affect the gut microbiome and its subsequent effect on development and treatment of colorectal cancer is needed for applicable recommendations that can be made for dietary modulation of the gut microbiota for improved health outcomes.","PeriodicalId":64349,"journal":{"name":"Journal of Nutritional Oncology","volume":"6 1","pages":"152 - 158"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41532727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative Reduction in Serum Albumin Predicts Complications after Rectal Cancer Surgery 直肠癌症术后血清白蛋白降低预测并发症
Journal of Nutritional Oncology Pub Date : 2021-11-15 DOI: 10.34175/jno202104003
Yi-Fan Cheng, Yan Chen, Yong Lu, Chang-Bao Liu
{"title":"Postoperative Reduction in Serum Albumin Predicts Complications after Rectal Cancer Surgery","authors":"Yi-Fan Cheng, Yan Chen, Yong Lu, Chang-Bao Liu","doi":"10.34175/jno202104003","DOIUrl":"https://doi.org/10.34175/jno202104003","url":null,"abstract":"Abstract: Background The serum albumin (Alb) level often decreases early in the postoperative period. However, it is unclear whether a decline in the serum albumin level (ΔAlb) is a predictor of postoperative complications. We aimed to determine the relationship between the ΔAlb and complications following surgery for rectal cancer (RC). Methods We retrospectively collected the records of patients aged ≥ 18 years who underwent RC surgery between January 2015 and August 2018. We determined the cut-off value of the ΔAlb using subject working characteristic curve analysis and analyzed complications above grade II according to the Clavien-Dindo classification. Single and multifactor analyses of the risk factors for postoperative complications were performed. Results A total of 430 RC patients were included in this study. The area under the ΔAlb curve was 0.786, with a critical value of 22%. We selected 20% as the critical point for grouping patients. The total postoperative complication rate was significantly higher in patients who had a ≥ 20% serum Alb decline than those had a < 20% serum Alb decline (< 20% ΔAlb group); with rates of 51.5% and 16%, respectively (P < 0.001). A multifactorial logistic regression analysis revealed that the ΔAlb (odds ratio [OR] = 4.95, 95% CI = 3.126-7.838 P < 0.001), surgical approach (OR = 2.374, 95% CI = 1.335-4.224 P = 0.003), and blood loss (> 200 ml) (OR = 1.684, 95% CI = 1.043-2.716 P = 0.033) were independent risk factors for postoperative complications follow RC surgery. Conclusions The ΔAlb predicted the incidence of postoperative complications in patients after RC surgery. This could help identify patients at risk of complications early during the perioperative period, thereby helping to more effectively manage high-risk patients.","PeriodicalId":64349,"journal":{"name":"Journal of Nutritional Oncology","volume":"6 1","pages":"169 - 175"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46344837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
β-hydroxy-β-methylbutyrate Improves Chronic Renal Failure-Induced Sarcopenia in SD Rats by Regulating Autophagy β-羟基-β-甲基丁酸通过调节自噬改善SD大鼠慢性肾衰竭所致的肌少症
Journal of Nutritional Oncology Pub Date : 2021-11-15 DOI: 10.34175/jno202104005
Z. Zhang, Liuqing Yang, Ya Nan Yang, Yunping Wang, Longlong Zhang, Kun-Hua Wang, M. Weng
{"title":"β-hydroxy-β-methylbutyrate Improves Chronic Renal Failure-Induced Sarcopenia in SD Rats by Regulating Autophagy","authors":"Z. Zhang, Liuqing Yang, Ya Nan Yang, Yunping Wang, Longlong Zhang, Kun-Hua Wang, M. Weng","doi":"10.34175/jno202104005","DOIUrl":"https://doi.org/10.34175/jno202104005","url":null,"abstract":"Abstract: Background Chronic renal failure-induced sarcopenia (CRF-S) seriously affects public health by increasing morbidity and mortality. This study evaluated the therapeutic effects of β-hydroxy-β-methylbutyrate acid (HMB) and the underlying mechanism in an adenine-induced CRF-S rat model. Methods Sprague Dawley rats were divided into control, model (CRF-S), and HMB treatment (CRF-S+HMB) groups. The rats in the CRF-S group received 250 mg/kg/d adenine by oral gavage every day for 14 days, followed by administration every other day until the 28th day. In the CRF-S+HMB group, each rat was given 320 mg/kg/d HMB by oral gavage starting from 7 days prior to adenine treatment, and this treatment was maintained for a total of 35 days. The body weight, right anterior tibial muscle weight, blood serum parameters, gastrocnemius muscle and renal tissue histology, and expression of autophagyrelated transcripts and proteins were evaluated. Results A rat model of CRF-S was successfully established via adenine gavage, as indicated by reduced body weight and muscle weights, and markers of sarcopenia. There were increased mRNA levels of LC3B, Beclin1, Ulk1, Atg5, Atg7, Atg13 and vps-34, and increased protein expression levels of LC3B and P62. In the rats with HMB intervention, the body weight, right anterior tibial weight and gastrocnemius muscle histology were not significantly different from those in the control group, and the expression levels of autophagy-related proteins (LC3B and P62) were consistent with those in the control group. Conclusion We successfully established a rat model of CRF-S using adenine administered via oral gavage, and observed that HMB treatment prevented CRF-S, apparently by regulating autophagy. HMB may be an effective agent for the prevention and treatment of CRF-S.","PeriodicalId":64349,"journal":{"name":"Journal of Nutritional Oncology","volume":"6 1","pages":"186 - 195"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48548503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating Factors Influencing the Stability of Enteral Nutritional Emulsions Designed for Cancer Patients 癌症患者肠溶营养乳稳定性影响因素的研究
Journal of Nutritional Oncology Pub Date : 2021-08-15 DOI: 10.34175/jno202103006
Qin Qin Li, Danqing Hou, Zhuang Ding, S. Prakash, Yu Ying Liu, Hanping Shi, Jun Han, Zhengping Wang
{"title":"Investigating Factors Influencing the Stability of Enteral Nutritional Emulsions Designed for Cancer Patients","authors":"Qin Qin Li, Danqing Hou, Zhuang Ding, S. Prakash, Yu Ying Liu, Hanping Shi, Jun Han, Zhengping Wang","doi":"10.34175/jno202103006","DOIUrl":"https://doi.org/10.34175/jno202103006","url":null,"abstract":"Abstract: Objective A commercially available reference product was “re-engineered” and the target emulsion was formulated to contain the same energy density, as well as the same percentage of energy sources, as the reference product. The particle size and distribution, polydispersity index (PDI), and zeta-potential of emulsions were measured as indices to analyse the quality of the emulsions. Methods The centrifugal stability (Ke) was examined as the main measure of the stability of the target emulsion. Critical parameters affecting the stability of emulsions were also determined, while the temperature was fixed at 30°C, shear speed at 3500 r/min, and shear time was 15 min. The optimal quantity of emulsifier was also studied in the crude homogenate. Results A relatively stable emulsion could be obtained by using PC-50 at a dosage of 2% as the emulsifier. A 2: 1 proportion of whey protein to casein, a 1: 1 proportion of maltodextrin (DE 10-15) to maltodextrin (DE 15-20) and medium chain triglyceride (MCT) in powder form were used to obtain the most desirable emulsion. Conclusion This study explored the critical parameters that influence the stability of a total nutrition enteral emulsion designed for cancer patients, providing useful information for further industrialisation of this and other emulsion products.","PeriodicalId":64349,"journal":{"name":"Journal of Nutritional Oncology","volume":"6 1","pages":"140 - 148"},"PeriodicalIF":0.0,"publicationDate":"2021-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45217746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
More Cycles of Intravenous Chemotherapy are Associated with Reduced Growth in Children with Retinoblastoma 更多的静脉化疗周期与视网膜母细胞瘤儿童生长减慢有关
Journal of Nutritional Oncology Pub Date : 2021-08-15 DOI: 10.34175/jno202103004
Yu Qiong Yang, L. Yin, Xin Lin, Bing Hao, Xiaorong Guan, Hongxia Xu, Hongfeng Yuan
{"title":"More Cycles of Intravenous Chemotherapy are Associated with Reduced Growth in Children with Retinoblastoma","authors":"Yu Qiong Yang, L. Yin, Xin Lin, Bing Hao, Xiaorong Guan, Hongxia Xu, Hongfeng Yuan","doi":"10.34175/jno202103004","DOIUrl":"https://doi.org/10.34175/jno202103004","url":null,"abstract":"Abstract: Background Chemotherapy can have a negative impact on the growth of children with different cancers. However, few studies have examined whether intravenous chemotherapy (IVC) affects the growth of children with retinoblastoma (RB). The present study evaluated the height differences (actual height compared to the agestandardized value) and survival of pediatric RB patients treated with IVC. Methods This was an observational cohort study. A total of 87 pediatric RB patients were included. The study population was stratified into two groups based on the number of chemotherapy cycles administered (≤ 4 versus > 4). The height at baseline (before IVC), height after IVC and overall survival were compared between the two groups. Results Before IVC, no height differences were observed between the two groups (P = 0.585). After IVC, all of the patients had a reduced height compared to the agestandardized height (P = 0.035). Patients who underwent more cycles of chemotherapy had a greater height difference compared to those who received fewer cycles (P = 0.008). For those who had reduced height, the difference was positively associated with the number of chemotherapy cycles (r = 0.279, P = 0.043). Among the patients who exhibited a greater height difference, those who underwent more than four cycles of chemotherapy had a decreased overall survival (P = 0.042). Conclusions Pediatric RB patients who underwent more cycles of chemotherapy were more likely to have a reduced height. Further studies are needed to determine the optimal treatment strategy to prevent the reduced growth while maintaining the benefits of chemotherapy.","PeriodicalId":64349,"journal":{"name":"Journal of Nutritional Oncology","volume":"6 1","pages":"126 - 133"},"PeriodicalIF":0.0,"publicationDate":"2021-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42978782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MiR-34a Inhibits Cell Proliferation and Migration in Osteosarcoma by Downregulating DNMT1 MiR-34a通过下调DNMT1抑制骨肉瘤细胞增殖和迁移
Journal of Nutritional Oncology Pub Date : 2021-08-15 DOI: 10.34175/jno202103003
Peng-Fei Wang, C. Jia, H. Xiao
{"title":"MiR-34a Inhibits Cell Proliferation and Migration in Osteosarcoma by Downregulating DNMT1","authors":"Peng-Fei Wang, C. Jia, H. Xiao","doi":"10.34175/jno202103003","DOIUrl":"https://doi.org/10.34175/jno202103003","url":null,"abstract":"Abstract: Objective To investigate the effects of DNA methyl transferase 1 (DNMT1) gene regulation by miR-34a in osteosarcoma (OS) MG63 cells and to determine the possible mechanisms. Methods A miR-34a mimic, mimic negative control (NC), miR-34a inhibitor, or inhibitor-NC were transfected into MG63 cells using Lipofectamine 3000. Cell viability was measured using the MTT assay. The mRNA levels of DNMT1 in MG63 cells were detected by qPCR. The proliferation of MG63 cells was detected by the CCK8 method. The protein expression of DNMT1 was measured by Western blotting. The effects of DNMT1 on the migration of MG63 cells were examined by a cell migration assay. The apoptosis of MG63 cells was detected by flow cytometry. Results The mRNA levels of DNMT1 were up-regulated in MG63 cells treated with the miR-34a inhibitor compared to other groups. The growth of MG63 cells was significantly increased in these cells. The protein expression of DNMT1 and the cell proliferation and migration decreased in the miR-34a mimic-treated group compared to the cells treated with the miR-34a inhibitor or the negative control (both P < 0.05). Conclusion By targeting the DNMT1 gene, miR-34a reduces the expression level of DNMT1 in MG63 cells, thereby affecting the viability, migration, proliferation, and apoptosis of MG63 cells. Interventions targeting the miR-34a/DNMT1 axis may represent a novel targeted therapy for OS.","PeriodicalId":64349,"journal":{"name":"Journal of Nutritional Oncology","volume":"6 1","pages":"117 - 125"},"PeriodicalIF":0.0,"publicationDate":"2021-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41317714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Values of the Prognostic Nutrition Index and the Patient Generated -Subjective Global Assessment during the Nutritional Assessment of Patients with Gastrointestinal Tumors 胃肠道肿瘤患者营养评估中的预后营养指数和患者主观整体评估的价值
Journal of Nutritional Oncology Pub Date : 2021-08-15 DOI: 10.34175/jno202103005
Jiangyan Wei, Hongxia Yan, Qi Li
{"title":"The Values of the Prognostic Nutrition Index and the Patient Generated -Subjective Global Assessment during the Nutritional Assessment of Patients with Gastrointestinal Tumors","authors":"Jiangyan Wei, Hongxia Yan, Qi Li","doi":"10.34175/jno202103005","DOIUrl":"https://doi.org/10.34175/jno202103005","url":null,"abstract":"Abstract: Objective To compare the value and consistency among the Patient Generated -Subjective Global Assessment (PG-SGA) and the Prognostic Nutrition Index (PNI) for assessing nutritional status in gastrointestinal tumor patients. Methods 251 patients from gastric cancer surgical ward from January 2019 to January 2020 were recruited through convenience sampling in this respective study. Nutritional screening and assessment were conducted for 251 gastrointestinal tumor patients using the nutritional risk screening 2002 (NRS 2002) PG-SGA, and the PNI. PNI was calculated using the serum albumin level and the total lymphocyte count obtained from the patients’ routine laboratory examination when they were admitted to the hospital. The receiver operating characteristic (ROC) of the PG-SGA and the PNI were plotted with the NRS 2002 used as the gold standard, and the diagnostic value of the PG-SGA and PNI was reflected by the area under the curve (AUC), sensitivity, specificity and Youden index. We then determined the optimal cut-off for the PNI and tested the consistency of the PG-SGA and PNI. Results The optimal cut-off point for the PNI was calculated to be 50.78. The AUC of the PG-SGA was 0.908 (95% CI 0.871-0.944). The sensitivity was 89.9%, specificity was 76.2% and the Youden index was 0.661. The AUC of the PNI was 0.594 (95% CI 0.516-0.572). The sensitivity was 73.8%, specificity was 44.3% and the Youden index was 0.181. In the consistency test, the kappa value was 0.838 (P < 0.001). Conclusion The PNI is of limited value for assessing malnutrition, although it did have good consistency with the PG-SGA. The combination of the PNI and PG-SGA can be used for diagnosing assessing malnutrition in clinical practice.","PeriodicalId":64349,"journal":{"name":"Journal of Nutritional Oncology","volume":"6 1","pages":"134 - 139"},"PeriodicalIF":0.0,"publicationDate":"2021-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42654619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validity of the Patient-Generated Subjective Global Assessment (PG-SGA) in Colorectal Cancer Patients in China 中国结直肠癌患者主观整体评估(PG-SGA)的有效性
Journal of Nutritional Oncology Pub Date : 2021-08-15 DOI: 10.34175/jno202103002
Ruifeng Yin, Ling Li Fu, Ping Chen, Zhenming Fu, Hong-xia Xu, C. Song, M. Cong, Hanping Shi
{"title":"Validity of the Patient-Generated Subjective Global Assessment (PG-SGA) in Colorectal Cancer Patients in China","authors":"Ruifeng Yin, Ling Li Fu, Ping Chen, Zhenming Fu, Hong-xia Xu, C. Song, M. Cong, Hanping Shi","doi":"10.34175/jno202103002","DOIUrl":"https://doi.org/10.34175/jno202103002","url":null,"abstract":"Abstract: Objective The patient-generated subjective global assessment (PG-SGA) is a nutritional assessment tool specially designed for cancer patients. This study tested the validity of the PG-SGA for the nutritional assessment of colorectal cancer (CRC) patients in China. Methods A total of 8,093 Chinese patients with any stage CRC were enrolled in this cross-sectional, observational study. Within the first 48 hours of admission, patients were evaluated using the PG-SGA, nutritional risk screening 2002 (NRS 2002), Karnofsky Performance Status (KPS), and some anthropometric parameters, including the triceps skinfold thickness (TSF), mid-arm circumference (MAC), mid-arm muscle circumference (MAMC), hand grip strength (HGS), maximum left calf circumference (MLCC), and maximum right calf circumference (MRCC), among others. Spearman’s correlation test was performed to analyze item-total score correlations and correlations between the total PG-SGA score and other parameters or performance scores, further testing convergent validity. The discriminative ability of the PG-SGA was measured by comparing different characteristics between several nutritional groups. A principal component analysis was performed with selected parameters to evaluate the construct validity. Results The average total PG-SGA score of all patients was 5.69 ± 4.46, and they had a median age of 59 years (interquartile range (IQR), 51-67 years) and an average body mass index (BMI) of 22.57 ± 3.29 kg/m2. The item-total correlations of the total PG-SGA score between the global PG-SGA rating (Spearman, r = 0.94) and PG-SGA score (patient-generated) (Spearman, r = 0. 97) were strong. Significant correlations were also found between the total PG-SGA score and other nutritional screening tools, including the BMI (Spearman, r = -0.26), KPS (Spearman, r = -0.36), and NRS 2002 (Spearman, r = -0.47). Well-nourished (41.2%), mildly or moderately malnourished (35.3%) and severely malnourished (23.5%) groups defined according to the PG-SGA had significantly different characteristics. Patients with a worse nutritional status tended to have a decreased BMI (well-nourished, 23.32 kg/m2 vs. mildly or moderately malnourished, 22.52 kg/m2 vs. severely malnourished, 21.35 kg/m2; P < 0.001), hemoglobin, body fat mass, muscle mass, protein mass, TSF, MAC, HGS, MAMC, and MLCC, and a dramatically increased C-reactive protein level. The Kaiser-Meyer-Olkin measure was > 0.7, and the P value of Bartlett’s test of sphericity was < 0.001. One component was extracted by the principal component analysis, and the analysis showed that the total PG-SGA score explained the total variances of 97.3%. Conclusion The PG-SGA is a valid tool for evaluating the nutritional status for Chinese CRC patients.","PeriodicalId":64349,"journal":{"name":"Journal of Nutritional Oncology","volume":"6 1","pages":"109 - 116"},"PeriodicalIF":0.0,"publicationDate":"2021-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43578427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Dose-response Meta-analysis of Egg Intake and Breast Cancer Risk 鸡蛋摄入量与乳腺癌症风险的剂量反应Meta-analysis
Journal of Nutritional Oncology Pub Date : 2021-05-15 DOI: 10.34175/jno202102005
Peng Ma, Fei Fei Feng, Ziang Shi, Ke Di Xu, Y. Zou, Yan Wang, S. Ning, C. Song
{"title":"A Dose-response Meta-analysis of Egg Intake and Breast Cancer Risk","authors":"Peng Ma, Fei Fei Feng, Ziang Shi, Ke Di Xu, Y. Zou, Yan Wang, S. Ning, C. Song","doi":"10.34175/jno202102005","DOIUrl":"https://doi.org/10.34175/jno202102005","url":null,"abstract":"Abstract: Aim Eggs are one of the most nutritious foods in nature, but there is no unified conclusion about the association between egg intake and breast cancer risk. Methods The PubMed and Web of Science databases for the literature on egg intake and breast cancer risk were searched for papers published during the last 10 years. These were then filtered according to the inclusion and exclusion criteria. Stata16.0 software was applied to perform a metaanalysis, the generalized least squares method and constrained cubic spline model were used to assess the dose-response trends between egg intake and breast cancer risk. Results A total of 9 articles were included: 6 case control studies and 3 cohort studies. The Newcastle-Ottawa scale (NOS) values of the included articles were all ≥ 6 points. The pooled relative risks (RR) of egg intake and breast cancer risk was 0.91 (95% CI: 0.69-1.19). The dose-response analysis showed a linear trend for egg intake and breast cancer risk (P = 0.689). With every 10 g/day increase in egg intake, the incidence of breast cancer increased by 2% (RR = 1.02, 95% CI: 0.99-1.05). However, these results were not statistically significant. Conclusion This meta-analysis found no significant association between egg intake and breast cancer.","PeriodicalId":64349,"journal":{"name":"Journal of Nutritional Oncology","volume":"6 1","pages":"81 - 89"},"PeriodicalIF":0.0,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42705287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Relationship of the preoperative NRS 2002 score, PG-SGA score, and serum indices with postoperative complications in patients with gastric cancer 胃癌患者术前NRS 2002评分、PG-SGA评分及血清指标与术后并发症的关系
Journal of Nutritional Oncology Pub Date : 2021-05-15 DOI: 10.34175/jno202102004
Daohang Huang, Xiangcun Wu, C. Wang, Junmin Chen, Kui Jia, Jing Zhou, L. Lu, Yong Sheng Zhang, Jing Jin, K. Huang
{"title":"Relationship of the preoperative NRS 2002 score, PG-SGA score, and serum indices with postoperative complications in patients with gastric cancer","authors":"Daohang Huang, Xiangcun Wu, C. Wang, Junmin Chen, Kui Jia, Jing Zhou, L. Lu, Yong Sheng Zhang, Jing Jin, K. Huang","doi":"10.34175/jno202102004","DOIUrl":"https://doi.org/10.34175/jno202102004","url":null,"abstract":"Abstract: Objective To examine the utility of the Nutrition Risk Screening 2002 (NRS 2002), Patient-Generated Subjective Global Assessment (PG-SGA) and serum factors for the preoperative evaluation of gastric cancer patients. Methods We examined 181 gastric cancer patients treated at the First Affiliated Hospital of Guangxi Medical University from January 2015 to January 2018. Nutritional assessments were administered within 48 h of admission. The body mass index (BMI) and serum factors were measured, and information on preoperative nutritional support and postoperative complications was recorded. Results Both the NRS 2002 and PG-SGA had positive correlations with age (P < 0.05), and negative correlations with albumin, prealbumin, transferrin, hemoglobin, BMI, and bodyweight (P < 0.05). The NRS 2002 and PG-SGA scores were positively correlated with each other (r = 0.683, P < 0.01), but had poor consistency (κ = 0.357, P < 0.01). During the preoperative period, 33.2% of patients received nutritional support, mainly enteral nutrition. The nutritional risk group (NRS 2002 ≥ 3) received more support than the group without nutritional risk (NRS 2002 < 3; P < 0.05). Patients with nutritional risk or malnutrition who received preoperative nutritional support had fewer postoperative complications than unsupported patients. The overall rate of complications was 12.2%, and the rate of severe complications (grade III or above) was 5.5%. The malnutrition and nutritional risk groups had higher rates of severe complications. Conclusions The combined application of the NRS 2002, PG-SGA, BMI, and serum nutritional indices was useful for the nutritional screening and assessment of preoperative gastric cancer patients. The NRS 2002 and PG-SGA provided guidance on the need for nutritional support during the preoperative period.","PeriodicalId":64349,"journal":{"name":"Journal of Nutritional Oncology","volume":"6 1","pages":"74 - 80"},"PeriodicalIF":0.0,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44150554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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