A Dose-response Meta-analysis of Egg Intake and Breast Cancer Risk

Abstract: Aim Eggs are one of the most nutritious foods in nature, but there is no unified conclusion about the association between egg intake and breast cancer risk. Methods The PubMed and Web of Science databases for the literature on egg intake and breast cancer risk were searched for papers published during the last 10 years. These were then filtered according to the inclusion and exclusion criteria. Stata16.0 software was applied to perform a metaanalysis, the generalized least squares method and constrained cubic spline model were used to assess the dose-response trends between egg intake and breast cancer risk. Results A total of 9 articles were included: 6 case control studies and 3 cohort studies. The Newcastle-Ottawa scale (NOS) values of the included articles were all ≥ 6 points. The pooled relative risks (RR) of egg intake and breast cancer risk was 0.91 (95% CI: 0.69-1.19). The dose-response analysis showed a linear trend for egg intake and breast cancer risk (P = 0.689). With every 10 g/day increase in egg intake, the incidence of breast cancer increased by 2% (RR = 1.02, 95% CI: 0.99-1.05). However, these results were not statistically significant. Conclusion This meta-analysis found no significant association between egg intake and breast cancer.