Journal of Inclusion Phenomena and Macrocyclic Chemistry最新文献_第2页

NMR methods for studying inclusion complexes focused on chiral hosts 研究以手性宿主为重点的包涵复合物的核磁共振方法

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2024-07-04 DOI: 10.1007/s10847-024-01251-3

Sylwia Jopa, Jacek Wójcik, Andrzej Ejchart, Michał Nowakowski

引用次数: 0

Encapsulation investigation of molnupiravir drug guest using cucurbituril hosts through the DFT approach 通过 DFT 方法研究使用葫芦素宿主包囊莫仑比拉韦药物客体的情况

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2024-07-02 DOI: 10.1007/s10847-024-01250-4

Wandee Rakrai, Butsayamat Rattanadon, Chanukorn Tabtimsai, Chatthai Kaewtong, Banchob Wanno

引用次数: 0

GFN2-xTB study of the inclusion of thymol and carvacrol in β-cyclodextrin 在β-环糊精中加入百里酚和香芹酚的 GFN2-xTB 研究

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2024-06-14 DOI: 10.1007/s10847-024-01249-x

Erick Ferreira Lacerda, Gleicy Teixeira, Cleber Paulo Andrada Anconi

{"title":"GFN2-xTB study of the inclusion of thymol and carvacrol in β-cyclodextrin","authors":"Erick Ferreira Lacerda, Gleicy Teixeira, Cleber Paulo Andrada Anconi","doi":"10.1007/s10847-024-01249-x","DOIUrl":"10.1007/s10847-024-01249-x","url":null,"abstract":"<div>Thymol and carvacrol belong to the class of terpenoids that usually contribute to the flavor, color, and development of plants, and their complexation with CD has been recently reported. Due to their structural similarities, including such guests in CD poses a challenging task to theoretical methodologies. With the present contribution, we applied the recently developed GFN2-xTB multi-equilibrium approach to study the inclusion of those guests into β-CD. The inclusion of 1-adamantane carboxylic acid in β-CD was also investigated for comparison. The study was conducted with a progressive increase in the number of systems in steps, comprising 792, 1,188, and 1,584 systems. Therefore, for the three guest/host pairs studied, complete optimization in vacuum and water with the ALPB continuum method was applied to 10,692 systems at the GFN2-xTB level of theory. Furthermore, single-point calculations at the B97-3c/def2-TZVPP level of theory were carried out using the SMD solvation model. As a result, beyond determining the experimental trend, we addressed that the additional degree of freedom represented by the gamma Euler parameter decreased the errors related to the estimated adjusted binding constants. On the other hand, the use of the B97-3c/def2-TZVPP in conjunction with the set of systems selected by GFN2-xTB (ALPB) must be further investigated since the experimental trend was obtained only with a basis in the difference in electronic energies.<h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"104 9-10","pages":"487 - 499"},"PeriodicalIF":2.3,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141344660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crystallization experiments of the wheel-and-axle host compound, 1,4-phenylene-bis(di-p-tolylmethanol), from pyridine and methylpyridine mixtures 从吡啶和甲基吡啶混合物中结晶出 1,4-苯基-双（二对甲苯甲醇）轮轴主化合物的实验

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2024-06-12 DOI: 10.1007/s10847-024-01248-y

Benita Barton, Jarryd A. Vorgers, Eric C. Hosten

{"title":"Crystallization experiments of the wheel-and-axle host compound, 1,4-phenylene-bis(di-p-tolylmethanol), from pyridine and methylpyridine mixtures","authors":"Benita Barton, Jarryd A. Vorgers, Eric C. Hosten","doi":"10.1007/s10847-024-01248-y","DOIUrl":"10.1007/s10847-024-01248-y","url":null,"abstract":"<div>1,4-Phenylene-bis(di-p-tolylmethanol) (H), a host compound with the wheel-and-axle design, formed complexes with organic guest solvents pyridine (PYR) and 2-, 3- and 4-methylpyridine (2MP, 3MP and 4MP). The host: guest (H: G) ratios were 1:3, 1:2, 1:2 and 1:1, respectively. Host crystallization experiments from mixed guests demonstrated H to prefer both PYR and 4MP; however, it was established that these difficult-to-separate (by fractional distillations) guest mixtures cannot be purified/separated by means of H through supramolecular chemistry strategies owing to these selectivities for PYR and 4MP being less than optimal. Single crystal X-ray diffraction experiments showed that each guest compound was held in its complex by means of a classical hydrogen bond with H, and that one of the preferred guests, PYR, experienced a significantly shorter contact of this type than the other guests. Hirshfeld surface analyses demonstrated that PYR was also involved in a greater percentage of (guest)N···H(host) interactions compared with the other guest molecules. Thermal analyses, on the other hand, revealed that 4MP (also a favoured guest species) formed the most stable complex of the four in this investigation. These results with H were compared to those obtained when employing a closely related host compound from a previous report, 1,4-bis(diphenylhydroxymethyl)benzene: while both host species preferred the same guests (PYR and 4MP), the extent of the selectivity of that host compound compared with H in the present work was significantly more enhanced. Thus, minor modifications may deleteriously affect the selectivity behaviour of closely related host compounds.</div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"104 9-10","pages":"473 - 485"},"PeriodicalIF":2.3,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10847-024-01248-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141353620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new amino functionalized thio-modified β-cyclodextrin based ligand and its Fe(III) complex with physico‑chemical and antibacterial activity: an integrated experimental and computational investigation 具有物理化学和抗菌活性的新型氨基功能化硫代改性β-环糊精配体及其铁（III）配合物：实验与计算的综合研究

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2024-06-10 DOI: 10.1007/s10847-024-01247-z

Pritika Gurung, Ananya Das, Sudarshan Pradhan, Anmol Chettri, Tanmoy Dutta, Biswajit Sinha

{"title":"A new amino functionalized thio-modified β-cyclodextrin based ligand and its Fe(III) complex with physico‑chemical and antibacterial activity: an integrated experimental and computational investigation","authors":"Pritika Gurung, Ananya Das, Sudarshan Pradhan, Anmol Chettri, Tanmoy Dutta, Biswajit Sinha","doi":"10.1007/s10847-024-01247-z","DOIUrl":"10.1007/s10847-024-01247-z","url":null,"abstract":"<div>β-Cyclodextrin plays a crucial role in augmenting the activity of metal complexes by ameliorating their solubility, stability, and reactivity, therefore the thio-functionalized β-cyclodextrin based amino ligand mono-6-deoxy-(o-aminobenzylthio)-β-cyclodextrin (4) was synthesized and analyzed by elemental analyses, AAS, UV–visible, FTIR, and 1H NMR spectroscopy. The newly synthesized Fe III) complex was soluble in water. The Fe(III) complex's spectral analysis using FTIR confirmed that the ligand aided the metal ion coordinate by way of the sulfur atom of the β-cyclodextrin moiety and the nitrogen atoms of the two ligand molecules, with two H2O occupying the fifth and sixth coordination sites. Additionally, the mass spectrometry verifies that the intended Fe(III) complex has synthesized. Density functional theory (DFT) was used to calculate different electronic parameters of the optimized structure of Fe(III) complex to reveal its stability. Antimicrobial metal complexes that are suitable for therapeutic application are known to be more stable and bioavailable when β-cyclodextrin is introduced, therefore studies have been done to inquire into the possible comparative in vitro antibacterial activity of the Fe(III) complex and free ligand against two gram positive (Bacillus subtilis, and Staphylococcus aureus) and two gram negative bacteria (Escherichia coli, Klebsiella pneumoniae) strains. Molecular docking was used to further corroborate these capabilities.</div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"104 9-10","pages":"461 - 471"},"PeriodicalIF":2.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10847-024-01247-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141360523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interaction of rhodamine B with sulfobetaine tetrapentylcalix[4]resorcinarene in the range of millimolar concentrations 罗丹明 B 在毫摩尔浓度范围内与磺基甜菜碱四戊基钙[4]间苯二酚的相互作用

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2024-06-04 DOI: 10.1007/s10847-024-01246-0

Zuchra R. Gilmullina, Victor V. Syakaev, Julia E. Morozova, Albina Yu. Ziganshina, Igor S. Antipin

{"title":"The interaction of rhodamine B with sulfobetaine tetrapentylcalix[4]resorcinarene in the range of millimolar concentrations","authors":"Zuchra R. Gilmullina, Victor V. Syakaev, Julia E. Morozova, Albina Yu. Ziganshina, Igor S. Antipin","doi":"10.1007/s10847-024-01246-0","DOIUrl":"10.1007/s10847-024-01246-0","url":null,"abstract":"<div>The effective binding of Rhodamine B (RhB), a xanthene dye, in solutions of amphiphilic sulfobetaine tetrapentylcalix[4]resorcinarene (C5-SB) at millimolar concentrations has been found. Using the FT-PGSE NMR technique, it was determined that the binding fraction (Pb) of RhB in the solution with a С(RhB)/С(С5-SB) ratio of 3.75 mM/5 mM was 0.57, whereas in a solution with an order of magnitude lower concentration, the Pb was only 0.12. This significant difference in interaction is also supported by 2D NOESY and 1H NMR spectra. Based on fluorimetry data, it appears that the influence of C5-SB on the spectral properties of RhB increases as the C5-SB/RhB molar ratio increases, but decreases as the concentration of C5-SB and RhB decreases. By comparing the spectral properties of RhB in the presence of C5-SB and tetrapentylcalix[4]resorcinarene with carboxylic (C5-COO−) and trimethylammonium (C5-N+Me3) peripheral groups, an assumption about the driving forces behind RhB, which led to an enhancement of the emission properties of the dye, was made. The study demonstrates the possibility of controlling the emissive properties of a xanthene dye by binding it to a supramolecular associate with amphiphilic calix [4] resorcinarene.</div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"104 9-10","pages":"449 - 459"},"PeriodicalIF":2.3,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141253927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of new rotaxanes from related crown compounds 从相关冠化合物中合成新的轮烷并确定其特性

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2024-05-28 DOI: 10.1007/s10847-024-01245-1

Abdullah Najdhashemi, Samad Bavili Tabrizi, Mirzaagha Babazadeh

{"title":"Synthesis and characterization of new rotaxanes from related crown compounds","authors":"Abdullah Najdhashemi, Samad Bavili Tabrizi, Mirzaagha Babazadeh","doi":"10.1007/s10847-024-01245-1","DOIUrl":"10.1007/s10847-024-01245-1","url":null,"abstract":"<div>Physical manipulation can be carried out on molecules and cells through the utilization of nanomachines which are machines with nano dimensions. There are different types of nanomachines. Among them, rotaxanes stand out as the most well-known. The term of rotaxane originates from the combination of the Latin words wheel and axis. The application of nanomachines is identifying and measuring the concentration of toxic substances in the environment, targeted drug delivery and cancer diagnosis. The objective of this study is to synthesize and identify several new nanomachines in the form of rotaxanes (internally locked molecules) with nanopharmaceutical properties from the corresponding crown compounds. In the first step, 2,2-dimethylphenol was converted into bisphenol compound (1) in reaction with thionyl chloride. Bisphenol compound (1) was converted into methyl diester compound (2) in reaction with methyl chloroacetate. The methyl diester compound (2) reacts with the appropriate diamine to form the diamide macrocycle compound (3). Rod (4) is prepared from the reaction of diethylene glycol ditosylate, 4,4-bipyridine and a bulk phenol such as 4-tert-butylphenol in DMF. Each of the rings in the presence of the prepared rod leads to the corresponding rotaxane compound (5). Chemical structure of the obtained compounds were established by 1HNMR, 13CNMR, FT-IR and SEM spectroscopic methods.</div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"104 7-8","pages":"415 - 437"},"PeriodicalIF":2.3,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141169051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trans-to-cis isomerization of a platinum(II) complex with two triphosphine ligands via coordination with gold(I) ions 带有两个三膦配体的铂(II)配合物通过与金(I)离子配位实现反式-顺式异构化

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2024-05-10 DOI: 10.1007/s10847-024-01228-2

Kazuki Nagasato, Taichi Baba, Hayato Soma, Nobuto Yoshinari

{"title":"Trans-to-cis isomerization of a platinum(II) complex with two triphosphine ligands via coordination with gold(I) ions","authors":"Kazuki Nagasato, Taichi Baba, Hayato Soma, Nobuto Yoshinari","doi":"10.1007/s10847-024-01228-2","DOIUrl":"10.1007/s10847-024-01228-2","url":null,"abstract":"<div>The reaction of a square-planar platinum(II) complex containing two bis(2-diphenylphosphinoethyl)phenylphosphine (triphos), [Pt(triphos)2](NO3)2, with [Au(tu)2]Cl (tu = thiourea) gave a new trinuclear AuI2PtII complex, [Pt(triphos)2{Au(tu)}2]Cl2(NO3)2, through Au-P coordination. While the [Pt(triphos)2]2+ unit in [Pt(triphos)2](NO3)2 adopted the trans-meso configuration, only the cis-racemic isomer was observed for [Pt(triphos)2{Au(tu)}2]Cl2(NO3)2. 31P NMR spectroscopy indicated rapid equilibrium among the possible isomers of [Pt(triphos)2]2+, which facilitated the trans-to-cis transformation at the PtII center in this system. Additionally, we observed that this structural transformation led to an increase in the emission intensity.</div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"104 5-6","pages":"257 - 268"},"PeriodicalIF":2.3,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10847-024-01228-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140939868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetics and thermodynamics of β-cyclodextrin-NH2/β-carotene complexation: how much energy is required to include a hydrophobic group in the macrocycle cavity? β-环糊精-NH2/β-胡萝卜素复合物的动力学和热力学：在大环空腔中加入疏水基团需要多少能量？

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2024-05-03 DOI: 10.1007/s10847-024-01240-6

Yara Luiza Coelho, Hauster Maximiler Campos de Paula, Lívia Neves Santa Rosa, Isabela Araujo Marques, Nícolas Glanzmann, Camilla Fonseca Silva, Adilson David da Silva, Clebio Soares Nascimento Jr., Ana Clarissa dos Santos Pires, Luis Henrique Mendes da Silva

{"title":"Kinetics and thermodynamics of β-cyclodextrin-NH2/β-carotene complexation: how much energy is required to include a hydrophobic group in the macrocycle cavity?","authors":"Yara Luiza Coelho, Hauster Maximiler Campos de Paula, Lívia Neves Santa Rosa, Isabela Araujo Marques, Nícolas Glanzmann, Camilla Fonseca Silva, Adilson David da Silva, Clebio Soares Nascimento Jr., Ana Clarissa dos Santos Pires, Luis Henrique Mendes da Silva","doi":"10.1007/s10847-024-01240-6","DOIUrl":"10.1007/s10847-024-01240-6","url":null,"abstract":"<div>To improve the efficiency of cyclodextrins as carotenoid carriers, the kinetics and thermodynamics of the inclusion complex formation between modified β-cyclodextrin (βCD-NH2) and β-carotene (βCT) were studied using surface plasmon resonance (SPR) at pH 7.4 and theoretical calculations. The observed dissociation rate of the [βCD-NH2/βCT]° inclusion complex is small ((2.59times 1{0}^{-1} {text{s}}^{-1})), indicating that βCD-NH2 only interacted with the βCT ionone group to form inclusion complex. The βCD-NH2/βCT binding constant is (2.80times 1{0}^{4} text{L} {text{m}text{o}text{l}}^{-1}) (at 298.15 K), and its temperature dependence indicates that the [βCD-NH2/βCT]° formation is driven by hydrophobic interactions (({Delta }H^circ = 28.83 text{k}text{J} text{m}text{o}{text{l}}^{-1}) and (T{Delta }S^circ = 54.21 text{k}text{J} text{m}text{o}{text{l}}^{-1})) caused mainly by the βCT end group desolvation. In contrast, the formation of the [βCD-NH2/βCT]‡ activated complex via association between free molecules and dissociation of [βCD-NH2/βCT]° occurred with the overcoming of an energy barrier ((E_{a}^{ddag } = 40.77~{text{kJ mol}}^{{ - 1}} ~) and ({E}_{d}^{ddag}=11.94 text{k}text{J} text{m}text{o}{text{l}}^{-1})) and decrease in entropy ((T{varDelta S}_{a}^{ddag}=-11.70 text{k}text{J} text{m}text{o}{text{l}}^{-1}) and (T{varDelta S}_{d}^{ddag}=- 65.92 text{k}text{J} text{m}text{o}{text{l}}^{-1})).</div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"104 7-8","pages":"395 - 405"},"PeriodicalIF":2.3,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140889001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of a novel bone adhesive (crosslinked phytic acid-gelatin coordinated with magnesium phosphate and calcined dolomite, and montmorillonite) for enhancing adhesion strength and biocompatibility 制造新型骨粘合剂（与磷酸镁、煅烧白云石和蒙脱石配位的交联植酸明胶），以增强粘合强度和生物相容性

IF 2.3 4区化学

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2024-04-24 DOI: 10.1007/s10847-024-01234-4

Man-Na Hu, Xue-Jing Qu, Xiao-Lan Chen, Dan He, Guo-Ya Wang, Jia-Hui Liu, Tania Roy, Alfin Kurniawan, Chun-Hui Zhou

{"title":"Fabrication of a novel bone adhesive (crosslinked phytic acid-gelatin coordinated with magnesium phosphate and calcined dolomite, and montmorillonite) for enhancing adhesion strength and biocompatibility","authors":"Man-Na Hu, Xue-Jing Qu, Xiao-Lan Chen, Dan He, Guo-Ya Wang, Jia-Hui Liu, Tania Roy, Alfin Kurniawan, Chun-Hui Zhou","doi":"10.1007/s10847-024-01234-4","DOIUrl":"10.1007/s10847-024-01234-4","url":null,"abstract":"<div>Bone adhesives are known as a promising fracture treatment material because they can quickly heal broken bones. However, the existing bone adhesives have the disadvantages of weak binding ability to bone tissue, non-absorption, or difficulty in curing under wet conditions, which limits their wide application in the field of bone tissue engineering. In this study, the raw material of magnesium phosphate bone adhesive was modified, and the composite material of magnesium phosphate bone repair was prepared by the method of solid–liquid blending crosslinking. Mineral-organic composite, a new type of bone adhesive was prepared using calcined dolomite and montmorillonite as mineral components, phytic acid and gelatin as organic components. The compressive strength, porosity and bonding strength of the magnesium phosphate-based bone adhesive were analyzed by Fourier transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy. When the dosage of dolomite is 8 wt% and the concentration of gelatin is 9 wt%, the adhesion strength of the bone adhesive is 2.04 MPa after 168 h placement. And the compressive strength of the bone adhesive was 6.66 MPa after 168 h placement. After the prepared bone adhesives were immersed in SBF solution for 14 and 21 days, EDS analysis showed that the accumulated material was bone-like hydroxyapatite, indicating that the prepared bone adhesives had good osteogenic activity. In addition, it was also found that the bone adhesive had fluid absorption ability and no cytotoxicity. So, conclusively it can be stated that such newly synthesized bone adhesive has significant medical potential.</div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"104 5-6","pages":"317 - 334"},"PeriodicalIF":2.3,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140662588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0