Journal of Inclusion Phenomena and Macrocyclic Chemistry最新文献

{"title":"Correction: Identification of facial nerve using flexible electrodes via impedance spectroscopy during parotidectomy","authors":"Jinhwan Kim, Yangkyu Park, Hyeon Woo Kim, Hyong-Ho Cho","doi":"10.1007/s10847-026-01353-0","DOIUrl":"10.1007/s10847-026-01353-0","url":null,"abstract":"","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 of","pages":"387 - 387"},"PeriodicalIF":1.6,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148202947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Room-temperature chemical extraction of cellulose nanocrystals from residual carpentry wood chips: a proof-of-concept study","authors":"Sami Zaidi,&nbsp;Imene Bekri Abbes,&nbsp;Besma Mellah","doi":"10.1007/s10847-026-01345-0","DOIUrl":"10.1007/s10847-026-01345-0","url":null,"abstract":"<div><p>The requirements for high thermal energy in conventional nanocellulose extraction methods remain a major limitation for the sustainable valorization of lignocellulosic residues. In this study, a chemical route operating entirely at room-temperature (~ 25 °C) is proposed for converting residual carpentry wood chips (WC) into cellulose nanocrystals (CNCs) <i>via</i> sequential alkalization, bleaching, and sulfuric acid hydrolysis. The process achieved a 56% yield of CNCs based on the initial mass of WC. A set of characterization techniques was employed to evaluate the structural and physicochemical properties of the obtained material. Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) confirmed the efficient removal of non-cellulosic components while preserving the cellulose I_β crystalline structure. Furthermore, the crystallinity index was found to increase from 51% in the raw wood chips to 68% in the final material, indicating effective removal of amorphous components. Scanning electron microscopy (SEM) revealed the formation of a cohesive nanostructured film upon drying. Dynamic light scattering measurements indicated nanoscale particle dimensions (~ 5 nm hydrodynamic diameter), while zeta potential analysis (-14.8 mV) suggested moderate colloidal stability. Although direct nanoscale imaging techniques such as transmission electron microscopy (TEM) and/or atomic force microscopy (AFM) were not performed, the combined structural and physicochemical analyses strongly suggest the formation of CNCs. Overall, this work provides a laboratory-scale proof-of-concept for a potentially energy-efficient CNCs production route enabling the valorization of low-value wood waste into high-performance bio-nanomaterials.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 of","pages":"325 - 338"},"PeriodicalIF":1.6,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148202928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of reducing steric repulsion on allosteric coextraction of sodium and other metals using calix[4]arene derivatives with two different lengths of carboxylic groups","authors":"Keisuke Ohto,&nbsp;Shigemasa Kuwata,&nbsp;Akikazu Shioya,&nbsp;Shintaro Morisada,&nbsp;Hidetaka Kawakita,&nbsp;Kazuharu Yoshizuka,&nbsp;Katsutoshi Inoue","doi":"10.1007/s10847-026-01343-2","DOIUrl":"10.1007/s10847-026-01343-2","url":null,"abstract":"<div><p>Tetraacetic acid and crossed carboxylic acid derivatives of calix[4]arene were prepared and investigated for extraction of various metal ions in the absence and presence of sodium ion. The extraction equilibrium constants and separation factors of Cu(II), Zn(II), and Co(II) with three carboxylic acid derivatives of calix[4]arene were determined, both in the absence and presence of sodium ion, to evaluate the effect of allosteric coextraction of sodium and the other metal ions. Extraction in the presence of sodium ion was enhanced by an allosteric effect compared with that in its absence. The extent of enhancement depended on the extraction reagents, as the crossed carboxylic acid derivatives of calix[4]arene possess longer carboxylic acid groups that relieve steric repulsion between two metal cations. The extent of enhancement also depended on the concentration of coexisting sodium ion.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 of","pages":"307 - 316"},"PeriodicalIF":1.6,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148202926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis, DFT studies and cathepsin B inhibitory activity of a tripodal hydroxypyranone chelator and its coordination with trivalent metal ions","authors":"Shalini Singh,&nbsp;B. K. Kanungo,&nbsp;Chanchal Vashisth,&nbsp;Neera Raghav,&nbsp;Minati Baral","doi":"10.1007/s10847-026-01340-5","DOIUrl":"10.1007/s10847-026-01340-5","url":null,"abstract":"<div>\u0000 \u0000 <p>A novel hydroxypyranone-based tripodal chelator, NHPY (tris((5-hydroxy-4-oxo-4H-pyran-2-yl)methyl)2,2’,2’’-nitrilotriactate was synthesized and the binding interactions with trivalent metal ions were studied meticulously using computational and experimental approaches. The chelator was designed to utilize the hydroxyl and carbonyl groups of the pyranone ring to successfully coordinate with metal ions, and it was synthesized via a condensation reaction that produced a highly chelating tripodal chelator. The coordination properties were analysed via solution studies, including potentiometric titrations, and spectrophotometric titrations. The chelator displayed selectivity and strong binding affinity for trivalent metal ions, such as Fe(III), Cr(III), Al(III), and Ga(III) with stability constants determined for each complex. For various complexes involved in this research, the complexation studies demonstrated high formation constants with the formation of species ML, MLH, MLH₂, and MLH_− 1. Spectral shifts caused by the addition of metal ions and corresponding modifications to the solution properties indicated that stable metal-ligand complexes were formed. DFT studies were performed to understand the molecular features of the electronic structure and the binding interactions between the two species. As a result of the DFT data collected, geometries, electronic distributions, and binding strengths were evaluated to further substantiate the experimental results. Additionally, NHPY had been identified through in-vitro testing as a highly potent Cathepsin B inhibitor. Experimental validation of its therapeutic application was conducted via molecular docking studies demonstrating the compounds’ ability to inhibit inflammatory responses, cancer progression, and Alzheimer’s disease. Thus, the collection of data through these approaches indicates that hydroxypyranone-derived chelators may represent future applications for the detection of metal ions, to facilitate environmental clean-up, and as therapeutic agents to treat metal dysregulation in living systems.</p>\u0000 </div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 of","pages":"339 - 362"},"PeriodicalIF":1.6,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148202948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of macrocyclic host-guest systems by liquid-liquid extraction","authors":"Kazuharu Yoshizuka,&nbsp;Manja Kubeil,&nbsp;Holger Stephan","doi":"10.1007/s10847-026-01341-4","DOIUrl":"10.1007/s10847-026-01341-4","url":null,"abstract":"<div><p>Macrocyclic compounds have advanced the molecular recognition of many organic and inorganic guest molecules, utilizing in particular their high degree of pre-organization. This has led to a number of attractive applications, for example in sensor technology, selective separation processes, and the manufacture of advanced materials, right through to the development of artificial enzymes. Liquid-liquid extraction has accompanied these developments from the outset and has contributed, on the one hand, to a better understanding of the fundamentals of molecular recognition processes and, on the other hand, to the development of practical methods for the effective and selective separation of different guest molecules using macrocyclic compounds. Extraction offers the possibility to investigate host-guest systems where the reaction partners have very different solubility properties. The use of the radiotracer method in particular provides very reliable data with a high degree of accuracy. This approach yields highly accurate separation and selectivity factors, as well as information on the lipophilicity of host compounds and even thermodynamic parameters, which provide insight into the enthalpic and entropic contributions of the molecular recognition process.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 of","pages":"265 - 278"},"PeriodicalIF":1.6,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10847-026-01341-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148202912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy metal ion extraction and DFT study of complexation of thiacalix[4]arene thioethers with podand and crown-ether topology","authors":"Sergey A. Karalash,&nbsp;Yulia E. Balashova,&nbsp;Svetlana E. Solovieva,&nbsp;Igor S. Antipin,&nbsp;Ekaterina V. Skorb,&nbsp;Anton A. Muravev","doi":"10.1007/s10847-026-01336-1","DOIUrl":"10.1007/s10847-026-01336-1","url":null,"abstract":"<div>\u0000 \u0000 <p>Here we report on the heavy metal ion binding behavior of <i>cone</i> and <i>1</i>,<i>3-alternate</i> thiacalix[4]arene thioethers, with the binding motifs preorganized in podand and crown-ether topologies. The liquid-phase extraction of picrate salts of Ag, Hg(II), Cu, Pb, Zn, and Cd identified the highest degree of recovery of Ag and Hg(II) salts, in agreement with the previously reported data. Surprisingly, the distally (thioethyl)propyloxy-disubstituted thiacalix[4]arene <i>cone</i>-SS showed a preferable extractability of Hg²⁺ ions vs. Ag⁺ ions, while other ligands were selective towards Ag⁺ ions. DFT calculations of model Hg²⁺ ion complexes of thiacalixarene thioethers revealed favorable cation–π interactions with adjacent benzene ring and ion–dipole interactions with sulfur or oxygen atoms of thiacrown-ether macrocycle or linear thioethers, which resulted in exocyclic coordination to thiacrown-ether ring and distortion of benzene rings. The Ag⁺ ion binding mechanism involved not only coordination to the sulfur atoms of thioethers, but also epithio groups of thiacalix[4]arene and hydroxyl groups on the lower rim of macrocycle.</p>\u0000 </div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 of","pages":"317 - 324"},"PeriodicalIF":1.6,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148202914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Main Group metal ion coordination chemistry: factors influencing solid state structures of Group 1 complexes","authors":"Jack Harrowfield","doi":"10.1007/s10847-026-01339-y","DOIUrl":"10.1007/s10847-026-01339-y","url":null,"abstract":"<div>\u0000 \u0000 <p>Analysis of published structures of alkali metal ion complexes of the isomeric 2-, 3- and 4-nitrophenoxides has been applied in an endeavour to identify the forces operative in determining the coordination modes adopted. Aside from a single instance in which hydrogen-bonding appears to exclude direct coordination, all three nitrophenoxide ligands exhibit the capacity to interact as unidentate, chelating and/or bridging species. In variously hydrated complexes, different balance points are reached in the competition between hydrogen-bonding and direct coordination. While stacking of the aromatic units is commonly observed, there is limited evidence to assign this to other than dispersion force interactions. With the heavier alkali metal ions, cation-π interactions can be detected in some cases.</p>\u0000 </div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 of","pages":"279 - 291"},"PeriodicalIF":1.6,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148202913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The scientific contributions of Peter Comba: bispidine ligands, molecular modeling, and beyond","authors":"Mauro Mocerino,&nbsp;Yang Kim","doi":"10.1007/s10847-026-01337-0","DOIUrl":"10.1007/s10847-026-01337-0","url":null,"abstract":"","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 of","pages":"257 - 263"},"PeriodicalIF":1.6,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148202939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Water-soluble pillar[5]arenes: synthetic strategies, host–guest chemistry, and emerging supramolecular platforms for anticancer drug delivery","authors":"Angelina Yuliana Dwi Cahya,&nbsp;Atthar Luqman Ivansyah,&nbsp;Robby Roswanda,&nbsp;Deana Wahyuningrum","doi":"10.1007/s10847-026-01338-z","DOIUrl":"10.1007/s10847-026-01338-z","url":null,"abstract":"<div><p>Cavity-bearing macrocycles play a pivotal role in supramolecular chemistry, particularly in the construction of host–guest systems for biomedical applications. Although classical macrocycles such as cyclodextrins, cucurbiturils, crown ethers, and calixarenes exhibit useful molecular recognition properties, their biomedical applications are often limited by poor aqueous solubility and limited structural tunability. Pillar[n]arenes (P[n]As), a relatively recent class of rigid and highly symmetrical macrocycles, have emerged as promising alternatives for drug delivery applications. In particular, pillar[5]arene (P[5]A) offers versatile platforms for chemical functionalization at both rims, enabling the development of water-soluble derivatives (WP5As) with tunable physicochemical properties and strong host–guest binding affinities driven by multiple noncovalent interactions. Recent studies have demonstrated that WP5As can efficiently encapsulate a wide range of therapeutic agents, enhance drug solubility, and enable controlled and stimuli-responsive release. This review summarizes recent advances in the synthesis and functional modification of P[5]A derivatives and highlights their growing potential as smart supramolecular nanocarriers for cancer therapy and other biomedical applications.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 3-4","pages":"183 - 197"},"PeriodicalIF":1.6,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limits to the heterogenization of a copper-bispidine aziridination catalyst on NU-1000","authors":"Thomas Kieble,&nbsp;Nadjana Schneider,&nbsp;Tobias Saxl,&nbsp;Frank Kirschhöfer,&nbsp;Peter G. Weidler,&nbsp;Stefan Heißler,&nbsp;Thomas Josephy,&nbsp;Katharina Bleher","doi":"10.1007/s10847-026-01334-3","DOIUrl":"10.1007/s10847-026-01334-3","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, we investigated whether a tetradentate copper-bispidine complex can be heterogenized in the Zr-based metal-organic framework NU-1000. The ligand used is a rigid N-donor system based on the 3,7-diazabicyclo[3.3.1]nonane scaffold, and its copper complex is known for efficiently catalyzing the aziridination of styrene. Because different residual anions are commonly present in metal-organic frameworks, we first probed the influence of the counterion in homogeneous catalysis by synthesizing a series of copper-bispidine complexes bearing different counterions. In homogeneous solution under an inert atmosphere, the counterion had a pronounced effect on the aziridination yields. Under air, however, oxygen oxidized the catalytically active Cu(I) species, while water/hydroxido ligation became dominant and acted as co-ligands, thereby diminishing the impact of the counterion. Immobilization was targeted via solvent-assisted ligand incorporation (SALI). To this end, the methyl esters on the ligand backbone were converted to carboxylates to enable binding to the Zr₆O₆ nodes of NU-1000. Immobilization of the copper complex in NU-1000 follows Langmuir behavior; however, powder X-ray diffraction and attenuated total reflection - Fourier transform infrared spectroscopy measurements show that, under the conditions employed, the immobilization is predominantly superficial. Significant leaching prevented reliable catalytic testing of the immobilisates. Overall, direct SALI-based loading of the copper-bispidine system onto NU-1000 proved unstable; the results identify the key limitations (surface deposition and leaching) and suggest that alternative support materials or anchoring strategies may enable robust heterogenization of this catalyst class.</p>\u0000 </div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 of","pages":"293 - 305"},"PeriodicalIF":1.6,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10847-026-01334-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148202925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}