Journal of Inclusion Phenomena and Macrocyclic Chemistry最新文献

{"title":"Water-soluble pillar[5]arenes: synthetic strategies, host–guest chemistry, and emerging supramolecular platforms for anticancer drug delivery","authors":"Angelina Yuliana Dwi Cahya,&nbsp;Atthar Luqman Ivansyah,&nbsp;Robby Roswanda,&nbsp;Deana Wahyuningrum","doi":"10.1007/s10847-026-01338-z","DOIUrl":"10.1007/s10847-026-01338-z","url":null,"abstract":"<div><p>Cavity-bearing macrocycles play a pivotal role in supramolecular chemistry, particularly in the construction of host–guest systems for biomedical applications. Although classical macrocycles such as cyclodextrins, cucurbiturils, crown ethers, and calixarenes exhibit useful molecular recognition properties, their biomedical applications are often limited by poor aqueous solubility and limited structural tunability. Pillar[n]arenes (P[n]As), a relatively recent class of rigid and highly symmetrical macrocycles, have emerged as promising alternatives for drug delivery applications. In particular, pillar[5]arene (P[5]A) offers versatile platforms for chemical functionalization at both rims, enabling the development of water-soluble derivatives (WP5As) with tunable physicochemical properties and strong host–guest binding affinities driven by multiple noncovalent interactions. Recent studies have demonstrated that WP5As can efficiently encapsulate a wide range of therapeutic agents, enhance drug solubility, and enable controlled and stimuli-responsive release. This review summarizes recent advances in the synthesis and functional modification of P[5]A derivatives and highlights their growing potential as smart supramolecular nanocarriers for cancer therapy and other biomedical applications.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 3-4","pages":"183 - 197"},"PeriodicalIF":1.6,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zn-Modified composite materials based on hydroxyapatite and Cucurbit[n]urils","authors":"A.E. Ukhov,&nbsp;D.A. Fedorishin,&nbsp;D.S. Zaitsev,&nbsp;N.M. Korotchenko,&nbsp;A.A. Bakibaev","doi":"10.1007/s10847-026-01335-2","DOIUrl":"10.1007/s10847-026-01335-2","url":null,"abstract":"<div><p>Zinc-modified hydroxyapatite (ZnₓHA) is a promising biomaterial for bone implants due to its osteoconductivity and antimicrobial properties. This work explores the functionalization of porous zinc-substituted hydroxyapatite (Zn₀.₅HA), synthesized via a wet precipitation method, with cucurbit[n]nurils (CB[n], <i>n</i> = 6, 7, 8) to develop composite materials. The composites were characterized by FTIR spectroscopy and scanning electron microscopy (SEM), revealing distinct surface morphologies dependent on the CB[n] type. All composites exhibited high hemocompatibility (hemolysis &lt; 5%). However, functionalization with CB[n] led to a statistically significant decrease in antibacterial activity against Escherichia coli compared to unmodified Zn₀.₅HA. This reduction correlates with the macrocycle cavity size and is attributed to the complexation of Zn²⁺ ions, which likely modulates their release. A comparative analysis of the properties of all composite types is presented. The results demonstrate the feasibility of creating biocompatible Zn₀.₅HA-CB[n] platforms, highlighting the interplay between surface modification and functional performance.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 3-4","pages":"243 - 256"},"PeriodicalIF":1.6,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porous β-CD polymer-based metal oxide systems: in-situ construction and tuning for boosted photocatalytic performance","authors":"G. Lakshmi,&nbsp;P. Velusamy","doi":"10.1007/s10847-025-01326-9","DOIUrl":"10.1007/s10847-025-01326-9","url":null,"abstract":"<div>\u0000 \u0000 <p>In recent days, photocatalytic wastewater in treatment has gained popularity in number of ways. Several organic contaminants in water can be smashed down by photocatalysis, which uses free sun light energy. Because photocatalytic technologies may provide high efficiencies and are reasonably priced, they have garnered interest due to their potential environmental benefits. In this work, we focused on the way β-CD may impact the photocatalytic performance of blended semiconductor nanocomposites (ZnO/TiO₂), (ZnO/CeO₂), (TiO₂/CeO₂), and (ZnO/CuO) and NR dye photocatalytic degradation by solar light irradiation is used to compare the photocatalytic degradation ability of all modified photocatalysts with that of bare semiconductors. A 4:1 weight ratio was employed when combining bare semiconductors to produce the blended composite. The Structural, optical and complexation pattern of β-CD with dye were investigated by XRD, FESEM, UV-DRS, FT-IR and UV–Vis spectral analysis. Investigations were carried out on factors such initial pollutant concentration, catalyst dosage, pH and irradiation duration. By measuring COD, the mineralization of NR dye was confirmed. In comparison to among all the photocatalysts, the modified nanocomposites (ZnO/TiO₂)-β-CD, (ZnO/CeO₂)-β-CD, (TiO₂/CeO₂)-β-CD and (ZnO/CuO)-β-CD were more effective in degrading of NR dye. These findings demonstrated the involvement of β-CD in the photocatalytic degradation of NR dye (ZnO/TiO₂), (ZnO/CeO₂), (TiO₂/CeO₂) and (ZnO/CuO), performing 2.2 times better than (ZnO/TiO₂), (ZnO/CeO₂), (TiO₂/CeO₂), (ZnO/CuO), and 4.9 times better than ZnO, TiO₂, CeO₂and CuO.</p>\u0000 </div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 3-4","pages":"199 - 213"},"PeriodicalIF":1.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obituary to Professor Toschitake Iwamoto","authors":"Janusz Lipkowski,&nbsp;Reiko Kuroda","doi":"10.1007/s10847-026-01333-4","DOIUrl":"10.1007/s10847-026-01333-4","url":null,"abstract":"","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 3-4","pages":"169 - 170"},"PeriodicalIF":1.6,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creation of helicene-based circularly polarized luminescence switching systems","authors":"Chihiro Maeda","doi":"10.1007/s10847-026-01328-1","DOIUrl":"10.1007/s10847-026-01328-1","url":null,"abstract":"<div>\u0000 \u0000 <p>Helicenes, composed of ortho-fused aromatic rings, have been recognized as excellent chiral dyes capable of showing circularly polarized luminescence (CPL) derived from inherent chirality. Although general carbohelicenes show CPL, weak fluorescence is often emitted in blue region. In contrast, incorporation of heteroatoms into the π-framework or periphery of helicenes modulates the electronic state, leading to intense fluorescence in the visible region. Furthermore, heteroatoms can respond to external stimuli such as acid/base, metal ions, and redox agents. Therefore, heteroatom-functionalized helicenes are good candidates for chiroptical switching systems with the changes in wavelength, intensity, on/off, and sign of CPL. Although examples of CPL switching systems were limited as compared to those of circular dichroism (CD) switching systems, they have been increasing gradually in the last decade. This review summarizes recent developments of helicene-based CPL switching systems, which are classified into pH-, coordination-, and redox-triggered switching systems.</p>\u0000 </div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 3-4","pages":"171 - 181"},"PeriodicalIF":1.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10847-026-01328-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting inclusion capabilities in metal-organic frameworks via topological (delta)–Sombor index and QSPR modeling","authors":"Yali Li,&nbsp;Guoping Zhang,&nbsp;Sadia Noureen,&nbsp;Maira Kiran,&nbsp;Sahar Aftab,&nbsp;Adnan Aslam","doi":"10.1007/s10847-026-01331-6","DOIUrl":"10.1007/s10847-026-01331-6","url":null,"abstract":"<div><p>This study demonstrates the effectiveness of the <span>(delta)</span>-Sombor index—a refined graph-theoretical descriptor—for the topological characterization and Quantitative Structure-Property Relationship (QSPR) modeling of Metal-Organic Frameworks (MOFs). We derived explicit analytical formulas for the <span>(delta)</span>-Sombor index of two representative coordination systems: a Zn(II)-isophthalate-Dptztz framework and a Nd(III)-Hepna coordination polymer. Furthermore, a comprehensive QSPR analysis was performed on a diverse set of fifty organic linkers. The <span>(delta)</span>-Sombor index exhibited strong correlations with key physicochemical properties—including partition coefficient (logP), molar refractivity (MR), topological polar surface area (tPSA), and solubility (LogS)—as validated through linear, polynomial, and ridge regression models. The high sensitivity of the <span>(delta)</span>-Sombor index to subtle variations in atomic connectivity and coordination geometry underscores its utility as a robust predictive tool for understanding and designing framework materials in which pore geometry and connectivity govern inclusion phenomena. Our findings confirm its significant potential for accelerating the rational design of MOFs with tailored supramolecular host properties, thereby bridging graph theory with the chemistry of molecular inclusion.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 3-4","pages":"229 - 242"},"PeriodicalIF":1.6,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction within the inclusion complex between β-cyclodextrin and 3-(5,6-dihydro- [1,3] dithiolo[4,5-b][1,4]dithiin-2-yl)-4-hydroxy-5-methoxybenzaldehyde","authors":"Chaima Aouachria,&nbsp;Tahar Abbaz,&nbsp;Amel Bendjeddou,&nbsp;Lakhemici Kaboub,&nbsp;Didier Villemin,&nbsp;Abdelkrim Gouasmia","doi":"10.1007/s10847-026-01329-0","DOIUrl":"10.1007/s10847-026-01329-0","url":null,"abstract":"<div><p>The inclusion complex formed between β-cyclodextrin (β-CD) and 3-(5,6-dihydro- [1, 3]dithiolo[4,5-b] [1, 4]dithiin-2-yl)-4-hydroxy-5-methoxybenzaldehyde (DTMB) was investigated using a combined semi-empirical and density functional theory (DFT) approach. Two possible inclusion orientations of the guest molecule within the β-CD cavity were examined in both gas phase and aqueous medium. Initial geometry optimizations were performed using the PM3 method, followed by full optimizations at the MN15L/6-311G(2d, p) level of theory. Complexation, interaction, and deformation energies, as well as thermodynamic parameters, were calculated to assess the stability of the inclusion complexes. The results indicate that orientation B, in which the aromatic moiety of DTMB is oriented toward the primary hydroxyl rim of β-CD, is energetically more favorable in both phases. Frontier molecular orbital analysis and global reactivity descriptors further support the higher stability of this orientation. Natural bond orbital (NBO) and noncovalent interaction (NCI) analyses reveal that the complexation process is mainly governed by van der Waals interactions and hydrogen bonding. In addition, ¹H NMR chemical shifts were computed using the GIAO method and show good agreement with the experimental data, providing further validation of the proposed inclusion modes. Overall, this study offers detailed insights into the structural features, energetics, and interaction mechanisms of DTMB/β-CD inclusion complexes and contributes to a better understanding of host–guest systems involving sulfur-rich aromatic compounds.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 3-4","pages":"215 - 228"},"PeriodicalIF":1.6,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclodextrins as supramolecular agents for enhancing the separation performance of deep eutectic solvents: an overview of food and pharmaceutical applications","authors":"Shima Saffarionpour","doi":"10.1007/s10847-025-01323-y","DOIUrl":"10.1007/s10847-025-01323-y","url":null,"abstract":"<div>\u0000 \u0000 <p>With the culmination of the research on the development of novel and green solvents in the separation industries, there has been a spurred interest recently in the development of cyclodextrin (CD)-based supramolecular deep eutectic solvents (DESs) or SUPRADES. The SUPRADESs prepared from CDs and carboxylic acids or the stimuli-responsive ones formulated with fatty acids can promote the separation of countless hydrophobic compounds among others polyphenols, terpenoids, or proteins from plant-based sources. Additionally, in combination with polymers (e.g. chitosan), SUPRADESs have been used for designing bioactive films. As chiral selectors, CDs added to DESs can contribute to the enantioseparation of chiral therapeutic compounds in capillary electrophoresis (CE) and electrokinetic chromatography (EKC). They can additionally aid with the enantiorecognition of chiral amino acids in biphasic systems. Given their efficacious roles in augmenting the separation and delivery performance of DESs, this review study enfolds their potential applications in the food and pharmaceutical industries.</p>\u0000 </div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 1-2","pages":"65 - 93"},"PeriodicalIF":1.6,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147340643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective alternative host-guest separation strategies for mixed pyridine/methylpyridines with thioxanthenyl- and xanthenyl-derived host molecules","authors":"Danica B. Trollip,&nbsp;Benita Barton,&nbsp;Mino R. Caira,&nbsp;Eric C. Hosten","doi":"10.1007/s10847-025-01324-x","DOIUrl":"10.1007/s10847-025-01324-x","url":null,"abstract":"<div><p><i>N</i>,<i>N’</i>-Bis(9-(4-fluorophenyl)-9-thioxanthenyl)ethylenediamine (<b>H1</b>) and <i>N</i>,<i>N’</i>-bis(9-(4-fluorophenyl)-9-xanthenyl)ethylenediamine (<b>H2</b>) were demonstrated to have inclusion ability for pyridine (PYR) and the methylpyridine isomers (2MP, 3MP and 4MP); H:G ratios were 1:1 or 1:2. When guests competed, the host selectivities were observed to be in the order 4MP &gt; 3MP &gt; 2MP &gt; &gt; PYR (<b>H1</b>) and PYR &gt; 4MP &gt; 2MP &gt; &gt; 3MP (<b>H2</b>) and so substitution of the sulfur atom for oxygen in the central B ring of the host compound resulted in significant changes in the host selectivity behaviour. Owing to the fact that these guests present as mixtures in the chemical industry and are difficult to separate through fractional distillations as a result of their comparable boiling points, we subsequently investigated whether these host compounds have the ability to separate binary pyridyl mixtures in various molar ratios through supramolecular chemistry strategies. As such, it was demonstrated that <b>H1</b> has the ability to separate the 80:20 4MP/PYR solution (K = infinite, in favour of 4MP), while <b>H2</b> was even more effective, able to separate numerous of the binary mixtures employed here. Thermal experiments demonstrated that <b>H1</b>·4MP (4MP being preferred by <b>H1</b>) was thermally more stable than the other three complexes; <b>H1</b>·PYR (least favoured guest) was unstable even at ambient conditions. The affinity behaviour of <b>H2</b>, however, could not be as readily explained through thermal analyses. All of the complexes presented here experienced numerous non-covalent short contacts, including a (host)N–H···N(guest) classical hydrogen bond in each one (this was only absent in <b>H1</b>·2MP). This technique also provided the reasons for the affinity of <b>H1</b> for 4MP and its constant low preference for PYR, and also why <b>H2</b> favoured PYR and never 3MP.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 1-2","pages":"139 - 156"},"PeriodicalIF":1.6,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147340097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Host-guest interactions of chiral Schiff-base macrocyclic Zn(II) complexes with α-amino acids","authors":"Chao Huang,&nbsp;Xiao-Mao Tian,&nbsp;Li-Xia Chen,&nbsp;Bi-Xue Zhu","doi":"10.1007/s10847-025-01325-w","DOIUrl":"10.1007/s10847-025-01325-w","url":null,"abstract":"<div><p>Two chiral Schiff-base macrocyclic Zn(II) complexes (<b>M</b>_{<i>R</i>,<i>R</i>} and <b>M</b>_{<i>S</i>,<i>S</i>}) were synthesized from the condensation reaction of 3,3’-methylene-bis(2-hydroxy-5-methylbenzaldehyde) and 1<i>R</i>,2<i>R</i>- or 1<i>S</i>,2<i>S</i>-cyclohexanediamine in the presence of Zn(NO₃)₂. Their structures were characterized using ¹H/¹³C NMR, ESI-MS, and elemental analysis, and the crystal structure of <b>M</b>_{<i>R</i>,<i>R</i>} was further determined via single-crystal X-ray diffraction. In the solution of MeOH/H₂O (9:1), the UV-Vis spectra were utilized for the host-guest interaction studies between <b>M</b>_{<i>R</i>,<i>R</i>} or <b>M</b>_{<i>S</i>,<i>S</i>} and a series of <i>α</i>-amino acid enantiomers. The results demonstrated that both <b>M</b>_{<i>R</i>,<i>R</i>} and <b>M</b>_{<i>S</i>,<i>S</i>} exhibited quantifiable binding interactions with <i>D</i>-/<i>L</i>-Arginine (Arg), <i>D</i>-/<i>L</i>-Lysine (Lys), and <i>D</i>-/<i>L</i>-Glutamic acid (Glu), and the binding ratio was consistently 1:1. Moreover, the density functional theory (DFT) calculation indicated that the binding affinity as well as the observed enantioselectivity of <b>M</b>_{<i>R</i>,<i>R</i>} or <b>M</b>_{<i>S</i>,<i>S</i>} toward these amino acid enantiomers was mainly attributed to the hydrogen-bonding interactions between the amino acid enantiomers with the bridging water molecules located in the binuclear Zn(II) complexes.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"106 1-2","pages":"157 - 167"},"PeriodicalIF":1.6,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147340163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}