Journal of Inclusion Phenomena and Macrocyclic Chemistry最新文献

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Organic porous solid as promising iodine capture materials 有机多孔固体是很有前途的碘捕获材料
IF 2.3 4区 化学
Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2022-01-23 DOI: 10.1007/s10847-022-01128-3
Ya-Nan Yu, Zheng Yin, Li-Hui Cao, Yang-Min Ma
{"title":"Organic porous solid as promising iodine capture materials","authors":"Ya-Nan Yu,&nbsp;Zheng Yin,&nbsp;Li-Hui Cao,&nbsp;Yang-Min Ma","doi":"10.1007/s10847-022-01128-3","DOIUrl":"10.1007/s10847-022-01128-3","url":null,"abstract":"<div><p>Facing the dual pressure of increasing global energy demand and heavy task in carbon emission reduction on schedule, nuclear renaissance is being seriously discussed as transitive choice before full renewable energy supply, yet there is a crucial concern about radioactive safety. The treatment of radioactive iodine is particularly important and challenging because of its high ratio in fission product, extremely long radioactive periods up to several millions of years, as well as easy diffusion in the whole ecosystem. Given that several challenge including easy sublimation, high water solubility, diverse existing species of I<sub>2</sub>, I<sup>−</sup>, I<sub>2n+1</sub><sup>−</sup> and organic iodine, biocompatibility and strong aggregation in thyroid, rapid capture and permanent storage of iodine is requested. Comparing to inorganic adsorbents of zeolite and inorganic–organic hybrid MOFs, pure organic porous solid are emerging as new and promising iodine capture material. Their high iodine affinity and adsorption capacity, good stability in various environments, facile modification and functionalization, intrinsic structural flexibility guaranteed the outstanding performance in iodine capture. Four main categories of organic cages, supramolecular framework connected by weak interaction, covalent organic frameworks and polymers with intrinsic microporosity were summarized and discussed, from the viewpoints of design principles, iodine capture performance, and adsorbent-iodine interactions. As the main prospect, we hope this work will attracting more researchers to study porous organic materials and address the challenge of effective capture of radioactive iodine.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"102 5-6","pages":"395 - 427"},"PeriodicalIF":2.3,"publicationDate":"2022-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10847-022-01128-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4892753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Preparation and recognition property of an acyclic cucurbit[n]uril dimer 一种无环葫芦[n]脲二聚体的制备及其识别性能
IF 2.3 4区 化学
Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2022-01-21 DOI: 10.1007/s10847-022-01130-9
Fang Zhou, Da Ma, Yamin Liu
{"title":"Preparation and recognition property of an acyclic cucurbit[n]uril dimer","authors":"Fang Zhou,&nbsp;Da Ma,&nbsp;Yamin Liu","doi":"10.1007/s10847-022-01130-9","DOIUrl":"10.1007/s10847-022-01130-9","url":null,"abstract":"<div><p>A new acyclic cucurbit[<i>n</i>]uril (CB[<i>n</i>]) dimer is synthesized by copper-catalyzed azide-alkyne cycloaddition or “click” reaction. The acyclic CB[<i>n</i>] dimer possesses two cavities, and is able to encapsulate two guest molecules simultaneously. This dimer is discovered to be high affinity host molecule for a wide variety of dyes, pharmaceutical drugs and guest molecules.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"102 5-6","pages":"487 - 491"},"PeriodicalIF":2.3,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4819807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Spectral studies of protonated and anionic forms of porphyrins with an asymmetric substitution system 不对称取代系统中质子化和阴离子形式卟啉的光谱研究
IF 2.3 4区 化学
Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2022-01-21 DOI: 10.1007/s10847-022-01131-8
Yulia B. Ivanova, Svetlana G. Pukhovskaya, Alexey V. Lyubimtsev, Anna O. Plotnikova, Sergei A. Syrbu
{"title":"Spectral studies of protonated and anionic forms of porphyrins with an asymmetric substitution system","authors":"Yulia B. Ivanova,&nbsp;Svetlana G. Pukhovskaya,&nbsp;Alexey V. Lyubimtsev,&nbsp;Anna O. Plotnikova,&nbsp;Sergei A. Syrbu","doi":"10.1007/s10847-022-01131-8","DOIUrl":"10.1007/s10847-022-01131-8","url":null,"abstract":"<div><p>The directed synthesis of asymmetrically substituted porphyrins—tetraphenylporphyrine derivatives containing amino acid residues as a functional group, which can be used as “anchor” groups, for incorporation into the structure of a protein molecule, was carried out. The obtained compounds were characterized by a number of spectral methods confirming their structure and purity. Their base and acid ionization constants in the AN–HClO<sub>4</sub> and DMSO–potassium cryptate (KOH[222])—systems were measured by spectrophotometric titration. It was found that the asymmetric substitution architecture contributed to the stabilization of the protonated forms of porphyrins. This allowed, for the first time, to extract and spectrally characterize the mono- and doubly-protonated forms (H<sub>3</sub>P<sup>+</sup> and H<sub>4</sub>P<sup>2+</sup>) of each ligands in the AN–HClO<sub>4</sub> system. The analysis of the spectral changes of the monoamino derivative led to identify three stages of the protonation, which first involves the nitrogen atom of the periphery substituent (p<i>K</i><sub>b</sub> = 13.26) and then the central nitrogen atoms of the macrocycle (p<i>K</i><sub>b1</sub> = 11.50; p<i>K</i><sub>b2</sub> = 9.65; p<i>K</i><sub>b1,2</sub> = 21.15). The relative stability of the first intermediate is assumed to be caused by charge delocalization. The electron-donor nature of the solvent in the DMSO–KOH [222] system led to the leveling of the ionization constants for the first and second stages, which allowed us to determine only the total values for the porphyrins studied. The successive stages of acid–base interactions were analyzed in the article.</p><h3>Graphical abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"102 5-6","pages":"493 - 505"},"PeriodicalIF":2.3,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4822038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Recent advances in therapeutical applications of the versatile hydroxypyridinone chelators 多用途羟基吡啶酮螯合剂治疗应用的最新进展
IF 2.3 4区 化学
Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2022-01-16 DOI: 10.1007/s10847-021-01114-1
Shailza Sharma, Minati Baral, B. K. Kanungo
{"title":"Recent advances in therapeutical applications of the versatile hydroxypyridinone chelators","authors":"Shailza Sharma,&nbsp;Minati Baral,&nbsp;B. K. Kanungo","doi":"10.1007/s10847-021-01114-1","DOIUrl":"10.1007/s10847-021-01114-1","url":null,"abstract":"<div><p>Hydroxypyridinones (HOPOs) are excellent class of chelators that have been gaining attention in the field of pharmaceutical drugs by their high chelating efficacy and specificity with different metal ions. Among all the metal ions, they exhibit a high binding affinity towards iron (III) and are clinically used as iron chelators nowadays. The HOPO family has different isomers, out of which 3,4-HOPO possesses applicability for designing drugs. The effect of methyl substitution on different positions of pyridinone ring also plays an essential role in deciding the pM values, thus describing the metal affinity. Several metal ions like Fe, Al, Cu, Zn, and some actinides are found to exhibit good chelation efficacy with HOPOs. In terms of denticity, there are various forms of HOPO. Among these, discussion on bidentate, tetradentate, hexadentate, octadentate, and dendrimers will be done here. This review systematically summarizes the various literature reports on the design and pharmacological activities of the newly developed HOPOs and their derivatives, including antibiotics, anticancer, and antineurodegeneratives.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"102 3-4","pages":"169 - 200"},"PeriodicalIF":2.3,"publicationDate":"2022-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4648974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Lanthanide complexes with polyaminopolycarboxylates as prospective NMR/MRI diagnostic probes: peculiarities of molecular structure, dynamics and paramagnetic properties 镧系化合物与聚氨基聚羧酸盐配合物作为未来核磁共振/核磁共振诊断探针:分子结构、动力学和顺磁性的特性
IF 2.3 4区 化学
Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2021-11-11 DOI: 10.1007/s10847-021-01112-3
Eugeny N. Zapolotsky, Yanyang Qu, Sergey P. Babailov
{"title":"Lanthanide complexes with polyaminopolycarboxylates as prospective NMR/MRI diagnostic probes: peculiarities of molecular structure, dynamics and paramagnetic properties","authors":"Eugeny N. Zapolotsky,&nbsp;Yanyang Qu,&nbsp;Sergey P. Babailov","doi":"10.1007/s10847-021-01112-3","DOIUrl":"10.1007/s10847-021-01112-3","url":null,"abstract":"<div><p>The paramagnetic lanthanide complexes with polyaminopolycarboxylate (PAPC) ligands attract considerable attention from the standpoint of potential applications thereof as relaxation agents used in medical magnetic resonance imaging (MRI) and in luminescent materials, as well as owing to promising use thereof as paramagnetic labels for studying the properties of biopolymers since they exhibit thermodynamic stability, good solubility in aqueous media and moderate toxicity. For the last decades, the NMR methods have been used to determine the physical and chemical properties of paramagnetic Ln compounds. The studies concerning paramagnetic NMR lanthanide-induced shifts (LISs) in dissolved Ln complexes, as well as the analysis of band shape as a function of temperature make it possible to obtain valuable information on the structure, intra- and intermolecular dynamics and paramagnetic properties thereof. This review is devoted solely to the following features: firstly, the processes of intramolecular dynamics of lanthanide complexes with polyamino-polycarboxylate ligands such as DOTA, EDTA and DTPA and their derivatives studied by NMR; secondly, the LISs of lanthanide complexes with EDTA, DOTA, DTPA and some of their derivatives depending on temperature and pH. Moreover, in this review, for the first time, the dependence of the activation energy of molecular dynamics in complexes with polydentate ligands on the atomic number of the lanthanide cation is analyzed and a monotonic change in energy is detected, which is due to the effect of lanthanide contraction. It should be noted that this phenomenon is quite general and may also appear in the future in many other series of lanthanide complexes with both other multidentate ligands and with bidentate and monodentate ligands. In the future, it is possible to predict the dependence of the properties of certain lanthanide complexes on the ionic radius of the lanthanide cation based on the approaches presented in the review. In this review, we have also presented the dynamic NMR as the main research method widely used to analyze the processes of molecular dynamics, and the structural studies based on the NMR relaxation spectroscopy and LIS analysis.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"102 1-2","pages":"1 - 33"},"PeriodicalIF":2.3,"publicationDate":"2021-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4473487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Studies on cobalt(III) complexes of a cyanoethyl derivative of an isomeric hexamethyl tetraazamacrocyclic ligand 六甲基四氮杂环异构体氰乙基衍生物钴(III)配合物的研究
IF 2.3 4区 化学
Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2021-11-05 DOI: 10.1007/s10847-021-01110-5
Mohammad Abu Sayed, Saswata Rabi, Pradip Paul, Lucky Dey, Benu Kumar Dey, Zinnat A. Begum, Ismail M. M. Rahman, Tapashi Ghosh Roy
{"title":"Studies on cobalt(III) complexes of a cyanoethyl derivative of an isomeric hexamethyl tetraazamacrocyclic ligand","authors":"Mohammad Abu Sayed,&nbsp;Saswata Rabi,&nbsp;Pradip Paul,&nbsp;Lucky Dey,&nbsp;Benu Kumar Dey,&nbsp;Zinnat A. Begum,&nbsp;Ismail M. M. Rahman,&nbsp;Tapashi Ghosh Roy","doi":"10.1007/s10847-021-01110-5","DOIUrl":"10.1007/s10847-021-01110-5","url":null,"abstract":"<div><p>A 14-membered hexamethyl-tetraazamacrocycle, viz. Me<sub>6</sub>[14]diene.2HClO<sub>4</sub> (L.2HClO<sub>4</sub>), afforded a mixture of isomeric ligands, Me<sub>6</sub>[14]anes, upon reduction with NaBH<sub>4</sub> and extraction by CHCl<sub>3</sub> at pH &gt; 12. These ligands were separated by fractional crystallization from xylene and were designated as ‘tet-a’ and ‘tet-b.’ The interaction of ‘tet-b’ with excess acrylonitrile was fairly stereoselective and formed an <i>N</i>-pendent derivative, ‘tet-bx’, in which two cyano-ethyl groups were attached to trans <i>N</i>-atoms that are sterically less crowded. Aeration of ‘tet-bx’ and cobalt(II) acetate salt in methanol, followed by its treatment with HCl, yielded a bluish-green product, viz. <i>trans</i>-[Co(‘tet-bx’)Cl<sub>2</sub>]Cl. <i>trans</i>-[Co(‘tet-bx’)Cl<sub>2</sub>]Cl underwent axial substitution reactions with KSCN and KNO<sub>3</sub> and subsequent axial substitution and anion exchange reactions with NaNO<sub>2</sub>, KBr, and KI to produce six-coordinated octahedral complexes, viz. bluish-green <i>trans</i>-[Co(‘tet-bx’)(NCS)<sub>2</sub>]Cl, light-blue <i>trans</i>-[Co(‘tet-bx’)(NO<sub>3</sub>)<sub>2</sub>]Cl, yellow <i>trans</i>-[Co(‘tet-bx’)(NO<sub>2</sub>)<sub>2</sub>]NO<sub>2</sub>, green <i>trans</i>-[Co(‘tet-bx’)Br<sub>2</sub>]Br, and red <i>trans</i>-[Co(‘tet-bx’)I<sub>2</sub>]I. These complexes were characterized using different modern analytical and spectroscopic techniques. The antibacterial activities of the <i>N</i>-pendent ligand and its cobalt(III) complexes on four types of selected bacteria were investigated.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"102 3-4","pages":"251 - 259"},"PeriodicalIF":2.3,"publicationDate":"2021-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4225754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Size-complementary effects of PEG diamine 1,1’-disubstituted ferrocene on incorporations of β- and γ-cyclodextrins and syntheses of poly(pseudo)rotaxanes with lower coverages therefrom 聚乙二醇二胺1,1′-二取代二茂铁对β-和γ-环糊精结合及低覆盖率聚(伪)轮烷合成的尺寸互补效应
IF 2.3 4区 化学
Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2021-10-09 DOI: 10.1007/s10847-021-01104-3
Rong-hao Song, Ming Gao, Xue Geng, Lin Ye, Ai-ying Zhang, Zeng-guo Feng
{"title":"Size-complementary effects of PEG diamine 1,1’-disubstituted ferrocene on incorporations of β- and γ-cyclodextrins and syntheses of poly(pseudo)rotaxanes with lower coverages therefrom","authors":"Rong-hao Song,&nbsp;Ming Gao,&nbsp;Xue Geng,&nbsp;Lin Ye,&nbsp;Ai-ying Zhang,&nbsp;Zeng-guo Feng","doi":"10.1007/s10847-021-01104-3","DOIUrl":"10.1007/s10847-021-01104-3","url":null,"abstract":"<p>Poly(ethylene glycol) diamine 1,1’-disubstituted ferrocene was utilized as a size-com-plementary site to synthesize lower coverage pseudopolyrotaxanes (pPRs) from self-assemblies with β- and γ-cyclodextrins (CDs). After end-capping β-CD pPRs using N-(triphenylmethyl)glycine (Trt-Gly-OH), an exact β-CD [3]polyrotaxane (PR) was created. However, an unexpected γ-CD [2]PR and a predictive chain folded stranded γ-CD pPR were identified from end-capped γ-CD pPRs.</p>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"102 1-2","pages":"99 - 108"},"PeriodicalIF":2.3,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4400092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Additional information 额外的信息
IF 2.3 4区 化学
Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2021-10-01 DOI: 10.1007/s10847-021-01105-2
{"title":"Additional information","authors":"","doi":"10.1007/s10847-021-01105-2","DOIUrl":"10.1007/s10847-021-01105-2","url":null,"abstract":"","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"101 3-4","pages":"361 - 361"},"PeriodicalIF":2.3,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4058261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
trans-α,α,α′,α′-Tetraphenyl-9,10-dihydro-9,10-ethanoanthracene-11,12-dimethanol and its tetra(p-chlorophenyl) derivative: roof-shaped host compounds for the purification of aromatic C8H10 isomeric guest mixtures 反式-α,α,α′,α′-四苯基-9,10-二氢-9,10-四氮杂蒽-11,12-二甲醇及其四(对氯苯基)衍生物:用于提纯芳香族 C8H10 异构客体混合物的屋顶形主化合物
IF 2.3 4区 化学
Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2021-09-08 DOI: 10.1007/s10847-021-01102-5
Benita Barton, Ulrich Senekal, Eric C. Hosten
{"title":"trans-α,α,α′,α′-Tetraphenyl-9,10-dihydro-9,10-ethanoanthracene-11,12-dimethanol and its tetra(p-chlorophenyl) derivative: roof-shaped host compounds for the purification of aromatic C8H10 isomeric guest mixtures","authors":"Benita Barton,&nbsp;Ulrich Senekal,&nbsp;Eric C. Hosten","doi":"10.1007/s10847-021-01102-5","DOIUrl":"10.1007/s10847-021-01102-5","url":null,"abstract":"<div><p>Roof-shaped host compounds <i>trans</i>-α,α,α′,α′-tetraphenyl-9,10-dihydro-9,10-ethanoanthracene-11,12-dimethanol <b>H3</b> and <i>trans</i>-α,α,α′,α′-tetra(<i>p</i>-chlorophenyl)-9,10-dihydro-9,10-ethanoanthracene-11,12-dimethanol <b>H6</b> were assessed for their host potential and selectivity behaviour when presented with single or mixed guest solvents comprising <i>o</i>-xylene, <i>m</i>-xylene, <i>p</i>-xylene and ethylbenzene (<i>o</i>-Xy, <i>m</i>-Xy, <i>p</i>-Xy and EB). <b>H3</b> included each solvent with 3:1 host:guest ratios, while the ratios preferred by <b>H6</b> were more varied (4:3, 1:1 and 3:2). More importantly, the selectivity behaviour of these two host compounds was observed to be entirely different: <b>H3</b> possessed only a very modest preference for <i>o</i>-Xy (37.9–68.2%) when recrystallized from various equimolar binary, ternary and quaternary guest mixtures, while <b>H6</b> was considerably more selective, preferring <i>m</i>-Xy (the least favoured guest of <b>H3</b>) with selectivities ranging from 57.7 to 91.4% in analogous conditions. The latter result was obtained in <i>o</i>-Xy/<i>m</i>-Xy mixtures and demonstrates that <b>H6</b> may be employed as a purification tool for mixtures of these two xylenes via host–guest chemistry protocols. A single crystal diffraction experiment on 3(<b>H3</b>)·<i>o</i>-Xy (containing the preferred guest of <b>H3</b>) revealed that the guest was retained in the host crystal by means of a singular (host)<i>m</i>-Ar–H···π(guest) interaction that measured 2.73 Å (148°) as well as numerous other host···guest interactions involving only the aromatic protons of the free host phenyl groups and the guest methyl protons or aromatic carbons and protons (2.20–2.54 Å, 121–125°). Thermal analyses explained the preference of <b>H3</b> for <i>o</i>-Xy, while these were less informative for the complexes of <b>H6</b>.\u0000</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"102 1-2","pages":"77 - 87"},"PeriodicalIF":2.3,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10847-021-01102-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4368852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beta-carotene/cyclodextrin-based inclusion complex: improved loading, solubility, stability, and cytotoxicity β -胡萝卜素/环糊精包合物:改善负载,溶解度,稳定性和细胞毒性
IF 2.3 4区 化学
Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2021-08-25 DOI: 10.1007/s10847-021-01100-7
Mahsa Yazdani, Omid Tavakoli, Mehdi Khoobi, Yi Shuan Wu, Mohammad Ali Faramarzi, Elham Gholibegloo, Shabnam Farkhondeh
{"title":"Beta-carotene/cyclodextrin-based inclusion complex: improved loading, solubility, stability, and cytotoxicity","authors":"Mahsa Yazdani,&nbsp;Omid Tavakoli,&nbsp;Mehdi Khoobi,&nbsp;Yi Shuan Wu,&nbsp;Mohammad Ali Faramarzi,&nbsp;Elham Gholibegloo,&nbsp;Shabnam Farkhondeh","doi":"10.1007/s10847-021-01100-7","DOIUrl":"10.1007/s10847-021-01100-7","url":null,"abstract":"<div><p>Beta-carotene (BC) is a vitamin A precursor and has potential anticancer benefits, but the delivery of BC is hindered by its low solubility and storage instability. To overcome these challenges, this study investigated the use of fabricated cyclodextrin-based nanosponges (CDNS) using different ratios of two cross-linkers, epiclon (EPI) and hexamethylene diisocyanate (HMDI) to form inclusion complex with BC. The ratios of crosslinkers to βCD for two most optimaly encapsulated CDNSs-BC were determined to be 2:1 for EPI and 4:1 for HMDI with loading efficiency of 61.46% and 59.61%, respectively. The charachterization tests were carefully done for two optimal CDNSs. Encapsulation significantly improved the solubility by ~ 10 folds, 30-day storage stability by 40% compared to BCs. The in vitro release of the two encapsulated products showed no burst release. The MTT assay revealed a variable increase in cytotoxic effect in both normal and cancer cells compared to free BC. Overall, the CDNSs appear to be promising carriers for the delivery of BCs.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"102 1-2","pages":"55 - 64"},"PeriodicalIF":2.3,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10847-021-01100-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4958591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
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