Xiang Li, Lijiao Chen, Yongning Yang, Mingfang Ma, Deng Liu, Zhaolou Li
{"title":"Hydroxypropyl β-cyclodextrin-crosslinked konjac glucomannan supramolecular hydrogel as dual-action drug carrier for a sustained release","authors":"Xiang Li, Lijiao Chen, Yongning Yang, Mingfang Ma, Deng Liu, Zhaolou Li","doi":"10.1007/s10847-023-01212-2","DOIUrl":null,"url":null,"abstract":"<div><p>A hydroxypropyl β-cyclodextrin (HPCD)/5-fluorouracil (5-FU) inclusion complex was loaded into konjac glucomannan hydrogel successfully by co-assembly. The influence of HPCD on the structure and properties of konjac glucomannan (KGM) hydrogel was investigated. The networks of KGM/HPCD hydrogel became flat and firm after HPCD intervened. The KGM/HPCD hydrogel had diversified microstructures including HPCD molecular cavities, porous lamellar structure in fibrous bands. The X-ray diffractometry (XRD) results reflected amorphous characters of the KGM/HPCD xerogel. The analytical data of Fourier transform infrared spectrometry (FT-IR) and differential scanning calorimetry (DSC) confirmed the supramolecular interactions between KGM and HPCD molecules in the gel network were mainly H-bonding interactions. HPCD improved KGM/HPCD hydrogel by crosslinking physically to construct a novel drug delivery system in the presence of sodium carbonate. The KGM/HPCD hydrogel achieved more effective and sustained drug release, in which HPCD cavities shared responsibility for the controlled release of chemotherapeutic 5-FU molecules. Rheological measurements also showed the presence of HPCD increased the elastic modulus (G') of the novel KGM/HPCD hydrogel. </p><h3>Graphical abstract</h3><p>Through co-assembly, a green drug delivery system was successfully constructed with hydroxypropyl β-cyclodextrin/5-fluorouracil inclusion complex loaded into konjac glucomannan hydrogel. By dialysis experiments, the drug 5-fluorouracil release rate from the inclusion complex loaded hydrogel was prolongated remarkably compared to that from single 5-fluorouracil loaded hydrogel. For the inclusion complex loaded hydrogel with different 5-fluorouracil concentrations, or under different physiological conditions, the drug cumulative release appeared also evident difference. This green drug delivery system has important potential application in medical engineering material.</p>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10847-023-01212-2","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 0
Abstract
A hydroxypropyl β-cyclodextrin (HPCD)/5-fluorouracil (5-FU) inclusion complex was loaded into konjac glucomannan hydrogel successfully by co-assembly. The influence of HPCD on the structure and properties of konjac glucomannan (KGM) hydrogel was investigated. The networks of KGM/HPCD hydrogel became flat and firm after HPCD intervened. The KGM/HPCD hydrogel had diversified microstructures including HPCD molecular cavities, porous lamellar structure in fibrous bands. The X-ray diffractometry (XRD) results reflected amorphous characters of the KGM/HPCD xerogel. The analytical data of Fourier transform infrared spectrometry (FT-IR) and differential scanning calorimetry (DSC) confirmed the supramolecular interactions between KGM and HPCD molecules in the gel network were mainly H-bonding interactions. HPCD improved KGM/HPCD hydrogel by crosslinking physically to construct a novel drug delivery system in the presence of sodium carbonate. The KGM/HPCD hydrogel achieved more effective and sustained drug release, in which HPCD cavities shared responsibility for the controlled release of chemotherapeutic 5-FU molecules. Rheological measurements also showed the presence of HPCD increased the elastic modulus (G') of the novel KGM/HPCD hydrogel.
Graphical abstract
Through co-assembly, a green drug delivery system was successfully constructed with hydroxypropyl β-cyclodextrin/5-fluorouracil inclusion complex loaded into konjac glucomannan hydrogel. By dialysis experiments, the drug 5-fluorouracil release rate from the inclusion complex loaded hydrogel was prolongated remarkably compared to that from single 5-fluorouracil loaded hydrogel. For the inclusion complex loaded hydrogel with different 5-fluorouracil concentrations, or under different physiological conditions, the drug cumulative release appeared also evident difference. This green drug delivery system has important potential application in medical engineering material.
期刊介绍:
The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites.
The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.