Hydroxypropyl β-cyclodextrin-crosslinked konjac glucomannan supramolecular hydrogel as dual-action drug carrier for a sustained release

IF 2.3 4区 化学 Q2 Agricultural and Biological Sciences
Xiang Li, Lijiao Chen, Yongning Yang, Mingfang Ma, Deng Liu, Zhaolou Li
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引用次数: 0

Abstract

A hydroxypropyl β-cyclodextrin (HPCD)/5-fluorouracil (5-FU) inclusion complex was loaded into konjac glucomannan hydrogel successfully by co-assembly. The influence of HPCD on the structure and properties of konjac glucomannan (KGM) hydrogel was investigated. The networks of KGM/HPCD hydrogel became flat and firm after HPCD intervened. The KGM/HPCD hydrogel had diversified microstructures including HPCD molecular cavities, porous lamellar structure in fibrous bands. The X-ray diffractometry (XRD) results reflected amorphous characters of the KGM/HPCD xerogel. The analytical data of Fourier transform infrared spectrometry (FT-IR) and differential scanning calorimetry (DSC) confirmed the supramolecular interactions between KGM and HPCD molecules in the gel network were mainly H-bonding interactions. HPCD improved KGM/HPCD hydrogel by crosslinking physically to construct a novel drug delivery system in the presence of sodium carbonate. The KGM/HPCD hydrogel achieved more effective and sustained drug release, in which HPCD cavities shared responsibility for the controlled release of chemotherapeutic 5-FU molecules. Rheological measurements also showed the presence of HPCD increased the elastic modulus (G') of the novel KGM/HPCD hydrogel.

Graphical abstract

Through co-assembly, a green drug delivery system was successfully constructed with hydroxypropyl β-cyclodextrin/5-fluorouracil inclusion complex loaded into konjac glucomannan hydrogel. By dialysis experiments, the drug 5-fluorouracil release rate from the inclusion complex loaded hydrogel was prolongated remarkably compared to that from single 5-fluorouracil loaded hydrogel. For the inclusion complex loaded hydrogel with different 5-fluorouracil concentrations, or under different physiological conditions, the drug cumulative release appeared also evident difference. This green drug delivery system has important potential application in medical engineering material.

Abstract Image

羟丙基β-环糊精交联魔芋葡甘露聚糖超分子水凝胶作为持续释放的双效药物载体
通过共组装法将羟丙基β-环糊精(HPCD)/5-氟尿嘧啶(5-FU)包合复合物成功地负载到魔芋葡甘露聚糖水凝胶中。研究了 HPCD 对魔芋葡甘露聚糖(KGM)水凝胶结构和性能的影响。HPCD介入后,KGM/HPCD水凝胶的网络变得平整而坚固。KGM/HPCD水凝胶具有多样化的微观结构,包括HPCD分子空穴、纤维带中的多孔层状结构。X 射线衍射(XRD)结果显示 KGM/HPCD 水凝胶具有非晶态特征。傅立叶变换红外光谱法(FT-IR)和差示扫描量热法(DSC)的分析数据证实了凝胶网络中 KGM 和 HPCD 分子之间的超分子相互作用主要是 H 键相互作用。HPCD通过物理交联改进了KGM/HPCD水凝胶,从而在碳酸钠存在下构建了一种新型的给药系统。KGM/HPCD 水凝胶实现了更有效、更持久的药物释放,其中的 HPCD 空腔分担了控制释放化疗药物 5-FU 分子的责任。流变学测量还表明,HPCD的存在提高了新型KGM/HPCD水凝胶的弹性模量(G')。图解摘要通过共组装,成功构建了一种将羟丙基β-环糊精/5-氟尿嘧啶包合物负载于魔芋葡甘露聚糖水凝胶中的绿色给药系统。通过透析实验,与单一的 5-氟尿嘧啶水凝胶相比,包合物水凝胶的 5-氟尿嘧啶药物释放速率明显延长。不同5-氟尿嘧啶浓度或不同生理条件下,包合物水凝胶的药物累积释放量也出现了明显差异。这种绿色给药系统在医学工程材料中具有重要的应用潜力。
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来源期刊
CiteScore
3.30
自引率
8.70%
发文量
0
审稿时长
3-8 weeks
期刊介绍: The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.
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