Journal of Flow Chemistry最新文献_第5页

Two photons are better than one: continuous flow synthesis of ꞵ-lactones through a doubly photochemically-activated Paternò-Büchi reaction 两个光子胜过一个光子：通过双重光化学激活的 Paternò-Büchi 反应连续流合成ꞵ-内酯

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-12-15 DOI: 10.1007/s41981-023-00297-7

Federica Minuto, Emanuele Farinini, Serena De Negri, Riccardo Leardi, Davide Ravelli, Pavlo Solokha, Andrea Basso

引用次数: 0

HO-SAS catalyzed protection and deprotection of aldehydes and alcohols in continuous flow reactors 连续流反应器中的 HO-SAS 催化醛和醇的保护和脱保护作用

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-12-13 DOI: 10.1007/s41981-023-00298-6

Takahide Fukuyama, Toshiaki Hirano, Kengo Takamura

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Methyl acetate production by reactive distillation using a vertical plate microdistillator 竖板式微蒸馏器反应精馏生产醋酸甲酯

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-12-01 DOI: 10.1007/s41981-023-00294-w

Yosuke Muranaka, Taisuke Maki, Soma Matsumoto, Kazuhiro Mae

{"title":"Methyl acetate production by reactive distillation using a vertical plate microdistillator","authors":"Yosuke Muranaka, Taisuke Maki, Soma Matsumoto, Kazuhiro Mae","doi":"10.1007/s41981-023-00294-w","DOIUrl":"10.1007/s41981-023-00294-w","url":null,"abstract":"<div><p>Micro-distillation is one of the unit operation technologies that are looking toward innovation through on-site and on-demand production system. In this study, a simple structure microdistillator consisting of some plates was applied to reactive distillation, and its potential was investigated. As a target reaction, the heterogeneous esterification between acetic acid and methanol using a solid acid catalyst was employed. The effects of feedstock supply rate, feedstock composition, and device temperature on operation stability and conversion were examined. By controlling the feedstock supply rate and temperature properly, a stable operation with a conversion of approximately 100% was successfully achieved. The amount of methyl acetate produced per weight of catalyst was greater in the reactive distillation using a microdistillator than in the batch reaction, soon after the start of the reaction. Thus, it was demonstrated that the reactive distillation using a microdistillator was able to achieve highly efficient reactions with short reaction time and small amounts of catalyst.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 1","pages":"289 - 295"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138528263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telescoped synthesis of vicinal diamines via ring-opening of electrochemically generated aziridines in flow 流动中电化学生成的aziridine开环套筒合成邻二胺

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-11-29 DOI: 10.1007/s41981-023-00296-8

Marharyta Laktsevich-Iskryk, Anastasiya Krech, Mihhail Fokin, Mariliis Kimm, Tatsiana Jarg, Timothy Noël, Maksim Ošeka

{"title":"Telescoped synthesis of vicinal diamines via ring-opening of electrochemically generated aziridines in flow","authors":"Marharyta Laktsevich-Iskryk, Anastasiya Krech, Mihhail Fokin, Mariliis Kimm, Tatsiana Jarg, Timothy Noël, Maksim Ošeka","doi":"10.1007/s41981-023-00296-8","DOIUrl":"10.1007/s41981-023-00296-8","url":null,"abstract":"<div><p>A vicinal diamine motif can be found in numerous natural compounds and pharmaceuticals, making it an important synthetic target. Herein, we report a telescoped synthesis of vicinal diamines under continuous flow conditions. This approach involves the electrochemical aziridination of alkenes with primary amines, followed by the strain-release driven ring-opening using various nitrogen nucleophiles. The efficacy of the developed method was demonstrated through the synthesis of diverse symmetrically and non-symmetrically substituted vicinal diamines, as well as vicinal amino azides, which can be further hydrogenated to diamines in flow. Additionally, <i>O</i>-centered nucleophiles were employed for the ring-opening of aziridines in our telescoped synthesis, yielding vicinal amino ethers and alcohol. This process offers a streamlined and efficient pathway for the direct synthesis of valuable products from readily available starting materials, bypassing the isolation of unstable aziridine intermediates.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 1","pages":"139 - 147"},"PeriodicalIF":2.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138528137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of gas-solid direct contact on gas-liquid-solid reaction performance in a flow reactor 流动反应器中气固直接接触对气液固反应性能的影响

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-11-28 DOI: 10.1007/s41981-023-00295-9

Shusaku Asano, Hiroyuki Miyamura, Mizuki Matsushita, Shinji Kudo, Shū Kobayashi, Jun-ichiro Hayashi

{"title":"Impact of gas-solid direct contact on gas-liquid-solid reaction performance in a flow reactor","authors":"Shusaku Asano, Hiroyuki Miyamura, Mizuki Matsushita, Shinji Kudo, Shū Kobayashi, Jun-ichiro Hayashi","doi":"10.1007/s41981-023-00295-9","DOIUrl":"10.1007/s41981-023-00295-9","url":null,"abstract":"<p>Although gas-liquid-solid reactions, such as catalytic hydrogenation, have a long history, a fundamental understanding of the flow behavior and its effect on the reaction is lacking for flow chemistry applications using powder catalysts. This study revealed the distinctive effect of gas-solid direct contact on the surface of a powder catalyst. Direct gas–solid contact accelerates the reaction beyond the theoretical maximum of the batch reaction system, where gaseous species are supplied to the catalyst surface after dissolution into the liquid. The benefit of direct contact is further pronounced in systems with low-solubility gaseous species. Liquid holdup analysis revealed that the micro-concavities of the catalyst support is crucial for sustaining the liquid using capillary forces and supplying the liquid substrate to the catalyst surface even under high gas flow rate conditions. The gas-to-liquid flow rate ratio (G/L) is a decisive factor for direct gas–solid contact, whereas the flow direction, whether upflow or downflow, has no impact on powder catalysts with a size of a few hundred microns.</p>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 1","pages":"329 - 335"},"PeriodicalIF":2.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138528146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing N-arylation productivity: the amplified potential of electrophotocatalysis in flow 提高n -芳基化生产力:流动中光电催化的放大潜力

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-11-28 DOI: 10.1007/s41981-023-00290-0

Jolien De Ketelaere, Thomas S. A. Heugebaert

引用次数: 0

Investigations on the continuous flow generation of 2,6-dichloro-N-fluoropyridinium tetrafluoroborate using F2 gas F2气连续流动生成2,6-二氯- n -氟吡啶的研究

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-11-28 DOI: 10.1007/s41981-023-00291-z

Kevin Simon, Desiree Znidar, Gabriel Glotz, Doris Dallinger, C. Oliver Kappe

引用次数: 0

Asymmetric electrochemical synthesis in flow 流动中的不对称电化学合成

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-11-28 DOI: 10.1007/s41981-023-00293-x

Daniele Mazzarella

引用次数: 0

Continuous Flow Generation of Highly Reactive Organometallic Intermediates: A Recent Update 高活性有机金属中间体的连续流动生成:最新进展

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-11-28 DOI: 10.1007/s41981-023-00292-y

Mauro Spennacchio, Philipp Natho, Michael Andresini, Marco Colella

引用次数: 0

Nitration process of 2-(2,4-dichlorophenyl)-4-(difluoromethyl)-5-methyl-1,2,4-triazol-3-one in a microreactor 微反应器中 2-(2,4-二氯苯基)-4-(二氟甲基)-5-甲基-1,2,4-三唑-3-酮的硝化过程

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-11-09 DOI: 10.1007/s41981-023-00289-7

Jian-yang Cao, Jing Hou, Le-wu Zhan, Bin-dong Li

{"title":"Nitration process of 2-(2,4-dichlorophenyl)-4-(difluoromethyl)-5-methyl-1,2,4-triazol-3-one in a microreactor","authors":"Jian-yang Cao, Jing Hou, Le-wu Zhan, Bin-dong Li","doi":"10.1007/s41981-023-00289-7","DOIUrl":"10.1007/s41981-023-00289-7","url":null,"abstract":"<div><p>In a continuous flow microreactor system, a continuous nitration process of 2-(2,4-dichloro-5-nitrophenyl)-4-(difluoromethyl)-5-methyl-1,2,4-triazol-3-one which is the key intermediate for the synthesis of important triazolinone herbicide Sulfentrazone was developed. The effects of molar ratio of mixed acids, molar ratio of nitric acid to substrate, reaction temperature, total flow rate and residence time in the microreactor on nitration reaction were studied. The results showed that when the flow rate of the material was 60 mL/min, the molar ratio of nitrate to sulfur mixed acid was 1:6, the molar ratio of nitric acid to raw material was 1.1:1, the reaction temperature was 60 ℃, and the residence time was 30 s, the product can be obtained in 97% yield. Compared with the results of nitration process using traditional batch reactors, the use of continuous flow microreactors improved reaction efficiency and achieved higher yields. A characterization kinetics study was conducted on this reaction, and the pre-exponential-factor and activation energy for 2-(2,4-dichlorophenyl)-4-(difluoromethyl)-5-methyl-1,2,4-triazol-3-one nitration were obtained. The activation energy of the reaction is 40.204 kJ/mol. The continuous flow microreactor system greatly increased liquid-liquid two phases mass transfer efficiency, while accurately controlling the reaction temperature and residence time in the reactor.</p></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 1","pages":"281 - 288"},"PeriodicalIF":2.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135290770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0