Journal of Flow Chemistry最新文献_第5页

Solid dosing in High-Throughput Experimentation: generalization of mass enhancer technologies for submilligram scale 高通量实验中的固体配料：亚毫克级质量增强器技术的通用化

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2024-01-09 DOI: 10.1007/s41981-023-00304-x

Taline Kerackian, Géraud Chacktas, Didier Durand, Eugénie Romero

引用次数: 0

Application of stop-flow micro-tubing reactor system in organic reaction development 停流微管反应器系统在有机反应开发中的应用

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-12-28 DOI: 10.1007/s41981-023-00302-z

Qian Wang, Ruize Yin, Zihan Wang, Yanbin Zhang, Jie Wu

{"title":"Application of stop-flow micro-tubing reactor system in organic reaction development","authors":"Qian Wang, Ruize Yin, Zihan Wang, Yanbin Zhang, Jie Wu","doi":"10.1007/s41981-023-00302-z","DOIUrl":"10.1007/s41981-023-00302-z","url":null,"abstract":"<div><p>Recently demonstrated as a novel reaction screening technology, the stop-flow micro-tubing (SFMT) reactors amalgamate features from continuous micro-flow and conventional batch reactors, resulting in a more logical and rigorous synthesis approach. When compared to traditional batch reactors, SFMT provides a safer and more efficient alternative, particularly suitable for chemical reactions under drastic conditions. The incorporation of commercially available transparent micro-tubing into SFMT makes it an excellent choice for light-mediated reactions, ensuring more uniform exposure to light. And SFMT stands apart from continuous-flow reactors by offering a notably convenient screening approach that is unrestricted by residence time and reactor size, while also effectively eradicating the risk of cross-contamination. The successful reactions developed within the SFMT reactor can be easily translated to continuous-flow synthesis for large-scale production. Overall, the SFMT reactor system exhibits similarities to continuous-flow reactors while surpassing batch reactors, especially for reactions involving gas reagents and/or requiring light illumination. This review aims to provide a comprehensive survey of the synthetic application of SFMT.</p></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 1","pages":"97 - 107"},"PeriodicalIF":2.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139055350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous synthesis of ε-caprolactone in a microreactor and kinetics insights into its side reactions 在微反应器中连续合成ε-己内酯及其副反应动力学研究

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-12-27 DOI: 10.1007/s41981-023-00301-0

Bin Wu, Xindi Feng, Wei Du, Zhixiang Li, Gang Qian, Xuezhi Duan, Xinggui Zhou, Zhen Liu, Jing Zhang

{"title":"Continuous synthesis of ε-caprolactone in a microreactor and kinetics insights into its side reactions","authors":"Bin Wu, Xindi Feng, Wei Du, Zhixiang Li, Gang Qian, Xuezhi Duan, Xinggui Zhou, Zhen Liu, Jing Zhang","doi":"10.1007/s41981-023-00301-0","DOIUrl":"10.1007/s41981-023-00301-0","url":null,"abstract":"<div><p>Nowadays <i>ε</i>-caprolactone, the monomer of biodegradable polycaprolactone, is mainly produced via the strong exothermic Baeyer–Villiger oxidation of cyclohexanone in semi-batch reactors. In this work, the continuous synthesis of <i>ε</i>-caprolactone was conducted in a self-designed microreactor system to address its strong exothermic feature, resulting in a cyclohexanone conversion of 90.3% and an <i>ε</i>-caprolactone yield of 82.6%. Analysis using a liquid chromatography equipped with high resolution time-of-flight mass spectrometer suggested that the byproducts mainly consist of <i>ε</i>-caprolactone oligomers in the form of dimer, trimer, and tetramer. Such oligomers were produced via hydrolysis of <i>ε</i>-caprolactone, followed by esterification of the hydrolysis product, 6-hydroxyhexanoic acid. Kinetic studies suggest that the hydrolysis reaction orders for <i>ε</i>-caprolactone and water are 0.75 and 2.52, respectively, while dimerization of 6-hydroxyhexanoic acid is a zero-order reaction. The activation energies of the hydrolysis and dimerization were ~ 77.5 kJ·mol<sup>−1</sup> and ~ 55.4 kJ·mol<sup>−1</sup>, respectively. Density functional theory calculations revealed the significant catalytic effect of acetic acid on both side reactions, where the dimerization of 6-hydroxyhexanoic acid proceeds through an alkoxy pathway.</p></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 1","pages":"337 - 347"},"PeriodicalIF":2.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139055245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flow chemical laboratory practice for undergraduate students: synthesis of paracetamol 本科生流程化学实验室实践：扑热息痛的合成

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-12-27 DOI: 10.1007/s41981-023-00303-y

Bettina Rávai, Máté János Orosz, Orsolya Péterfi, Dorián László Galata, Erika Bálint

{"title":"Flow chemical laboratory practice for undergraduate students: synthesis of paracetamol","authors":"Bettina Rávai, Máté János Orosz, Orsolya Péterfi, Dorián László Galata, Erika Bálint","doi":"10.1007/s41981-023-00303-y","DOIUrl":"10.1007/s41981-023-00303-y","url":null,"abstract":"<div><p>Generally, chemical engineering students get well acquainted with the batch synthesis of various active pharmaceutical ingredients, however, only tiny focus is provided to undergraduates on the topic of flow chemistry. In this paper, we report that students participating in the chemical engineering BSc course at the Budapest University of Technology and Economics were encouraged to perform the flow synthesis of paracetamol, a common pain painkiller. Two different synthetic routes for the continuous production of paracetamol were investigated and compared the batch and flow methods. Thus, these experiments allowed the students to discover flow chemistry for themselves under supervision: how to set up a flow system, how to carry out a reaction continuously, and to experience the advantages of flow chemistry over batch synthesis. In addition, students also got familiar with <i>in-line</i> Fourier transform infrared spectroscopy, as one of the reactions was monitored in real-time.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><img></picture></div><div><p>The educational manuscript covers the field of continuous flow synthesis of paracetamol supplemented with in-line Fourier transform infrared spectroscopy, which was developed for undergraduate students in the chemical engineering BSc course at the Budapest University of Technology and Economics</p></div></div></figure></div></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 2","pages":"409 - 415"},"PeriodicalIF":2.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41981-023-00303-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139055234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous synthesis of boron-doped carbon nitride supported silver nanoparticles in an ultrasound-assisted coiled flow inverter microreactor 在超声辅助盘流变频微反应器中连续合成掺硼氮化碳支撑的银纳米粒子

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-12-22 DOI: 10.1007/s41981-023-00300-1

Yu-tian Tao, Ke-Jun Wu, Chao-Hong He

{"title":"Continuous synthesis of boron-doped carbon nitride supported silver nanoparticles in an ultrasound-assisted coiled flow inverter microreactor","authors":"Yu-tian Tao, Ke-Jun Wu, Chao-Hong He","doi":"10.1007/s41981-023-00300-1","DOIUrl":"10.1007/s41981-023-00300-1","url":null,"abstract":"<div><p>The combination of ultrasound and microreactors for the synthesis of nanomaterials is becoming increasingly popular, but effectively altering the ultrasonic field at the microscale to control the crystallization process remains a challenge. Herein, we investigated numerically and experimentally the effects of the ultrasonic field on the synthesis of boron-doped carbon nitride supported silver nanoparticles based on our homemade ultrasound-assisted coiled flow inverter microreactor (UCFIR). Specifically, the ultrasound promotes the radial mixing in the coiled flow inverter microreactor, even under low Reynolds number 10, resulting in better control over the crystallization process. The effects of key parameters, such as ultrasonic field distribution and ultrasonic power, on the particle size and size distribution of Ag/B-g-C<sub>3</sub>N<sub>4</sub> have been demonstrated. The results show that when the ultrasound transducer is positioned on the ‘abc’ sides, the Ag/B-g-C<sub>3</sub>N<sub>4</sub> with small and uniform Ag particles (4.12 ± 1.12 nm) can be obtained. As ultrasound power increased (0–176 W) and residence time decreased (17.5–140 s), the size of silver nanoparticles decreased, and their distribution narrowed.</p></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 1","pages":"177 - 196"},"PeriodicalIF":2.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138944876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous-flow Synthesis of Anisotropic Plasmonic Nanostructures 各向异性质子纳米结构的连续流合成

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-12-18 DOI: 10.1007/s41981-023-00299-5

Vini Singh, Perali Ramu Sridhar, R. Singh

引用次数: 0

Two photons are better than one: continuous flow synthesis of ꞵ-lactones through a doubly photochemically-activated Paternò-Büchi reaction 两个光子胜过一个光子：通过双重光化学激活的 Paternò-Büchi 反应连续流合成ꞵ-内酯

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-12-15 DOI: 10.1007/s41981-023-00297-7

Federica Minuto, Emanuele Farinini, Serena De Negri, Riccardo Leardi, Davide Ravelli, Pavlo Solokha, Andrea Basso

引用次数: 0

HO-SAS catalyzed protection and deprotection of aldehydes and alcohols in continuous flow reactors 连续流反应器中的 HO-SAS 催化醛和醇的保护和脱保护作用

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-12-13 DOI: 10.1007/s41981-023-00298-6

Takahide Fukuyama, Toshiaki Hirano, Kengo Takamura

引用次数: 0

Methyl acetate production by reactive distillation using a vertical plate microdistillator 竖板式微蒸馏器反应精馏生产醋酸甲酯

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-12-01 DOI: 10.1007/s41981-023-00294-w

Yosuke Muranaka, Taisuke Maki, Soma Matsumoto, Kazuhiro Mae

{"title":"Methyl acetate production by reactive distillation using a vertical plate microdistillator","authors":"Yosuke Muranaka, Taisuke Maki, Soma Matsumoto, Kazuhiro Mae","doi":"10.1007/s41981-023-00294-w","DOIUrl":"10.1007/s41981-023-00294-w","url":null,"abstract":"<div><p>Micro-distillation is one of the unit operation technologies that are looking toward innovation through on-site and on-demand production system. In this study, a simple structure microdistillator consisting of some plates was applied to reactive distillation, and its potential was investigated. As a target reaction, the heterogeneous esterification between acetic acid and methanol using a solid acid catalyst was employed. The effects of feedstock supply rate, feedstock composition, and device temperature on operation stability and conversion were examined. By controlling the feedstock supply rate and temperature properly, a stable operation with a conversion of approximately 100% was successfully achieved. The amount of methyl acetate produced per weight of catalyst was greater in the reactive distillation using a microdistillator than in the batch reaction, soon after the start of the reaction. Thus, it was demonstrated that the reactive distillation using a microdistillator was able to achieve highly efficient reactions with short reaction time and small amounts of catalyst.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 1","pages":"289 - 295"},"PeriodicalIF":2.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138528263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telescoped synthesis of vicinal diamines via ring-opening of electrochemically generated aziridines in flow 流动中电化学生成的aziridine开环套筒合成邻二胺

IF 2 4区化学

Journal of Flow Chemistry Pub Date : 2023-11-29 DOI: 10.1007/s41981-023-00296-8

Marharyta Laktsevich-Iskryk, Anastasiya Krech, Mihhail Fokin, Mariliis Kimm, Tatsiana Jarg, Timothy Noël, Maksim Ošeka

{"title":"Telescoped synthesis of vicinal diamines via ring-opening of electrochemically generated aziridines in flow","authors":"Marharyta Laktsevich-Iskryk, Anastasiya Krech, Mihhail Fokin, Mariliis Kimm, Tatsiana Jarg, Timothy Noël, Maksim Ošeka","doi":"10.1007/s41981-023-00296-8","DOIUrl":"10.1007/s41981-023-00296-8","url":null,"abstract":"<div><p>A vicinal diamine motif can be found in numerous natural compounds and pharmaceuticals, making it an important synthetic target. Herein, we report a telescoped synthesis of vicinal diamines under continuous flow conditions. This approach involves the electrochemical aziridination of alkenes with primary amines, followed by the strain-release driven ring-opening using various nitrogen nucleophiles. The efficacy of the developed method was demonstrated through the synthesis of diverse symmetrically and non-symmetrically substituted vicinal diamines, as well as vicinal amino azides, which can be further hydrogenated to diamines in flow. Additionally, <i>O</i>-centered nucleophiles were employed for the ring-opening of aziridines in our telescoped synthesis, yielding vicinal amino ethers and alcohol. This process offers a streamlined and efficient pathway for the direct synthesis of valuable products from readily available starting materials, bypassing the isolation of unstable aziridine intermediates.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 1","pages":"139 - 147"},"PeriodicalIF":2.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138528137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0