高通量实验中的固体配料：亚毫克级质量增强器技术的通用化

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Flow Chemistry Pub Date : 2024-01-09 DOI:10.1007/s41981-023-00304-x

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引用次数: 0

摘要

摘要高通量实验（HTE）是发现和优化反应的有力工具，它的出现正在改变有机化学家设计实验的方式。这是一种以最少的时间和试剂消耗对反应进行深入研究的绝佳方法。然而，要在学术界和工业界全面推行 HTE，还需要让更多的人了解它。在这种情况下，有必要开发出可供亚毫克级配料使用的固体配料方法。本文旨在为适用于 HTE 活动的纳摩尔级配料提出稳健的质量增强器解决方案。图表摘要

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Solid dosing in High-Throughput Experimentation: generalization of mass enhancer technologies for submilligram scale

Abstract

The emergence of High-Throughput Experimentation (HTE) as a powerful tool for reaction discovery and optimization is changing the way organic chemists are designing their experiments. It is a fantastic way to largely investigate a reaction, in a minimum of time and reagent consumption. However, HTE needs to be accessible to a wide audience for a full implementation in academic and industrial sectors. In that context, developing accessible solid dosing methodologies for submilligram dispensing is necessary. This paper aims at proposing robust mass enhancers solutions for nanomole scale dosing applicable to HTE campaigns.

Graphical abstract

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来源期刊

Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

6.40

自引率

3.70%

发文量

审稿时长

>12 weeks

期刊介绍： The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.