连续流反应器中的 HO-SAS 催化醛和醇的保护和脱保护作用

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Flow Chemistry Pub Date : 2023-12-13 DOI:10.1007/s41981-023-00298-6

Takahide Fukuyama, Toshiaki Hirano, Kengo Takamura

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引用次数: 0

摘要

我们使用具有羟基的磺酸官能化硅胶（HO-SAS）作为固体酸催化剂，研究了醛的流动缩醛和醇的 THP 保护。脂肪醛和芳香醛在 5 分钟的停留时间内与甲醇发生反应，生成乙缩醛产物，收率良好甚至极佳。伯醇、仲醇和叔醇的 THP 保护反应进展顺利，生成了相应的产物。这两种反应都不需要中和过程。通过连续操作还实现了可扩展的合成。使用 HO-SAS 填料流反应器进行脱保护反应也很有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

HO-SAS catalyzed protection and deprotection of aldehydes and alcohols in continuous flow reactors

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HO-SAS catalyzed protection and deprotection of aldehydes and alcohols in continuous flow reactors

We investigated the flow acetalization of aldehydes and THP protection of alcohols using sulfonic acid-functionalized silica gel having hydroxy moiety (HO-SAS) as the solid acid catalyst. The reaction both aliphatic and aromatic aldehydes reacted with methanol within 5 min of residence time to give acetalization product in good to excellent yield. THP protection of primary, secondary, and tertiary alcohols proceeded well to the corresponding products. Both reactions did not require a neutralization process. Scalable syntheses were also achieved with continuous operation. The deprotection reactions were also effective using HO-SAS packed flow reactors.

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来源期刊

Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

6.40

自引率

3.70%

发文量

审稿时长

>12 weeks

期刊介绍： The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.