Journal of Environmental Health Science and Engineering最新文献

{"title":"Comprehensive systematic review and meta-analysis of microplastic prevalence and abundance in freshwater fish species: the effect of fish species habitat, feeding behavior, and Fulton’s condition factor","authors":"Ramin Nabizadeh Nodehi,&nbsp;Mahdi Hadi,&nbsp;Ahmad Hosseinzadeh,&nbsp;Nahid Azizi","doi":"10.1007/s40201-024-00907-z","DOIUrl":"10.1007/s40201-024-00907-z","url":null,"abstract":"<div><p>Microplastics are emerging pollutants that cause health problems for aquatic organisms. Fish is one of the important organisms because of its consumption by humankind. The present study examines the abundance and prevalence of microplastics in freshwater fish species through a systematic review study while considering five important factors, i.e. water resources, habitat, feeding behavior, Fulton’s condition factor, and microplastic characteristics. A comprehensive meta-analysis was undertaken to evaluate relevant publications in terms of microplastic abundance. Articles published up to July 30, 2022 were found through Global search engines including, Web of Science, Scopus, and PubMed. In total, 786 articles were found that 53 and 42 articles were used for qualitative review and meta-analysis, respectively. This was carried out by a random-effects model with high heterogeneity (I² = 99.76%). According to the data, the highest attention in microplastic research in body part and water sources are related to gastrointestinal tract (<i>n</i> = 259 (~ 80%)) and rivers (<i>n</i> = 189 (~ 58%)), respectively. According to the results, the average microplastic prevalence range was 5 -100%, and microplastic abundance was within the 0.04–204 items range per individual. The difference between microplastic prevalence and abundance for the key factors for parametric and nonparametric data were analyzed using Analysis of variance (ANOVA) and the Kruskal-Wallis test, respectively. According to the Baujat plot, two studies (ID: 27 and 25) revealed the minimal influence of microplastics abundance. Conclusively, the average microplastics abundance according to the pooled data, varied between 2.23 and 2.48, with a mean of 2.35 items per individual in the studies overall. It is concluded that the amount of ingested microplastics by fish is related only to physiology (height, weight, and body structure) but not feeding behavior, habitat, and surrounding water.</p></div>","PeriodicalId":628,"journal":{"name":"Journal of Environmental Health Science and Engineering","volume":"22 2","pages":"365 - 380"},"PeriodicalIF":3.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141258945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-assisted heterogeneous process for organic dye pollutants destruction using the novel MIL-101(Fe)/ZrO2/MnFe2O4 nanocomposite catalyst from water medium","authors":"Meysam Sadeghi,&nbsp;Pourya Zarshenas","doi":"10.1007/s40201-024-00906-0","DOIUrl":"10.1007/s40201-024-00906-0","url":null,"abstract":"<div><p>The heterogeneous sonocatalysis is considered as an impressive remediation approach to eliminate the dyeing wastewaters. Among the efficient sonocatalytic remediation, nanocomposite sonocatalysts have grabbed special attention in recent years. In the presence research, the novel MIL-101(Fe)/ZrO₂/MnFe₂O₄ nanocomposite as a magnetically retrievable catalyst was elaborated using the ultrasound-assisted hydrothermal route and its sonocatalytic performance was tested applying the methylene blue (MB), rhodamine B (RhB), congo red (CR), and methyl orange (MO) organic dyes under US/H₂O₂ system. The as-fabricated nanocomposite is well identified via FESEM, TEM, EDX, EDX elemental dot mappings, AFM, FTIR, XRD, BET, UV-Vis DRS, and VSM. The sonocatalytic destruction outcomes have demonstrated that the MIL-101(Fe)/ZrO₂/MnFe₂O₄ shows appreciable performance for the destruction of MB, RhB, CR, and MO with the yields of 98.17%, 96.35%, 93.40%, and 89.82%, respectively under the optimized conditions of irradiation time of 7 min, dye concentration of 25 mg/L, catalyst amount of 10 mg, US power intensity of 100 W, H₂O₂ concentration of 4 mM, pH of 7, and temperature of 25 ± 1 °C. The fitted kinetic curves were exhibited a first-order model and the half-life time (t_1/2) and reaction rate constant (k_app) of the MB sonodestruction were determined to be 1.20 min and 0.5768 min⁻¹ employing the MIL-101(Fe)/ZrO₂/MnFe₂O₄/US/H₂O₂ system, respectively. The free ^•OH radicals were having a crucial role in the MB sonodestruction reaction, affirmed via quenching the experiments. Besides, the reusing experiments indicate that the MIL-101(Fe)/ZrO₂/MnFe₂O₄ represents propitious stability and long durability and reminded more than 93% after four cycles.</p><h3>Graphical Abstract</h3><p>The metal-organic framework MIL-101(Fe)/ZrO₂/MnFe₂O₄ heterojunction magnetically retrievable nanocomposite was successfully prepared and used as a new sonocatalyst for the destruction of MB, RhB, CR, and MO toxic organic dye pollutants from water medium.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":628,"journal":{"name":"Journal of Environmental Health Science and Engineering","volume":"22 2","pages":"483 - 501"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141189768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of infectious droplet dispersion in a hospital examination room cooled by split-type air conditioner","authors":"Bahadır Erman Yüce,&nbsp;Onur Can Kalay,&nbsp;Fatih Karpat,&nbsp;Adem Alemdar,&nbsp;Şehime Gülsün Temel,&nbsp;Aslı Görek Dilektaşlı,&nbsp;Emel Bülbül Başkan,&nbsp;Cüneyt Özakın,&nbsp;Burhan Coşkun","doi":"10.1007/s40201-024-00905-1","DOIUrl":"10.1007/s40201-024-00905-1","url":null,"abstract":"<div><p>The novel coronavirus (SARS-CoV-2) outbreak has spread worldwide, and the World Health Organization (WHO) declared a global pandemic in March 2020. The transmission mechanism of SARS-CoV-2 in indoor environments has begun to be investigated in all aspects. In this regard, many numerical studies on social distancing and the protection of surgical masks against infection risk have neglected the evaporation of the particles. Meanwhile, a 1.83 m (6 feet) social distancing rule has been recommended to reduce the infection risk. However, it should be noted that most of the studies were conducted in static air conditions. Air movement in indoor environments is chaotic, and it is not easy to track all droplets in a ventilated room experimentally. Computational Fluid Dynamics (CFD) enables the tracking of all particles in a ventilated environment. This study numerically investigated the airborne transmission of infectious droplets in a hospital examination room cooled by a split-type air conditioner with the CFD method. Different inlet velocities (1, 2, 3 m/s) were considered and investigated separately. Besides, the hospital examination room is a model of one of the Bursa Uludag University Hospital examination rooms. The patient, doctor, and some furniture are modeled in the room. Particle diameters considered ranged from 2 to 2000 μm. The evaporation of the droplets is not neglected, and the predictions of particle tracks are shown. As a result, locations with a high infection risk were identified, and the findings that could guide the design/redesign of the hospital examination rooms were evaluated.</p></div>","PeriodicalId":628,"journal":{"name":"Journal of Environmental Health Science and Engineering","volume":"22 2","pages":"471 - 482"},"PeriodicalIF":3.0,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40201-024-00905-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141169275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of caffeine in wastewater using MOF and perovskite materials: optimization, kinetics, and adsorption isotherm modelling","authors":"Amira Essam,&nbsp;Samaa Imam Eldek,&nbsp;Nabila Shehata","doi":"10.1007/s40201-024-00904-2","DOIUrl":"10.1007/s40201-024-00904-2","url":null,"abstract":"<div><p>Pharmaceuticals and personal care products (PPCPs) have been increasingly used all over the world and they have been reported on water cycle and cause contamination. Among these pharmaceuticals is caffeine (CAF). In this work, CAF removal from aqueous samples by metal–organic framework (UIO-66) and perovskite (La_0.7Sr_0.3FeO₃) was achieved. Detailed studies on the preparation of MOFs and perovskite oxides compounds have been presented. Extensive characterizations such as X-Ray diffraction (XRD), field emission scanning electron microscope (FESEM), Fourier transform infrared spectra (FT-IR), N₂ adsorption–desorption isotherms were also carried out to assure proper formation and to better understand the physico-chemical behavior of the synthesized samples before and after adsorption. Batch experiments of CAF adsorption onto both MOFs and perovskite were performed to compare the effectiveness of both materials on the removal competence of the CAF residue at different conditions including the effect of pH, initial concentration, and contact time. It was observed that the adsorption capacity of CAF by MOF increased with increasing acidity. On the other hand, the adsorption capacity of perovskite is stable in pH 4–10. The maximum adsorption capacities of UiO-66 and perovskite toward CAF are high as 62.5 mg g⁻¹ and 35.25 mg g⁻¹, respectively. Equilibrium isotherms were investigated by numerous models: Langmuir, Freundlich, Temkin, Redlich-Peterson, Sips, Langmuir-Freundlich, Toth, Kahn, Baudu, and Fritz Schlunder. Moreover, the kinetics of the CAF@MOF and CAF@Perovskite systems have been studied by five kinetic models (Pseudo-1st -order (PFO), Pseudo-2nd -order (PSO), Mixed 1st, 2nd-order, Intraparticle diffusion and Avrami). The best model described the adsorption of CAF onto both of MOF and perovskite was the mixed 1st, 2nd-order model. The metal–organic framework and perovskite were applied to quickly extract CAF from water samples successfully. The maximum removal percentage obtained for MOF and perovskite was 0.89% and 0.94% respectively within 30 min contact time which suggests that these materials are considered as promising adsorbents for CAF.</p></div>","PeriodicalId":628,"journal":{"name":"Journal of Environmental Health Science and Engineering","volume":"22 1","pages":"345 - 360"},"PeriodicalIF":3.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40201-024-00904-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141120865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective degradation of tetracycline in aqueous solution by an electro-Fenton process using chemically modified carbon/α-FeOOH as catalyst","authors":"My Linh Nguyen,&nbsp;Hoang Long Ngo,&nbsp;Thuy Tien Nguyen Hoang,&nbsp;Duc Trung Le,&nbsp;Duy Dat Nguyen,&nbsp;Quang Sang Huynh,&nbsp;Thi Tuyet Trinh Nguyen,&nbsp;Thanh Tung Nguyen,&nbsp;Ruey-Shin Juang","doi":"10.1007/s40201-024-00902-4","DOIUrl":"10.1007/s40201-024-00902-4","url":null,"abstract":"<div><p>This study applied an electro-Fenton process using chemically modified activated carbon derived from rubber seed shells loaded with α-FeOOH (RSCF) as catalyst to remove tetracycline residues from aquatic environment. Catalyst characteristics were evaluated using SEM, EDS, XRD, and XPS, showing successful insertion of iron onto the activated carbon. The effects of the parameters were investigated, and the highest treatment efficiency was achieved at pH of 3, Fe: H₂O₂ ratio (w/w) of 500:1, catalyst dose of 1 g/L, initial TCH concentration of 100 mg/L, and electric current of 150 mA, with more than 90% of TCH being eliminated within 30 min. Furthermore, even after five cycles of use, the treatment efficiency remains above 90%. The rate constant is calculated to be 0.218 min^-1, with high regression coefficients (<i>R</i>² = 0.93). The activation energy (E_a) was found to be 32.2 kJ/mol, indicating that the degradation of TCH was a simple reaction with a low activation energy. These findings showed that the RSCF is a highly efficient and cost-effective catalyst for TCH degradation. Moreover, the use of e-Fenton process has the advantage of high efficiency, low cost thanks to the recyclability of the catalyst, and environmental friendliness thanks to less use of H₂O₂.</p></div>","PeriodicalId":628,"journal":{"name":"Journal of Environmental Health Science and Engineering","volume":"22 1","pages":"313 - 327"},"PeriodicalIF":3.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141063535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term exposure to air pollution on cardio-respiratory, and lung cancer mortality: a systematic review and meta-analysis","authors":"Behrooz Karimi,&nbsp;Sadegh Samadi","doi":"10.1007/s40201-024-00900-6","DOIUrl":"10.1007/s40201-024-00900-6","url":null,"abstract":"<div><p>Air pollution is a major cause of specific deaths worldwide. This review article aimed to investigate the results of cohort studies for air pollution connected with the all-cause, cardio-respiratory, and lung cancer mortality risk by performing a meta-analysis. Relevant cohort studies were searched in electronic databases (PubMed/Medline, Web of Science, and Scopus). We used a random effect model to estimate the pooled relative risks (RRs) and their 95% CIs (confidence intervals) of mortality. The risk of bias for each included study was also assessed by Office of Health Assessment and Translation (OHAT) checklists. We applied statistical tests for heterogeneity and sensitivity analyses. The registration code of this study in PROSPERO was CRD42023422945. A total of 88 cohort studies were eligible and included in the final analysis. The pooled relative risk (RR) per 10 μg/m³ increase of fine particulate matter (PM_2.5) was 1.080 (95% CI 1.068–1.092) for all-cause mortality, 1.058 (95% CI 1.055–1.062) for cardiovascular mortality, 1.066 (95%CI 1.034–1.097) for respiratory mortality and 1.118 (95% CI 1.076–1.159) for lung cancer mortality. We observed positive increased associations between exposure to PM_2.5, PM₁₀, black carbon (BC), and nitrogen dioxide (NO₂) with all-cause, cardiovascular and respiratory diseases, and lung cancer mortality, but the associations were not significant for nitrogen oxides (NOx), sulfur dioxide (SO₂) and ozone (O₃). The risk of mortality for males and the elderly was higher compared to females and younger age. The pooled effect estimates derived from cohort studies provide substantial evidence of adverse air pollution associations with all-cause, cardiovascular, respiratory, and lung cancer mortality.</p></div>","PeriodicalId":628,"journal":{"name":"Journal of Environmental Health Science and Engineering","volume":"22 1","pages":"75 - 95"},"PeriodicalIF":3.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40201-024-00900-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140941146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved rare mercury recovery from fluorescent lamp wastes through simultaneous leaching and heating","authors":"Leyla Karamzadeh,&nbsp;Esmaeil Salahi,&nbsp;Iman Mobasherpour,&nbsp;Armin Rajabi,&nbsp;Masomeh Javaheri","doi":"10.1007/s40201-024-00901-5","DOIUrl":"10.1007/s40201-024-00901-5","url":null,"abstract":"<div><p>Mercury is one of the main components of fluorescent lamps. Considering the adverse effects of mercury on human health and the environment, recovery of mercury-containing fluorescent lamps is very important in developed countries. The glass parts of used fluorescent lamps are among the dangerous wastes whose mercury content should be reduced to the lowest possible level according to international standards. The aim of this research is to achieve a systematic approach to minimize the amount of mercury present in fluorescent lamp glass residues according to the European Commission EC95/2002 regulations. In order to extract mercury from glasses, glass pieces were washed with deionized water, using stirring to increase washing efficiency. In order to achieve the maximum amount of extraction, parameters such as ratio of glass to deionized water (S/L), stirring time, temperature and pH were changed. The results showed that, the highest mercury extraction rate is about 98% and in the conditions S/L = 0.1, stirring time of 12 h, temperature of 60 °C and pH 1, which is using a combination of HCl and H₃PO₄ acid 5% with a ratio of 1:4 has been obtained. The success of this method not only increases environmental sustainability, but also classifies the resulting glass waste as non-hazardous.</p></div>","PeriodicalId":628,"journal":{"name":"Journal of Environmental Health Science and Engineering","volume":"22 1","pages":"305 - 312"},"PeriodicalIF":3.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140881961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic and structural response of a multispecies biofilm to environmental perturbations induced by the continuous increase of benzimidazole fungicides in a permeable reactive biobarrier","authors":"María Luisa Alvarado-Gutiérrez,&nbsp;Nora Ruiz-Ordaz,&nbsp;Juvencio Galíndez-Mayer,&nbsp;Fortunata Santoyo-Tepole,&nbsp;Jaime García-Mena,&nbsp;Khemlal Nirmalkar,&nbsp;Everardo Curiel-Quesada","doi":"10.1007/s40201-024-00903-3","DOIUrl":"10.1007/s40201-024-00903-3","url":null,"abstract":"<div><h3>Purpose</h3><p>This work explores the dynamics of spatiotemporal changes in the taxonomic structure of biofilms and the degradation kinetics of three imidazole group compounds: carbendazim (CBZ), methyl thiophanate (MT), and benomyl (BN) by a multispecies microbial community attached to a fixed bed horizontal tubular reactor (HTR). This bioreactor mimics a permeable reactive biobarrier, which helps prevent the contamination of water bodies by pesticides in agricultural wastewater.</p><h3>Methods</h3><p>To rapidly quantify the microbial response to crescent loading rates of benzimidazole compounds, a gradient system was used to transiently raise the fungicide volumetric loading rates, measuring the structural and functional dynamics response of a microbial community in terms of the volumetric removal rates of the HTR entering pollutants.</p><h3>Results</h3><p>The loading rate gradient of benzimidazole compounds severely impacts the spatiotemporal taxonomic structure of the HTR biofilm-forming microbial community. Notable differences with the original structure in HTR stable conditions can be noted after three historical contingencies (CBZ, MT, and BN gradient loading rates). It was evidenced that the microbial community did not return to the composition prior to environmental disturbances; however, the functional similarity of microbial communities after steady state reestablishment was observed.</p><h3>Conclusions</h3><p>The usefulness of the method of gradual delivery of potentially toxic agents for a microbial community immobilized in a tubular biofilm reactor was shown since its functional and structural dynamics were quickly evaluated in response to fungicide composition and concentration changes. The rapid adjustment of the contaminants’ removal rates indicates that even with changes in the taxonomic structure of a microbial community, its functional redundancy favors its adjustment to gradual environmental disturbances.</p></div>","PeriodicalId":628,"journal":{"name":"Journal of Environmental Health Science and Engineering","volume":"22 1","pages":"329 - 344"},"PeriodicalIF":3.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140941677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomonitoring polycyclic aromatic hydrocarbon levels in domestic kitchens using commonly grown culinary herbs","authors":"Bettina Eck-Varanka,&nbsp;Katalin Hubai,&nbsp;Nora Kováts,&nbsp;Gábor Teke","doi":"10.1007/s40201-024-00898-x","DOIUrl":"10.1007/s40201-024-00898-x","url":null,"abstract":"<div><p>Cooking is a significant source of polycyclic aromatic hydrocarbon (PAHs) emissions in indoor environments. A one-month biomonitoring study was carried out in previously selected rural Hungarian kitchens to evaluate cooking-related PAHs concentrations in 4 common kitchen vegetables such as basil, parsley, rocket and chives. The study had two mainobjectives: firstly, to follow PAHs accumulation pattern and to find out if this pattern can be associated with different cooking habits. Also, the usefulness of culinary herbs for indoor bioaccumulation studies was assessed. The 2-ring naphthalene was the dominant PAH in the majority of the samples, its concentrations were in the range of 25.4 µg/kg and 274 µg/kg, of 3-ring PAHs the prevalency of phenanthrene was observed, with highest concentration of 62 µg/kg. PAHs accumulation pattern in tested plants clearly indicated differences in cooking methods and cooking oils used in the selected households. Use of lard and animal fats in general resulted in the high concentrations of higher molecular weight (5- and 6-ring) PAHs, while olive oil usage could be associated with the emission of 2- and 3-ring PAHs. Culinary herbs, however, accumulated carcinogenic PAHs such as benzo[a]anthracene (highest concentration 11.9 µg/kg), benzo[b]fluoranthene (highest concentration 13.8 µg/kg) and chrysene (highest concentration 20.1 µg/kg) which might question their safe use.</p></div>","PeriodicalId":628,"journal":{"name":"Journal of Environmental Health Science and Engineering","volume":"22 1","pages":"295 - 303"},"PeriodicalIF":3.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40201-024-00898-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140671939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining biomarkers of susceptibility with toxicodynamic models: a novel approach for assessing modifying factors","authors":"Samaneh Dehghani,&nbsp;Masud Yunesian","doi":"10.1007/s40201-024-00896-z","DOIUrl":"10.1007/s40201-024-00896-z","url":null,"abstract":"<div><p>Biomarkers of susceptibility are indicative of an individual’s capacity to react to particular exposures, whereas toxicodynamic models elucidate the correlation between exposure and response. In this article, a novel methodology is presented for the evaluation of modifying factors in the field of toxicology. The proposed approach involves the integration of biomarkers of susceptibility with toxicodynamic models. Through the integration of these two methodologies, scientists are able to gain a more comprehensive understanding of the impact of modifying factors, such as genetic polymorphisms or epigenetic profiles, on an individual’s reaction to toxic substances. This methodology has the potential to facilitate a more thorough evaluation of the hazards linked to the contact with combinations of chemicals and the cumulative effects of such exposures. The utilization of biomarkers in the evaluation of exposure for risk assessment is progressively incorporating the examination of susceptibility factors alongside exposure factors. This may involve the identification of a particular genetic polymorphism for a metabolic enzyme. The integration of ecotoxicological tests with models is crucial for achieving a comprehensive assessment. This approach exhibits the potential to enhance our comprehension of disease causation and facilitate the identification of populations that may exhibit an elevated susceptibility to disease.</p></div>","PeriodicalId":628,"journal":{"name":"Journal of Environmental Health Science and Engineering","volume":"22 1","pages":"361 - 364"},"PeriodicalIF":3.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140669724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}