中华结核和呼吸杂志最新文献

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[Hydrogen sulfide modulates acute lung injury in sepsis by inhibiting NLRP3 inflammasome activation in mice]. [硫化氢通过抑制小鼠NLRP3炎性体激活调节脓毒症急性肺损伤]。
中华结核和呼吸杂志 Pub Date : 2025-02-12 DOI: 10.3760/cma.j.cn112147-20240718-00413
H T Qian, Q H Chen
{"title":"[Hydrogen sulfide modulates acute lung injury in sepsis by inhibiting NLRP3 inflammasome activation in mice].","authors":"H T Qian, Q H Chen","doi":"10.3760/cma.j.cn112147-20240718-00413","DOIUrl":"10.3760/cma.j.cn112147-20240718-00413","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the effects and mechanisms of the hydrogen sulfide donor GYY4137 on acute lung injury in sepsis. <b>Methods:</b> An acute lung injury model was established using the method of cecal ligation and puncture(CLP). Mice received an intraperitoneal injection of GYY4137 (50 mg/kg) or saline 30 minutes after surgery. C57BL/6J mice were divided into four groups: the sham operation group (Sham), the sham operation with GYY4137 group (GYY4137), the sepsis group (CLP), and the sepsis with GYY4137 group (CLP+GYY4137). Respiratory parameters (minute ventilation volume and expiratory flow 50) were measured using a whole-body plethysmography system. Lung tissue was evaluated by hematoxylin and eosin (H&E) staining, and inflammatory cells were identified by immunofluorescence. mRNA expression of inflammatory factors (interleukin-1β, interleukin-6) and adhesion molecules (vascular endothelial cadherin, intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1) were quantified by real-time quantitative polymerase chain reaction (RT-PCR). Levels of NLRP3, Pro-IL-1β, IL-1β, and the cyclic guanosine monophosphate synthase (cGAS)/stimulator of interferon genes (Sting)/NF-κB signaling proteins were analyzed by Western blotting. <i>In vitro</i>, murine pulmonary microvascular endothelial cells were cultured and exposed to lipopolysaccharide (LPS, 1 μg/ml) and GYY4137 (25 μmol/L) to simulate sepsis-induced damage and to study the mechanism of hydrogen sulfide action. Levels of inflammatory factors and adhesion molecules in cells were quantified by RT-PCR. Data were analyzed for normal distribution using Shapiro-Wilk test, then variance homogeneity by Brown-Forsythe test. <i>P</i>-value<0.05 was set as statistical significance for all analyses. <b>Results:</b> (1) MV and EF50 values were significantly lower in the CLP group [(36.32±3.91)ml/min and (1.43±0.26)ml/s, respectively] compared to the Sham group [(50.14±6.07)ml/min and (2.70±0.46)ml/s, respectively]. These parameters were higher in the CLP+GYY4137 group [(45.83±2.33)ml/min and (2.02±0.16)ml/s, respectively] compared to the CLP group (<i>P</i><0.05). (2) Severe lung tissue damage, alveolar collapse, increased septal thickening and exudation were observed in the CLP group and significantly reduced in the CLP+GYY4137 group (<i>P</i><0.05). (3) Infiltration of inflammatory cells and mRNA levels of inflammatory factors and adhesion molecules were increased in the CLP group compared to the Sham group (<i>P</i><0.05), and decreased in the CLP+GYY4137 group compared to the CLP group (<i>P</i><0.05). (4) Protein levels of NLRP3, Pro-IL-1β, IL-1β, cGAS, Sting, and NF-κB were higher in the CLP group compared to the Sham group (<i>P</i><0.05) and were reduced in the CLP+GYY4137 group compared to the CLP group (<i>P</i><0.05). (5) LPS induced higher levels of inflammatory factors and adhesion molecules in pulmonary endothelial cells compared to the control, which were redu","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 2","pages":"130-137"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Preliminary study on the role of siglec-9 expression in peripheral blood of acute respiratory distress syndrome patients]. [急性呼吸窘迫综合征患者外周血siglece -9表达作用的初步研究]。
中华结核和呼吸杂志 Pub Date : 2025-02-12 DOI: 10.3760/cma.j.cn112147-20240620-00350
X G Liu, Z H Lu, Y C Cai, Z Yang, X W Sun, J Zhu, X Su
{"title":"[Preliminary study on the role of siglec-9 expression in peripheral blood of acute respiratory distress syndrome patients].","authors":"X G Liu, Z H Lu, Y C Cai, Z Yang, X W Sun, J Zhu, X Su","doi":"10.3760/cma.j.cn112147-20240620-00350","DOIUrl":"10.3760/cma.j.cn112147-20240620-00350","url":null,"abstract":"<p><p><b>Objective:</b> Sialic acid-binding immunoglobulin-like lectin (siglec)-9 is a type Ⅰ transmembrane protein that plays an important role in intrinsic immunity. In this study, we examined the siglec-9 expression levels in mononuclear macrophages, neutrophils and plasma from peripheral blood of acute respiratory distress syndrome (ARDS) patients and investigated its clinical value. <b>Methods:</b> Peripheral blood was obtained from ARDS patients (<i>n</i>=54) admitted to the Department of Respiratory and Critical Care Medicine, Nanjing Jinling Hospital and the Second People's Hospital of Wuhu, Anhui Province, China, from July 2021 to October 2022. Healthy volunteers (<i>n</i>=50) from the physical examination center and hospitalized patients (<i>n</i>=47) with lung infection were included as control groups. The expression of cellular and plasma siglec-9 was detected by flow cytometry and ELISA separately. <b>Results:</b> Compared with lung infection group and healthy control group, the expression of monocytes and plasma siglec-9 in ARDS group increased significantly. But there was no significant difference in the expression of monocytes and plasma siglec-9 between lung infection group and healthy control group. The level of plasma siglec-9 was significantly higher in moderate-severe ARDS patients than that in mild patients (<i>P</i><0.05). Multivariable logistic regression analysis showed that IL-6, LDH and plasma siglec-9 were independent risk factors of ARDS, while plasma siglec-9, IL-6 and APACHE Ⅱ were independent risk factors of moderate-severe ARDS. <b>Conclusion:</b> The expression of siglec-9 in the plasma of ARDS patients is positively correlated with the severity of ARDS, which has a certain value in the assessment of ARDS.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 2","pages":"123-129"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ultrasound study for quantitative assessment of diaphragm dysfunction in patients with sepsis]. [超声定量评价脓毒症患者膈肌功能障碍的研究]。
中华结核和呼吸杂志 Pub Date : 2025-02-12 DOI: 10.3760/cma.j.cn112147-20240620-00348
G Y Jiao, Y J Liu, K Y Yang, W H Kong, Y Q Chen
{"title":"[Ultrasound study for quantitative assessment of diaphragm dysfunction in patients with sepsis].","authors":"G Y Jiao, Y J Liu, K Y Yang, W H Kong, Y Q Chen","doi":"10.3760/cma.j.cn112147-20240620-00348","DOIUrl":"10.3760/cma.j.cn112147-20240620-00348","url":null,"abstract":"<p><p><b>Objective:</b> To systematically assess diaphragm dysfunction in patients with sepsis. Based on previous findings that diaphragm excursion and diaphragm thickening fraction (DTF) significantly decrease in septic patients, this study further analyzed the diaphragm contraction velocity and excursion-time index (E-T index) in relation to diaphragm contraction time. <b>Methods:</b> A total of 59 patients with pneumonia-induced sepsis from Shengjing Hospital of China Medical University were recruited (sepsis group). Healthy individuals undergoing routine health check-ups during the same period were recruited as the control group, matched for age and sex (1∶1). General baseline data were collected, and bedside ultrasound was used to measure diaphragm thickness, DTF, diaphragm excursion, inspiratory time, diaphragm E-T index, and per-minute E-T index (calculated as the quiet breathing diaphragm E-T index multiplied by the respiratory rate). Correlation analyses were performed between diaphragm ultrasound indicators and the Sequential Organ Failure Assessment (SOFA) score. SPSS 21.0 was used for statistical analysis. <b>Results:</b> (1) There was no statistically significant difference in diaphragm thickness between the sepsis group and the control group (end of quiet expiratory: (2.06±0.35)mm <i>vs</i>. (1.96±0.37)mm, <i>t</i>=-1.516, <i>P</i>>0.05; end of maximum inspiratory: 3.18(2.86, 3.61)mm <i>vs</i>. 3.04(2.73, 3.27)mm, <i>Z</i>=-1.688, <i>P</i>>0.05), while DTF was significantly lower in the sepsis group compared to the control group (0.49±0.17 <i>vs</i>. 0.65±0.17, <i>t</i>=5.360, <i>P</i><0.05). (2) In both quiet breathing and deep breathing states, diaphragm excursion was lower in the sepsis group than in the control group (quiet breathing: <i>t</i>=-4.187, <i>P</i><0.05; deep breathing: <i>t</i>=-11.720, <i>P</i><0.05), and inspiratory time was shorter in the sepsis group (quiet breathing: <i>t</i>=-7.410, <i>P</i><0.05; deep breathing: <i>t</i>=-6.348, <i>P</i><0.05). (3) In the quiet breathing state, the diaphragm contraction velocity in the sepsis group was faster than in the control group (<i>Z</i>=2.330, <i>P</i><0.05), while in the deep breathing state, the diaphragm contraction velocity in the sepsis group was lower than in the control group (<i>Z</i>=-3.383, <i>P</i><0.05). (4) In the quiet breathing state, the diaphragm E-T index was lower in the sepsis group than in the control group (<i>Z</i>=-5.762, <i>P</i><0.05); however, the per-minute E-T index compensated to normal by increasing the respiratory rate. In the deep breathing state, the diaphragm E-T index, which had the highest correlation with the SOFA score (<i>r</i>=-0.882, <i>P</i><0.05), was lower in the sepsis group than in the control group (<i>Z</i>=-7.974, <i>P</i><0.05). <b>Conclusions:</b> Bedside ultrasound can systematically quantify diaphragm contraction dysfunction in patients with sepsis. In the quiet breathing state, septic patients exhibit a pattern of","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 2","pages":"116-122"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Annual progress of new drugs and new regimens for anti-tuberculosis treatment (2024)]. [抗结核新药新方案年度进展(2024年)]。
中华结核和呼吸杂志 Pub Date : 2025-02-12 DOI: 10.3760/cma.j.cn112147-20241016-00615
L Yao, S J Tang
{"title":"[Annual progress of new drugs and new regimens for anti-tuberculosis treatment (2024)].","authors":"L Yao, S J Tang","doi":"10.3760/cma.j.cn112147-20241016-00615","DOIUrl":"10.3760/cma.j.cn112147-20241016-00615","url":null,"abstract":"<p><p>China remains one of the countries with a high burden of tuberculosis (TB), with an estimated 748, 000 cases each year, ranking third in the world. The research and development of new drugs and new protocols plays a key role in the face of the requirements of the WHO's End TB Strategy. There are multiple new drugs in the clinical trial stage, such as macozinone, sutezoid, alpiberctin, and GSK3036656. The effectiveness, safety, and resistance issues of marketed drugs such as linezolid, bedaquiline, and delamanid are also of great concern. Meanwhile, short-term treatments for sensitive and drug-resistant TB have always been a hot topic in clinical research. WHO has also updated the preventive treatment plan for people at high risk of TB. This article reviews the literature published from October 1, 2023 to September 30, 2024.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 2","pages":"170-175"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances in the understanding of heterogeneous characteristics and comprehensive management of post-tuberculosis lung disease]. [对结核后肺部疾病异质性特征及综合治疗的认识进展]。
中华结核和呼吸杂志 Pub Date : 2025-02-12 DOI: 10.3760/cma.j.cn112147-20240701-00375
Z K Sheng, X Y Gai, Y C Sun
{"title":"[Advances in the understanding of heterogeneous characteristics and comprehensive management of post-tuberculosis lung disease].","authors":"Z K Sheng, X Y Gai, Y C Sun","doi":"10.3760/cma.j.cn112147-20240701-00375","DOIUrl":"10.3760/cma.j.cn112147-20240701-00375","url":null,"abstract":"<p><p>Post-tuberculosis lung disease (PTLD) is a heterogeneous group of diseases characterized by symptoms such as cough, fatigue and shortness of breath, along with chest imaging abnormalities, and impaired lung function in some patients. Even after successful treatment, nearly 30%-50% of patients continue to suffer from various forms of PTLD, causing great harm to individuals and societies. The etiology and pathogenesis of PTLD are complex and involve the interaction of the host immune response, pathogens and environmental factors. Due to the limited understanding of PTLD, it is often underdiagnosed and misdiagnosed. Therefore, it is crucial to increase clinicians' awareness of this condition. This review aims to summarize recent advances in the diagnosis and treatment of PTLD.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 2","pages":"181-185"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chinese expert consensus on diagnosis and treatment of non-tuberculous mycobacterial pulmonary disease complicated with bronchiectasis]. 【非结核性分枝杆菌肺病合并支气管扩张的诊治中国专家共识】。
中华结核和呼吸杂志 Pub Date : 2025-02-12 DOI: 10.3760/cma.j.cn112147-20240808-00471
{"title":"[Chinese expert consensus on diagnosis and treatment of non-tuberculous mycobacterial pulmonary disease complicated with bronchiectasis].","authors":"","doi":"10.3760/cma.j.cn112147-20240808-00471","DOIUrl":"10.3760/cma.j.cn112147-20240808-00471","url":null,"abstract":"<p><p>The incidence and prevalence of non-tuberculous mycobacterial pulmonary disease (NTM-PD) and bronchiectasis have been both increasing. NTM-PD can lead to bronchiectasis, and <i>vice versa</i>, with each condition mutually exacerbating the other. Macrolides play a pivotal role in NTM-PD treatment. Additionally, long-term, low-dose oral macrolides are preferred to prevent recurrent acute exacerbations in bronchiectasis patients. However, using macrolides alone may risk inducing non-tuberculous mycobacteria (NTM) resistance in bronchiectasis patients potentially infected with NTM. The European Respiratory Society (ERS) and British Thoracic Society (BTS) guidelines advocate for NTM screening among bronchiectasis patients before receiving long-term, low-dose oral macrolide therapy. Consequently, the focus in clinical practice has shifted towards diagnosing and managing the coexistence of NTM-PD and bronchiectasis. Recognizing these developments, Chinese respiratory experts have established the \"<i>Expert consensus on diagnosis and treatment of non-tuberculous mycobacterial pulmonary disease and bronchiectasis</i>.\"In this expert consensus,systematic reviews were conducted for each of the 10 Population,Intervention,Comparator,Outcome(PICO)questions. Recommendations were formulated,written,and graded using the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)approach. Fourteen evidence-based recommendations regarding the diagnosis and treatment of NTM-PD in conjunction with bronchiectasis are presented. In the future,it is hoped that this consensus will enhance the diagnosis and treatment of NTM-PD and bronchiectasis comorbidity in China.<b>Question 1</b>:Is etiological testing necessary when bronchiectasis is diagnosed in NTM-PD patients?<b>Recommendation 1</b>:Bronchiectasis of different etiologies requires distinct treatment strategies and prognoses. Therefore,when NTM-PD patients are diagnosed with bronchiectasis,it is recommended its etiology be investigated. This investigation will aid in the diagnosis,treatment,and prognosis of patients with this comorbidity(1C).<b>Recommendation 2</b>:Methods to investigate and evaluate the etiology of bronchiectasis include:(1)obtaining medical history and clinical symptoms;(2)performing a sputum culture,complete blood count,serum immunoglobulin levels(IgG,IgM,IgA),Aspergillus-specific IgE,and serum total IgE levels,and pulmonary function tests;(3)If genetic or autoimmune diseases are suspected,performing additional relevant specialized tests.<b>Question 2</b>:What are the clinical characteristics of bronchiectasis patients who should be screened for NTM infection?What tests and samples are recommended?<b>Recommendation 3</b>:Bronchiectasis patients meeting the following criteria should be evaluated for possible NTM infection:(1)newly diagnosed bronchiectasis patients;(2)those with unexplained clinical or radiographic exacerbations of bronchiectasis;(3)patients with bronchiectasis pl","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 2","pages":"101-115"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Myocardial infection by Mycobacterium: a case report]. 【分枝杆菌心肌感染1例报告】。
中华结核和呼吸杂志 Pub Date : 2025-01-12 DOI: 10.3760/cma.j.cn112147-20241126-00701
H N Liu, C G Yang, M C Pan, W W Zhu, M Y Wang, H M Dong
{"title":"[Myocardial infection by Mycobacterium: a case report].","authors":"H N Liu, C G Yang, M C Pan, W W Zhu, M Y Wang, H M Dong","doi":"10.3760/cma.j.cn112147-20241126-00701","DOIUrl":"10.3760/cma.j.cn112147-20241126-00701","url":null,"abstract":"<p><p>Mycobacterial infections of the cardiovascular system are rare and only a few reports provide detailed pathological information. This report presented a rare case of asymptomatic myocardial mycobacterial infection identified at autopsy. The patient died from pulmonary thromboembolism. The Myocardial mycobacterial lesions were found during the histological examination. Although myocardial tuberculosis was considered highly probable, real-time quantitative fluorescence PCR tests for <i>Mycobacterium tuberculosis</i> on paraffin-embedded heart and lung tissues were negative. This report discusses the predisposed populations, routes of dissemination, clinical manifestations, associations with cardiovascular events, and diagnosis and treatment of mycobacterium infections, with a focus on myocardial tuberculosis, to enhance clinicians' understanding of myocardial mycobacterium infections.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 1","pages":"57-59"},"PeriodicalIF":0.0,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical characteristics of immunocompromised patients infected with COVID-19]. [感染 COVID-19 的免疫力低下患者的临床特征]。
中华结核和呼吸杂志 Pub Date : 2025-01-12 DOI: 10.3760/cma.j.cn112147-20240218-00083
S N Li, W T Ni, R Li, Y W Chen, Z C Gao
{"title":"[Clinical characteristics of immunocompromised patients infected with COVID-19].","authors":"S N Li, W T Ni, R Li, Y W Chen, Z C Gao","doi":"10.3760/cma.j.cn112147-20240218-00083","DOIUrl":"10.3760/cma.j.cn112147-20240218-00083","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the clinical features of COVID-19 infection in hospitalized immunocompromised patients in comparison with immunocompetent patients. <b>Methods:</b> A single-center retrospective observational study was conducted on 213 inpatients diagnosed with COVID-19 in the Peking University People's Hospital between December 2022 and October 2023. They were divided into an immunocompromised group (102 patients, 47.9%) and an immunocompetent group(111 patients, 52.1%), and clinical data were compared between the two groups. The immunocompromised group was further divided into death group (18 cases, 17.6%) and non-death group (84 cases, 82.4%). The differences in laboratory examination findings were compared. Further analysis was performed on the lymphocyte subset differences between the death group(10 patients, 9.8%) and the non-death group (36 patients, 35.3%) with complete data. <b>Results:</b> The proportion of severe and critical cases and the mortality rate, were significantly higher in the immunocompromised group than the immunocompetent group (47.1% <i>vs</i>. 40.5%, 18.6% <i>vs</i>. 9.0%, 17.6% <i>vs</i>. 9.0%,<i>P<</i>0.05). The immunocompromised group had lower vaccination rate (26.5% <i>vs</i>. 44.1%, <i>P</i><0.05). Hypertension, kidney disease and infections were more common in the immunocompromised group (63.7% <i>vs</i>. 48.6%, 30.4% <i>vs</i>. 9.0%, 49.0% <i>vs</i>. 19.8%, all <i>P</i><0.05). CT findings of consolidation (40.2% <i>vs</i>. 18.9%), rate of antiviral treatment (48.0% <i>vs</i>. 30.6%) and the positive duration of viral nucleic acid [median 14(7.0, 19.3) days <i>vs</i>. 9(7.0, 18.0) days] were higher in the immunocomprised group (all <i>P</i><0.05). Lactate dehydrogenase (LDH), procalcitonin (PCT), interleukin-6 (IL-6) and ferritin were higher in the immunocompromised group than those in the immunocompetent group (all <i>P</i><0.05). In the death group, neutrophils (NEU), C-reactive protein (CRP), PCT, IL-6, ferritin and D-dimer were higher, while lymphocytes (LY), CD4<sup>+</sup>T-cells, CD8<sup>+</sup>T-cells, B-cell counts and hemoglobin (HGB) were significantly lower than those in the non-death group (all <i>P</i><0.05). <b>Conclusions:</b> More than 60% of patients in the immunocompromised group were classified as severe or critical type, with a higher mortality rate and decreased ability to clear severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Decreases in total lymphocytes, CD4<sup>+</sup>T lymphocytes, CD8<sup>+</sup>T lymphocytes, and B lymphocytes, along with elevated levels of procalcitonin, ferritin, and D-dimer, indicated poor prognosis.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 1","pages":"35-42"},"PeriodicalIF":0.0,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pulmonary Kaposi sarcoma after lung transplantation: a case report and literature review]. [肺移植术后肺卡波西肉瘤1例报告及文献复习]。
中华结核和呼吸杂志 Pub Date : 2025-01-12 DOI: 10.3760/cma.j.cn112147-20240901-00524
Q Y Lian, L L Wang, X N Lin, P H Xu, X H Wang, Y Y Gu, L H Li, C R Ju
{"title":"[Pulmonary Kaposi sarcoma after lung transplantation: a case report and literature review].","authors":"Q Y Lian, L L Wang, X N Lin, P H Xu, X H Wang, Y Y Gu, L H Li, C R Ju","doi":"10.3760/cma.j.cn112147-20240901-00524","DOIUrl":"10.3760/cma.j.cn112147-20240901-00524","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the clinical features, diagnosis, and treatment of pulmonary Kaposi sarcoma (KS) after lung transplantation. <b>Methods:</b> A case of pulmonary KS after bilateral lung transplantation was retrospectively analyzed. Two key words \"Kaposi sarcoma\" and \"lung transplant*\" were used to search for relevant literature in SinoMed, Wanfang Data, CNKI, PubMed, Embase, Cochrane Library and Web of Science, with a cut-off date of July 31<sup>st</sup>, 2024. <b>Results:</b> Five months after bilateral lung transplantation, the patient developed multiple solid nodules in both transplanted lungs, which were diagnosed as KS by histopathological examination. After reduction of immunosuppression and the prescription of sirolimus, the lung lesions regressed. A total of 40 English articles were identified; after screening, 25 patients with KS following lung transplantation were included in the study. Including this case, 26 patients were included, comprising 19 males and 7 females, with a mean age of 15~68(52.3±13.7) years. Of these, 18 underwent bilateral lung transplantation, 3 had single lung transplantation, and the transplant types for 5 patients were unknown. The median interval between KS diagnosis and transplantation was 8.0 months (<i>IQR</i> 6.0-18.0). There were 11 cases of disseminated KS, 7 cases of pulmonary KS, 4 cases of skin KS, 2 cases of gastric KS, 1 case of small intestinal KS, and 1 case of lymph node KS. Of the patients, 10 responded to treatment, 15 died, and the outcome of 1 patient outcome was unknown. <b>Conclusions:</b> The clinical manifestations of KS after lung transplantation are non-specific and diagnosis is based on histopathology. Reducing immunosuppression in conjunction with rapamycin-targeted protein inhibitors may be an effective treatment strategy.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"48 1","pages":"50-56"},"PeriodicalIF":0.0,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Safety monitoring and countermeasures of anticoagulant drugs for pulmonary thromboembolism]. [肺血栓栓塞抗凝药物安全监测及对策]。
中华结核和呼吸杂志 Pub Date : 2024-12-12 DOI: 10.3760/cma.j.cn112147-20240607-00319
Y J Ding, L Zhang, Q Y Li
{"title":"[Safety monitoring and countermeasures of anticoagulant drugs for pulmonary thromboembolism].","authors":"Y J Ding, L Zhang, Q Y Li","doi":"10.3760/cma.j.cn112147-20240607-00319","DOIUrl":"https://doi.org/10.3760/cma.j.cn112147-20240607-00319","url":null,"abstract":"<p><p>The safe use of anticoagulant drugs is a major challenge in the clinical management of pulmonary thromboembolism (PTE). This paper presents a comprehensive review of the recent literature, summarizing and evaluating the classification and historical development of anticoagulants, monitoring strategies for their administration, selection and safety considerations for special patient populations (such as those with malignant tumors, pregnant women or obese patients) and specific disease states (including platelet disorders, severe renal insufficiency, active bleeding and pulmonary hypertension). It also discusses current research into countermeasures for anticoagulant-related bleeding. Based on personal experience and expertise in this field, we propose an approach to managing the safety of anticoagulant therapy.</p>","PeriodicalId":61512,"journal":{"name":"中华结核和呼吸杂志","volume":"47 12","pages":"1170-1175"},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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