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Are M1 and M2 macrophages Effectual Players in Pathological Conditions? M1和M2巨噬细胞在病理状态下起作用吗?
抗癌研究 Pub Date : 2022-05-30 DOI: 10.26689/par.v6i3.3962
E. Abdollahi, N. Saghafi, Maliheh Hasanzade
{"title":"Are M1 and M2 macrophages Effectual Players in Pathological Conditions?","authors":"E. Abdollahi, N. Saghafi, Maliheh Hasanzade","doi":"10.26689/par.v6i3.3962","DOIUrl":"https://doi.org/10.26689/par.v6i3.3962","url":null,"abstract":"Pathologic inflammatory conditions are frequently correlated with dynamic alterations through macrophage activation, with classically activated M1 cells associated with promoting and sustaining inflammation and M2 cells implicated in resolving or smoldering chronic inflammation. Inflammation is a common feature of various chronic diseases, and it has direct involvement in the emergence and progression of these conditions. Macrophages participate in an autoregulatory loop characterizing inflammatory process, as they produce a wide range of biologically active mediators that exert either deleterious or beneficial effects during inflammation. Therefore, balancing the ratio of M1/M2 macrophages can help to ameliorate the inflammatory landscape of pathological conditions. This review will explore the role of macrophage polarization in distant pathological inflammatory conditions, such as cancer, autoimmunity, renal inflammation, stroke, and atherosclerosis, while sharing macrophage-driven pathogenesis.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42414607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Value of Peripheral Blood Circulating Tumor Cells and Cell-Free DNA Combined Detection in Triple-Negative Breast Cancer 外周血循环肿瘤细胞和无细胞DNA联合检测在癌症三阴性中的临床价值
抗癌研究 Pub Date : 2022-05-30 DOI: 10.26689/par.v6i3.4019
Jirui Sun, Shu-Tao Ma, Hong Chen, Huijuan Geng, Jinku Zhang
{"title":"Clinical Value of Peripheral Blood Circulating Tumor Cells and Cell-Free DNA Combined Detection in Triple-Negative Breast Cancer","authors":"Jirui Sun, Shu-Tao Ma, Hong Chen, Huijuan Geng, Jinku Zhang","doi":"10.26689/par.v6i3.4019","DOIUrl":"https://doi.org/10.26689/par.v6i3.4019","url":null,"abstract":"Objective: To determine the clinical value of combined detection of circulating tumor cells (CTCs) and cell-free DNA (cfDNA) in peripheral blood of patients with triple-negative breast cancer. Method: 41 patients with breast cancer admitted to the First Central Hospital of Baoding from January 2020 to December 2021 were selected and recruited into the experimental group, 42 patients with benign breast cancer admitted during the same period were recruited into the conditional control group, and 41 healthy patients admitted during the same period were recruited into the blank control group. The positive rate of peripheral blood CTCs, the level of cfDNA, and the diagnostic efficacy of peripheral blood CTCs, cfDNA alone and the combination thereof for breast cancer were analyzed. Result: The positive rates of peripheral blood CTCs in the experimental group, the conditional control group, and the blank control group were 43.90%, 11.90%, and 9.74%, respectively, and there was significant difference among the groups. The levels of cfDNA in peripheral blood of the experimental group, the conditional control group, and the blank control group were 0.26 ± 0.08 bp, 0.17 ± 0.03 bp, and 0.15 ± 0.04 bp, respectively, which were statistically significant. The detection levels of 100 bp hTERT/ng·ml-1 and 241 bp hTERT/ng·ml-1 in the experimental group were significantly higher than those in the conditional control group and the blank control group. The accuracy of peripheral blood CTCs detection in the three groups was 66.21%, the accuracy of cfDA241 bp / 100 bp hTERT detection was 80.41%, and the accuracy of combined detection of peripheral blood CTCs and cfDNA was 94.03%. Conclusion: The clinical application of peripheral blood CTCs combined with cfDNA level detection can increase detection accuracy, provide data support for clinicians, and improve the clinical diagnostic effect of triple-negative breast cancer.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48405983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress of Traditional Chinese and Western Medicine in Hyperthyroid Heart Disease 甲状腺功能亢进性心脏病的中西医研究进展
抗癌研究 Pub Date : 2022-05-30 DOI: 10.26689/par.v6i3.3984
Shu-ying Li, Mingjun Zhao
{"title":"Research Progress of Traditional Chinese and Western Medicine in Hyperthyroid Heart Disease","authors":"Shu-ying Li, Mingjun Zhao","doi":"10.26689/par.v6i3.3984","DOIUrl":"https://doi.org/10.26689/par.v6i3.3984","url":null,"abstract":"In recent years, hyperthyroid heart disease has become a condition with high incidence rate and high mortality rate. This paper discusses the pathogenesis, treatment, and influencing factors of hyperthyroid heart disease from two different angles – traditional Chinese medicine and western medicine – in hope to provide a reference basis for the treatment of hyperthyroid heart disease.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48999328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lei Genping’s Experience in Treating Recurrent Urinary Tract Infection 雷根平治疗复发性尿路感染的经验
抗癌研究 Pub Date : 2022-05-20 DOI: 10.26689/par.v6i3.3886
Lin Xia, Genping Lei
{"title":"Lei Genping’s Experience in Treating Recurrent Urinary Tract Infection","authors":"Lin Xia, Genping Lei","doi":"10.26689/par.v6i3.3886","DOIUrl":"https://doi.org/10.26689/par.v6i3.3886","url":null,"abstract":"In modern medicine, the therapeutic effect in recurrent urinary tract infection is often unsatisfactory. Lei Genping believes that urinary tract infection is mainly caused by the evil of dampness and heat invading the lower jiao (area below the navel). A prolonged disease course would result in the deficiency of spleen and kidney as well as the stagnation of liver and qi. The initial treatment should focus on clearing heat and detoxifying dampness. In the long run, the treatment criteria include tonifying the spleen and kidney, while clearing heat and dampness as well as regulating liver qi.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44564586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Melanoma: Current Status and Prospects 黑色素瘤的治疗:现状和前景
抗癌研究 Pub Date : 2022-05-20 DOI: 10.26689/par.v6i3.3875
Zhiyou Ye
{"title":"Treatment of Melanoma: Current Status and Prospects","authors":"Zhiyou Ye","doi":"10.26689/par.v6i3.3875","DOIUrl":"https://doi.org/10.26689/par.v6i3.3875","url":null,"abstract":"Melanoma is a tumor caused by the deterioration of melanocytes. Both genetic factors and environmental factors contribute to the occurrence of the disease. Melanoma accounts for about 1% to 3% of all malignant tumors, and its prevalence is increasing year by year at the rate of 3% to 5%. With the exception of early surgical resection, there is a lack of specific treatment for patients with melanoma, and many of them have poor prognosis. Treatment strategies for advanced melanoma have been developing rapidly in recent years. Many new therapeutic drugs have emerged and are being tested in recent years. This review focuses on the current development of melanoma treatment (specifically, gene targeted therapy and immunotherapy) and discusses future treatment possibilities.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42700421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Research Progress in the Application of Lycium Barbarum Polysaccharide in Ophthalmic Diseases 枸杞多糖在眼科疾病中的应用研究进展
抗癌研究 Pub Date : 2022-05-20 DOI: 10.26689/par.v6i3.3885
Yanna Lin, Hui-qian Wu
{"title":"Research Progress in the Application of Lycium Barbarum Polysaccharide in Ophthalmic Diseases","authors":"Yanna Lin, Hui-qian Wu","doi":"10.26689/par.v6i3.3885","DOIUrl":"https://doi.org/10.26689/par.v6i3.3885","url":null,"abstract":"Lycium barbarum polysaccharides (LBP) are widely used in age-related macular degeneration, glaucoma, diabetic retinopathy, and other eye diseases. With further studies on the pharmacological action of Lycium barbarum polysaccharides in recent years, researchers have found that Lycium barbarum polysaccharides (LBP) play a protective role in the treatment of various eye diseases through anti-oxidation, scavenging oxygen free radicals, and inhibiting inflammatory reaction as well as cell senescence. This paper reviews the application of Lycium barbarum polysaccharides in ophthalmology.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47554816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in the Use of Natural Products for the Treatment of Lung Cancer 天然产物治疗癌症的研究进展
抗癌研究 Pub Date : 2022-05-20 DOI: 10.26689/par.v6i3.3727
Songshan Teng, Zhuoxuan Liang, Tong Lyu, Yunchen Yang, Mengying Gou, Xiaoqiong He
{"title":"Progress in the Use of Natural Products for the Treatment of Lung Cancer","authors":"Songshan Teng, Zhuoxuan Liang, Tong Lyu, Yunchen Yang, Mengying Gou, Xiaoqiong He","doi":"10.26689/par.v6i3.3727","DOIUrl":"https://doi.org/10.26689/par.v6i3.3727","url":null,"abstract":"Lung cancer is a malignant disease with high morbidity and mortality, which affects the quality of life of patients. It has become one of the most serious public health problems in the world. Most natural products have a variety of anti-tumor activities. In recent years, scholars at home and abroad have studied the anti-tumor effect and mechanism of natural products from many aspects, especially in lung cancer. In this paper, the review on the active components of natural products in the treatment of lung cancer will provide a basis for subsequent treatment of lung cancer.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47068903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experience in Treating Viral Myocarditis with Master Lei’s Huoxue Decoction 雷师傅活血汤治疗病毒性心肌炎的体会
抗癌研究 Pub Date : 2022-05-20 DOI: 10.26689/par.v6i3.3882
Guoxing Sun, H. Fan
{"title":"Experience in Treating Viral Myocarditis with Master Lei’s Huoxue Decoction","authors":"Guoxing Sun, H. Fan","doi":"10.26689/par.v6i3.3882","DOIUrl":"https://doi.org/10.26689/par.v6i3.3882","url":null,"abstract":"Modern medical treatment of viral myocarditis by suppressing viral replication and improving cardiomyocyte metabolism has a good effect on the acute infectious period of viral myocarditis, but the curative rate is poor, especially the sequelae of viral myocarditis, which often lingers for years to decades. The use of traditional Chinese medicine can achieve a certain curative effect by promoting the positive and dispelling evil spirits as well as balancing yin and yang. After long-term observation, it is found to have clear effect on improving myocardial injury caused by viral myocarditis.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45453392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Efficacy of Hyperbaric Oxygen Therapy at Different Pressures in the Treatment of Sudden Deafness 不同压力高压氧治疗突发性耳聋的临床疗效观察
抗癌研究 Pub Date : 2022-03-23 DOI: 10.26689/par.v6i2.3805
Xinli Feng, Shuang Dong, Jun Wang, Jie Yang, Yamei Wang, Dahui Zhang, G. Peng, Jinhua Luo
{"title":"Clinical Efficacy of Hyperbaric Oxygen Therapy at Different Pressures in the Treatment of Sudden Deafness","authors":"Xinli Feng, Shuang Dong, Jun Wang, Jie Yang, Yamei Wang, Dahui Zhang, G. Peng, Jinhua Luo","doi":"10.26689/par.v6i2.3805","DOIUrl":"https://doi.org/10.26689/par.v6i2.3805","url":null,"abstract":"Objective: To analyze the efficacy of hyperbaric oxygen at different pressures in the treatment of sudden deafness. Methods: Eighty-two patients with sudden deafness treated in the Affiliated Hospital of Hebei University from September 2019 to September 2021 were selected as the research subjects. The patients were randomly divided into study group 1 and study group 2, and they were treated with hyperbaric oxygen on the basis of routine treatment, in which the pressure used was 1.8 ATA and 2.2 ATA, respectively. Oxygen was delivered via the pressure stabilizing mask for 60 minutes. The patients received two courses of treatment, each lasting 10 days. The changes in hearing (pure tone audiometry) and the clinical efficacy of both the groups were compared before and after treatment. The data obtained were statistically analyzed using SPSS 19.0. Results: The total effective rate of study group 1 was 90.00%, while that of study group 2 was 76.19%. The differences between the two groups were statistically significant (p < 0.05). Conclusion: For patients with sudden deafness treated with hyperbaric oxygen, the clinical efficacy of 1.8 ATA is more significant than that of 2.2 ATA.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46710153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Analysis of the Value of Gastroscopic Biopsy and Surgical Pathology in the Diagnosis of Gastric Cancer 胃镜活检与手术病理对胃癌诊断价值的比较分析
抗癌研究 Pub Date : 2022-03-23 DOI: 10.26689/par.v6i2.3702
Xiujuan Guo
{"title":"Comparative Analysis of the Value of Gastroscopic Biopsy and Surgical Pathology in the Diagnosis of Gastric Cancer","authors":"Xiujuan Guo","doi":"10.26689/par.v6i2.3702","DOIUrl":"https://doi.org/10.26689/par.v6i2.3702","url":null,"abstract":"Objective: To explore and analyze the diagnostic value of gastroscopic biopsy and surgical pathology in improving the diagnostic accuracy of gastric cancer. Methods: From May 2019 to June 2020, 80 patients with gastric cancer treated in Shuyang Xiehe Hospital were selected and divided into two groups, a control group and a study group, with 40 cases in each group, based on the examination method individually selected by the patients. The patients in the control group were investigated via gastroscopy, while those in the study group were investigated by surgical pathology. The diagnostic values of the two methods were compared and analyzed. Results: The diagnostic accuracy of patients in the study group was 100%, which was higher than that of the control group. The tissue type, lesion morphology, and cancer differentiation of the study group were better than those of the control group. There was significant difference between the two methods (P < 0.05). Conclusion: Surgical and pathological examination can improve the diagnostic accuracy of gastric cancer, comprehensively analyze the patient’s condition, and provide corresponding theoretical basis for follow-up treatment, so that patients can obtain more active and effective treatment, reduce pain, and improve their quality of life.","PeriodicalId":61025,"journal":{"name":"抗癌研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45193203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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